SUPERFAMILY 1.75 HMM library and genome assignments server

SPOC domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SPOC domain-like [ 100938]
Superfamily:   SPOC domain-like [ 100939] (3)
Families:   SPOC domain [ 101856]
  Ku70 subunit middle domain [ 100940]
  Ku80 subunit middle domain [ 100943]


Superfamily statistics
Genomes (1,043) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,263 4,077 3
Proteins 2,239 4,067 3


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.006180.0000006367Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000064150Moderately InformativeDirect
Molecular Function (MF)DNA binding0.000000014080.00636InformativeInherited
Molecular Function (MF)structure-specific DNA binding0.000000000016270.0000000000000536Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000000009454 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000003257 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000000002489 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00001446 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.08342 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001994 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.02212 Least Informative Inherited
Biological Process (BP) developmental process 0.009865 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.0401 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.0000000000001116 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000000001002 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.000000000003782 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00000000001652 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00000000006611 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.00000000009393 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000001576 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.00002955 Moderately Informative Direct
Biological Process (BP) immune system process 0.00009137 Moderately Informative Direct
Biological Process (BP) organ development 0.0005144 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.04477 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8238 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01565 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03516 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.005494 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.0487 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3769 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 0.002907 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1774 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) DNA repair 0 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0000000000003466 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.000000000003353 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00001901 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001162 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0001294 Informative Direct
Biological Process (BP) epithelium development 0.0001853 Informative Direct
Biological Process (BP) tube development 0.0004051 Informative Direct
Biological Process (BP) reproductive structure development 0.0005183 Informative Direct
Biological Process (BP) single organism reproductive process 0.04293 Informative Inherited
Biological Process (BP) cardiovascular system development 0.006224 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.02846 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.03287 Informative Inherited
Biological Process (BP) positive regulation of RNA metabolic process 0.1233 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1889 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2079 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.252 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.007221 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01589 Informative Inherited
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-templated 0.000000000007174 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000005055 Highly Informative Direct
Biological Process (BP) placenta development 0.0000000006775 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0000000007221 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.000000002895 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0000000498 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.0000005869 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000000683 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0000007695 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.000001536 Highly Informative Direct
Biological Process (BP) gene silencing 0.000216 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.01629 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.4588 Highly Informative Inherited
Molecular Function (MF) binding 0.0000006367 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2709 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0004427 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.000432 Informative Direct
Molecular Function (MF) DNA binding 0.00636 Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.0000000000000536 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding 1 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000003933 Least Informative Direct
Cellular Component (CC) protein complex 0.1576 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.02958 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.6184 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0002838 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.04477 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.003849 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.01757 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased leukocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult sense organ0Moderately InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentTelomere0.000000000000004758Highly InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionNucleotide-binding0.04301Least InformativeInherited
Molecular functionATP-binding0.00000004197Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000001811Least InformativeDirect
Post-translational modificationActivator0.00002048Moderately InformativeDirect
Post-translational modificationHelicase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SPOC domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the SPOC domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]