SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the cardiovascular system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the cardiovascular system [HP:0001626] <4>(28|34) (29|19|16)
- 1:   Abnormality of the vasculature [HP:0002597] <14>(12|10) (13|8|2)
- 1:   Abnormality of cardiovascular system physiology [HP:0011025] <9>(7|8) (8|2|0)
- 1:   Abnormality of the fetal cardiovascular system [HP:0010948] <7>(0|0) (0|0|0)
- 1:   Abnormality of cardiac morphology [HP:0001627] <5>(15|23) (15|12|15)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
GLA-domain0Direct
SAND domain-like0Direct
Notch domain0Direct
SMAD MH1 domain0Direct
BRK domain-like0Direct
LEM domain0Direct
Smc hinge domain0Direct
(Trans)glycosidases0.003175Inherited
Glycosyl hydrolase domain0.008945Inherited
TB module/8-cys domain0.03708Inherited
FnI-like domain0.04313Inherited
Growth factor receptor domain0.06209Inherited
Myosin rod fragments0.06438Inherited
MHC antigen-recognition domain0.1661Inherited
GroEL equatorial domain-like0.1661Inherited
Actin-like ATPase domain0.247Inherited
E set domains0.2511Inherited
Ribosomal protein S5 domain 2-like0.2605Inherited
Tropomyosin0.2605Inherited
Snake toxin-like0.2605Inherited
DEATH domain0.2678Inherited
Voltage-gated potassium channels0.395Inherited
WD40 repeat-like0.417Inherited
alpha/beta-Hydrolases0.4199Inherited
RNA-binding domain, RBD0.5595Inherited
Trypsin-like serine proteases0.6073Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6635Inherited
Nicotinic receptor ligand binding domain-like0.6635Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
GLA-domain0Direct
Smc hinge domain0Direct
LEM domain0Direct
SMAD domain0Direct
ZZ domain0Direct
BRK domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Notch domain0Direct
beta-glycanases0Direct
Amylase, catalytic domain0Direct
Actin/HSP700Direct
SMAD MH1 domain0Direct
EGF-type module0.001407Inherited
Tetratricopeptide repeat (TPR)0.008629Inherited
Erythroid transcription factor GATA-10.01342Inherited
Noncollagenous (NC1) domain of collagen IV0.01342Inherited
LIM domain0.02819Inherited
TB module/8-cys domain0.02819Inherited
Myosin rod fragments0.05146Inherited
ABC transporter ATPase domain-like0.07583Inherited
Histone lysine methyltransferases0.07921Inherited
VWC domain0.07921Inherited
BC N-terminal domain-like0.1413Inherited
MHC antigen-recognition domain0.1413Inherited
BC ATP-binding domain-like0.1413Inherited
T-box0.148Inherited
Tropomyosin0.2307Inherited
Reprolysin-like0.2411Inherited
C1 set domains (antibody constant domain-like)0.4517Inherited
Voltage-gated potassium channels0.4822Inherited
G proteins0.5654Inherited
Eukaryotic proteases0.6202Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6388Inherited
Nicotinic receptor ligand binding domain-like0.6388Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0Direct
LEM domain0Direct
Notch domain0Direct
GLA-domain0Direct
Smc hinge domain0Direct
BRK domain-like0Direct
SAND domain-like0Direct
(Trans)glycosidases0.001948Inherited
Glycosyl hydrolase domain0.005984Inherited
TB module/8-cys domain0.02795Inherited
FnI-like domain0.03287Inherited
Growth factor receptor domain0.04885Inherited
Myosin rod fragments0.05083Inherited
MHC antigen-recognition domain0.1404Inherited
GroEL equatorial domain-like0.1404Inherited
Actin-like ATPase domain0.2161Inherited
E set domains0.2201Inherited
Snake toxin-like0.2292Inherited
Tropomyosin0.2292Inherited
Ribosomal protein S5 domain 2-like0.2292Inherited
DEATH domain0.2358Inherited
SMAD/FHA domain0.271Inherited
Voltage-gated potassium channels0.3602Inherited
WD40 repeat-like0.3822Inherited
alpha/beta-Hydrolases0.3849Inherited
RNA-binding domain, RBD0.5243Inherited
Trypsin-like serine proteases0.5724Inherited
Nicotinic receptor ligand binding domain-like0.6299Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.6299Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.004197Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.005984Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.01043Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.01135Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.02795Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02795Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.02867Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.02867Inherited
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.05747Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.1404Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1404Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1462Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.1462Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.2403Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.6299Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0Direct
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.0004859Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.005984Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.005984Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.005984Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.02795Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02795Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.02795Inherited
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.05747Inherited
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0.05747Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.08781Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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