SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): respiratory system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   respiratory system phenotype [MP:0005388] <2>(31|46) (34|28|14)
- 1:   abnormal respiratory system physiology [MP:0002133] <21>(16|26) (17|14|9)
- 1:   abnormal respiratory system morphology [MP:0002132] <10>(16|24) (20|17|9)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.00000007724Direct
Homeodomain-like0.00004802Direct
FnI-like domain0.00008474Direct
EGF/Laminin0.00009033Direct
4-helical cytokines0.0002137Direct
Snake toxin-like0.000437Direct
Growth factor receptor domain0.002625Inherited
L27 domain0.004267Inherited
Cystine-knot cytokines0.006391Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.006915Inherited
ACT-like0.006915Inherited
HLH, helix-loop-helix DNA-binding domain0.008961Inherited
Kringle-like0.01008Inherited
STAT0.01363Inherited
E2F-DP heterodimerization region0.01363Inherited
Flavoproteins0.01363Inherited
Transcription factor STAT-4 N-domain0.01363Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02458Inherited
Riboflavin synthase domain-like0.02458Inherited
Family A G protein-coupled receptor-like0.06963Inherited
Toll/Interleukin receptor TIR domain0.1246Inherited
DEATH domain0.1421Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.15Inherited
PGBD-like0.1558Inherited
TNF receptor-like0.182Inherited
Nuclear receptor ligand-binding domain0.2209Inherited
Hemopexin-like domain0.238Inherited
PH domain-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
p53 DNA-binding domain-like0Direct
Lamin A/C globular tail domain0Direct
Homeodomain0.0000007397Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0000147Direct
Extracellular domain of cell surface receptors0.0000147Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00004423Direct
Forkhead DNA-binding domain0.00006354Direct
VWC domain0.0001714Direct
Growth factor receptor domain0.0005776Direct
Short-chain cytokines0.0006224Direct
Cell cycle transcription factor e2f-dp0.0008971Direct
L domain0.001182Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001182Inherited
NADPH-cytochrome p450 reductase-like0.001182Inherited
EGF-type module0.002917Inherited
L27 domain0.003197Inherited
Interferons/interleukin-10 (IL-10)0.004436Inherited
E2F dimerization segment0.004436Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.004492Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.005017Inherited
Interleukin 17F, IL-17F0.005017Inherited
Phenylalanine metabolism regulatory domain0.005017Inherited
HLH, helix-loop-helix DNA-binding domain0.008912Inherited
STAT DNA-binding domain0.01055Inherited
STAT0.01055Inherited
Transcription factor STAT-4 N-domain0.01055Inherited
Kringle modules0.01831Inherited
Protein kinases, catalytic subunit0.02715Inherited
Rhodopsin-like0.05222Inherited
TNF receptor-like0.07546Inherited
C-type lectin domain0.0839Inherited
Toll/Interleukin receptor TIR domain0.09432Inherited
MMP N-terminal domain0.1425Inherited
DEATH domain, DD0.1458Inherited
Matrix metalloproteases, catalytic domain0.1683Inherited
Nuclear receptor0.1789Inherited
Transforming growth factor (TGF)-beta0.2136Inherited
Nuclear receptor ligand-binding domain0.2148Inherited
Hemopexin-like domain0.2242Inherited
LIM domain0.2852Inherited
Phosphotyrosine-binding domain (PTB)0.7282Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
p53-like transcription factors0.00000003526Direct
Homeodomain-like0.00002514Direct
FnI-like domain0.00004497Direct
EGF/Laminin0.00004785Direct
4-helical cytokines0.0001158Direct
Snake toxin-like0.0002432Direct
Growth factor receptor domain0.001571Inherited
L27 domain0.002618Inherited
Cystine-knot cytokines0.004006Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.00435Inherited
ACT-like0.00435Inherited
HLH, helix-loop-helix DNA-binding domain0.005734Inherited
Kringle-like0.006505Inherited
Transcription factor STAT-4 N-domain0.008944Inherited
E2F-DP heterodimerization region0.008944Inherited
STAT0.008944Inherited
Flavoproteins0.008944Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01681Inherited
Riboflavin synthase domain-like0.01681Inherited
Protein kinase-like (PK-like)0.01874Inherited
Family A G protein-coupled receptor-like0.05162Inherited
Toll/Interleukin receptor TIR domain0.09786Inherited
DEATH domain0.113Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.1199Inherited
PGBD-like0.125Inherited
"Winged helix" DNA-binding domain0.146Inherited
TNF receptor-like0.1484Inherited
Nuclear receptor ligand-binding domain0.1842Inherited
Hemopexin-like domain0.2002Inherited
WD40 repeat-like0.4685Inherited
PH domain-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00001092Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0009832Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0009832Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001783Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002618Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.00435Inherited
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0.00435Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00524Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.008874Inherited
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0.008944Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.008944Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.008944Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008944Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.008944Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008944Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01294Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.01715Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.02557Inherited
    52799,49562
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.02851Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02851Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.03359Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.03367Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.03989Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.125Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1842Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.5195Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.0001849Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0009832Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001061Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003741Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.003741Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.008944Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.008944Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.009872Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01715Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.02851Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.06119Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1484Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.3567Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)