SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of blood and blood-forming tissues

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of blood and blood-forming tissues [HP:0001871] <9>(15|17) (18|9|4)
- 1:   Abnormality of erythrocytes [HP:0001877] <11>(1|1) (2|1|0)
- 1:   Abnormal bleeding [HP:0001892] <10>(5|5) (7|1|0)
- 1:   Abnormality of bone marrow cell morphology [HP:0005561] <7>(0|1) (1|0|0)
- 1:   Hematological neoplasm [HP:0004377] <7>(2|2) (3|0|0)
- 1:   Abnormal thrombosis [HP:0001977] <5>(2|2) (2|0|0)
- 1:   Abnormality of thrombocytes [HP:0001872] <5>(3|3) (3|1|0)
- 1:   Abnormality of coagulation [HP:0001928] <4>(2|2) (2|1|0)
- 1:   Abnormality of leukocytes [HP:0001881] <4>(5|6) (6|5|3)
- 1:   Extramedullary hematopoiesis [HP:0001978](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Integrin beta tail domain0Direct
SMAD MH1 domain0Direct
SH2 domain0.0000008275Direct
GLA-domain0.001266Inherited
TNF receptor-like0.002011Inherited
DEATH domain0.002352Inherited
SET domain0.01314Inherited
FYVE/PHD zinc finger0.02433Inherited
BEACH domain0.02673Inherited
Trypsin-like serine proteases0.03046Inherited
vWA-like0.05158Inherited
Globin-like0.06156Inherited
FnI-like domain0.06775Inherited
Integrin domains0.1014Inherited
Ribosomal protein S5 domain 2-like0.2516Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
SMAD domain0Direct
Integrin beta EGF-like domains0Direct
Integrin beta tail domain0Direct
SMAD MH1 domain0Direct
SH2 domain0.0000004852Direct
GLA-domain0.0007886Direct
LIM domain0.007151Inherited
PWWP domain0.007151Inherited
TNF receptor-like0.009534Inherited
Eukaryotic proteases0.0126Inherited
BEACH domain0.02036Inherited
Histone lysine methyltransferases0.02389Inherited
Integrin A (or I) domain0.02426Inherited
PHD domain0.02937Inherited
Globins0.04968Inherited
Integrin domains0.085Inherited
VWC domain0.1036Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0Direct
Integrin beta tail domain0Direct
SH2 domain0.0000003405Direct
GLA-domain0.0007113Direct
TNF receptor-like0.001185Inherited
DEATH domain0.00141Inherited
SET domain0.009048Inherited
RNI-like0.009048Inherited
FYVE/PHD zinc finger0.01771Inherited
BEACH domain0.01962Inherited
Trypsin-like serine proteases0.02252Inherited
vWA-like0.03987Inherited
Globin-like0.04837Inherited
PH domain-like0.04851Inherited
FnI-like domain0.05366Inherited
Integrin domains0.08275Inherited
Ribosomal protein S5 domain 2-like0.2206Inherited
Homeodomain-like0.9992Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,55550
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    55550,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0.0002131Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.003341Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.01962Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.1071Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55550,56112,56112
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    50729,55550,56112
  • 50729 - PH domain-like
  • 55550 - SH2 domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.006883Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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