SUPERFAMILY 1.75 HMM library and genome assignments server


IP3 receptor type 1 binding core, domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   IP3 receptor type 1 binding core, domain 2 [ 100909]
Families:   IP3 receptor type 1 binding core, domain 2 [ 81895]


Superfamily statistics
Genomes (148) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,298 1,342 1
Proteins 789 823 1


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 3.114e-14 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.44e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.329e-07 Least Informative Direct
Biological Process (BP) developmental process 0.007705 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.7533 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 9.237e-12 Moderately Informative Direct
Biological Process (BP) cellular localization 9.238e-12 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.446e-08 Moderately Informative Direct
Biological Process (BP) regulation of localization 2.153e-08 Moderately Informative Direct
Biological Process (BP) system process 1.859e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1.627e-06 Moderately Informative Direct
Biological Process (BP) tissue development 4.176e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 4.682e-05 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0005205 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.3308 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.00499 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.98 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1223 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.02668 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.7344 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.002202 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01105 Moderately Informative Inherited
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) cardiovascular system development 1.84e-09 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 1.203e-08 Informative Direct
Biological Process (BP) muscle structure development 4.531e-08 Informative Direct
Biological Process (BP) intracellular signal transduction 5.68e-08 Informative Direct
Biological Process (BP) organ morphogenesis 4.243e-07 Informative Direct
Biological Process (BP) muscle tissue development 2.098e-06 Informative Direct
Biological Process (BP) cytoplasmic transport 2.78e-06 Informative Direct
Biological Process (BP) response to organonitrogen compound 3.328e-06 Informative Direct
Biological Process (BP) regulation of system process 2.042e-05 Informative Direct
Biological Process (BP) protein localization to organelle 2.235e-05 Informative Direct
Biological Process (BP) response to organic cyclic compound 2.385e-05 Informative Direct
Biological Process (BP) transmembrane transport 2.422e-05 Informative Direct
Biological Process (BP) protein complex assembly 0.0002111 Informative Direct
Biological Process (BP) cell death 0.001433 Informative Inherited
Biological Process (BP) response to inorganic substance 0.271 Informative Inherited
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 9.931e-12 Highly Informative Direct
Biological Process (BP) response to alkaloid 3.682e-10 Highly Informative Direct
Biological Process (BP) response to hypoxia 5.185e-09 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 1.224e-08 Highly Informative Direct
Biological Process (BP) muscle organ development 3.733e-08 Highly Informative Direct
Biological Process (BP) muscle fiber development 4.168e-08 Highly Informative Direct
Biological Process (BP) protein homooligomerization 1.976e-07 Highly Informative Direct
Biological Process (BP) developmental maturation 9.512e-06 Highly Informative Direct
Biological Process (BP) ossification 6.647e-05 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0003041 Highly Informative Direct
Molecular Function (MF) binding 1.604e-05 Least Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 6.277e-13 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 1.093e-09 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 0 Highly Informative Direct
Cellular Component (CC) membrane 4.351e-14 Least Informative Direct
Cellular Component (CC) cytoplasmic part 4.052e-08 Least Informative Direct
Cellular Component (CC) protein complex 2.395e-06 Least Informative Direct
Cellular Component (CC) intracellular organelle part 5.959e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.5996 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.02756 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.005196 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.4725 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) contractile fiber part 5.523e-09 Informative Direct
Cellular Component (CC) integral to membrane 8.317e-09 Informative Direct
Cellular Component (CC) nuclear envelope 0.0007899 Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0 Highly Informative Direct
Cellular Component (CC) sarcomere 2.972e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 3.23e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.007424Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0006853InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat4.84e-15Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein1.055e-10Least InformativeDirect
Post-translational modificationS-nitrosylation4.9e-09InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a IP3 receptor type 1 binding core, domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the IP3 receptor type 1 binding core, domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]