SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): growth/size/body phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   growth/size/body phenotype [MP:0005378] <10>(57|87) (64|37|15)
- 1:   heterotaxia [MP:0004133] <10>(0|2) (1|0|0)
- 1:   abnormal head morphology [MP:0000432] <8>(12|24) (16|8|3)
- 1:   abnormal neck morphology [MP:0012719] <6>(0|0) (0|0|0)
- 1:   abnormal body composition [MP:0005451] <5>(15|25) (17|11|4)
- 1:   abnormal prenatal growth/weight/body size [MP:0004196] <4>(9|13) (10|7|4)
- 1:   abnormal birth body size [MP:0009701] <3>(5|5) (5|1|0)
- 1:   abnormal body wall morphology [MP:0003385] <3>(1|1) (2|0|0)
- 1:   abnormal chest morphology [MP:0004134] <3>(1|0) (1|0|0)
- 1:   abnormal postnatal growth/weight/body size [MP:0002089] <3>(32|46) (37|23|8)
- 1:   distended abdomen [MP:0001270] <1>(1|2) (1|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Notch domain0Direct
FabD/lysophospholipase-like0Direct
Mib/herc2 domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
KA1-like0Direct
Glutamine synthetase/guanido kinase0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
JAB1/MPN domain0Direct
Tricorn protease domain 20Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Guanido kinase N-terminal domain0Direct
Lamin A/C globular tail domain0Direct
p53 tetramerization domain0Direct
A heparin-binding domain0Direct
GAT-like domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ACT-like0Direct
SRF-like0Direct
Nuclear receptor coactivator interlocking domain0Direct
Assembly domain of cartilage oligomeric matrix protein0Direct
Homeodomain-like0.0000158Direct
p53-like transcription factors0.00003837Direct
HLH, helix-loop-helix DNA-binding domain0.00006573Direct
Nuclear receptor ligand-binding domain0.0001245Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0009727Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.001907Inherited
Riboflavin synthase domain-like0.001907Inherited
ENTH/VHS domain0.01424Inherited
"Winged helix" DNA-binding domain0.01723Inherited
SMAD MH1 domain0.02233Inherited
Flavoproteins0.02233Inherited
Cystine-knot cytokines0.03551Inherited
Galactose-binding domain-like0.05468Inherited
Frizzled cysteine-rich domain0.06602Inherited
GroEL apical domain-like0.07056Inherited
Intermediate filament protein, coiled coil region0.07664Inherited
YWTD domain0.1063Inherited
Clathrin adaptor appendage domain0.1089Inherited
STAT0.1089Inherited
Transcription factor STAT-4 N-domain0.1089Inherited
(Trans)glycosidases0.1131Inherited
BRCT domain0.1503Inherited
Thioesterase/thiol ester dehydrase-isomerase0.1711Inherited
TB module/8-cys domain0.1998Inherited
Insulin-like0.1998Inherited
Cyclin-like0.2505Inherited
Nucleic acid-binding proteins0.2519Inherited
FnI-like domain0.2529Inherited
ALDH-like0.2883Inherited
beta-sandwich domain of Sec23/240.4097Inherited
4-helical cytokines0.4793Inherited
TNF-like0.9874Inherited
Family A G protein-coupled receptor-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Tetrahydrofolate dehydrogenase/cyclohydrolase0Direct
Rel/Dorsal transcription factors, DNA-binding domain0Direct
GAT domain0Direct
CPH domain0Direct
Retinoblastoma tumor suppressor domains0Direct
A heparin-binding domain0Direct
PAS domain of steroid receptor coactivator 1A, NCo-A10Direct
Pyridoxal-dependent decarboxylase0Direct
gamma-adaptin C-terminal appendage domain-like0Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
Kinase associated domain 1, KA10Direct
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
Hexokinase0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Notch domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
NADPH-cytochrome p450 reductase-like0Direct
IP3 receptor type 1 binding core, domain 20Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
ATP-dependent DNA ligase catalytic domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
HCDH C-domain-like0Direct
Mib/herc2 domain0Direct
APC10-like0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
SMAD4-binding domain of oncoprotein Ski0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Guanido kinase N-terminal domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Alkaline phosphatase0Direct
Guanido kinase catalytic domain0Direct
Adenosine/AMP deaminase0Direct
Assembly domain of cartilage oligomeric matrix protein0Direct
Cullin repeat0Direct
Neurotrophin0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
SRF-like0Direct
Phenylalanine metabolism regulatory domain0Direct
p53 DNA-binding domain-like0Direct
Lamin A/C globular tail domain0Direct
HLH, helix-loop-helix DNA-binding domain0.00005979Direct
Nuclear receptor0.0000713Direct
Nuclear receptor ligand-binding domain0.00009797Direct
Homeodomain0.0001649Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001346Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003624Inherited
Cell cycle transcription factor e2f-dp0.004886Inherited
Paired domain0.004886Inherited
Laminin-type module0.005964Inherited
Inositol polyphosphate 5-phosphatase (IPP5)0.009157Inherited
Growth factor receptor domain0.01674Inherited
VHS domain0.01716Inherited
SMAD MH1 domain0.01716Inherited
SMAD domain0.01716Inherited
Extracellular domain of cell surface receptors0.01967Inherited
Forkhead DNA-binding domain0.03476Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.03929Inherited
T-box0.04804Inherited
Myb/SANT domain0.04804Inherited
Frizzled cysteine-rich domain0.05577Inherited
DIX domain0.05717Inherited
Intermediate filament protein, coiled coil region0.06744Inherited
Histone lysine methyltransferases0.08831Inherited
YWTD domain0.09157Inherited
STAT DNA-binding domain0.09238Inherited
STAT0.09238Inherited
Transcription factor STAT-4 N-domain0.09238Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.1026Inherited
Transforming growth factor (TGF)-beta0.1214Inherited
Insulin-like0.1777Inherited
TB module/8-cys domain0.1777Inherited
VWC domain0.2088Inherited
Transducin (alpha subunit), insertion domain0.2182Inherited
CalX-beta domain0.2628Inherited
ALDH-like0.2628Inherited
Cold shock DNA-binding domain-like0.2777Inherited
DEP domain0.2866Inherited
Glutathione peroxidase-like0.3831Inherited
DEATH domain, DD0.4194Inherited
PDZ domain0.5058Inherited
I set domains0.7434Inherited
TNF-like0.984Inherited
Rhodopsin-like1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
CAPPD, an extracellular domain of amyloid beta A4 protein0Direct
A heparin-binding domain0Direct
GAT-like domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Nuclear receptor coactivator interlocking domain0Direct
FabD/lysophospholipase-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
JAB1/MPN domain0Direct
SRF-like0Direct
Mib/herc2 domain-like0Direct
Lamin A/C globular tail domain0Direct
Notch domain0Direct
Tricorn protease domain 20Direct
p53 tetramerization domain0Direct
Amyloid beta a4 protein copper binding domain (domain 2)0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Assembly domain of cartilage oligomeric matrix protein0Direct
KA1-like0Direct
Guanido kinase N-terminal domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
ACT-like0Direct
Glutamine synthetase/guanido kinase0Direct
Homeodomain-like0.000007872Direct
p53-like transcription factors0.00001987Direct
HLH, helix-loop-helix DNA-binding domain0.00003471Direct
Nuclear receptor ligand-binding domain0.0000667Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0005541Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.001124Inherited
Riboflavin synthase domain-like0.001124Inherited
Growth factor receptor domain0.008857Inherited
ENTH/VHS domain0.009354Inherited
"Winged helix" DNA-binding domain0.01147Inherited
SMAD MH1 domain0.01518Inherited
Flavoproteins0.01518Inherited
Cystine-knot cytokines0.02492Inherited
DNase I-like0.02735Inherited
Galactose-binding domain-like0.03959Inherited
Frizzled cysteine-rich domain0.04865Inherited
GroEL apical domain-like0.05234Inherited
Intermediate filament protein, coiled coil region0.05729Inherited
YWTD domain0.08216Inherited
Transcription factor STAT-4 N-domain0.08426Inherited
Clathrin adaptor appendage domain0.08426Inherited
STAT0.08426Inherited
(Trans)glycosidases0.08795Inherited
SET domain0.1029Inherited
BRCT domain0.1202Inherited
Thioesterase/thiol ester dehydrase-isomerase0.1386Inherited
Insulin-like0.1645Inherited
TB module/8-cys domain0.1645Inherited
Transducin (alpha subunit), insertion domain0.2004Inherited
TIMP-like0.2057Inherited
Cyclin-like0.2117Inherited
Nucleic acid-binding proteins0.2129Inherited
FnI-like domain0.2139Inherited
ALDH-like0.247Inherited
CalX-like0.247Inherited
beta-sandwich domain of Sec23/240.3633Inherited
WD40 repeat-like0.3637Inherited
4-helical cytokines0.4317Inherited
TNF-like0.9671Inherited
Family A G protein-coupled receptor-like0.9857Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    50729,57889
  • 50729 - PH domain-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    56491,89811
  • 56491 - A heparin-binding domain
  • 89811 - Amyloid beta a4 protein copper binding domain (domain 2)
  • 0Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    64268,103657
  • 64268 - PX domain
  • 103657 - BAR/IMD domain-like
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    48034,55931
  • 48034 - Guanido kinase N-terminal domain
  • 55931 - Glutamine synthetase/guanido kinase
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    54236,50729
  • 54236 - Ubiquitin-like
  • 50729 - PH domain-like
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    46955,63763
  • 46955 - Putative DNA-binding domain
  • 63763 - SAND domain-like
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0002743Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003043Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.03584Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.05068Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.05234Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.05234Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.06813Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.08426Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08426Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08426Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.09332Inherited
    53223,51735
  • 53223 - Aminoacid dehydrogenase-like, N-terminal domain
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.09514Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.1645Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2004Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0005694Direct
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.02827Inherited
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.08426Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.08426Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.08426Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2028Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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