SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): liver/biliary system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   liver/biliary system phenotype [MP:0005370] <2>(27|31) (33|18|10)
- 1:   abnormal hepatobiliary system morphology [MP:0002138] <4>(20|24) (24|13|5)
- 1:   abnormal hepatobiliary system physiology [MP:0002139] <4>(10|12) (13|11|7)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Families 57/38 glycoside transferase middle domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Thioesterase/thiol ester dehydrase-isomerase0Direct
(Trans)glycosidases0.000009603Direct
Nuclear receptor ligand-binding domain0.00002464Direct
Acyl-CoA dehydrogenase NM domain-like0.0001921Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0001921Direct
4-helical cytokines0.0001981Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0003348Direct
STAT0.0008538Direct
Flavoproteins0.0008538Direct
Transcription factor STAT-4 N-domain0.0008538Direct
Glycoside hydrolase/deacetylase0.0009658Direct
alpha/beta-Hydrolases0.001324Inherited
p53-like transcription factors0.001458Inherited
Terpenoid cyclases/Protein prenyltransferases0.004894Inherited
Alpha-macroglobulin receptor domain0.008422Inherited
DHS-like NAD/FAD-binding domain0.01584Inherited
SH2 domain0.0161Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.05494Inherited
Riboflavin synthase domain-like0.05494Inherited
ABC transporter transmembrane region0.06516Inherited
Leucine zipper domain0.07305Inherited
YWTD domain0.0731Inherited
SOCS box-like0.09539Inherited
A DNA-binding domain in eukaryotic transcription factors0.1153Inherited
Trypsin-like serine proteases0.331Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
alpha-mannosidase, domain 20Direct
alpha-mannosidase, C-terminal domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
alpha-mannosidase0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Nuclear receptor ligand-binding domain0.00001946Direct
Nuclear receptor0.00003718Direct
STAT DNA-binding domain0.0005806Direct
STAT0.0005806Direct
Transcription factor STAT-4 N-domain0.0005806Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0.0006455Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.0006455Direct
NADPH-cytochrome p450 reductase-like0.0006455Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.0006455Direct
Rel/Dorsal transcription factors, DNA-binding domain0.0009781Direct
Fatty acid binding protein-like0.003653Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.006047Inherited
Complement components0.006183Inherited
Alpha-macroglobulin receptor domain0.006183Inherited
Sir2 family of transcriptional regulators0.006183Inherited
Erythroid transcription factor GATA-10.01208Inherited
SH2 domain0.01479Inherited
ABC transporter transmembrane region0.03437Inherited
ABC transporter ATPase domain-like0.03742Inherited
Insulin-like0.05752Inherited
YWTD domain0.06114Inherited
Leucine zipper domain0.06516Inherited
SOCS box-like0.08084Inherited
LDL receptor-like module0.09665Inherited
A DNA-binding domain in eukaryotic transcription factors0.1006Inherited
Eukaryotic proteases0.2693Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Thioesterase/thiol ester dehydrase-isomerase0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Families 57/38 glycoside transferase middle domain0Direct
(Trans)glycosidases0.000004721Direct
Nuclear receptor ligand-binding domain0.00001255Direct
Acyl-CoA dehydrogenase C-terminal domain-like0.0001039Direct
Acyl-CoA dehydrogenase NM domain-like0.0001039Direct
4-helical cytokines0.0001071Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0001845Direct
Transcription factor STAT-4 N-domain0.0004862Direct
STAT0.0004862Direct
Flavoproteins0.0004862Direct
Glycoside hydrolase/deacetylase0.0005502Direct
alpha/beta-Hydrolases0.0007642Direct
p53-like transcription factors0.0008486Direct
Terpenoid cyclases/Protein prenyltransferases0.003028Inherited
Alpha-macroglobulin receptor domain0.005358Inherited
DHS-like NAD/FAD-binding domain0.01048Inherited
SH2 domain0.01068Inherited
HCP-like0.01928Inherited
Lipocalins0.02253Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.03981Inherited
Riboflavin synthase domain-like0.03981Inherited
ABC transporter transmembrane region0.04795Inherited
Insulin-like0.05166Inherited
Leucine zipper domain0.05435Inherited
YWTD domain0.05438Inherited
SOCS box-like0.07287Inherited
LDL receptor-like module0.08456Inherited
C-type lectin-like0.08543Inherited
A DNA-binding domain in eukaryotic transcription factors0.08982Inherited
Trypsin-like serine proteases0.2872Inherited
Family A G protein-coupled receptor-like0.8996Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54637,54637
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 54637 - Thioesterase/thiol ester dehydrase-isomerase
  • 0Direct
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0Direct
    57414,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.0001039Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001352Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0004862Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004862Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004862Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.0008024Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.001376Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.005078Inherited
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0.009003Inherited
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.01048Inherited
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.01928Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04795Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.07904Inherited
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0.1856Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    57414,57440,57440
  • 57414 - Hairpin loop containing domain-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0004862Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0004862Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.003039Inherited
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0.009003Inherited
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.009003Inherited
    63825,57196,63825
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.01928Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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