SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): nervous system phenotype

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   nervous system phenotype [MP:0003631] <2>(91|123) (103|75|46)
- 1:   abnormal nervous system physiology [MP:0003633] <37>(40|57) (49|28|16)
- 1:   abnormal nervous system morphology [MP:0003632] <15>(71|97) (80|62|43)


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Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Metallothionein0Direct
NHL repeat0Direct
Notch domain0Direct
Tubby C-terminal domain-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
L27 domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Synuclein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Hedgehog/DD-peptidase0Direct
Hedgehog/intein (Hint) domain0Direct
Nicotinic receptor ligand binding domain-like0.00000000289Direct
Neurotransmitter-gated ion-channel transmembrane pore0.00000000289Direct
Homeodomain-like0.00000001154Direct
PDZ domain-like0.000002627Direct
Periplasmic binding protein-like I0.000003244Direct
Voltage-gated potassium channels0.00008505Direct
HLH, helix-loop-helix DNA-binding domain0.0001366Direct
Periplasmic binding protein-like II0.0001743Direct
Nuclear receptor ligand-binding domain0.0007354Direct
Spectrin repeat0.001357Inherited
Sema domain0.001614Inherited
Frizzled cysteine-rich domain0.002031Inherited
Galactose-binding domain-like0.00477Inherited
Plexin repeat0.006449Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.006496Inherited
E2F-DP heterodimerization region0.01131Inherited
Orange domain-like0.01131Inherited
SNF-like0.01595Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.02253Inherited
Doublecortin (DC)0.02253Inherited
Concanavalin A-like lectins/glucanases0.02371Inherited
Caspase-like0.0281Inherited
GTPase activation domain, GAP0.02831Inherited
SNARE fusion complex0.03372Inherited
Metallo-dependent hydrolases0.03753Inherited
Proton glutamate symport protein0.04438Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.04438Inherited
Fibronectin type III0.04475Inherited
PH domain-like0.05211Inherited
p53-like transcription factors0.05393Inherited
Protein kinase-like (PK-like)0.06484Inherited
Family A G protein-coupled receptor-like0.07717Inherited
GDNF receptor-like0.0851Inherited
SRF-like0.0851Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.08794Inherited
Riboflavin synthase domain-like0.08794Inherited
HCP-like0.1147Inherited
DNA-binding domain0.1147Inherited
Cap-Gly domain0.1147Inherited
Second domain of FERM0.1167Inherited
Growth factor receptor domain0.1174Inherited
SH3-domain0.1252Inherited
Clc chloride channel0.1292Inherited
EGF/Laminin0.1301Inherited
Cyclin-like0.132Inherited
Bcl-2 inhibitors of programmed cell death0.1364Inherited
Cystine-knot cytokines0.1876Inherited
L domain-like0.1916Inherited
GAF domain-like0.1934Inherited
Flavoproteins0.2042Inherited
Kringle-like0.2223Inherited
TIMP-like0.2543Inherited
Actin-like ATPase domain0.2735Inherited
ARM repeat0.2917Inherited
E set domains0.2972Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.3116Inherited
PLP-dependent transferases0.3197Inherited
Cadherin-like0.3429Inherited
4-helical cytokines0.3793Inherited
CBS-domain pair0.3797Inherited
FAD/NAD(P)-binding domain0.388Inherited
(Trans)glycosidases0.4066Inherited
BAR/IMD domain-like0.4066Inherited
Spermadhesin, CUB domain0.4079Inherited
Multidrug efflux transporter AcrB transmembrane domain0.4306Inherited
Immunoglobulin0.4733Inherited
PreATP-grasp domain0.5406Inherited
SAM/Pointed domain0.5795Inherited
Complement control module/SCR domain0.6083Inherited
Bromodomain0.6142Inherited
SAP domain0.6377Inherited
HD-domain/PDEase-like0.672Inherited
Glutathione synthetase ATP-binding domain-like0.6976Inherited
Toll/Interleukin receptor TIR domain0.7361Inherited
Intermediate filament protein, coiled coil region0.789Inherited
ABC transporter transmembrane region0.8203Inherited
beta-beta-alpha zinc fingers0.8679Inherited
Cysteine proteinases1Inherited


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Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Transcriptional factor tubby, C-terminal domain0Direct
Retinoblastoma tumor suppressor domains0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
DIX domain0Direct
Notch domain0Direct
NHL repeat0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Hedgehog (development protein), N-terminal signaling domain0Direct
Synapsin domain0Direct
Synapsin C-terminal domain0Direct
Hedgehog C-terminal (Hog) autoprocessing domain0Direct
Synuclein0Direct
Neurotrophin0Direct
L27 domain0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Metallothionein0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Lamin A/C globular tail domain0Direct
Nicotinic receptor ligand binding domain-like0.000000002568Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000002568Direct
Homeodomain0.000000005772Direct
Phosphate binding protein-like0.000002938Direct
Laminin G-like module0.00000964Direct
L-arabinose binding protein-like0.00003978Direct
PDZ domain0.00005296Direct
HLH, helix-loop-helix DNA-binding domain0.0001534Direct
Nuclear receptor0.0001985Direct
Nuclear receptor ligand-binding domain0.0006647Direct
Sema domain0.001357Inherited
Laminin-type module0.001606Inherited
Frizzled cysteine-rich domain0.001606Inherited
Fibroblast growth factors (FGF)0.002007Inherited
Hypoxia-inducible factor Hif2a, C-terminal domain0.003795Inherited
DEP domain0.004474Inherited
Spectrin repeat0.005592Inherited
Plexin repeat0.005717Inherited
Voltage-gated potassium channels0.006563Inherited
Hairy Orange domain0.008602Inherited
Caspase catalytic domain0.008638Inherited
SNF-like0.0129Inherited
Doublecortin (DC)0.0178Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0178Inherited
E2F dimerization segment0.0178Inherited
SNARE fusion complex0.02821Inherited
I set domains0.03556Inherited
Pyridoxal-dependent decarboxylase0.03557Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.03557Inherited
NADPH-cytochrome p450 reductase-like0.03557Inherited
Proton glutamate symport protein0.03557Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.03557Inherited
Ephrin ectodomain0.03557Inherited
Fibronectin type III0.05016Inherited
Rhodopsin-like0.05384Inherited
SMAD MH1 domain0.05604Inherited
SMAD domain0.05604Inherited
Cell cycle transcription factor e2f-dp0.06845Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.06845Inherited
Paired domain0.06845Inherited
GDNF receptor-like0.07085Inherited
Multidrug efflux transporter AcrB transmembrane domain0.07085Inherited
Formate/glycerate dehydrogenases, substrate-binding domain0.07085Inherited
Mib/herc2 domain0.07085Inherited
alpha-catenin/vinculin0.07085Inherited
beta-glycanases0.07085Inherited
SRF-like0.07085Inherited
Ephrin receptor ligand binding domain0.07644Inherited
Actin/HSP700.08157Inherited
Calmodulin-like0.08619Inherited
Protein kinases, catalytic subunit0.09254Inherited
Cap-Gly domain0.09974Inherited
Clc chloride channel0.1145Inherited
Rel/Dorsal transcription factors, DNA-binding domain0.1219Inherited
Bcl-2 inhibitors of programmed cell death0.1219Inherited
Tetramerization domain of potassium channels0.1219Inherited
Extended AAA-ATPase domain0.1244Inherited
SH3-domain0.1402Inherited
Ngr ectodomain-like0.1551Inherited
cAMP-binding domain0.1587Inherited
Phosphotyrosine-binding domain (PTB)0.1715Inherited
GAF domain0.1728Inherited
L domain0.1728Inherited
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain0.1846Inherited
Forkhead DNA-binding domain0.2092Inherited
Motor proteins0.2344Inherited
Long-chain cytokines0.2515Inherited
SAM (sterile alpha motif) domain0.2628Inherited
G proteins0.2653Inherited
Fibronectin type II module0.2721Inherited
EGF-type module0.2781Inherited
Formate/glycerate dehydrogenases, NAD-domain0.2891Inherited
Cadherin0.2942Inherited
EF-hand modules in multidomain proteins0.3064Inherited
Pleckstrin-homology domain (PH domain)0.3106Inherited
Cyclin0.3229Inherited
CBS-domain pair0.3612Inherited
C1 set domains (antibody constant domain-like)0.3756Inherited
Acetylcholinesterase-like0.3834Inherited
p120GAP domain-like0.3834Inherited
Growth factor receptor domain0.3978Inherited
Transforming growth factor (TGF)-beta0.4059Inherited
Spermadhesin, CUB domain0.4059Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.4079Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4254Inherited
POU-specific domain0.4494Inherited
Papain-like0.4825Inherited
BAR domain0.5203Inherited
Leucine zipper domain0.5333Inherited
PDEase0.575Inherited
Complement control module/SCR domain0.606Inherited
Bromodomain0.6084Inherited
SAP domain0.6211Inherited
Classic zinc finger, C2H20.6989Inherited
Synaptotagmin-like (S variant)0.7485Inherited
MAM domain0.7788Inherited
Intermediate filament protein, coiled coil region0.7889Inherited
Toll/Interleukin receptor TIR domain0.8143Inherited
ABC transporter transmembrane region0.8486Inherited
ABC transporter ATPase domain-like0.9302Inherited
SH2 domain0.9368Inherited
Canonical RBD0.9639Inherited
V set domains (antibody variable domain-like)1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Metallothionein0Direct
Hedgehog/DD-peptidase0Direct
Composite domain of metallo-dependent hydrolases0Direct
L27 domain0Direct
NHL repeat0Direct
Hedgehog/intein (Hint) domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Lamin A/C globular tail domain0Direct
Synuclein0Direct
Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain0Direct
Oligoxyloglucan reducing end-specific cellobiohydrolase0Direct
Notch domain0Direct
Tubby C-terminal domain-like0Direct
Nicotinic receptor ligand binding domain-like0.000000001277Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000001277Direct
Homeodomain-like0.00000000511Direct
PDZ domain-like0.000001263Direct
Periplasmic binding protein-like I0.000001562Direct
Voltage-gated potassium channels0.00004514Direct
HLH, helix-loop-helix DNA-binding domain0.0000733Direct
Periplasmic binding protein-like II0.00009371Direct
Nuclear receptor ligand-binding domain0.0004169Direct
Spectrin repeat0.0007848Direct
Sema domain0.0009435Direct
Frizzled cysteine-rich domain0.001197Inherited
Galactose-binding domain-like0.002944Inherited
Plexin repeat0.00405Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.004083Inherited
E2F-DP heterodimerization region0.00733Inherited
Orange domain-like0.00733Inherited
SNF-like0.01056Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0153Inherited
Doublecortin (DC)0.0153Inherited
Concanavalin A-like lectins/glucanases0.01617Inherited
Caspase-like0.01933Inherited
GTPase activation domain, GAP0.0195Inherited
SNARE fusion complex0.02357Inherited
Metallo-dependent hydrolases0.0265Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain0.03155Inherited
Proton glutamate symport protein0.03155Inherited
Fibronectin type III0.03183Inherited
PH domain-like0.03755Inherited
p53-like transcription factors0.03902Inherited
Protein kinase-like (PK-like)0.04773Inherited
SMAD MH1 domain0.04941Inherited
Family A G protein-coupled receptor-like0.05772Inherited
SRF-like0.06424Inherited
Mib/herc2 domain-like0.06424Inherited
GDNF receptor-like0.06424Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.06656Inherited
Riboflavin synthase domain-like0.06656Inherited
DNA-binding domain0.08934Inherited
HCP-like0.08934Inherited
Cap-Gly domain0.08934Inherited
Glutamine synthetase/guanido kinase0.08934Inherited
Second domain of FERM0.09107Inherited
Growth factor receptor domain0.09167Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.09615Inherited
SH3-domain0.09842Inherited
Clc chloride channel0.102Inherited
EGF/Laminin0.1028Inherited
Cyclin-like0.1044Inherited
Bcl-2 inhibitors of programmed cell death0.1082Inherited
Cystine-knot cytokines0.1534Inherited
L domain-like0.1571Inherited
GAF domain-like0.1587Inherited
Flavoproteins0.1687Inherited
BRCT domain0.1856Inherited
Kringle-like0.1856Inherited
TIMP-like0.2152Inherited
Actin-like ATPase domain0.2333Inherited
ARM repeat0.25Inherited
E set domains0.2553Inherited
cAMP-binding domain-like0.2685Inherited
Formate/glycerate dehydrogenase catalytic domain-like0.2688Inherited
PLP-dependent transferases0.2766Inherited
Cadherin-like0.2986Inherited
4-helical cytokines0.3333Inherited
CBS-domain pair0.3339Inherited
FAD/NAD(P)-binding domain0.3421Inherited
(Trans)glycosidases0.3603Inherited
BAR/IMD domain-like0.3603Inherited
Spermadhesin, CUB domain0.3615Inherited
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain0.3835Inherited
Multidrug efflux transporter AcrB transmembrane domain0.3835Inherited
Cysteine-rich domain0.4136Inherited
Immunoglobulin0.4256Inherited
Leucine zipper domain0.4811Inherited
PreATP-grasp domain0.4932Inherited
SAM/Pointed domain0.5327Inherited
Complement control module/SCR domain0.5619Inherited
Bromodomain0.568Inherited
SAP domain0.5926Inherited
HD-domain/PDEase-like0.6278Inherited
Glutathione synthetase ATP-binding domain-like0.6547Inherited
"Winged helix" DNA-binding domain0.6937Inherited
Toll/Interleukin receptor TIR domain0.695Inherited
Intermediate filament protein, coiled coil region0.7503Inherited
P-loop containing nucleoside triphosphate hydrolases0.7642Inherited
ABC transporter transmembrane region0.7839Inherited
beta-beta-alpha zinc fingers0.8349Inherited
SH2 domain0.8998Inherited
Cysteine proteinases0.9978Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49299,49299
  • 49299 - PKD domain
  • 49299 - PKD domain
  • 0Direct
    101288,50156
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 0Direct
    55166,51294
  • 55166 - Hedgehog/DD-peptidase
  • 51294 - Hedgehog/intein (Hint) domain
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    48452,81901
  • 48452 - TPR-like
  • 81901 - HCP-like
  • 0Direct
    64593,74853
  • 64593 - Intermediate filament protein, coiled coil region
  • 74853 - Lamin A/C globular tail domain
  • 0Direct
    48726,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    46966,51045
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    47473,57850
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    57184,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    56496,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    50044,50156
  • 50044 - SH3-domain
  • 50156 - PDZ domain-like
  • 0Direct
    50729,49562
  • 50729 - PH domain-like
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    57196,56496
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    49265,49899
  • 49265 - Fibronectin type III
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    51045,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000000001277Direct
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.00003928Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0.00006416Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.0001798Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.000534Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0006203Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0.0009435Direct
    47459,158457
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 158457 - Orange domain-like
  • 0.00733Inherited
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 0.00733Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0153Inherited
    47986,52129
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0.0153Inherited
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0.0153Inherited
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0.0153Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.0265Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.03155Inherited
    63501,50242
  • 63501 - Frizzled cysteine-rich domain
  • 50242 - TIMP-like
  • 0.03155Inherited
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.04013Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.04794Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.05953Inherited
    57535,49854
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.06424Inherited
    56112,47769
  • 56112 - Protein kinase-like (PK-like)
  • 47769 - SAM/Pointed domain
  • 0.06656Inherited
    103575,48726
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.06656Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.06739Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.07227Inherited
    49562,48350
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48350 - GTPase activation domain, GAP
  • 0.08934Inherited
    81324,81324
  • 81324 - Voltage-gated potassium channels
  • 81324 - Voltage-gated potassium channels
  • 0.102Inherited
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 0.1082Inherited
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.1587Inherited
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1587Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1587Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1587Inherited
    56112,55073
  • 56112 - Protein kinase-like (PK-like)
  • 55073 - Nucleotide cyclase
  • 0.1687Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.1704Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1856Inherited
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.2261Inherited
    52283,51735
  • 52283 - Formate/glycerate dehydrogenase catalytic domain-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.2688Inherited
    49854,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.2688Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2728Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3018Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3154Inherited
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.3339Inherited
    50044,55550
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 0.3723Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.374Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.3835Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.3905Inherited
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.4199Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.5363Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.5409Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.695Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.7772Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.7839Inherited
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.8653Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57196,90193,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    48726,82895,82895
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,49899,49899
  • 57184 - Growth factor receptor domain
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    46966,51045,47473
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 47473 - EF-hand
  • 0Direct
    63825,57196,57424
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 0Direct
    57196,56496,49899
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    48726,48726,82895
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    49899,57196,56496
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 56496 - Fibrinogen C-terminal domain-like
  • 0Direct
    50044,50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    101288,50156,50044
  • 101288 - L27 domain
  • 50156 - PDZ domain-like
  • 50044 - SH3-domain
  • 0Direct
    49785,49899,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    49899,49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    46966,46966,51045
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 51045 - WW domain
  • 0Direct
    57196,57424,57424
  • 57196 - EGF/Laminin
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0Direct
    56496,49899,49899
  • 56496 - Fibrinogen C-terminal domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    47473,47473,57850
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 57850 - RING/U-box
  • 0Direct
    51045,47473,47473
  • 51045 - WW domain
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0Direct
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0008763Direct
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003137Inherited
    49899,57196,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.003445Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.003619Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.005686Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.006279Inherited
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.01056Inherited
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.0153Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.0153Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.02291Inherited
    48065,50729,50044
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 50044 - SH3-domain
  • 0.03155Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.03155Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04013Inherited
    57535,49854,57535
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 0.06424Inherited
    49854,57535,49854
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 49854 - Spermadhesin, CUB domain
  • 0.06424Inherited
    101912,103575,48726
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 48726 - Immunoglobulin
  • 0.06656Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1082Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1587Inherited
    49854,57535,57535
  • 49854 - Spermadhesin, CUB domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.1587Inherited
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.1587Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3818Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.4689Inherited
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.6764Inherited
    57667,57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 0.7305Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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