SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the immune system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the immune system [HP:0002715] <3>(16|23) (19|10|3)
- 1:   Abnormality of immune system physiology [HP:0010978] <9>(11|15) (12|5|0)
- 1:   Abnormality of the lymphatic system [HP:0100763] <8>(4|4) (5|3|0)
- 1:   Abnormality of cellular immune system [HP:0010987] <2>(5|6) (6|5|3)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Immunoglobulin0.000001548Direct
SH2 domain0.00002877Direct
(Trans)glycosidases0.0009215Direct
TNF receptor-like0.003392Inherited
DEATH domain0.005298Inherited
FYVE/PHD zinc finger0.006038Inherited
SET domain0.01884Inherited
PX domain0.03449Inherited
TSP-1 type 1 repeat0.04675Inherited
Globin-like0.08025Inherited
GroEL equatorial domain-like0.0865Inherited
Complement control module/SCR domain0.1096Inherited
SH3-domain0.3815Inherited
LDL receptor-like module0.6678Inherited
Trypsin-like serine proteases0.8041Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
C2 set domains0Direct
Netrin-like domain (NTR/C345C module)0Direct
beta-glycanases0Direct
Anaphylotoxins (complement system)0Direct
SH2 domain0.00001297Direct
Tetratricopeptide repeat (TPR)0.0000944Direct
C1 set domains (antibody constant domain-like)0.0004038Direct
Histone lysine methyltransferases0.003374Inherited
Arylsulfatase0.005171Inherited
Tandem AAA-ATPase domain0.00528Inherited
LIM domain0.009478Inherited
PWWP domain0.009478Inherited
PHD domain0.01232Inherited
TNF receptor-like0.01297Inherited
PX domain0.02501Inherited
TSP-1 type 1 repeat0.0345Inherited
TNF-like0.04714Inherited
Globins0.06193Inherited
Complement control module/SCR domain0.08681Inherited
Integrin A (or I) domain0.1826Inherited
SH3-domain0.3379Inherited
LDL receptor-like module0.6313Inherited
Eukaryotic proteases0.7033Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Anaphylotoxins (complement system)0Direct
Immunoglobulin0.0000006462Direct
SH2 domain0.00001328Direct
(Trans)glycosidases0.0005041Direct
TNF receptor-like0.002094Inherited
DEATH domain0.003393Inherited
FYVE/PHD zinc finger0.003912Inherited
SET domain0.01338Inherited
PX domain0.02583Inherited
TSP-1 type 1 repeat0.03595Inherited
TNF-like0.04927Inherited
Globin-like0.06427Inherited
GroEL equatorial domain-like0.06958Inherited
Complement control module/SCR domain0.08983Inherited
SH3-domain0.3469Inherited
alpha/beta-Hydrolases0.3736Inherited
LDL receptor-like module0.6344Inherited
Trypsin-like serine proteases0.7741Inherited
Homeodomain-like0.9977Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0004021Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.005421Inherited
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.02583Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.02587Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.06958Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1453Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.009694Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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