SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): skeleton phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   skeleton phenotype [MP:0005390] <2>(40|56) (43|36|25)
- 1:   abnormal skeleton morphology [MP:0005508] <11>(36|52) (38|33|24)
- 1:   abnormal skeleton physiology [MP:0001533] <10>(12|15) (14|11|6)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Homeodomain-like0Direct
BTG domain-like0Direct
p53-like transcription factors0.000001293Direct
Growth factor receptor domain0.000007833Direct
EGF/Laminin0.0002104Direct
FnI-like domain0.0008586Direct
Cystine-knot cytokines0.002833Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006402Inherited
(Trans)glycosidases0.006814Inherited
Alkaline phosphatase-like0.008267Inherited
Snake toxin-like0.009716Inherited
TB module/8-cys domain0.01139Inherited
Insulin-like0.01139Inherited
Kringle-like0.01394Inherited
TNF-like0.01854Inherited
HLH, helix-loop-helix DNA-binding domain0.02297Inherited
Nuclear receptor ligand-binding domain0.02973Inherited
Tudor/PWWP/MBT0.03658Inherited
TIMP-like0.03985Inherited
Clc chloride channel0.05218Inherited
Transducin (alpha subunit), insertion domain0.0567Inherited
Bromodomain0.06036Inherited
HMG-box0.0659Inherited
YWTD domain0.07989Inherited
Flavoproteins0.1134Inherited
Hemopexin-like domain0.136Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.15Inherited
Riboflavin synthase domain-like0.15Inherited
GLA-domain0.15Inherited
PGBD-like0.1524Inherited
Glycosyl hydrolase domain0.1609Inherited
Kazal-type serine protease inhibitors0.162Inherited
4-helical cytokines0.2204Inherited
Metalloproteases ("zincins"), catalytic domain0.2269Inherited
PYP-like sensor domain (PAS domain)0.3121Inherited
TNF receptor-like0.3212Inherited
L domain-like0.5246Inherited
Toll/Interleukin receptor TIR domain0.5854Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
DIX domain0Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
BTG domain-like0Direct
p53 DNA-binding domain-like0Direct
Homeodomain0.000000000000003342Direct
Growth factor receptor domain0.00008116Direct
Paired domain0.0002996Direct
E2F dimerization segment0.0007909Direct
VWC domain0.0008191Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0009699Direct
Extracellular domain of cell surface receptors0.0009699Direct
Arylsulfatase0.001018Inherited
Transforming growth factor (TGF)-beta0.0018Inherited
T-box0.002558Inherited
Integrin A (or I) domain0.003722Inherited
EGF-type module0.004952Inherited
I set domains0.004986Inherited
Insulin-like0.008439Inherited
TB module/8-cys domain0.008439Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.008785Inherited
Netrin-like domain (NTR/C345C module)0.01001Inherited
beta-glycanases0.01001Inherited
Cytochrome p450 reductase N-terminal domain-like0.01001Inherited
Kringle modules0.01457Inherited
TNF-like0.01507Inherited
Nuclear receptor0.01701Inherited
HLH, helix-loop-helix DNA-binding domain0.02124Inherited
Integrin beta tail domain0.02322Inherited
Nuclear receptor ligand-binding domain0.02556Inherited
MBT repeat0.02978Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02978Inherited
NADPH-cytochrome p450 reductase-like0.02978Inherited
Clc chloride channel0.04191Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.04238Inherited
Transducin (alpha subunit), insertion domain0.04661Inherited
Bromodomain0.05128Inherited
Laminin G-like module0.05256Inherited
HMG-box0.05742Inherited
YWTD domain0.06685Inherited
Neutral endopeptidase (neprilysin)0.09656Inherited
Hemopexin-like domain0.1211Inherited
GLA-domain0.1314Inherited
Link domain0.1314Inherited
MMP N-terminal domain0.1359Inherited
Forkhead DNA-binding domain0.1394Inherited
TNF receptor-like0.152Inherited
Matrix metalloproteases, catalytic domain0.1646Inherited
SAM (sterile alpha motif) domain0.3204Inherited
EF-hand modules in multidomain proteins0.391Inherited
Long-chain cytokines0.4513Inherited
Ngr ectodomain-like0.4932Inherited
Toll/Interleukin receptor TIR domain0.5236Inherited
G proteins0.9446Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Homeodomain-like0Direct
BTG domain-like0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.0000006118Direct
Growth factor receptor domain0.000003837Direct
EGF/Laminin0.0001139Direct
FnI-like domain0.000489Direct
Cystine-knot cytokines0.001697Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.004014Inherited
(Trans)glycosidases0.004286Inherited
Alkaline phosphatase-like0.005252Inherited
Snake toxin-like0.006265Inherited
Insulin-like0.007388Inherited
TB module/8-cys domain0.007388Inherited
Kringle-like0.009145Inherited
TNF-like0.01241Inherited
HLH, helix-loop-helix DNA-binding domain0.01561Inherited
Nuclear receptor ligand-binding domain0.02055Inherited
Integrin beta tail domain0.0206Inherited
Tudor/PWWP/MBT0.02578Inherited
TIMP-like0.02819Inherited
Clc chloride channel0.03762Inherited
Transducin (alpha subunit), insertion domain0.04118Inherited
Bromodomain0.04412Inherited
Concanavalin A-like lectins/glucanases0.04722Inherited
HMG-box0.04854Inherited
YWTD domain0.06001Inherited
Flavoproteins0.0882Inherited
Hemopexin-like domain0.1079Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.12Inherited
GLA-domain0.12Inherited
Riboflavin synthase domain-like0.12Inherited
PGBD-like0.122Inherited
Glycosyl hydrolase domain0.1295Inherited
Kazal-type serine protease inhibitors0.1305Inherited
4-helical cytokines0.1838Inherited
Metalloproteases ("zincins"), catalytic domain0.1899Inherited
PYP-like sensor domain (PAS domain)0.2693Inherited
TNF receptor-like0.2779Inherited
Cyclin-like0.3167Inherited
L domain-like0.4774Inherited
Toll/Interleukin receptor TIR domain0.5389Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49265,53300
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0002916Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000397Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.0006773Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0008066Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.002517Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.002784Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.002856Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00426Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.007388Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.008944Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.008985Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.008985Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.01467Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.0206Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0206Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.027Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.027Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.02809Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.02809Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.03762Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04118Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05163Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.05398Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.06001Inherited
    63748,63748
  • 63748 - Tudor/PWWP/MBT
  • 63748 - Tudor/PWWP/MBT
  • 0.06021Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.06021Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.122Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1295Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1295Inherited
    57903,57903
  • 57903 - FYVE/PHD zinc finger
  • 57903 - FYVE/PHD zinc finger
  • 0.1754Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2044Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.3228Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49265,49265,53300
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 53300 - vWA-like
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00006809Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0006773Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.002517Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002517Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.002517Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.002856Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.004128Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.007508Inherited
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0.008944Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.008944Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.008985Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01332Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01808Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.0206Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.027Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.027Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03762Inherited
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.05398Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0882Inherited
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.2789Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.6425Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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