SUPERFAMILY 1.75 HMM library and genome assignments server

Dimerization cofactor of HNF-1 alpha superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerisation interlock [ 47405] (4)
Superfamily:   Dimerization cofactor of HNF-1 alpha [ 100957]
Families:   Dimerization cofactor of HNF-1 alpha [ 100958]


Superfamily statistics
Genomes (64) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 164 172 4
Proteins 164 172 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0003923 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00025 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0000000003182 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000236 Least Informative Direct
Biological Process (BP) developmental process 0.000007838 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003472 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000002653 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0006601 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001316 Least Informative Inherited
Biological Process (BP) localization 0.008583 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3731 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1206 Least Informative Inherited
Biological Process (BP) reproduction 0.00000002314 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0004648 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001206 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0000000000007592 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0000000000001396 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0000001775 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000000000006728 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000000178 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0000000000003063 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000174 Moderately Informative Direct
Biological Process (BP) organ development 0.00000001194 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.000000000001883 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00004517 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000004709 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0000005539 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.000007408 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001527 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1317 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.000001156 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0.000009868 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) secretion by cell 0.000000001292 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000344 Informative Direct
Biological Process (BP) reproductive system development 0.0000001564 Informative Direct
Biological Process (BP) nitrogen compound transport 0.000000008773 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001965 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04738 Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.00000000001078 Highly Informative Direct
Biological Process (BP) hormone transport 0.0000000000000161 Highly Informative Direct
Biological Process (BP) signal release 0.0000000000029 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) amide transport 0.0000000000002373 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) renal system development 0.000004569 Highly Informative Direct
Molecular Function (MF) binding 0.00009265 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.0000000009412 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 0.00000000001701 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000000002899 Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0008442 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.00000000000001188 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00000009608 Least Informative Direct
Cellular Component (CC) protein complex 0.000003059 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0544 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00000006818 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01154 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.04532 Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization cofactor of HNF-1 alpha domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization cofactor of HNF-1 alpha superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]