SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): behavior/neurological phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   behavior/neurological phenotype [MP:0005386] <1>(37|49) (44|36|21)
- 1:   abnormal behavior [MP:0004924] <17>(36|48) (43|32|19)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Metallothionein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
AXH domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ACT-like0Direct
SRF-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Family A G protein-coupled receptor-like0.0000006195Direct
Nuclear receptor ligand-binding domain0.000008458Direct
Nicotinic receptor ligand binding domain-like0.00001656Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00001656Direct
Voltage-gated potassium channels0.00003817Direct
Periplasmic binding protein-like I0.0007454Direct
Periplasmic binding protein-like II0.001009Inherited
PYP-like sensor domain (PAS domain)0.004449Inherited
p53-like transcription factors0.004681Inherited
SNF-like0.0057Inherited
Homeodomain-like0.009585Inherited
Transducin (alpha subunit), insertion domain0.02501Inherited
STAT0.0369Inherited
Flavoproteins0.0369Inherited
Transcription factor STAT-4 N-domain0.0369Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.04377Inherited
Riboflavin synthase domain-like0.04377Inherited
Cyclin-like0.05698Inherited
PreATP-grasp domain0.0768Inherited
Glutathione synthetase ATP-binding domain-like0.1029Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1341Inherited
(Trans)glycosidases0.1375Inherited
PDZ domain-like0.1563Inherited
Glycosyl hydrolase domain0.2079Inherited
Spectrin repeat0.2517Inherited
Protein kinase-like (PK-like)0.2786Inherited
Second domain of FERM0.3411Inherited
Concanavalin A-like lectins/glucanases0.5446Inherited
Cadherin-like0.9516Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
IP3 receptor type 1 binding core, domain 20Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
AXH domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Synapsin domain0Direct
Synapsin C-terminal domain0Direct
Neurotrophin0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Metallothionein0Direct
SRF-like0Direct
Phenylalanine metabolism regulatory domain0Direct
p53 DNA-binding domain-like0Direct
Nuclear receptor0.000001416Direct
Rhodopsin-like0.00000659Direct
Nuclear receptor ligand-binding domain0.000007161Direct
Nicotinic receptor ligand binding domain-like0.00001267Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00001267Direct
Phosphate binding protein-like0.00008351Direct
Tetramerization domain of potassium channels0.003067Inherited
SNF-like0.004318Inherited
L-arabinose binding protein-like0.005211Inherited
Homeodomain0.005365Inherited
Voltage-gated potassium channels0.01461Inherited
Pyridoxal-dependent decarboxylase0.02001Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02001Inherited
NADPH-cytochrome p450 reductase-like0.02001Inherited
Laminin-type module0.0202Inherited
Transducin (alpha subunit), insertion domain0.02043Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02043Inherited
STAT DNA-binding domain0.02946Inherited
STAT0.02946Inherited
Transcription factor STAT-4 N-domain0.02946Inherited
beta-glycanases0.04497Inherited
Extended AAA-ATPase domain0.05276Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.06454Inherited
Laminin G-like module0.08458Inherited
PDZ domain0.08947Inherited
Fibroblast growth factors (FGF)0.09044Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.09805Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1169Inherited
Spectrin repeat0.1258Inherited
Extracellular domain of cell surface receptors0.1705Inherited
Leucine zipper domain0.2631Inherited
Protein kinases, catalytic subunit0.3929Inherited
T-box0.4042Inherited
Calponin-homology domain, CH-domain0.4431Inherited
Motor proteins0.5792Inherited
Cadherin0.933Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Metallothionein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
SRF-like0Direct
p53 tetramerization domain0Direct
IP3 receptor type 1 binding core, domain 20Direct
AXH domain0Direct
ACT-like0Direct
Family A G protein-coupled receptor-like0.0000002883Direct
Nuclear receptor ligand-binding domain0.000004164Direct
Nicotinic receptor ligand binding domain-like0.000008275Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000008275Direct
Voltage-gated potassium channels0.00001975Direct
Periplasmic binding protein-like I0.0004215Direct
Periplasmic binding protein-like II0.0005754Direct
PYP-like sensor domain (PAS domain)0.002736Inherited
p53-like transcription factors0.002886Inherited
SNF-like0.003544Inherited
Homeodomain-like0.006176Inherited
Transducin (alpha subunit), insertion domain0.01711Inherited
Transcription factor STAT-4 N-domain0.02602Inherited
STAT0.02602Inherited
Flavoproteins0.02602Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0311Inherited
Riboflavin synthase domain-like0.0311Inherited
Cyclin-like0.04142Inherited
PreATP-grasp domain0.05741Inherited
Glutathione synthetase ATP-binding domain-like0.0792Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.1063Inherited
(Trans)glycosidases0.1092Inherited
Actin-like ATPase domain0.1092Inherited
PDZ domain-like0.1255Inherited
Glycosyl hydrolase domain0.1722Inherited
Spectrin repeat0.2128Inherited
Leucine zipper domain0.2284Inherited
Protein kinase-like (PK-like)0.2381Inherited
Second domain of FERM0.2968Inherited
FAD/NAD(P)-binding domain0.3344Inherited
4-helical cytokines0.3525Inherited
Calponin-homology domain, CH-domain0.4038Inherited
Concanavalin A-like lectins/glucanases0.4973Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5231Inherited
P-loop containing nucleoside triphosphate hydrolases0.889Inherited
Cadherin-like0.9265Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    103473,103473
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000008275Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.00004745Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.001278Inherited
    50044,48065
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 0.007508Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.007508Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.01711Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01711Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01767Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02602Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02602Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.02602Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02602Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.02873Inherited
    52799,52799
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 52799 - (Phosphotyrosine protein) phosphatases II
  • 0.0311Inherited
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.0409Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.0551Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.05721Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.06657Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1566Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1722Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.9482Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0Direct
    103473,103473,141571
  • 103473 - MFS general substrate transporter
  • 103473 - MFS general substrate transporter
  • 141571 - Pentapeptide repeat-like
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50044,48065,50729
  • 50044 - SH3-domain
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.007508Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.01767Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01767Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02602Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02602Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.1927Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2171Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.9351Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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