SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): reproductive system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   reproductive system phenotype [MP:0005389] <2>(37|40) (45|13|5)
- 1:   abnormal reproductive system physiology [MP:0001919] <12>(19|29) (25|8|2)
- 1:   abnormal reproductive system morphology [MP:0002160] <10>(28|32) (34|11|5)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Nuclear receptor ligand-binding domain0.0000002218Direct
Cystine-knot cytokines0.00004785Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0003437Direct
SMAD MH1 domain0.000462Direct
Tudor/PWWP/MBT0.0007726Direct
PAZ domain0.00159Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00159Inherited
Insulin-like0.002069Inherited
Galactose-binding domain-like0.008969Inherited
Bcl-2 inhibitors of programmed cell death0.01179Inherited
The spindle assembly checkpoint protein mad20.01642Inherited
Cysteine-rich DNA binding domain, (DM domain)0.01714Inherited
4-helical cytokines0.02548Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.03438Inherited
STAT0.03642Inherited
Transcription factor STAT-4 N-domain0.03642Inherited
Homeodomain-like0.1262Inherited
Nucleic acid-binding proteins0.1286Inherited
Alpha-macroglobulin receptor domain0.1311Inherited
PYP-like sensor domain (PAS domain)0.141Inherited
Ribonuclease H-like0.169Inherited
SMAD/FHA domain0.1963Inherited
Alkaline phosphatase-like0.2021Inherited
ADP-ribosylation0.2205Inherited
Terpenoid cyclases/Protein prenyltransferases0.2386Inherited
Ribosomal protein S5 domain 2-like0.2386Inherited
Blood coagulation inhibitor (disintegrin)0.3258Inherited
SAICAR synthase-like0.4115Inherited
Fibronectin type III0.4532Inherited
Snake toxin-like0.4552Inherited
EGF/Laminin0.594Inherited
L domain-like0.7192Inherited
Immunoglobulin1Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
p53 DNA-binding domain-like0Direct
Nuclear receptor ligand-binding domain0.000000164Direct
Nuclear receptor0.00000119Direct
Tudor domain0.00001384Direct
Transforming growth factor (TGF)-beta0.00009296Direct
SMAD MH1 domain0.0002982Direct
SMAD domain0.0002982Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.001064Inherited
PAZ domain0.001064Inherited
Insulin-like0.001412Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.003644Inherited
NADPH-cytochrome p450 reductase-like0.003644Inherited
Bcl-2 inhibitors of programmed cell death0.008703Inherited
The spindle assembly checkpoint protein mad20.01201Inherited
Cysteine-rich DNA binding domain, (DM domain)0.01269Inherited
Protein kinases, catalytic subunit0.02028Inherited
STAT DNA-binding domain0.02831Inherited
Single strand DNA-binding domain, SSB0.02831Inherited
STAT0.02831Inherited
Transcription factor STAT-4 N-domain0.02831Inherited
Extracellular domain of cell surface receptors0.03694Inherited
Short-chain cytokines0.05733Inherited
Long-chain cytokines0.05915Inherited
Astacin0.06884Inherited
Complement components0.112Inherited
Alpha-macroglobulin receptor domain0.112Inherited
Histone lysine methyltransferases0.1979Inherited
Blood coagulation inhibitor (disintegrin)0.3014Inherited
Reprolysin-like0.311Inherited
EGF-type module0.4289Inherited
Fibronectin type III0.4515Inherited
Ngr ectodomain-like0.6889Inherited
I set domains0.981Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Nuclear receptor ligand-binding domain0.0000001024Direct
Cystine-knot cytokines0.00002501Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001899Direct
SMAD MH1 domain0.0002578Direct
Tudor/PWWP/MBT0.0004381Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0009295Direct
PAZ domain0.0009295Direct
Insulin-like0.001221Inherited
Galactose-binding domain-like0.00574Inherited
Cyclin-like0.006361Inherited
Protein kinase-like (PK-like)0.007376Inherited
Bcl-2 inhibitors of programmed cell death0.007668Inherited
The spindle assembly checkpoint protein mad20.01091Inherited
Cysteine-rich DNA binding domain, (DM domain)0.01141Inherited
4-helical cytokines0.01744Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.02409Inherited
Transcription factor STAT-4 N-domain0.02564Inherited
STAT0.02564Inherited
Flavoproteins0.02564Inherited
Nuclear receptor coactivator interlocking domain0.03216Inherited
Homeodomain-like0.09936Inherited
Nucleic acid-binding proteins0.1014Inherited
Alpha-macroglobulin receptor domain0.1036Inherited
Clavaminate synthase-like0.1121Inherited
PYP-like sensor domain (PAS domain)0.1121Inherited
Ribonuclease H-like0.1368Inherited
SET domain0.1614Inherited
SMAD/FHA domain0.1614Inherited
Alkaline phosphatase-like0.1667Inherited
ADP-ribosylation0.1838Inherited
Terpenoid cyclases/Protein prenyltransferases0.2007Inherited
Ribosomal protein S5 domain 2-like0.2007Inherited
dsRNA-binding domain-like0.2425Inherited
Blood coagulation inhibitor (disintegrin)0.2821Inherited
Cytochrome P4500.3539Inherited
SAICAR synthase-like0.365Inherited
Fibronectin type III0.4057Inherited
Snake toxin-like0.4078Inherited
EGF/Laminin0.5474Inherited
L domain-like0.6773Inherited
Family A G protein-coupled receptor-like0.9954Inherited
Immunoglobulin1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001952Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.01435Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02564Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02564Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02564Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.03216Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.05237Inherited
    55486,57552
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 57552 - Blood coagulation inhibitor (disintegrin)
  • 0.2821Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.3946Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.9719Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.006416Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02564Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02564Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)