SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of metabolism/homeostasis

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of metabolism/homeostasis [HP:0001939] <29>(51|42) (53|21|9)
- 1:   Abnormality of urine homeostasis [HP:0003110] <28>(7|7) (8|3|0)
- 1:   Abnormality of carbohydrate metabolism/homeostasis [HP:0011013] <10>(11|10) (13|7|4)
- 1:   Abnormality of cell physiology [HP:0011017] <10>(3|2) (3|1|0)
- 1:   Abnormality of circulating protein level [HP:0010876] <10>(3|4) (4|2|1)
- 1:   Amyloidosis [HP:0011034] <8>(1|0) (1|0|0)
- 1:   Abnormality of carboxylic acid metabolism [HP:0004354] <6>(5|6) (8|2|0)
- 1:   Abnormality of lipid metabolism [HP:0003119] <6>(4|3) (4|1|0)
- 1:   Abnormality of temperature regulation [HP:0004370] <6>(4|5) (4|2|0)
- 1:   Abnormality of vitamin metabolism [HP:0100508] <6>(0|0) (0|0|0)
- 1:   Hyperbilirubinemia [HP:0002904] <5>(1|0) (1|0|0)
- 1:   Abnormal enzyme/coenzyme activity [HP:0012379] <4>(0|0) (0|0|0)
- 1:   Abnormality of nitrogen compound homeostasis [HP:0004364] <4>(3|2) (3|1|0)
- 1:   Abnormality of the heme biosynthetic pathway [HP:0010472] <4>(1|1) (1|0|0)
- 1:   Abnormality of Krebs cycle metabolism [HP:0000816] <3>(0|0) (0|0|0)
- 1:   Abnormality of ion homeostasis [HP:0003111] <3>(3|2) (3|0|0)
- 1:   Abnormality of nucleobase metabolism [HP:0010932] <3>(1|0) (1|0|0)
- 1:   Abnormality of acid-base homeostasis [HP:0004360] <2>(17|11) (17|5|2)
- 1:   Abnormality of calcium-phosphate metabolism [HP:0100530] <2>(0|0) (0|0|0)
- 1:   Abnormality of fluid regulation [HP:0011032] <2>(2|4) (2|1|0)
- 1:   Abnormality of glycoprotein metabolism [HP:0004367] <2>(0|0) (0|0|0)
- 1:   Abnormal homeostasis [HP:0012337] <1>(0|0) (0|0|0)
- 1:   Abnormality of superoxide metabolism [HP:0004358] <1>(0|0) (0|0|0)
- 1:   Food intolerance [HP:0012537] <1>(0|0) (0|0|0)
- 1:   Ketosis [HP:0001946] <1>(0|0) (0|0|0)
- 1:   Delayed oxidation of acetaldehyde [HP:0003533](0|0) (0|0|0)
- 1:   Elevated erythrocyte sedimentation rate [HP:0003565](1|0) (1|0|0)
- 1:   Gangrene [HP:0100758](0|0) (0|0|0)
- 1:   Glutathione synthetase deficiency [HP:0003343](0|0) (0|0|0)
- 1:   Molybdenum cofactor deficiency [HP:0003570](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
2Fe-2S ferredoxin-like0Direct
Subtilisin-like0Direct
Globin-like0Direct
4Fe-4S ferredoxins0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Galactose mutarotase-like0Direct
PRTase-like0Direct
Glycosyl hydrolase domain0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
(Trans)glycosidases0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
Apolipoprotein A-I0Direct
Thiolase-like0Direct
Band 7/SPFH domain0Direct
Terpenoid synthases0Direct
Sema domain0Direct
BPTI-like0Direct
CAD & PB1 domains0Direct
Smc hinge domain0Direct
Saposin0Direct
Single hybrid motif0.02152Inherited
FAD/NAD(P)-binding domain0.02878Inherited
MFS general substrate transporter0.05703Inherited
CoA-dependent acyltransferases0.05775Inherited
Adenine nucleotide alpha hydrolases-like0.05775Inherited
Alkaline phosphatase-like0.06422Inherited
Clc chloride channel0.09394Inherited
CBS-domain pair0.09928Inherited
Glutathione synthetase ATP-binding domain-like0.09928Inherited
ClpP/crotonase0.09928Inherited
alpha/beta-Hydrolases0.1465Inherited
PreATP-grasp domain0.1482Inherited
PX domain0.1507Inherited
Rudiment single hybrid motif0.1507Inherited
GAF domain-like0.1507Inherited
Aldolase0.2153Inherited
Calponin-homology domain, CH-domain0.2591Inherited
BRCT domain0.3101Inherited
Translation proteins0.3493Inherited
Myosin rod fragments0.3744Inherited
DEATH domain0.3783Inherited
C-type lectin-like0.512Inherited
Class II aaRS and biotin synthetases0.6003Inherited
Nucleotidylyl transferase0.6045Inherited
vWA-like0.8661Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.878Inherited
Nicotinic receptor ligand binding domain-like0.878Inherited
Voltage-gated potassium channels0.9917Inherited
Homeodomain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
Small Kunitz-type inhibitors & BPTI-like toxins0Direct
Filamin repeat (rod domain)0Direct
Globins0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Sema domain0Direct
Ras-binding domain, RBD0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
CAT-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Ferredoxin domains from multidomain proteins0Direct
RecA protein-like (ATPase-domain)0Direct
Apolipoprotein A-I0Direct
beta-glycanases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0Direct
Gonadodropin/Follitropin0Direct
Amylase, catalytic domain0Direct
Crotonase-like0Direct
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0Direct
Biotinyl/lipoyl-carrier proteins and domains0.01643Inherited
Noncollagenous (NC1) domain of collagen IV0.0465Inherited
BC N-terminal domain-like0.07807Inherited
Clc chloride channel0.07807Inherited
BC ATP-binding domain-like0.07807Inherited
Arylsulfatase0.0841Inherited
CBS-domain pair0.0841Inherited
GAF domain0.1282Inherited
BC C-terminal domain-like0.1282Inherited
PX domain0.1282Inherited
PDEase0.191Inherited
Calponin-homology domain, CH-domain0.2366Inherited
28-residue LRR0.2803Inherited
Pyrin domain, PYD0.2803Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.2803Inherited
Myosin rod fragments0.3484Inherited
Spectrin repeat0.476Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.6895Inherited
Integrin A (or I) domain0.7504Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8693Inherited
Nicotinic receptor ligand binding domain-like0.8693Inherited
Homeodomain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Thiolase-like0Direct
2Fe-2S ferredoxin-like0Direct
(Trans)glycosidases0Direct
Subtilisin-like0Direct
Galactose mutarotase-like0Direct
CAD & PB1 domains0Direct
Smc hinge domain0Direct
Saposin0Direct
Terpenoid synthases0Direct
Glycosyl hydrolase domain0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
Globin-like0Direct
Sema domain0Direct
4Fe-4S ferredoxins0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
PRTase-like0Direct
Acyl-CoA dehydrogenase NM domain-like0Direct
Acyl-CoA dehydrogenase C-terminal domain-like0Direct
Band 7/SPFH domain0Direct
BPTI-like0Direct
Apolipoprotein A-I0Direct
Single hybrid motif0.01538Inherited
FAD/NAD(P)-binding domain0.02121Inherited
MFS general substrate transporter0.04449Inherited
CoA-dependent acyltransferases0.04514Inherited
Adenine nucleotide alpha hydrolases-like0.04514Inherited
Alkaline phosphatase-like0.05069Inherited
GroEL equatorial domain-like0.07619Inherited
Clc chloride channel0.07619Inherited
Glutathione synthetase ATP-binding domain-like0.08088Inherited
CBS-domain pair0.08088Inherited
ClpP/crotonase0.08088Inherited
alpha/beta-Hydrolases0.1228Inherited
PreATP-grasp domain0.1243Inherited
GAF domain-like0.1265Inherited
PX domain0.1265Inherited
Rudiment single hybrid motif0.1265Inherited
Aldolase0.1861Inherited
Calponin-homology domain, CH-domain0.2278Inherited
BRCT domain0.2769Inherited
Translation proteins0.3148Inherited
Myosin rod fragments0.34Inherited
DEATH domain0.3437Inherited
Spectrin repeat0.3722Inherited
C-type lectin-like0.4768Inherited
Class II aaRS and biotin synthetases0.5653Inherited
Nucleotidylyl transferase0.5695Inherited
vWA-like0.8391Inherited
Nicotinic receptor ligand binding domain-like0.8515Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.8515Inherited
Voltage-gated potassium channels0.9718Inherited
Homeodomain-like0.9993Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    101912,103575
  • 101912 - Sema domain
  • 103575 - Plexin repeat
  • 0Direct
    54236,57889
  • 54236 - Ubiquitin-like
  • 57889 - Cysteine-rich domain
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0Direct
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.05206Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1265Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1265Inherited
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.1265Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.1265Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1861Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.2263Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.2769Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3581Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.8515Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    81296,81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 81296 - E set domains
  • 0Direct
    50044,55550,56112
  • 50044 - SH3-domain
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.1265Inherited
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0.1265Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.3148Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.3148Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3581Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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