SUPERFAMILY 1.75 HMM library and genome assignments server


NagB/RpiA/CoA transferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NagB/RpiA/CoA transferase-like [ 100949]
Superfamily:   NagB/RpiA/CoA transferase-like [ 100950] (8)
Families:   NagB-like [ 52513] (2)
  D-ribose-5-phosphate isomerase (RpiA), catalytic domain [ 75176]
  CoA transferase beta subunit-like [ 74657] (3)
  CoA transferase alpha subunit-like [ 74656] (6)
  IF2B-like [ 110513] (5)
  Methenyltetrahydrofolate synthetase [ 110520] (3)
  YkgG-like [ 142200]
  SorC sugar-binding domain-like [ 159545] (5)


Superfamily statistics
Genomes (3,157) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 34,059 94,334 41
Proteins 30,896 85,281 34


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.92481Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.010750.3398Least InformativeInherited
Biological Process (BP)regulation of cellular process0.67861Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)multicellular organismal process0.30411Least InformativeInherited
Biological Process (BP)developmental process0.021591Least InformativeInherited
Biological Process (BP)localization0.92631Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.96150.01903Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.84721Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.97271Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.9791Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.6281Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.97941Least InformativeInherited
Biological Process (BP)biosynthetic process0.5330.1488Least InformativeInherited
Biological Process (BP)protein metabolic process0.087260.8306Least InformativeInherited
Biological Process (BP)gene expression1.93e-079.606e-12Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process6.345e-082.86e-12Moderately InformativeDirect
Biological Process (BP)regulation of catalytic activity4.078e-065.121e-05Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process3.156e-063.746e-15Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.10925.603e-06Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.00010180.02658Moderately InformativeInherited
Biological Process (BP)response to organic substance0.55750.8914Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.27640.1465Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10.0002011Moderately InformativeInherited
Biological Process (BP)system process0.021390.25Moderately InformativeInherited
Biological Process (BP)cell differentiation0.00041420.23Moderately InformativeInherited
Biological Process (BP)nervous system development0.00014550.03522Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.10550.2007Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.03491Moderately InformativeInherited
Biological Process (BP)organ development0.62841Moderately InformativeInherited
Biological Process (BP)cellular localization0.19320.5661Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.18110.1923Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.12331Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.18620.005237Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.014550.000223Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.33210.7633Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.22280.5343Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.84610.68Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.019130.4305Moderately InformativeInherited
Biological Process (BP)reproduction9.557e-050.02174Moderately InformativeInherited
Biological Process (BP)translation1.644e-140InformativeDirect
Biological Process (BP)central nervous system development9.393e-091.918e-05InformativeDirect
Biological Process (BP)regulation of nucleoside metabolic process2.261e-095.37e-12InformativeDirect
Biological Process (BP)transmission of nerve impulse2.512e-050.0009806InformativeDirect
Biological Process (BP)regulation of nucleotide catabolic process3.565e-121.334e-12InformativeDirect
Biological Process (BP)single organism reproductive process3.621e-088.17e-06InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process5.517e-090InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process8.627e-116.557e-11InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.0011060.27InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.55340.1246InformativeInherited
Biological Process (BP)vesicle-mediated transport0.032690.3805InformativeInherited
Biological Process (BP)secretion by cell8.599e-050.03291InformativeInherited
Biological Process (BP)sexual reproduction0.14720.5003InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.0076940.2738InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.00029340.02116InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0052650.003851InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.012194.279e-08InformativeInherited
Biological Process (BP)hexose metabolic process1.924e-060.06319InformativeInherited
Biological Process (BP)reproductive structure development0.0019490.001708InformativeInherited
Biological Process (BP)amino sugar metabolic process00Highly InformativeDirect
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation0.00043824.419e-05Highly InformativeDirect
Biological Process (BP)folic acid-containing compound metabolic process1.165e-060.0003869Highly InformativeDirect
Biological Process (BP)gonad development8.266e-061.081e-07Highly InformativeDirect
Biological Process (BP)response to heat0.00033641.76e-05Highly InformativeDirect
Biological Process (BP)response to carbohydrate stimulus5.355e-050.0003651Highly InformativeDirect
Biological Process (BP)glial cell differentiation6.611e-130Highly InformativeDirect
Biological Process (BP)ovulation cycle process1.057e-071.896e-11Highly InformativeDirect
Biological Process (BP)regulation of membrane potential2.296e-071.991e-07Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process1.573e-100Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics1.75e-072.197e-10Highly InformativeDirect
Biological Process (BP)exocytosis9.512e-060.001333Highly InformativeInherited
Biological Process (BP)fertilization0.00043930.004844Highly InformativeInherited
Molecular Function (MF)binding0.21281Least InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)isomerase activity4.074e-140Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity1.546e-087.439e-10Moderately InformativeDirect
Molecular Function (MF)anion binding0.0064090.06519Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0023483.942e-07Moderately InformativeInherited
Molecular Function (MF)nucleic acid binding7.261e-130.001144Moderately InformativeInherited
Molecular Function (MF)RNA binding6.072e-053.52e-11InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity5.686e-141.036e-14InformativeDirect
Molecular Function (MF)purine ribonucleoside binding7.456e-050.0005958InformativeDirect
Molecular Function (MF)purine ribonucleoside triphosphate binding3.679e-050.0007908InformativeDirect
Molecular Function (MF)nucleotide binding0.00042910.4035InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds7.465e-070.001886InformativeInherited
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding00Highly InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses00Highly InformativeDirect
Molecular Function (MF)deaminase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity3.1e-091.321e-10Highly InformativeDirect
Cellular Component (CC)protein complex0.0010250.1189Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.22191.978e-07Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.3398 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.01903 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.1488 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.8306 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 5.603e-06 Moderately Informative Direct
Biological Process (BP) gene expression 9.606e-12 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0002011 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 2.86e-12 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 5.121e-05 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 3.746e-15 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.000223 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.02658 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8914 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1465 Moderately Informative Inherited
Biological Process (BP) system process 0.25 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.23 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03522 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2007 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.5661 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.1923 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.005237 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.7633 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.5343 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.68 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.6065 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.4305 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02174 Moderately Informative Inherited
Biological Process (BP) translation 0 Informative Direct
Biological Process (BP) central nervous system development 1.918e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 5.37e-12 Informative Direct
Biological Process (BP) carbohydrate catabolic process 4.279e-08 Informative Direct
Biological Process (BP) transmission of nerve impulse 0.0009806 Informative Direct
Biological Process (BP) regulation of nucleotide catabolic process 1.334e-12 Informative Direct
Biological Process (BP) single organism reproductive process 8.17e-06 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 6.557e-11 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.1246 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.00148 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.3805 Informative Inherited
Biological Process (BP) secretion by cell 0.03291 Informative Inherited
Biological Process (BP) sexual reproduction 0.5003 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.2738 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.02116 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.003851 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.27 Informative Inherited
Biological Process (BP) hexose metabolic process 0.06319 Informative Inherited
Biological Process (BP) reproductive structure development 0.001708 Informative Inherited
Biological Process (BP) amino sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 4.419e-05 Highly Informative Direct
Biological Process (BP) folic acid-containing compound metabolic process 0.0003869 Highly Informative Direct
Biological Process (BP) gonad development 1.081e-07 Highly Informative Direct
Biological Process (BP) response to heat 1.76e-05 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 0.0003651 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) pentose metabolic process 0.0006049 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.896e-11 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.991e-07 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 2.197e-10 Highly Informative Direct
Biological Process (BP) exocytosis 0.001333 Highly Informative Inherited
Biological Process (BP) fertilization 0.004844 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 3.942e-07 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 7.439e-10 Moderately Informative Direct
Molecular Function (MF) anion binding 0.06519 Moderately Informative Inherited
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.001144 Moderately Informative Inherited
Molecular Function (MF) RNA binding 3.52e-11 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 1.036e-14 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.0005958 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0007908 Informative Direct
Molecular Function (MF) nucleotide binding 0.4035 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.001886 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.00113 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0005247 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct
Molecular Function (MF) deaminase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 1.321e-10 Highly Informative Direct
Molecular Function (MF) thiolester hydrolase activity 0.0153 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1.978e-07 Least Informative Direct
Cellular Component (CC) protein complex 0.1189 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases1.442e-14Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases2.533e-05InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.01457InformativeInherited
Enzyme Commission (EC)In other compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2594Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.04394Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of brain morphology0.1373Moderately InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.001408InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.004252InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum1InformativeInherited
Phenotypic Abnormality (PA)Leukoencephalopathy4.432e-06Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0001445Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases8.007e-15InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.01301Highly InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0.2663Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Post-translational modificationHydrolase8.17e-07Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationRepressor3.132e-06Moderately InformativeDirect
Post-translational modificationInitiation factor1.49e-08InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)lipid metabolism0.9405Least InformativeInherited
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism0.2781Moderately InformativeInherited
UniPathway (UP)pentose phosphate pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NagB/RpiA/CoA transferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the NagB/RpiA/CoA transferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]