SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): muscle phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   muscle phenotype [MP:0005369] <2>(41|52) (43|29|23)
- 1:   abnormal muscle physiology [MP:0002106] <24>(23|33) (24|18|11)
- 1:   abnormal muscle morphology [MP:0002108] <13>(22|27) (22|17|17)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PapD-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Troponin coil-coiled subunits0Direct
Protein kinase-like (PK-like)0.00001814Direct
EGF/Laminin0.00009269Direct
SMAD MH1 domain0.0001241Direct
Growth factor receptor domain0.0002945Direct
p53-like transcription factors0.0004761Direct
alpha-catenin/vinculin-like0.0005391Direct
Calponin-homology domain, CH-domain0.0006042Direct
TB module/8-cys domain0.0006084Direct
Nuclear receptor ligand-binding domain0.001228Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.001299Inherited
Riboflavin synthase domain-like0.001299Inherited
MIR domain0.005791Inherited
IP3 receptor type 1 binding core, domain 20.007789Inherited
Myosin rod fragments0.008299Inherited
SRF-like0.008495Inherited
Calcium ATPase, transduction domain A0.01517Inherited
Flavoproteins0.01739Inherited
HLH, helix-loop-helix DNA-binding domain0.01937Inherited
Cystine-knot cytokines0.02437Inherited
Calcium ATPase, transmembrane domain M0.02663Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.03133Inherited
Homeodomain-like0.03394Inherited
Inhibitor of apoptosis (IAP) repeat0.07834Inherited
Voltage-gated potassium channels0.08299Inherited
Clavaminate synthase-like0.1068Inherited
WW domain0.1091Inherited
Actin-like ATPase domain0.1091Inherited
E set domains0.119Inherited
Nucleotide cyclase0.1593Inherited
B-box zinc-binding domain0.1881Inherited
Transducin (alpha subunit), insertion domain0.1933Inherited
Kazal-type serine protease inhibitors0.3146Inherited
POZ domain0.3482Inherited
"Winged helix" DNA-binding domain0.5772Inherited
Metalloproteases ("zincins"), catalytic domain0.5887Inherited
L domain-like0.7995Inherited
Family A G protein-coupled receptor-like0.8665Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Lamin A/C globular tail domain0Direct
SMAD MH1 domain0.00008685Direct
SMAD domain0.00008685Direct
Protein kinases, catalytic subunit0.0001459Direct
EGF-type module0.0002674Direct
Histone deacetylase, HDAC0.0004454Direct
TB module/8-cys domain0.0004454Direct
Meta-cation ATPase, catalytic domain P0.0004608Direct
Calponin-homology domain, CH-domain0.0005468Direct
Nuclear receptor0.0006138Direct
Calcium ATPase, transmembrane domain M0.0006838Direct
Nuclear receptor ligand-binding domain0.001151Inherited
L domain0.001603Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001603Inherited
NADPH-cytochrome p450 reductase-like0.001603Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.003138Inherited
Tetramerization domain of potassium channels0.003138Inherited
Growth factor receptor domain0.003598Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.003964Inherited
MIR domain0.004461Inherited
alpha-catenin/vinculin0.006332Inherited
SRF-like0.006332Inherited
Myosin rod fragments0.006753Inherited
Paired domain0.009278Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.01022Inherited
Homeodomain0.01309Inherited
Calcium ATPase, transduction domain A0.01317Inherited
Forkhead DNA-binding domain0.01461Inherited
Phoshoinositide 3-kinase (PI3K) helical domain0.01971Inherited
HLH, helix-loop-helix DNA-binding domain0.02064Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.0268Inherited
Laminin-type module0.03143Inherited
I set domains0.04476Inherited
Voltage-gated potassium channels0.05464Inherited
Inhibitor of apoptosis (IAP) repeat0.06671Inherited
Transforming growth factor (TGF)-beta0.09533Inherited
ZZ domain0.09951Inherited
Erythroid transcription factor GATA-10.09951Inherited
WW domain0.1015Inherited
LIM domain0.118Inherited
Adenylyl and guanylyl cyclase catalytic domain0.1481Inherited
B-box zinc-binding domain0.1766Inherited
Transducin (alpha subunit), insertion domain0.1796Inherited
Ovomucoid domain III-like0.1796Inherited
EF-hand modules in multidomain proteins0.2894Inherited
Phosphotyrosine-binding domain (PTB)0.4697Inherited
Extended AAA-ATPase domain0.5296Inherited
Rhodopsin-like0.8318Inherited
Ngr ectodomain-like0.8695Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Troponin coil-coiled subunits0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
PapD-like0Direct
Protein kinase-like (PK-like)0.000009112Direct
EGF/Laminin0.00004923Direct
SMAD MH1 domain0.00006648Direct
Growth factor receptor domain0.0001617Direct
p53-like transcription factors0.000266Direct
alpha-catenin/vinculin-like0.0003026Direct
Calponin-homology domain, CH-domain0.0003418Direct
TB module/8-cys domain0.0003443Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0005788Direct
Nuclear receptor ligand-binding domain0.0007051Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0.0007488Direct
Riboflavin synthase domain-like0.0007488Direct
Snake toxin-like0.001945Inherited
MIR domain0.003605Inherited
IP3 receptor type 1 binding core, domain 20.00493Inherited
Myosin rod fragments0.00528Inherited
SRF-like0.005409Inherited
Calcium ATPase, transduction domain A0.01001Inherited
Flavoproteins0.01158Inherited
HLH, helix-loop-helix DNA-binding domain0.013Inherited
Cystine-knot cytokines0.01665Inherited
Calcium ATPase, transmembrane domain M0.01828Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.02175Inherited
Homeodomain-like0.02376Inherited
Inhibitor of apoptosis (IAP) repeat0.0587Inherited
Voltage-gated potassium channels0.06252Inherited
Clavaminate synthase-like0.08269Inherited
WW domain0.08454Inherited
Actin-like ATPase domain0.08454Inherited
E set domains0.09305Inherited
Nucleotide cyclase0.1281Inherited
B-box zinc-binding domain0.1539Inherited
Transducin (alpha subunit), insertion domain0.1586Inherited
Kazal-type serine protease inhibitors0.2717Inherited
POZ domain0.3034Inherited
"Winged helix" DNA-binding domain0.5305Inherited
Metalloproteases ("zincins"), catalytic domain0.5423Inherited
L domain-like0.7614Inherited
Family A G protein-coupled receptor-like0.8333Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100909,49899
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49265,56112
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00000769Direct
    90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.00006648Direct
    47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0003026Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.001025Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.001312Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001312Inherited
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.001312Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.002452Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.002496Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.003263Inherited
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.00493Inherited
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0.00493Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.01145Inherited
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.01366Inherited
    57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01686Inherited
    100895,100895
  • 100895 - Kazal-type serine protease inhibitors
  • 100895 - Kazal-type serine protease inhibitors
  • 0.01686Inherited
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01686Inherited
    49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0.01686Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.02175Inherited
    48371,56112
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.03471Inherited
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.04726Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1586Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2256Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.2397Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.4016Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    48726,49265,48726
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0Direct
    48726,49265,56112
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    82109,100909,49899
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.00001928Direct
    47220,47220,47220
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 47220 - alpha-catenin/vinculin-like
  • 0.0003026Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0005092Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.001312Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001312Inherited
    90257,90257,90257
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 90257 - Myosin rod fragments
  • 0.001312Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.001312Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.001604Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.004906Inherited
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0.00493Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.00493Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.007151Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.01369Inherited
    57924,57924,57924
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 57924 - Inhibitor of apoptosis (IAP) repeat
  • 0.01686Inherited
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0.01686Inherited
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0.01686Inherited
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.02175Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.08487Inherited
    48726,49265,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.1004Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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