SUPERFAMILY 1.75 HMM library and genome assignments server

IP3 receptor type 1 binding core, domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   IP3 receptor type 1 binding core, domain 2 [ 100909]
Families:   IP3 receptor type 1 binding core, domain 2 [ 81895]


Superfamily statistics
Genomes (166) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,414 1,590 1
Proteins 858 983 1


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000000000001071 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000006055 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00005013 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.784 Least Informative Inherited
Biological Process (BP) developmental process 0.002515 Least Informative Inherited
Biological Process (BP) ion transport 0.0000000000001054 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000000001322 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000002196 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000004654 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000003438 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00003034 Moderately Informative Direct
Biological Process (BP) tissue development 0.0002015 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000281 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0006471 Moderately Informative Direct
Biological Process (BP) organ development 0.001346 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1403 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.2111 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02498 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.8357 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.02926 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.02576 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.3418 Moderately Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) muscle system process 0.00000000001724 Informative Direct
Biological Process (BP) intracellular signal transduction 0.0000000004595 Informative Direct
Biological Process (BP) cardiovascular system development 0.00000001487 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000003386 Informative Direct
Biological Process (BP) muscle structure development 0.0000004261 Informative Direct
Biological Process (BP) protein oligomerization 0.00000197 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000003048 Informative Direct
Biological Process (BP) regulation of system process 0.000005628 Informative Direct
Biological Process (BP) cytoplasmic transport 0.000005772 Informative Direct
Biological Process (BP) organ morphogenesis 0.00001382 Informative Direct
Biological Process (BP) protein localization to organelle 0.00002274 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00002451 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.00003579 Informative Direct
Biological Process (BP) response to inorganic substance 0.1401 Informative Inherited
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.000000000000093 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.0000000002 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0000000005168 Highly Informative Direct
Biological Process (BP) muscle organ development 0.000000008698 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00000002749 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.000000211 Highly Informative Direct
Biological Process (BP) ossification 0.0001191 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0005301 Highly Informative Direct
Molecular Function (MF) binding 0.0000003156 Least Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0008376 Moderately Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.000000003192 Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) gated channel activity 0 Highly Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.0000000000002436 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000002891 Least Informative Direct
Cellular Component (CC) protein complex 0.000002186 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00002062 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.08448 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4112 Least Informative Inherited
Cellular Component (CC) membrane region 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0001233 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.004787 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.5965 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.000000005985 Informative Direct
Cellular Component (CC) nuclear envelope 0.0006678 Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0.00000000000000457 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0002278 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscular disease0.01412Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.007789Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0007143InformativeDirect

Document: MP annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)nervous system0Least InformativeDirect
Drugbank ATC_code (DB)other analgesics and antipyretics0Moderately InformativeDirect
Drugbank ATC_code (DB)psychoanaleptics0Moderately InformativeDirect
Drugbank ATC_code (DB)paracetamol0InformativeDirect
Drugbank ATC_code (DB)xanthine derivatives0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.000000000000004814Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000000001062Least InformativeDirect
Post-translational modificationS-nitrosylation0.000000006187InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a IP3 receptor type 1 binding core, domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the IP3 receptor type 1 binding core, domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]