SUPERFAMILY 1.75 HMM library and genome assignments server

Mammalian Phenotype (MP): tumorigenesis

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Root: MP Hierarchy (mammalian/mouse phenotype from MGI_4.41)

Shortest distance to current term (+ for parents, - for children) MP term [MP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   mammalian phenotype [MP:0000001] <30>
0:   tumorigenesis [MP:0002006] <2>(30|34) (39|16|5)
- 1:   altered tumor pathology [MP:0010639] <4>(5|7) (7|5|2)
- 1:   altered tumor susceptibility [MP:0002166] <3>(24|28) (31|11|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
p53 tetramerization domain0Direct
Restriction endonuclease-like0Direct
Protein kinase-like (PK-like)0.00000009118Direct
DNA/RNA polymerases0.0001074Direct
SMAD MH1 domain0.0003461Direct
STAT0.0003461Direct
Transcription factor STAT-4 N-domain0.0003461Direct
4-helical cytokines0.0005442Direct
Nucleic acid-binding proteins0.001123Inherited
Rap/Ran-GAP0.002514Inherited
DNA-glycosylase0.002514Inherited
Cyclin-like0.002561Inherited
SMAD/FHA domain0.002617Inherited
p53-like transcription factors0.006656Inherited
SAND domain-like0.008011Inherited
Notch domain0.008011Inherited
DNA repair protein MutS, domain III0.008011Inherited
Snake toxin-like0.01316Inherited
Putative DNA-binding domain0.01673Inherited
PGBD-like0.01947Inherited
Integrin beta tail domain0.02882Inherited
Ribonuclease H-like0.03929Inherited
Hemopexin-like domain0.03929Inherited
BRCT domain0.0479Inherited
CCCH zinc finger0.06168Inherited
"Winged helix" DNA-binding domain0.06814Inherited
Kringle-like0.1132Inherited
ARM repeat0.2301Inherited
SET domain0.3281Inherited
Intermediate filament protein, coiled coil region0.4988Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Retinoblastoma tumor suppressor domains0Direct
p53 tetramerization domain0Direct
p53 DNA-binding domain-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Protein kinases, catalytic subunit0.000002703Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0.00004627Direct
STAT DNA-binding domain0.0002607Direct
STAT0.0002607Direct
SMAD MH1 domain0.0002607Direct
SMAD domain0.0002607Direct
Transcription factor STAT-4 N-domain0.0002607Direct
Interferons/interleukin-10 (IL-10)0.001341Inherited
DNA polymerase I0.001341Inherited
Rap/Ran-GAP0.001882Inherited
Pointed domain0.003382Inherited
Notch domain0.006239Inherited
DNA repair protein MutS, domain III0.006239Inherited
Matrix metalloproteases, catalytic domain0.006518Inherited
p120GAP domain-like0.01168Inherited
MMP N-terminal domain0.01751Inherited
DnaQ-like 3'-5' exonuclease0.01841Inherited
Forkhead DNA-binding domain0.02071Inherited
Single strand DNA-binding domain, SSB0.02414Inherited
Integrin beta tail domain0.02414Inherited
Hemopexin-like domain0.03598Inherited
Integrin beta EGF-like domains0.03742Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.04917Inherited
CCCH zinc finger0.05405Inherited
Ras-binding domain, RBD0.07827Inherited
FHA domain0.1152Inherited
Histone lysine methyltransferases0.1564Inherited
Phosphotyrosine-binding domain (PTB)0.4782Inherited
Intermediate filament protein, coiled coil region0.5021Inherited
ABC transporter ATPase domain-like0.5098Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
p53 tetramerization domain0Direct
Restriction endonuclease-like0Direct
Protein kinase-like (PK-like)0.00000004174Direct
DNA/RNA polymerases0.00005727Direct
Transcription factor STAT-4 N-domain0.0001911Direct
SMAD MH1 domain0.0001911Direct
STAT0.0001911Direct
4-helical cytokines0.0003057Direct
Nucleic acid-binding proteins0.0006443Direct
DNA-glycosylase0.001502Inherited
Rap/Ran-GAP0.001502Inherited
Cyclin-like0.001533Inherited
SMAD/FHA domain0.001566Inherited
Bcl-2 inhibitors of programmed cell death0.002461Inherited
p53-like transcription factors0.004185Inherited
DNA repair protein MutS, domain III0.005082Inherited
Notch domain0.005082Inherited
SAND domain-like0.005082Inherited
RING/U-box0.006609Inherited
Chromo domain-like0.008608Inherited
Snake toxin-like0.008608Inherited
Putative DNA-binding domain0.01113Inherited
PGBD-like0.01307Inherited
Integrin beta tail domain0.01988Inherited
Ribonuclease H-like0.0278Inherited
Hemopexin-like domain0.0278Inherited
BRCT domain0.0343Inherited
CCCH zinc finger0.04522Inherited
"Winged helix" DNA-binding domain0.05037Inherited
Cysteine-rich domain0.05046Inherited
ENTH/VHS domain0.05201Inherited
Kringle-like0.08802Inherited
SAM/Pointed domain0.133Inherited
ARM repeat0.1929Inherited
WW domain0.2153Inherited
SET domain0.2844Inherited
Metalloproteases ("zincins"), catalytic domain0.29Inherited
Cytochrome P4500.4278Inherited
Intermediate filament protein, coiled coil region0.4516Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.0001911Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001911Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001911Direct
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.0007468Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.001502Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.005082Inherited
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0.00528Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00528Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.01307Inherited
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0.01988Inherited
    52113,52113
  • 52113 - BRCT domain
  • 52113 - BRCT domain
  • 0.01988Inherited
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01988Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 0.02161Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.07977Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.1514Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.0001911Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.0001911Direct
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.005082Inherited
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.01988Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1227Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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