SUPERFAMILY 1.75 HMM library and genome assignments server


IP3 receptor type 1 binding core, domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   IP3 receptor type 1 binding core, domain 2 [ 100909]
Families:   IP3 receptor type 1 binding core, domain 2 [ 81895]


Superfamily statistics
Genomes (161) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,337 1,590 1
Proteins 815 983 1


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000000000000003722 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000000006449 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000004488 Least Informative Direct
Biological Process (BP) developmental process 0.004813 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6993 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000000004597 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.00000000002426 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000001331 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000003015 Moderately Informative Direct
Biological Process (BP) system process 0.000000202 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.000001684 Moderately Informative Direct
Biological Process (BP) signal transduction 0.00003482 Moderately Informative Direct
Biological Process (BP) tissue development 0.00004422 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0004612 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.3312 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.004437 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.9545 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1172 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.0227 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.748 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.002502 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.01139 Moderately Informative Inherited
Biological Process (BP) metal ion transport 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0 Informative Direct
Biological Process (BP) metal ion homeostasis 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 0 Informative Direct
Biological Process (BP) muscle system process 0.0000000000000665 Informative Direct
Biological Process (BP) cardiovascular system development 0.000000001538 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000001358 Informative Direct
Biological Process (BP) muscle structure development 0.00000005014 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000006006 Informative Direct
Biological Process (BP) programmed cell death 0.00000007096 Informative Direct
Biological Process (BP) organ morphogenesis 0.0000005166 Informative Direct
Biological Process (BP) cytoplasmic transport 0.00000211 Informative Direct
Biological Process (BP) muscle tissue development 0.000002127 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.000003917 Informative Direct
Biological Process (BP) protein localization to organelle 0.00001791 Informative Direct
Biological Process (BP) regulation of system process 0.00001991 Informative Direct
Biological Process (BP) transmembrane transport 0.00002285 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.00002747 Informative Direct
Biological Process (BP) protein complex assembly 0.0001784 Informative Direct
Biological Process (BP) response to inorganic substance 0.272 Informative Inherited
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) heart morphogenesis 0 Highly Informative Direct
Biological Process (BP) response to calcium ion 0.000000000008023 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.0000000004195 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000004919 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00000003414 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.00000003773 Highly Informative Direct
Biological Process (BP) protein homooligomerization 0.0000001672 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000008365 Highly Informative Direct
Biological Process (BP) ossification 0.0000778 Highly Informative Direct
Biological Process (BP) skeletal system development 0.0003011 Highly Informative Direct
Molecular Function (MF) binding 0.000000488 Least Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0000000000004414 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.000000002227 Informative Direct
Molecular Function (MF) phosphatidylinositol binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.00000000000002067 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000001681 Least Informative Direct
Cellular Component (CC) protein complex 0.000001564 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001175 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.5871 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.08068 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.004585 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.6897 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) contractile fiber part 0.00000000433 Informative Direct
Cellular Component (CC) integral to membrane 0.000000005995 Informative Direct
Cellular Component (CC) nuclear envelope 0.0007721 Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000000000000003132 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0001352 Highly Informative Direct

Document: GO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.007496Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0006874InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainRepeat0.000000000000004816Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationCalcium channel0Highly InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000000001056Least InformativeDirect
Post-translational modificationS-nitrosylation0.000000006239InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a IP3 receptor type 1 binding core, domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the IP3 receptor type 1 binding core, domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]