SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): endocrine/exocrine gland phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   endocrine/exocrine gland phenotype [MP:0005379] <2>(34|51) (41|27|10)
- 1:   abnormal gland morphology [MP:0002163] <18>(32|45) (39|25|10)
- 1:   abnormal gland physiology [MP:0002164] <13>(4|12) (7|6|2)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
N-acetylmuramoyl-L-alanine amidase-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Insulin-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
Homeodomain-like0.0000006689Direct
Nuclear receptor ligand-binding domain0.00000305Direct
p53-like transcription factors0.000009336Direct
Protein kinase-like (PK-like)0.0002436Direct
STAT0.0009139Direct
Transcription factor STAT-4 N-domain0.0009139Direct
SH2 domain0.001568Inherited
PAZ domain0.002779Inherited
HLH, helix-loop-helix DNA-binding domain0.002979Inherited
Tudor/PWWP/MBT0.00312Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006035Inherited
Notch domain0.00825Inherited
Caspase-like0.009034Inherited
4-helical cytokines0.01202Inherited
Nucleic acid-binding proteins0.01541Inherited
The spindle assembly checkpoint protein mad20.02313Inherited
PYP-like sensor domain (PAS domain)0.03389Inherited
Cystine-knot cytokines0.03793Inherited
Ribonuclease H-like0.06978Inherited
TNF receptor-like0.08853Inherited
beta-beta-alpha zinc fingers0.118Inherited
CCCH zinc finger0.1321Inherited
E set domains0.2958Inherited
Rhodanese/Cell cycle control phosphatase0.4008Inherited
Family A G protein-coupled receptor-like0.7045Inherited
EGF/Laminin0.7101Inherited
Intermediate filament protein, coiled coil region0.8294Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Insulin-like0Direct
Retinoblastoma tumor suppressor domains0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
p53 DNA-binding domain-like0Direct
Homeodomain0.000001318Direct
Nuclear receptor ligand-binding domain0.00000298Direct
Nuclear receptor0.00001605Direct
Paired domain0.00005978Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0003549Direct
Tudor domain0.0004374Direct
STAT DNA-binding domain0.0006509Direct
STAT0.0006509Direct
Pointed domain0.0006509Direct
Transcription factor STAT-4 N-domain0.0006509Direct
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.001193Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001194Inherited
SH2 domain0.001708Inherited
PAZ domain0.002037Inherited
Caspase catalytic domain0.003139Inherited
HLH, helix-loop-helix DNA-binding domain0.003262Inherited
L domain0.006158Inherited
Notch domain0.006158Inherited
Transforming growth factor (TGF)-beta0.01152Inherited
Growth factor receptor domain0.01637Inherited
The spindle assembly checkpoint protein mad20.01819Inherited
Cytochrome p450 reductase N-terminal domain-like0.01819Inherited
TNF receptor-like0.01916Inherited
Myeloperoxidase-like0.04437Inherited
Single strand DNA-binding domain, SSB0.04437Inherited
Short-chain cytokines0.09129Inherited
Long-chain cytokines0.09883Inherited
TNF-like0.102Inherited
CCCH zinc finger0.1181Inherited
DEATH domain, DD0.1245Inherited
Papain-like0.1652Inherited
Caspase recruitment domain, CARD0.1672Inherited
Cell cycle control phosphatase, catalytic domain0.2813Inherited
Phosphotyrosine-binding domain (PTB)0.3906Inherited
V set domains (antibody variable domain-like)0.5468Inherited
I set domains0.7694Inherited
Pleckstrin-homology domain (PH domain)0.8147Inherited
Intermediate filament protein, coiled coil region0.8286Inherited
Rhodopsin-like0.8363Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Hedgehog/DD-peptidase0Direct
Nuclear receptor coactivator interlocking domain0Direct
Hedgehog/intein (Hint) domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Insulin-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Homeodomain-like0.0000003131Direct
Nuclear receptor ligand-binding domain0.000001472Direct
p53-like transcription factors0.000004587Direct
Protein kinase-like (PK-like)0.0001321Direct
Transcription factor STAT-4 N-domain0.0005217Direct
STAT0.0005217Direct
SH2 domain0.0009154Direct
lambda repressor-like DNA-binding domains0.001434Inherited
PAZ domain0.001662Inherited
HLH, helix-loop-helix DNA-binding domain0.00179Inherited
Tudor/PWWP/MBT0.001883Inherited
Bcl-2 inhibitors of programmed cell death0.002477Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.003764Inherited
Notch domain0.00524Inherited
Caspase-like0.005789Inherited
4-helical cytokines0.007829Inherited
Nucleic acid-binding proteins0.01019Inherited
The spindle assembly checkpoint protein mad20.01573Inherited
PYP-like sensor domain (PAS domain)0.02371Inherited
Cystine-knot cytokines0.02681Inherited
SMAD MH1 domain0.03864Inherited
Heme-dependent peroxidases0.03864Inherited
Ribonuclease H-like0.05172Inherited
Growth factor receptor domain0.06295Inherited
TNF receptor-like0.06705Inherited
TNF-like0.08426Inherited
beta-beta-alpha zinc fingers0.0922Inherited
CCCH zinc finger0.1045Inherited
E set domains0.254Inherited
Rhodanese/Cell cycle control phosphatase0.3546Inherited
Family A G protein-coupled receptor-like0.6618Inherited
EGF/Laminin0.6676Inherited
Intermediate filament protein, coiled coil region0.7935Inherited
Cysteine proteinases0.9091Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002062Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0002712Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0005217Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005217Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005217Direct
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.001662Inherited
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.003285Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.00524Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00524Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.005721Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.005789Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01573Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.03048Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.03119Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.04053Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.04545Inherited
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.04545Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.06616Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.0677Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.08938Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1744Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1951Inherited
    54236,47031
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 0.4723Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.4951Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.6456Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0005217Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0005217Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.004937Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.00524Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.01132Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01613Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.1131Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.215Inherited
    54236,47031,50729
  • 54236 - Ubiquitin-like
  • 47031 - Second domain of FERM
  • 50729 - PH domain-like
  • 0.4723Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)