SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): hearing/vestibular/ear phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   hearing/vestibular/ear phenotype [MP:0005377] <2>(17|19) (20|14|5)
- 1:   abnormal ear physiology [MP:0003878] <9>(5|5) (6|2|0)
- 1:   abnormal ear morphology [MP:0002102] <4>(15|19) (18|13|5)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Homeodomain-like0.00000002282Direct
Nuclear receptor ligand-binding domain0.0000412Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0004501Direct
Serine protease inhibitors0.001283Inherited
Growth factor receptor domain0.002632Inherited
EGF/Laminin0.004419Inherited
Nicotinic receptor ligand binding domain-like0.006444Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.006444Inherited
Frizzled cysteine-rich domain0.009305Inherited
Cadherin-like0.05176Inherited
Second domain of FERM0.05285Inherited
(Trans)glycosidases0.07593Inherited
Cystine-knot cytokines0.1141Inherited
Voltage-gated potassium channels0.1652Inherited
PDZ domain-like0.2855Inherited
GTPase activation domain, GAP0.3733Inherited
SH3-domain0.5094Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Homeodomain0.00000004208Direct
Nuclear receptor0.00001432Direct
Nuclear receptor ligand-binding domain0.00002509Direct
DIX domain0.00002923Direct
Paired domain0.0001195Direct
Growth factor receptor domain0.003763Inherited
Nicotinic receptor ligand binding domain-like0.004503Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.004503Inherited
Frizzled cysteine-rich domain0.006541Inherited
Motor proteins0.01706Inherited
Laminin G-like module0.02155Inherited
DEP domain0.02311Inherited
Cadherin0.03604Inherited
Transducin (alpha subunit), insertion domain0.04643Inherited
Voltage-gated potassium channels0.05619Inherited
Transforming growth factor (TGF)-beta0.0891Inherited
PDZ domain0.1406Inherited
EGF-type module0.1435Inherited
SH3-domain0.4845Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Homeodomain-like0.00000001022Direct
Nuclear receptor ligand-binding domain0.00002137Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0002507Direct
Serine protease inhibitors0.0007377Direct
Growth factor receptor domain0.001574Inherited
EGF/Laminin0.002714Inherited
Nicotinic receptor ligand binding domain-like0.004046Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.004046Inherited
Frizzled cysteine-rich domain0.005979Inherited
HLH, helix-loop-helix DNA-binding domain0.008684Inherited
Cadherin-like0.03727Inherited
Second domain of FERM0.03816Inherited
Transducin (alpha subunit), insertion domain0.04348Inherited
(Trans)glycosidases0.0567Inherited
Cystine-knot cytokines0.08882Inherited
DEATH domain0.1229Inherited
Voltage-gated potassium channels0.1335Inherited
PDZ domain-like0.2446Inherited
GTPase activation domain, GAP0.3275Inherited
SH3-domain0.4622Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0000004494Direct
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0009475Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00111Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.002346Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.003543Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.004046Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.007314Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.0278Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.0293Inherited
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0.03021Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04348Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.0567Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.225Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.3133Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.0001395Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.000225Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.005233Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.007314Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.02583Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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