SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): homeostasis/metabolism phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   homeostasis/metabolism phenotype [MP:0005376] <7>(133|157) (140|83|35)
- 1:   abnormal homeostasis [MP:0001764] <27>(97|117) (103|58|23)
- 1:   abnormal metabolism [MP:0005266] <18>(23|20) (23|9|2)
- 1:   wounding [MP:0013027] <17>(0|0) (0|0|0)
- 1:   fibrosis [MP:0003045] <13>(9|9) (10|7|4)
- 1:   abnormal response to injury [MP:0005164] <9>(9|13) (11|6|3)
- 1:   abnormal physiological response to xenobiotic [MP:0008872] <3>(5|5) (5|2|0)
- 1:   amyloidosis [MP:0000604] <2>(1|3) (1|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Metallothionein0Direct
Rudiment single hybrid motif0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
HIT-like0Direct
BEACH domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Notch domain0Direct
Ammonium transporter0Direct
FabD/lysophospholipase-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Phenylalanine zipper0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
WGR domain-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Apolipoprotein A-I0Direct
KA1-like0Direct
DNA-glycosylase0Direct
CoA-dependent acyltransferases0Direct
Resistin0Direct
Riboflavin synthase domain-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GLA-domain0Direct
HMA, heavy metal-associated domain0Direct
Radical SAM enzymes0Direct
Carbon-nitrogen hydrolase0Direct
Flavoproteins0Direct
FAS1 domain0Direct
p53 tetramerization domain0Direct
AXH domain0Direct
Single hybrid motif0Direct
Glycosyl hydrolase domain0Direct
Transferrin receptor-like dimerisation domain0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
ACT-like0Direct
Six-hairpin glycosidases0Direct
Aldolase0Direct
Synuclein0Direct
Anaphylotoxins (complement system)0Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
Family A G protein-coupled receptor-like0.0000009601Direct
Cytochrome P4500.000002376Direct
ABC transporter transmembrane region0.0002808Direct
Nuclear receptor ligand-binding domain0.001017Inherited
Protein kinase-like (PK-like)0.001046Inherited
Hormone receptor domain0.001443Inherited
alpha/beta-Hydrolases0.002946Inherited
p53-like transcription factors0.003107Inherited
Aquaporin-like0.004267Inherited
(Trans)glycosidases0.008086Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.01207Inherited
4-helical cytokines0.01619Inherited
MFS general substrate transporter0.01761Inherited
DHS-like NAD/FAD-binding domain0.02137Inherited
LDL receptor-like module0.02345Inherited
CBS-domain pair0.02796Inherited
PLP-dependent transferases0.02823Inherited
Lipocalins0.02823Inherited
PYP-like sensor domain (PAS domain)0.03565Inherited
SMAD MH1 domain0.03587Inherited
STAT0.03587Inherited
Inhibitor of apoptosis (IAP) repeat0.03587Inherited
Transcription factor STAT-4 N-domain0.03587Inherited
Galactose mutarotase-like0.05946Inherited
Thioesterase/thiol ester dehydrase-isomerase0.05946Inherited
Phoshotransferase/anion transport protein0.0676Inherited
Kringle-like0.07634Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.08489Inherited
Lipoxigenase0.09658Inherited
FAD-binding/transporter-associated domain-like0.09658Inherited
GAT-like domain0.09658Inherited
Nuclear receptor coactivator interlocking domain0.09658Inherited
DEATH domain0.0987Inherited
Glycerol-3-phosphate (1)-acyltransferase0.102Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.102Inherited
Clc chloride channel0.102Inherited
Insulin-like0.102Inherited
Cystine-knot cytokines0.1096Inherited
ClpP/crotonase0.1525Inherited
Heme-dependent peroxidases0.1525Inherited
Multidrug efflux transporter AcrB transmembrane domain0.1525Inherited
Triple coiled coil domain of C-type lectins0.1564Inherited
Domain of poly(ADP-ribose) polymerase0.1564Inherited
SMAD/FHA domain0.1619Inherited
Transducin (alpha subunit), insertion domain0.187Inherited
Toll/Interleukin receptor TIR domain0.1879Inherited
Trypsin-like serine proteases0.1971Inherited
Actin-like ATPase domain0.2006Inherited
Thioredoxin-like0.2204Inherited
Caspase-like0.2224Inherited
Cation efflux protein transmembrane domain-like0.2239Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2239Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.2239Inherited
Putative DNA-binding domain0.2239Inherited
Complement control module/SCR domain0.2307Inherited
Alkaline phosphatase-like0.2649Inherited
EGF/Laminin0.2721Inherited
Hemopexin-like domain0.3068Inherited
WW domain0.3162Inherited
YWTD domain0.3192Inherited
DNA repair protein MutS, domain III0.3235Inherited
DNA polymerase beta, N-terminal domain-like0.3235Inherited
SH2 domain0.3347Inherited
PLC-like phosphodiesterases0.3369Inherited
ENTH/VHS domain0.3369Inherited
CAD & PB1 domains0.3369Inherited
Mitochondrial carrier0.3514Inherited
Ran binding protein zinc finger-like0.3514Inherited
Cytokine0.373Inherited
Calponin-homology domain, CH-domain0.4139Inherited
Plakin repeat0.4852Inherited
ADP-ribosylation0.5164Inherited
FAD/NAD(P)-binding domain0.5263Inherited
BRCT domain0.5295Inherited
Spectrin repeat0.5311Inherited
C-type lectin-like0.5654Inherited
HMG-box0.5923Inherited
Clathrin adaptor appendage domain0.6255Inherited
Nucleic acid-binding proteins0.6593Inherited
Carbonic anhydrase0.7133Inherited
Metallo-dependent hydrolases0.7391Inherited
Fibronectin type III0.7415Inherited
CCCH zinc finger0.827Inherited
HLH, helix-loop-helix DNA-binding domain0.8464Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8631Inherited
PH domain-like0.8774Inherited
TNF-like0.9517Inherited
SH3-domain1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited
Homeodomain-like1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Chromo barrel domain0Direct
Interleukin-1 (IL-1)0Direct
Tissue inhibitor of metalloproteinases, TIMP0Direct
Retinoblastoma tumor suppressor domains0Direct
FolH catalytic domain-like0Direct
MHCK/EF2 kinase0Direct
Pyridoxal-dependent decarboxylase0Direct
Choline/Carnitine O-acyltransferase0Direct
Kinase associated domain 1, KA10Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
Notch domain0Direct
5' to 3' exonuclease catalytic domain0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
FAS1 domain0Direct
Adapter protein APS, dimerisation domain0Direct
WGR domain0Direct
BEACH domain0Direct
Amylase, catalytic domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Crotonase-like0Direct
NADPH-cytochrome p450 reductase-like0Direct
Cytidylyltransferase0Direct
p53 tetramerization domain0Direct
RUNT domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Anaphylotoxins (complement system)0Direct
ATP-dependent DNA ligase catalytic domain0Direct
HCDH C-domain-like0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
AXH domain0Direct
GLA-domain0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Multidomain cupredoxins0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Transferrin receptor-like dimerisation domain0Direct
BC C-terminal domain-like0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
BC N-terminal domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
PA domain0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
Adenosine/AMP deaminase0Direct
Ammonium transporter0Direct
Resistin0Direct
Synuclein0Direct
Apolipoprotein A-I0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
HMA, heavy metal-associated domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Metallothionein0Direct
Phenylalanine metabolism regulatory domain0Direct
p53 DNA-binding domain-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
BC ATP-binding domain-like0Direct
Cytochrome P4500.000001944Direct
Rhodopsin-like0.00001772Direct
ABC transporter transmembrane region0.00004975Direct
ABC transporter ATPase domain-like0.0001293Direct
Nuclear receptor ligand-binding domain0.0009053Direct
Hormone receptor domain0.001108Inherited
Nuclear receptor0.001928Inherited
Aquaporin-like0.003225Inherited
Platelet-derived growth factor-like0.01699Inherited
LDL receptor-like module0.0203Inherited
CBS-domain pair0.02281Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.02429Inherited
Pancreatic lipase, N-terminal domain0.02876Inherited
Inhibitor of apoptosis (IAP) repeat0.02876Inherited
STAT DNA-binding domain0.02876Inherited
STAT0.02876Inherited
SMAD MH1 domain0.02876Inherited
SMAD domain0.02876Inherited
Sir2 family of transcriptional regulators0.02876Inherited
Transcription factor STAT-4 N-domain0.02876Inherited
Fibronectin type II module0.03597Inherited
Fatty acid binding protein-like0.05581Inherited
Ras-binding domain, RBD0.05759Inherited
CAD domain0.08173Inherited
Cytochrome b50.08173Inherited
Nuclear receptor coactivator interlocking domain0.08173Inherited
Pyrin domain, PYD0.08173Inherited
Animal lipoxigenases0.08173Inherited
EGF-type module0.08369Inherited
Insulin-like0.08811Inherited
Clc chloride channel0.08811Inherited
6-phosphogluconate dehydrogenase-like, N-terminal domain0.08811Inherited
Anion transport protein, cytoplasmic domain0.08811Inherited
Caspase catalytic domain0.1213Inherited
Myeloperoxidase-like0.135Inherited
GABA-aminotransferase-like0.135Inherited
GAT domain0.1365Inherited
gamma-adaptin C-terminal appendage domain-like0.1365Inherited
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A0.1365Inherited
Domain of poly(ADP-ribose) polymerase0.1365Inherited
beta-glycanases0.1365Inherited
Triple coiled coil domain of C-type lectins0.1365Inherited
SNF-like0.1489Inherited
Kringle modules0.1722Inherited
Transducin (alpha subunit), insertion domain0.1722Inherited
Long-chain cytokines0.1722Inherited
PLC-like (P variant)0.191Inherited
T-box0.1923Inherited
Myb/SANT domain0.1923Inherited
Interferons/interleukin-10 (IL-10)0.2024Inherited
Poly(ADP-ribose) polymerase, C-terminal domain0.2024Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.2024Inherited
E2F dimerization segment0.2024Inherited
Cation efflux protein transmembrane domain-like0.2024Inherited
Gelsolin-like0.2024Inherited
DEATH domain, DD0.2127Inherited
Complement control module/SCR domain0.2228Inherited
Toll/Interleukin receptor TIR domain0.2247Inherited
Eukaryotic proteases0.226Inherited
Penta-EF-hand proteins0.2466Inherited
EF-hand modules in multidomain proteins0.2678Inherited
Papain-like0.2776Inherited
Matrix metalloproteases, catalytic domain0.2821Inherited
Hemopexin-like domain0.2949Inherited
DNA polymerase beta, N-terminal domain-like0.2987Inherited
Lipoxigenase N-terminal domain0.2987Inherited
DNA repair protein MutS, domain III0.2987Inherited
Mammalian PLC0.3014Inherited
YWTD domain0.3014Inherited
WW domain0.3063Inherited
Spectrin repeat0.3063Inherited
Ran binding protein zinc finger-like0.3363Inherited
Mitochondrial carrier0.3363Inherited
SH2 domain0.3519Inherited
Interferon regulatory factor0.3692Inherited
Tyrosine-dependent oxidoreductases0.3925Inherited
Calponin-homology domain, CH-domain0.4118Inherited
Meta-cation ATPase, catalytic domain P0.4155Inherited
Growth factor receptor domain0.4226Inherited
FHA domain0.4253Inherited
Plakin repeat0.4615Inherited
Arylsulfatase0.4791Inherited
C-type lectin domain0.4883Inherited
28-residue LRR0.5054Inherited
Caspase recruitment domain, CARD0.5107Inherited
Transforming growth factor (TGF)-beta0.5923Inherited
HMG-box0.5923Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.6048Inherited
VHS domain0.6061Inherited
Pleckstrin-homology domain (PH domain)0.6468Inherited
Carbonic anhydrase0.701Inherited
Cyclin0.7696Inherited
Fibronectin type III0.7722Inherited
CCCH zinc finger0.8141Inherited
HLH, helix-loop-helix DNA-binding domain0.8622Inherited
TNF-like0.9493Inherited
G proteins0.9926Inherited
Homeodomain1Inherited
PHD domain1Inherited
SH3-domain1Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
WGR domain-like0Direct
Radical SAM enzymes0Direct
Metallothionein0Direct
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
ATP-dependent DNA ligase DNA-binding domain0Direct
GLA-domain0Direct
Transferrin receptor-like dimerisation domain0Direct
Resistin0Direct
Glycosyl hydrolase domain0Direct
FAS1 domain0Direct
Carbon-nitrogen hydrolase0Direct
FabD/lysophospholipase-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Apolipoprotein A-I0Direct
Aldolase0Direct
HMA, heavy metal-associated domain0Direct
Synuclein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
CoA-dependent acyltransferases0Direct
HIT-like0Direct
DNA-glycosylase0Direct
Notch domain0Direct
BEACH domain0Direct
Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain0Direct
p53 tetramerization domain0Direct
Phenylalanine zipper0Direct
5' to 3' exonuclease, C-terminal subdomain0Direct
AXH domain0Direct
Anaphylotoxins (complement system)0Direct
Rudiment single hybrid motif0Direct
Ammonium transporter0Direct
KA1-like0Direct
Six-hairpin glycosidases0Direct
Single hybrid motif0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
N-acetylmuramoyl-L-alanine amidase-like0Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0Direct
ACT-like0Direct
Riboflavin synthase domain-like0Direct
Flavoproteins0Direct
Family A G protein-coupled receptor-like0.0000004487Direct
Cytochrome P4500.000001143Direct
ABC transporter transmembrane region0.0001541Direct
Nuclear receptor ligand-binding domain0.0005806Direct
Protein kinase-like (PK-like)0.0005983Direct
Hormone receptor domain0.000839Direct
alpha/beta-Hydrolases0.00177Inherited
p53-like transcription factors0.001871Inherited
Aquaporin-like0.002618Inherited
(Trans)glycosidases0.005131Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.007856Inherited
4-helical cytokines0.01073Inherited
MFS general substrate transporter0.01173Inherited
DHS-like NAD/FAD-binding domain0.01446Inherited
LDL receptor-like module0.01597Inherited
CBS-domain pair0.01923Inherited
PLP-dependent transferases0.01943Inherited
Lipocalins0.01943Inherited
PYP-like sensor domain (PAS domain)0.02502Inherited
Inhibitor of apoptosis (IAP) repeat0.02519Inherited
Transcription factor STAT-4 N-domain0.02519Inherited
SMAD MH1 domain0.02519Inherited
STAT0.02519Inherited
Cytochrome b5-like heme/steroid binding domain0.04342Inherited
Thioesterase/thiol ester dehydrase-isomerase0.04342Inherited
Galactose mutarotase-like0.04342Inherited
Phoshotransferase/anion transport protein0.04992Inherited
Kringle-like0.05702Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.0641Inherited
Integrin domains0.06547Inherited
Bet v1-like0.07238Inherited
GAT-like domain0.07386Inherited
Lipoxigenase0.07386Inherited
Nuclear receptor coactivator interlocking domain0.07386Inherited
FAD-binding/transporter-associated domain-like0.07386Inherited
DEATH domain0.07566Inherited
Glycerol-3-phosphate (1)-acyltransferase0.07842Inherited
Insulin-like0.07842Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.07842Inherited
Clc chloride channel0.07842Inherited
Cystine-knot cytokines0.08495Inherited
ClpP/crotonase0.122Inherited
Heme-dependent peroxidases0.122Inherited
Multidrug efflux transporter AcrB transmembrane domain0.122Inherited
Domain of poly(ADP-ribose) polymerase0.1255Inherited
BRK domain-like0.1255Inherited
Triple coiled coil domain of C-type lectins0.1255Inherited
FnI-like domain0.1279Inherited
SMAD/FHA domain0.1304Inherited
SNF-like0.1324Inherited
Transducin (alpha subunit), insertion domain0.1529Inherited
Toll/Interleukin receptor TIR domain0.1538Inherited
Trypsin-like serine proteases0.1622Inherited
Actin-like ATPase domain0.1653Inherited
Thioredoxin-like0.1837Inherited
Caspase-like0.1857Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.187Inherited
Putative DNA-binding domain0.187Inherited
Cation efflux protein transmembrane domain-like0.187Inherited
6-phosphogluconate dehydrogenase C-terminal domain-like0.187Inherited
Complement control module/SCR domain0.1934Inherited
Alkaline phosphatase-like0.2254Inherited
EGF/Laminin0.232Inherited
DNase I-like0.241Inherited
Hemopexin-like domain0.2642Inherited
WW domain0.2734Inherited
YWTD domain0.2762Inherited
DNA polymerase beta, N-terminal domain-like0.2799Inherited
DNA repair protein MutS, domain III0.2799Inherited
SH2 domain0.2907Inherited
ENTH/VHS domain0.2928Inherited
CAD & PB1 domains0.2928Inherited
PLC-like phosphodiesterases0.2928Inherited
Mitochondrial carrier0.3065Inherited
Ran binding protein zinc finger-like0.3065Inherited
Cytokine0.3273Inherited
Calponin-homology domain, CH-domain0.3674Inherited
Plakin repeat0.4378Inherited
ADP-ribosylation0.4692Inherited
FAD/NAD(P)-binding domain0.4788Inherited
BRCT domain0.482Inherited
Spectrin repeat0.4836Inherited
C-type lectin-like0.5185Inherited
HMG-box0.5458Inherited
Clathrin adaptor appendage domain0.5799Inherited
Nucleic acid-binding proteins0.6145Inherited
Carbonic anhydrase0.6712Inherited
Metallo-dependent hydrolases0.698Inherited
Fibronectin type III0.7006Inherited
CCCH zinc finger0.7909Inherited
HLH, helix-loop-helix DNA-binding domain0.8119Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.8297Inherited
PH domain-like0.8452Inherited
TNF-like0.9267Inherited
Homeodomain-like0.9933Inherited
SH3-domain1Inherited
P-loop containing nucleoside triphosphate hydrolases1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    81837,50978
  • 81837 - BEACH domain
  • 50978 - WD40 repeat-like
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0Direct
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0Direct
    47473,103506
  • 47473 - EF-hand
  • 103506 - Mitochondrial carrier
  • 0Direct
    53474,49723
  • 53474 - alpha/beta-Hydrolases
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 0Direct
    117018,56091
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    82153,82153
  • 82153 - FAS1 domain
  • 82153 - FAS1 domain
  • 0Direct
    56112,54427
  • 56112 - Protein kinase-like (PK-like)
  • 54427 - NTF2-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    55021,56534
  • 55021 - ACT-like
  • 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
  • 0Direct
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0Direct
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    57424,50494
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0001541Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0008027Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.01943Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.02519Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02519Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02519Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.02952Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0358Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.04342Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.04342Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.04815Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.07386Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.07386Inherited
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0.07386Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.07798Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.07842Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.07842Inherited
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.07842Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.07842Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.122Inherited
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.1255Inherited
    57603,82895
  • 57603 - FnI-like domain
  • 82895 - TSP-1 type 1 repeat
  • 0.1255Inherited
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0.1255Inherited
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.1255Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1529Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.1576Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1726Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1861Inherited
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0.187Inherited
    51735,48179
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 48179 - 6-phosphogluconate dehydrogenase C-terminal domain-like
  • 0.187Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.187Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.2103Inherited
    55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.2263Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.2263Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.2532Inherited
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0.2799Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2799Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.2799Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.3186Inherited
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.3186Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.3186Inherited
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.361Inherited
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0.361Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.4378Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.4378Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.4808Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.4841Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.6335Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.909Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    50729,81837,50978
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 50978 - WD40 repeat-like
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57424,57424,50494
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    117018,56091,50249
  • 117018 - ATP-dependent DNA ligase DNA-binding domain
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    142921,47587,56399
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.00146Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.02519Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.02519Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.04342Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.04342Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.04342Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.07386Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.07386Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.108Inherited
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0.1255Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1324Inherited
    55753,55753,55753
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 55753 - Actin depolymerizing proteins
  • 0.187Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.187Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2075Inherited
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.2263Inherited
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.2799Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.2799Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.2799Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.2799Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.3987Inherited


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