SUPERFAMILY 1.75 HMM library and genome assignments server

Dimerization cofactor of HNF-1 alpha superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerisation interlock [ 47405] (4)
Superfamily:   Dimerization cofactor of HNF-1 alpha [ 100957]
Families:   Dimerization cofactor of HNF-1 alpha [ 100958]


Superfamily statistics
Genomes (65) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 166 172 4
Proteins 166 172 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0004269 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002498 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000000004622 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00001606 Least Informative Direct
Biological Process (BP) developmental process 0.00000801 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003776 Least Informative Direct
Biological Process (BP) positive regulation of biological process 0.00000000003643 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000299 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0007117 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.058 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001426 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.6429 Least Informative Inherited
Biological Process (BP) localization 0.009602 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1206 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.00000000000003411 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0004829 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001226 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.000000000001792 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000001485 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000001825 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000000000007793 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0000001833 Moderately Informative Direct
Biological Process (BP) reproductive process 0.000000006575 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000000003246 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0002731 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0000001788 Moderately Informative Direct
Biological Process (BP) organ development 0.00000001083 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000005203 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00003709 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000004815 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000005684 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000007601 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001387 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1315 Moderately Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00001053 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) secretion by cell 0.0000000007058 Informative Direct
Biological Process (BP) single organism reproductive process 0.000000003468 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0001175 Informative Direct
Biological Process (BP) reproductive structure development 0.00000006901 Informative Direct
Biological Process (BP) gland development 0.0000003663 Informative Direct
Biological Process (BP) positive regulation of RNA metabolic process 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.000000008911 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.04751 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.002016 Informative Inherited
Biological Process (BP) in utero embryonic development 0.00000002797 Highly Informative Direct
Biological Process (BP) kidney development 0.0000002378 Highly Informative Direct
Biological Process (BP) response to carbohydrate 0.00000000001094 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000000000001414 Highly Informative Direct
Biological Process (BP) signal release 0.000000000002899 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) amide transport 0.0000000000002285 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-templated 0 Highly Informative Direct
Molecular Function (MF) binding 0.00009952 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.000000001917 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.00000000001775 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000000002924 Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0008389 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00000000000001434 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000006264 Least Informative Direct
Cellular Component (CC) protein complex 0.000002879 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.7559 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0006926 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.3779 Moderately Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization cofactor of HNF-1 alpha domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization cofactor of HNF-1 alpha superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]