SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): embryogenesis phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   embryogenesis phenotype [MP:0005380] <1>(41|49) (44|23|14)
- 1:   abnormal embryogenesis/ development [MP:0001672] <13>(34|43) (37|20|9)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Tricorn protease domain 20Direct
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Homeodomain-like0.0000000002865Direct
p53-like transcription factors0.00001086Direct
"Winged helix" DNA-binding domain0.00002948Direct
beta-beta-alpha zinc fingers0.00004717Direct
Bromodomain0.00005087Direct
WD40 repeat-like0.0001882Direct
Protein kinase-like (PK-like)0.0003212Direct
SMAD MH1 domain0.0003832Direct
SET domain0.0004528Direct
Growth factor receptor domain0.0006452Direct
BRCT domain0.001594Inherited
Frizzled cysteine-rich domain0.003052Inherited
Snake toxin-like0.003619Inherited
Notch domain0.004627Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.009802Inherited
Nucleic acid-binding proteins0.01169Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.01169Inherited
DNA clamp0.01493Inherited
BRK domain-like0.01493Inherited
HCP-like0.01528Inherited
Cystine-knot cytokines0.01762Inherited
Cyclin-like0.02344Inherited
Nuclear receptor ligand-binding domain0.06774Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.07819Inherited
Terpenoid cyclases/Protein prenyltransferases0.08722Inherited
SMAD/FHA domain0.1008Inherited
Histone-fold0.1094Inherited
ALDH-like0.1216Inherited
Integrin beta tail domain0.1216Inherited
Alpha-macroglobulin receptor domain0.1216Inherited
SAM/Pointed domain0.1626Inherited
Ubiquitin-like0.1834Inherited
TIMP-like0.3897Inherited
WW domain0.5089Inherited
Ankyrin repeat0.5976Inherited
PDZ domain-like0.8374Inherited
Fibronectin type III0.9139Inherited
PH domain-like0.9505Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Tetrahydrofolate dehydrogenase/cyclohydrolase0Direct
Retinoblastoma tumor suppressor domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
DIX domain0Direct
p53 tetramerization domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
p53 DNA-binding domain-like0Direct
Homeodomain0.00000008349Direct
Bromodomain0.00003119Direct
T-box0.00008626Direct
Classic zinc finger, C2H20.0001032Direct
Histone lysine methyltransferases0.0001589Direct
SMAD MH1 domain0.0002341Direct
SMAD domain0.0002341Direct
Growth factor receptor domain0.0003574Direct
Forkhead DNA-binding domain0.001027Inherited
Extracellular domain of cell surface receptors0.001094Inherited
Protein kinases, catalytic subunit0.001921Inherited
Frizzled cysteine-rich domain0.002092Inherited
Notch domain0.003113Inherited
HMG-box0.005914Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.007138Inherited
Erythroid transcription factor GATA-10.009168Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.00975Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.0106Inherited
BRK domain-like0.0106Inherited
Transforming growth factor (TGF)-beta0.01449Inherited
Nuclear receptor0.0392Inherited
Integrin beta EGF-like domains0.04452Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.04452Inherited
Nuclear receptor ligand-binding domain0.05567Inherited
Integrin domains0.05643Inherited
Formate/glycerate dehydrogenases, NAD-domain0.0621Inherited
Cell cycle transcription factor e2f-dp0.07041Inherited
Complement components0.1011Inherited
ALDH-like0.1011Inherited
Integrin beta tail domain0.1011Inherited
Alpha-macroglobulin receptor domain0.1011Inherited
Ras-binding domain, RBD0.1059Inherited
DEP domain0.1383Inherited
ZZ domain0.1468Inherited
PHD domain0.1971Inherited
Third domain of FERM0.2767Inherited
SAM (sterile alpha motif) domain0.3389Inherited
WW domain0.4787Inherited
Ankyrin repeat0.5592Inherited
PDZ domain0.7463Inherited
Fibronectin type III0.9056Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nuclear receptor coactivator interlocking domain0Direct
Tricorn protease domain 20Direct
p53 tetramerization domain0Direct
Homeodomain-like0.0000000001263Direct
p53-like transcription factors0.000005376Direct
"Winged helix" DNA-binding domain0.00001513Direct
beta-beta-alpha zinc fingers0.00002466Direct
Bromodomain0.00002681Direct
WD40 repeat-like0.0001017Direct
Protein kinase-like (PK-like)0.0001766Direct
SMAD MH1 domain0.0002117Direct
SET domain0.0002525Direct
Growth factor receptor domain0.0003655Direct
BRCT domain0.0009325Direct
Frizzled cysteine-rich domain0.001836Inherited
Snake toxin-like0.002198Inherited
Notch domain0.00285Inherited
HMG-box0.005165Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006323Inherited
Nucleic acid-binding proteins0.007592Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.007592Inherited
BRK domain-like0.009843Inherited
DNA clamp0.009843Inherited
HCP-like0.01009Inherited
Cystine-knot cytokines0.01175Inherited
Cyclin-like0.01595Inherited
Nuclear receptor ligand-binding domain0.05003Inherited
Integrin domains0.05168Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.05856Inherited
Terpenoid cyclases/Protein prenyltransferases0.06603Inherited
SMAD/FHA domain0.07743Inherited
Histone-fold0.08478Inherited
Integrin beta tail domain0.09529Inherited
ALDH-like0.09529Inherited
Alpha-macroglobulin receptor domain0.09529Inherited
SAM/Pointed domain0.1311Inherited
Ubiquitin-like0.1497Inherited
TIMP-like0.3439Inherited
GTPase activation domain, GAP0.3536Inherited
WW domain0.4618Inherited
Ankyrin repeat0.5511Inherited
PDZ domain-like0.8022Inherited
Fibronectin type III0.8848Inherited
PH domain-like0.9254Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.00000617Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001277Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.00285Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.003288Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.006551Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.007204Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.009843Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.009843Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.01451Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.02295Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.02935Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.05856Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.09529Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.1304Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1786Inherited
    47031,50729
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.2012Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.3401Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.3703Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.0007899Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0008297Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.00285Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.009547Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.01009Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.05856Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.09529Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1688Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.2602Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.3401Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)