SUPERFAMILY 1.75 HMM library and genome assignments server


SPOC domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SPOC domain-like [ 100938]
Superfamily:   SPOC domain-like [ 100939] (3)
Families:   SPOC domain [ 101856]
  Ku70 subunit middle domain [ 100940]
  Ku80 subunit middle domain [ 100943]


Superfamily statistics
Genomes (1,043) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,262 4,077 3
Proteins 2,238 4,067 3


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.0054541.17e-06Least InformativeInherited
Molecular Function (MF)nucleic acid binding3.789e-070Moderately InformativeDirect
Molecular Function (MF)DNA binding1.229e-080.002503InformativeInherited
Molecular Function (MF)structure-specific DNA binding1.501e-114.09e-14Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 1.273e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.766e-13 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1.567e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.06351 Least Informative Inherited
Biological Process (BP) developmental process 0.01092 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05244 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001508 Least Informative Inherited
Biological Process (BP) homeostatic process 3.135e-14 Moderately Informative Direct
Biological Process (BP) cellular response to stress 6.896e-14 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 9.766e-14 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1.15e-13 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 2.458e-10 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 4.151e-07 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.289e-06 Moderately Informative Direct
Biological Process (BP) immune system process 9.959e-05 Moderately Informative Direct
Biological Process (BP) organ development 0.0006162 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.04183 Moderately Informative Inherited
Biological Process (BP) tissue development 0.176 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.05365 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.06394 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.0492 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.3198 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8245 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01262 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 8.05e-11 Informative Direct
Biological Process (BP) negative regulation of gene expression 1.33e-09 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 2.52e-09 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 2.482e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 5.064e-05 Informative Direct
Biological Process (BP) tube development 9.134e-05 Informative Direct
Biological Process (BP) epithelium development 0.0001103 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.02064 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.2591 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.3077 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.4119 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.5459 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.005992 Informative Inherited
Biological Process (BP) organ morphogenesis 0.006318 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01498 Informative Inherited
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) placenta development 7.133e-10 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 7.28e-10 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 7.957e-10 Highly Informative Direct
Biological Process (BP) double-strand break repair 2.141e-09 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 4.633e-09 Highly Informative Direct
Biological Process (BP) angiogenesis 2.734e-08 Highly Informative Direct
Biological Process (BP) pattern specification process 4.565e-07 Highly Informative Direct
Biological Process (BP) heart morphogenesis 6.086e-07 Highly Informative Direct
Biological Process (BP) response to salt stress 7.352e-07 Highly Informative Direct
Biological Process (BP) cellular response to radiation 9.926e-07 Highly Informative Direct
Biological Process (BP) gene silencing 0.0004324 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.01077 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.603 Highly Informative Inherited
Molecular Function (MF) binding 1.17e-06 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.293 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0004355 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000854 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0005354 Informative Direct
Molecular Function (MF) DNA binding 0.002503 Informative Inherited
Molecular Function (MF) structure-specific DNA binding 4.09e-14 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 2.684e-10 Least Informative Direct
Cellular Component (CC) protein complex 0.2401 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.06284 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.7055 Least Informative Inherited
Cellular Component (CC) nuclear part 0.002688 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.09476 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.004695 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.01104 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased leukocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sense organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentTelomere5.054e-15Highly InformativeDirect
Molecular functionNucleotide-binding0.04449Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionATP-binding4.22e-08Moderately InformativeDirect
Post-translational modificationHydrolase1.661e-11Least InformativeDirect
Post-translational modificationActivator2.046e-05Moderately InformativeDirect
Post-translational modificationHelicase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SPOC domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the SPOC domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]