SUPERFAMILY 1.75 HMM library and genome assignments server


Dimerization cofactor of HNF-1 alpha superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Dimerisation interlock [ 47405] (4)
Superfamily:   Dimerization cofactor of HNF-1 alpha [ 100957]
Families:   Dimerization cofactor of HNF-1 alpha [ 100958]


Superfamily statistics
Genomes (65) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 166 172 4
Proteins 166 172 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.000389 Least Informative Direct
Biological Process (BP) biosynthetic process 0.000247 Least Informative Direct
Biological Process (BP) regulation of metabolic process 2.894e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.34e-05 Least Informative Direct
Biological Process (BP) developmental process 7.804e-06 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003445 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.493e-07 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0006544 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001304 Least Informative Inherited
Biological Process (BP) localization 0.008359 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3712 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1193 Least Informative Inherited
Biological Process (BP) reproduction 2.277e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 1.931e-15 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0004524 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0001163 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 6.716e-13 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1.315e-13 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.468e-07 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 6.257e-13 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 1.47e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 2.893e-13 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 1.429e-07 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.08e-06 Moderately Informative Direct
Biological Process (BP) organ development 1.186e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.599e-12 Moderately Informative Direct
Biological Process (BP) cellular localization 4.463e-05 Moderately Informative Direct
Biological Process (BP) organic substance transport 4.697e-06 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 4.719e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 6.983e-06 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.001477 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.131 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1.114e-06 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 1.027e-05 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0 Informative Direct
Biological Process (BP) secretion by cell 1.262e-09 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0003486 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0 Informative Direct
Biological Process (BP) reproductive system development 1.567e-07 Informative Direct
Biological Process (BP) nitrogen compound transport 8.739e-09 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.001902 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.04791 Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 1.037e-11 Highly Informative Direct
Biological Process (BP) hormone transport 1.604e-14 Highly Informative Direct
Biological Process (BP) signal release 2.667e-12 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) endocrine system development 0 Highly Informative Direct
Biological Process (BP) amide transport 2.274e-13 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0 Highly Informative Direct
Biological Process (BP) renal system development 4.619e-06 Highly Informative Direct
Molecular Function (MF) binding 8.899e-05 Least Informative Direct
Molecular Function (MF) nucleic acid binding 9.232e-10 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) DNA binding 1.616e-11 Informative Direct
Molecular Function (MF) protein dimerization activity 2.957e-12 Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0008522 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 9.694e-15 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 9.294e-08 Least Informative Direct
Cellular Component (CC) protein complex 3.097e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.05442 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 6.849e-08 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.01172 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.04544 Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Dimerization cofactor of HNF-1 alpha domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Dimerization cofactor of HNF-1 alpha superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]