SUPERFAMILY 1.75 HMM library and genome assignments server


Plant invertase/pectin methylesterase inhibitor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Plant invertase/pectin methylesterase inhibitor [ 101148]
Families:   Plant invertase/pectin methylesterase inhibitor [ 101149] (2)


Superfamily statistics
Genomes (57) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 4,827 3,285 5
Proteins 4,770 3,263 5


Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0028710.4921Least InformativeInherited
Biological Process (BP)multicellular organismal process6.336e-050.02101Least InformativeInherited
Biological Process (BP)developmental process2.529e-050.007893Least InformativeInherited
Biological Process (BP)single-organism cellular process0.001920.2251Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis2.342e-050.002631Least InformativeInherited
Biological Process (BP)reproduction3.201e-060.0001111Moderately InformativeDirect
Biological Process (BP)multi-organism process9.886e-068.493e-10Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity8.611e-050.01619Moderately InformativeInherited
Biological Process (BP)cell differentiation4.013e-070.002225Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.017670.0194Moderately InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.00038340.0002314InformativeDirect
Biological Process (BP)growth2.122e-075.37e-06InformativeDirect
Biological Process (BP)negative regulation of catalytic activity2.493e-063.494e-05InformativeDirect
Biological Process (BP)multi-multicellular organism process3.914e-071.104e-06InformativeDirect
Biological Process (BP)cellular process involved in reproduction1.166e-076.92e-05InformativeDirect
Biological Process (BP)cellular component morphogenesis4.872e-050.005303InformativeInherited
Biological Process (BP)cell growth1.67e-084.042e-08Highly InformativeDirect
Biological Process (BP)developmental growth1.04e-094.373e-08Highly InformativeDirect
Biological Process (BP)cell morphogenesis involved in differentiation3.748e-090.001012Highly InformativeInherited
Molecular Function (MF)enzyme regulator activity1.039e-050.0004006Moderately InformativeDirect
Molecular Function (MF)enzyme inhibitor activity6.593e-072.542e-07InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.4921 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002631 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2251 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02101 Least Informative Inherited
Biological Process (BP) developmental process 0.007893 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02758 Least Informative Inherited
Biological Process (BP) reproduction 0.0001111 Moderately Informative Direct
Biological Process (BP) multi-organism process 8.493e-10 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.01619 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.002225 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0194 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0002314 Informative Direct
Biological Process (BP) growth 5.37e-06 Informative Direct
Biological Process (BP) negative regulation of catalytic activity 3.494e-05 Informative Direct
Biological Process (BP) multi-multicellular organism process 1.104e-06 Informative Direct
Biological Process (BP) cellular process involved in reproduction 6.92e-05 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 2.904e-06 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.005303 Informative Inherited
Biological Process (BP) cell growth 4.042e-08 Highly Informative Direct
Biological Process (BP) developmental growth 4.373e-08 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.001012 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.04548 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 6.243e-05 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.0004006 Moderately Informative Direct
Molecular Function (MF) enzyme inhibitor activity 2.542e-07 Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 6.178e-11 Highly Informative Direct
Cellular Component (CC) cell projection 0.002885 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 3.503e-05 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell wall biogenesis/degradation0InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)glycan metabolism0Moderately InformativeDirect
UniPathway (UP)glycan degradation0InformativeDirect
UniPathway (UP)pectin degradation0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR006501 SSF101148 Protein matches
Abstract

These sequences contain a plant domain of about 200 amino acids, characterised by four conserved cysteine residues. The functional importance of these residues has been studied in a pectinesterase inhibitor from Kiwi. The cysteine residues form two disulphide bonds: first to second and third to fourth [PubMed10880981]. Roughly half the members of this family have an adjacent C-terminal pectinesterase domain , suggesting that the pairing of the enzymatic domain and the cysteine domain reflect a conserved regulatory mechanism for this enzyme family.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Plant invertase/pectin methylesterase inhibitor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Plant invertase/pectin methylesterase inhibitor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]