SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): craniofacial phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   craniofacial phenotype [MP:0005382] <1>(20|35) (23|16|10)
- 1:   abnormal craniofacial morphology [MP:0000428] <5>(20|34) (23|15|10)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Homeodomain-like0Direct
Growth factor receptor domain0.0000366Direct
p53-like transcription factors0.00004781Direct
Cystine-knot cytokines0.0002111Direct
SMAD MH1 domain0.000579Direct
Intermediate filament protein, coiled coil region0.005783Inherited
TB module/8-cys domain0.01209Inherited
Alkaline phosphatase-like0.01237Inherited
Bromodomain0.01578Inherited
FnI-like domain0.01578Inherited
Snake toxin-like0.02195Inherited
(Trans)glycosidases0.08401Inherited
PGBD-like0.1844Inherited
Transducin (alpha subunit), insertion domain0.2218Inherited
Metalloproteases ("zincins"), catalytic domain0.242Inherited
Nuclear receptor ligand-binding domain0.2529Inherited
Hemopexin-like domain0.262Inherited
4-helical cytokines0.3859Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
Homeodomain0.00000000000001335Direct
Paired domain0.0000133Direct
Forkhead DNA-binding domain0.0003787Direct
SMAD MH1 domain0.0003812Direct
SMAD domain0.0003812Direct
DIX domain0.0004506Direct
Growth factor receptor domain0.0004929Direct
T-box0.0006049Direct
Arylsulfatase0.001101Inherited
Multidrug efflux transporter AcrB transmembrane domain0.002405Inherited
Transforming growth factor (TGF)-beta0.002422Inherited
Intermediate filament protein, coiled coil region0.004426Inherited
CalX-beta domain0.004496Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.004599Inherited
Laminin-type module0.006929Inherited
Pyridoxal-dependent decarboxylase0.007874Inherited
TB module/8-cys domain0.008871Inherited
Bromodomain0.01233Inherited
Extracellular domain of cell surface receptors0.02377Inherited
Neutral endopeptidase (neprilysin)0.02965Inherited
I set domains0.04231Inherited
VWC domain0.0471Inherited
DEATH domain, DD0.1293Inherited
MMP N-terminal domain0.1639Inherited
Matrix metalloproteases, catalytic domain0.1884Inherited
Transducin (alpha subunit), insertion domain0.1985Inherited
Nuclear receptor0.2021Inherited
Nuclear receptor ligand-binding domain0.2357Inherited
Hemopexin-like domain0.2402Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.4875Inherited
G proteins0.5662Inherited
Rhodopsin-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0Direct
p53 tetramerization domain0Direct
Growth factor receptor domain0.0000189Direct
p53-like transcription factors0.00002499Direct
Cystine-knot cytokines0.0001143Direct
SMAD MH1 domain0.0003272Direct
HLH, helix-loop-helix DNA-binding domain0.003321Inherited
Intermediate filament protein, coiled coil region0.003598Inherited
CalX-like0.003976Inherited
TB module/8-cys domain0.007872Inherited
Alkaline phosphatase-like0.008063Inherited
FnI-like domain0.01045Inherited
Bromodomain0.01045Inherited
Snake toxin-like0.01488Inherited
(Trans)glycosidases0.06337Inherited
PGBD-like0.1506Inherited
Transducin (alpha subunit), insertion domain0.1851Inherited
Cyclin-like0.1979Inherited
Metalloproteases ("zincins"), catalytic domain0.2039Inherited
Nuclear receptor ligand-binding domain0.2139Inherited
Hemopexin-like domain0.2226Inherited
4-helical cytokines0.3402Inherited
Family A G protein-coupled receptor-like0.9992Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0003961Direct
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.000501Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009388Direct
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.001524Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003418Inherited
    57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.003976Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.004014Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.004014Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.0153Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.0153Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.07262Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1256Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.1506Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1851Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00004235Direct
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.001538Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.002001Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.002001Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003976Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.007091Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.007091Inherited
    57603,57603,57603
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 57603 - FnI-like domain
  • 0.0153Inherited
    52540,52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.02694Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.03476Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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