SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the integument

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the integument [HP:0001574] <2>(28|39) (34|21|8)
- 1:   Abnormality of the skin [HP:0000951] <5>(24|32) (28|16|5)
- 1:   Abnormality of skin adnexa [HP:0011138] <4>(8|15) (11|7|2)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Multidrug efflux transporter AcrB transmembrane domain0Direct
Zn-dependent exopeptidases0Direct
Plakin repeat0Direct
RCC1/BLIP-II0Direct
SMAD MH1 domain0Direct
BRK domain-like0Direct
RuvA domain 2-like0Direct
FKBP-like0Direct
Anaphylotoxins (complement system)0Direct
Smc hinge domain0Direct
Intermediate filament protein, coiled coil region0.005456Inherited
(Trans)glycosidases0.03746Inherited
Snake toxin-like0.0587Inherited
Prefoldin0.06175Inherited
GroEL equatorial domain-like0.06175Inherited
FnI-like domain0.09186Inherited
PX domain0.1083Inherited
Integrin domains0.1753Inherited
ABC transporter transmembrane region0.2122Inherited
EGF/Laminin0.2547Inherited
Bromodomain0.3677Inherited
Adenine nucleotide alpha hydrolases-like0.3688Inherited
Globin-like0.496Inherited
Cysteine-rich domain0.6099Inherited
alpha/beta-Hydrolases0.6251Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7878Inherited
Nicotinic receptor ligand binding domain-like0.7878Inherited
SH3-domain0.8346Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Prefoldin0Direct
Class I aldolase0Direct
Smc hinge domain0Direct
Netrin-like domain (NTR/C345C module)0Direct
SMAD domain0Direct
ZZ domain0Direct
BRK domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
FKBP immunophilin/proline isomerase0Direct
beta-glycanases0Direct
Plakin repeat0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
SMAD MH1 domain0Direct
Anaphylotoxins (complement system)0Direct
Tandem AAA-ATPase domain0.0003695Direct
Intermediate filament protein, coiled coil region0.003656Inherited
ABC transporter ATPase domain-like0.01107Inherited
Integrin A (or I) domain0.01936Inherited
Tetratricopeptide repeat (TPR)0.02379Inherited
Histone lysine methyltransferases0.0264Inherited
VWC domain0.0264Inherited
PHD domain0.04806Inherited
ARID domain0.08822Inherited
PX domain0.08822Inherited
Laminin-type module0.1116Inherited
Integrin domains0.1493Inherited
Laminin G-like module0.1639Inherited
LIM domain0.2052Inherited
GLA-domain0.2267Inherited
Cadherin0.3294Inherited
Bromodomain0.3333Inherited
G proteins0.3576Inherited
Fibronectin type III0.4439Inherited
Globins0.4631Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.5812Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7651Inherited
Nicotinic receptor ligand binding domain-like0.7651Inherited
SH3-domain0.8178Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
SMAD MH1 domain0Direct
Plakin repeat0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
RuvA domain 2-like0Direct
RCC1/BLIP-II0Direct
Smc hinge domain0Direct
Zn-dependent exopeptidases0Direct
Anaphylotoxins (complement system)0Direct
FKBP-like0Direct
BRK domain-like0Direct
Intermediate filament protein, coiled coil region0.003504Inherited
SET domain0.01392Inherited
vWA-like0.02826Inherited
(Trans)glycosidases0.02826Inherited
Snake toxin-like0.04602Inherited
GroEL equatorial domain-like0.04855Inherited
Prefoldin0.04855Inherited
FnI-like domain0.07425Inherited
ARID-like0.08857Inherited
PX domain0.08857Inherited
Integrin domains0.149Inherited
Actin-like ATPase domain0.1637Inherited
ABC transporter transmembrane region0.1832Inherited
EGF/Laminin0.2236Inherited
GLA-domain0.2271Inherited
Bromodomain0.333Inherited
Adenine nucleotide alpha hydrolases-like0.334Inherited
Fibronectin type III0.4374Inherited
Globin-like0.4609Inherited
Cysteine-rich domain0.5751Inherited
alpha/beta-Hydrolases0.5906Inherited
Nicotinic receptor ligand binding domain-like0.7571Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.7571Inherited
SH3-domain0.806Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    55550,55550
  • 55550 - SH2 domain
  • 55550 - SH2 domain
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    49410,50242
  • 49410 - Alpha-macroglobulin receptor domain
  • 50242 - TIMP-like
  • 0Direct
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.0271Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0271Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.04855Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.09681Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.1139Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1832Inherited
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0.205Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.2377Inherited
    49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3289Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.406Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.7571Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.04602Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09025Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.205Inherited
    49899,49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.205Inherited
    49313,49313,49313
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 49313 - Cadherin-like
  • 0.3289Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)