SUPERFAMILY 1.75 HMM library and genome assignments server

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SPOC domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SPOC domain-like [ 100938]
Superfamily:   SPOC domain-like [ 100939] (3)
Families:   SPOC domain [ 101856]
  Ku70 subunit middle domain [ 100940]
  Ku80 subunit middle domain [ 100943]


Superfamily statistics
Genomes (1,042) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,261 4,077 3
Proteins 2,237 4,067 3


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.005970.0000007356Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.00000042480Moderately InformativeDirect
Molecular Function (MF)DNA binding0.000000013560.002454InformativeInherited
Molecular Function (MF)structure-specific DNA binding0.000000000016350.00000000000004275Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000000008767 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000000005737 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000007089 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.05908 Least Informative Inherited
Biological Process (BP) developmental process 0.00988 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.06787 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.001394 Least Informative Inherited
Biological Process (BP) cellular response to stress 0.000000000000075 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.000000000001177 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.000000000003164 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.00000000000448 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0000000000164 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.00000000001846 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000000007514 Moderately Informative Direct
Biological Process (BP) immune system process 0.00009241 Moderately Informative Direct
Biological Process (BP) organ development 0.0006225 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.04357 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1755 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.8759 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02466 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.03376 Moderately Informative Inherited
Biological Process (BP) signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.01489 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1926 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8218 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.006056 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01234 Moderately Informative Inherited
Biological Process (BP) chromosome organization 0 Informative Direct
Biological Process (BP) DNA metabolic process 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 0 Informative Direct
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.0000000000002637 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.000000000005181 Informative Direct
Biological Process (BP) negative regulation of biosynthetic process 0.00000000001036 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00002505 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00005425 Informative Direct
Biological Process (BP) tube development 0.00008943 Informative Direct
Biological Process (BP) epithelium development 0.00009557 Informative Direct
Biological Process (BP) negative regulation of developmental process 0.02001 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.1341 Informative Inherited
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.1637 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.2332 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.3353 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.00606 Informative Inherited
Biological Process (BP) organ morphogenesis 0.006231 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.01499 Informative Inherited
Biological Process (BP) response to ionizing radiation 0 Highly Informative Direct
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00000000002121 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000005856 Highly Informative Direct
Biological Process (BP) placenta development 0.0000000007151 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.000000000774 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00000000234 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000002862 Highly Informative Direct
Biological Process (BP) pattern specification process 0.0000004395 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0.0000006056 Highly Informative Direct
Biological Process (BP) response to salt stress 0.0000008407 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0000009361 Highly Informative Direct
Biological Process (BP) gene silencing 0.0004271 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0.01026 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.3878 Highly Informative Inherited
Molecular Function (MF) binding 0.0000007356 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.2821 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) lyase activity 0.0004391 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0007633 Moderately Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.0004748 Informative Direct
Molecular Function (MF) DNA binding 0.002454 Informative Inherited
Molecular Function (MF) structure-specific DNA binding 0.00000000000004275 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0000000004202 Least Informative Direct
Cellular Component (CC) protein complex 0.239 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.04636 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.6571 Least Informative Inherited
Cellular Component (CC) nuclear part 0.001611 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.08999 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.004808 Informative Inherited
Cellular Component (CC) nuclear chromosome part 0.01153 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune system organ morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic cell number0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased leukocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult sense organ0Moderately InformativeDirect
Fly Anatomy (FA)external sensory organ0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)DNA helicase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0Moderately InformativeDirect
Biological processDNA recombination0InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentChromosome0InformativeDirect
Cellular componentTelomere0.000000000000005054Highly InformativeDirect
Molecular functionNucleotide-binding0.04449Least InformativeInherited
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionATP-binding0.0000000422Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000001661Least InformativeDirect
Post-translational modificationActivator0.00002046Moderately InformativeDirect
Post-translational modificationHelicase0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SPOC domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the SPOC domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]