SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): digestive/alimentary phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   digestive/alimentary phenotype [MP:0005381] <2>(32|40) (34|15|5)
- 1:   abnormal digestive system morphology [MP:0000462] <19>(24|30) (24|11|1)
- 1:   abnormal digestive system physiology [MP:0001663] <18>(12|14) (15|4|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
p53-like transcription factors0.000000009769Direct
Homeodomain-like0.00001943Direct
Cystine-knot cytokines0.00003523Direct
Nuclear receptor ligand-binding domain0.001498Inherited
SMAD MH1 domain0.001587Inherited
4-helical cytokines0.007352Inherited
Kringle-like0.009729Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01628Inherited
FnI-like domain0.01755Inherited
Growth factor receptor domain0.01782Inherited
"Winged helix" DNA-binding domain0.0182Inherited
Notch domain0.01995Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.02401Inherited
Riboflavin synthase domain-like0.02401Inherited
Trefoil0.03966Inherited
Intermediate filament protein, coiled coil region0.05117Inherited
Toll/Interleukin receptor TIR domain0.05563Inherited
SEA domain0.06528Inherited
Flavoproteins0.06528Inherited
HLH, helix-loop-helix DNA-binding domain0.06865Inherited
DEATH domain0.08633Inherited
F-box domain0.1283Inherited
Family A G protein-coupled receptor-like0.2576Inherited
RNI-like0.2634Inherited
Rhodanese/Cell cycle control phosphatase0.3256Inherited
MFS general substrate transporter0.3962Inherited
Cytochrome P4500.5659Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
p53 DNA-binding domain-like0Direct
Forkhead DNA-binding domain0.0000003341Direct
Homeodomain0.000001563Direct
Rel/Dorsal transcription factors, DNA-binding domain0.00001421Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.0000426Direct
Transforming growth factor (TGF)-beta0.0005501Direct
SMAD MH1 domain0.001153Inherited
SMAD domain0.001153Inherited
Nuclear receptor ligand-binding domain0.001347Inherited
Nuclear receptor0.002151Inherited
T-box0.002639Inherited
Kringle modules0.004387Inherited
Interleukin 17F, IL-17F0.004956Inherited
Cytochrome p450 reductase N-terminal domain-like0.004956Inherited
Integrin beta tail domain0.01039Inherited
Pyridoxal-dependent decarboxylase0.01561Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.01561Inherited
Notch domain0.01561Inherited
NADPH-cytochrome p450 reductase-like0.01561Inherited
Pyrin domain, PYD0.01561Inherited
Short-chain cytokines0.01971Inherited
VWC domain0.02958Inherited
Interferons/interleukin-10 (IL-10)0.03204Inherited
Trefoil0.03204Inherited
Intermediate filament protein, coiled coil region0.0462Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.06881Inherited
HLH, helix-loop-helix DNA-binding domain0.06942Inherited
Toll/Interleukin receptor TIR domain0.09283Inherited
Caspase recruitment domain, CARD0.09439Inherited
F-box domain0.09439Inherited
Cell cycle control phosphatase, catalytic domain0.1138Inherited
28-residue LRR0.1469Inherited
Papain-like0.1486Inherited
Classic zinc finger, C2H20.2967Inherited
Cytochrome P4500.5589Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
p53-like transcription factors0.000000004314Direct
Homeodomain-like0.000009811Direct
Cystine-knot cytokines0.00001818Direct
Nuclear receptor ligand-binding domain0.0008733Direct
SMAD MH1 domain0.0009274Direct
4-helical cytokines0.004648Inherited
Kringle-like0.006273Inherited
Integrin beta tail domain0.008757Inherited
SpoIIaa-like0.008757Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.0108Inherited
FnI-like domain0.01169Inherited
Growth factor receptor domain0.01189Inherited
"Winged helix" DNA-binding domain0.01217Inherited
Notch domain0.01343Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.01637Inherited
Riboflavin synthase domain-like0.01637Inherited
Trefoil0.02804Inherited
Intermediate filament protein, coiled coil region0.03686Inherited
Toll/Interleukin receptor TIR domain0.04032Inherited
SEA domain0.04806Inherited
Flavoproteins0.04806Inherited
HLH, helix-loop-helix DNA-binding domain0.05082Inherited
DEATH domain0.0653Inherited
F-box domain0.1011Inherited
Family A G protein-coupled receptor-like0.2185Inherited
RNI-like0.2239Inherited
Rhodanese/Cell cycle control phosphatase0.2819Inherited
MFS general substrate transporter0.35Inherited
Cytochrome P4500.519Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.00001039Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0002217Direct
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0009274Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001803Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.002544Inherited
    55550,50044
  • 55550 - SH2 domain
  • 50044 - SH3-domain
  • 0.003649Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005899Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.008585Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.008757Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.009964Inherited
    55550,50729
  • 55550 - SH2 domain
  • 50729 - PH domain-like
  • 0.01343Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.1552Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0009577Direct
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.0009577Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.008757Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.01343Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.0794Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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