SUPERFAMILY 1.75 HMM library and genome assignments server


NagB/RpiA/CoA transferase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NagB/RpiA/CoA transferase-like [ 100949]
Superfamily:   NagB/RpiA/CoA transferase-like [ 100950] (8)
Families:   NagB-like [ 52513] (2)
  D-ribose-5-phosphate isomerase (RpiA), catalytic domain [ 75176]
  CoA transferase beta subunit-like [ 74657] (3)
  CoA transferase alpha subunit-like [ 74656] (6)
  IF2B-like [ 110513] (5)
  Methenyltetrahydrofolate synthetase [ 110520] (3)
  YkgG-like [ 142200]
  SorC sugar-binding domain-like [ 159545] (5)


Superfamily statistics
Genomes (2,454) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 27,153 94,334 41
Proteins 24,547 85,281 34


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus0.97091Least InformativeInherited
Biological Process (BP)multicellular organismal process0.53261Least InformativeInherited
Biological Process (BP)developmental process0.062121Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.56260.9796Least InformativeInherited
Biological Process (BP)single-organism metabolic process10.04295Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.41760.7391Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.038440.5342Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.79571Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process0.77570.2559Least InformativeInherited
Biological Process (BP)protein metabolic process0.14040.8476Least InformativeInherited
Biological Process (BP)gene expression1.458e-066.095e-12Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process6.015e-078.462e-13Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process9.186e-073.682e-14Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.00091442.173e-05Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00091555.425e-05Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.10737.11e-06Moderately InformativeInherited
Biological Process (BP)reproduction0.00036470.02531Moderately InformativeInherited
Biological Process (BP)response to organic substance0.67260.8577Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.36780.2024Moderately InformativeInherited
Biological Process (BP)system process0.030980.2654Moderately InformativeInherited
Biological Process (BP)cell differentiation0.0011080.2159Moderately InformativeInherited
Biological Process (BP)nervous system development0.00033080.03992Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.07920.3042Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.076961Moderately InformativeInherited
Biological Process (BP)organ development0.61291Moderately InformativeInherited
Biological Process (BP)cellular localization0.29120.563Moderately InformativeInherited
Biological Process (BP)cellular amino acid metabolic process0.084190.09353Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.098330.996Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.098190.00137Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.0016798.92e-06Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.40780.8952Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.45330.9642Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process0.84471Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.35210.5316Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.017610.199Moderately InformativeInherited
Biological Process (BP)homeostatic process0.017690.06287Moderately InformativeInherited
Biological Process (BP)central nervous system development3.912e-082.274e-05InformativeDirect
Biological Process (BP)single organism reproductive process1.088e-076.147e-06InformativeDirect
Biological Process (BP)pyridine-containing compound metabolic process1.956e-090InformativeDirect
Biological Process (BP)carbohydrate derivative catabolic process0.00092810.05263InformativeInherited
Biological Process (BP)oxidoreduction coenzyme metabolic process0.025720.0005679InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.46270.09299InformativeInherited
Biological Process (BP)vesicle-mediated transport0.074170.4233InformativeInherited
Biological Process (BP)secretion0.0006240.08374InformativeInherited
Biological Process (BP)sexual reproduction0.12240.4249InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.015390.3191InformativeInherited
Biological Process (BP)cellular modified amino acid metabolic process0.0001030.008353InformativeInherited
Biological Process (BP)posttranscriptional regulation of gene expression0.0073330.002942InformativeInherited
Biological Process (BP)carbohydrate catabolic process0.0024451.787e-07InformativeInherited
Biological Process (BP)hexose metabolic process8.075e-070.09604InformativeInherited
Biological Process (BP)reproductive system development0.0042950.001538InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.16920.007512InformativeInherited
Biological Process (BP)amino sugar metabolic process08.164e-14Highly InformativeDirect
Biological Process (BP)translational initiation00Highly InformativeDirect
Biological Process (BP)regulation of translation0.00049412.446e-05Highly InformativeDirect
Biological Process (BP)gonad development8.779e-061.266e-07Highly InformativeDirect
Biological Process (BP)response to heat0.00042670.0006523Highly InformativeDirect
Biological Process (BP)response to carbohydrate stimulus0.00011375.551e-05Highly InformativeDirect
Biological Process (BP)glial cell differentiation1.561e-120Highly InformativeDirect
Biological Process (BP)ovulation cycle process3.902e-073.548e-11Highly InformativeDirect
Biological Process (BP)regulation of membrane potential6.184e-071.345e-07Highly InformativeDirect
Biological Process (BP)pteridine-containing compound metabolic process2.883e-075.829e-07Highly InformativeDirect
Biological Process (BP)nicotinamide nucleotide metabolic process2.586e-110Highly InformativeDirect
Biological Process (BP)development of primary female sexual characteristics5.883e-073.936e-10Highly InformativeDirect
Biological Process (BP)exocytosis9.437e-060.001604Highly InformativeInherited
Biological Process (BP)fertilization0.00046750.003914Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)transferase activity0.22680.02788Least InformativeInherited
Molecular Function (MF)binding0.8971Least InformativeInherited
Molecular Function (MF)isomerase activity3.306e-110Moderately InformativeDirect
Molecular Function (MF)enzyme regulator activity4.31e-077.214e-09Moderately InformativeDirect
Molecular Function (MF)organic cyclic compound binding5.274e-060.0002513Moderately InformativeDirect
Molecular Function (MF)heterocyclic compound binding2.573e-060.0001804Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on ester bonds0.0076718.024e-06Moderately InformativeInherited
Molecular Function (MF)anion binding0.021720.08799Moderately InformativeInherited
Molecular Function (MF)RNA binding5.08e-052.528e-11InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity1.958e-131.61e-14InformativeDirect
Molecular Function (MF)nucleotide binding0.0017580.4312InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds2.745e-060.002291InformativeInherited
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding00Highly InformativeDirect
Molecular Function (MF)intramolecular oxidoreductase activity, interconverting aldoses and ketoses00Highly InformativeDirect
Molecular Function (MF)deaminase activity00Highly InformativeDirect
Molecular Function (MF)carboxylic ester hydrolase activity9.782e-092.856e-12Highly InformativeDirect
Cellular Component (CC)protein complex0.0020940.08765Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.1551.067e-06Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.04295 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.9796 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7391 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.5342 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.2559 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.8476 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 7.11e-06 Moderately Informative Direct
Biological Process (BP) gene expression 6.095e-12 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 8.462e-13 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 3.682e-14 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 8.92e-06 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 2.173e-05 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 5.425e-05 Moderately Informative Direct
Biological Process (BP) reproduction 0.02531 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8577 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2024 Moderately Informative Inherited
Biological Process (BP) system process 0.2654 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2159 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.03992 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3042 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.563 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.09353 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.996 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.00137 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.8952 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.9642 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.5316 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.627 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.199 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.06287 Moderately Informative Inherited
Biological Process (BP) oxidoreduction coenzyme metabolic process 0.0005679 Informative Direct
Biological Process (BP) central nervous system development 2.274e-05 Informative Direct
Biological Process (BP) carbohydrate catabolic process 1.787e-07 Informative Direct
Biological Process (BP) single organism reproductive process 6.147e-06 Informative Direct
Biological Process (BP) pyridine-containing compound metabolic process 0 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 0.09299 Informative Inherited
Biological Process (BP) cellular ketone metabolic process 0.004022 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.4233 Informative Inherited
Biological Process (BP) secretion 0.08374 Informative Inherited
Biological Process (BP) sexual reproduction 0.4249 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.3191 Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0.008353 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.002942 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.05263 Informative Inherited
Biological Process (BP) hexose metabolic process 0.09604 Informative Inherited
Biological Process (BP) reproductive system development 0.001538 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.007512 Informative Inherited
Biological Process (BP) amino sugar metabolic process 8.164e-14 Highly Informative Direct
Biological Process (BP) translational initiation 0 Highly Informative Direct
Biological Process (BP) regulation of translation 2.446e-05 Highly Informative Direct
Biological Process (BP) gonad development 1.266e-07 Highly Informative Direct
Biological Process (BP) response to heat 0.0006523 Highly Informative Direct
Biological Process (BP) response to carbohydrate stimulus 5.551e-05 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0 Highly Informative Direct
Biological Process (BP) ovulation cycle process 3.548e-11 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 1.345e-07 Highly Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 5.829e-07 Highly Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 3.936e-10 Highly Informative Direct
Biological Process (BP) exocytosis 0.001604 Highly Informative Inherited
Biological Process (BP) fertilization 0.003914 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.02788 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 8.024e-06 Moderately Informative Direct
Molecular Function (MF) isomerase activity 0 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 7.214e-09 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 0.0002513 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.0001804 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.08799 Moderately Informative Inherited
Molecular Function (MF) RNA binding 2.528e-11 Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) GTPase regulator activity 1.61e-14 Informative Direct
Molecular Function (MF) nucleotide binding 0.4312 Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.002291 Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on CH-OH group of donors 0.001057 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0004547 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0 Highly Informative Direct
Molecular Function (MF) deaminase activity 0 Highly Informative Direct
Molecular Function (MF) carboxylic ester hydrolase activity 2.856e-12 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1.067e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.08765 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases1.442e-14Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related c0InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases2.533e-05InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.01457InformativeInherited
Enzyme Commission (EC)In other compounds0Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
ONset and clinical course (ON)Juvenile onset0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.02473Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the central nervous system0.3869Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4637Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.4889Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.0889Moderately InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the central nervous system0.09284Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genital system0.1649Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.1885Moderately InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.0001512InformativeDirect
Phenotypic Abnormality (PA)Lethargy0.0002101InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0.01259InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.01459InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0.02497InformativeInherited
Phenotypic Abnormality (PA)Behavioural/Psychiatric Abnormality0.08661InformativeInherited
Phenotypic Abnormality (PA)Cessation of head growth2.504e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Leukoencephalopathy9.275e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebral hypomyelination1.574e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Personality changes3.727e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Delusions1.76e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Unsteady gait2.823e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability8.933e-06Highly InformativeDirect
Phenotypic Abnormality (PA)CNS demyelination1.192e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Memory impairment1.78e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Primary gonadal insufficiency6.317e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased serum progesterone6.317e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the optic nerve0.001415Highly InformativeInherited
Phenotypic Abnormality (PA)Hypertonia0.00286Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of vision0.05667Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.09035Highly InformativeInherited
Phenotypic Abnormality (PA)Amenorrhea0.2617Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0001469Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases0InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases2.585e-14InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Interconverting aldoses and ketoses, and related compounds0Highly InformativeDirect
Enzyme Commission (EC)Cyclo-ligases0.0132Highly InformativeInherited
Enzyme Commission (EC)Oxo-acid-lyases0.2454Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processInitiation factor1.118e-14InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Post-translational modificationHydrolase2.427e-07Least InformativeDirect
Post-translational modificationIsomerase0Moderately InformativeDirect
Post-translational modificationRepressor2.229e-06Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism0.2272Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)lipid metabolism1Least InformativeInherited
UniPathway (UP)carbohydrate degradation0Moderately InformativeDirect
UniPathway (UP)amine and polyamine metabolism0Moderately InformativeDirect
UniPathway (UP)proteinogenic amino-acid biosynthesis8.878e-16Moderately InformativeDirect
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)amino-sugar metabolism0InformativeDirect
UniPathway (UP)amine and polyamine degradation0InformativeDirect
UniPathway (UP)L-methionine biosynthesis0InformativeDirect
UniPathway (UP)pentose phosphate pathway0Highly InformativeDirect
UniPathway (UP)N-acetylneuraminate degradation0Highly InformativeDirect
UniPathway (UP)L-methionine biosynthesis via salvage pathway0Highly InformativeDirect
UniPathway (UP)beta-ketoadipate pathway4.726e-07Highly InformativeDirect
UniPathway (UP)ketone degradation1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 32 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NagB/RpiA/CoA transferase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 32 hidden Markov models representing the NagB/RpiA/CoA transferase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]