SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the skeletal system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the skeletal system [HP:0000924] <3>(56|60) (57|34|18)
- 1:   Ectopic calcification [HP:0010766] <25>(0|0) (0|0|0)
- 1:   Abnormality of skeletal morphology [HP:0011842] <12>(53|58) (55|32|18)
- 1:   Abnormality of skeletal physiology [HP:0011843] <6>(2|3) (2|1|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
TB module/8-cys domain0Direct
PX domain0Direct
SAND domain-like0Direct
Plakin repeat0Direct
Restriction endonuclease-like0Direct
Tubulin C-terminal domain-like0Direct
RCC1/BLIP-II0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
BRK domain-like0Direct
SNARE-like0Direct
RuvA domain 2-like0Direct
GroEL equatorial domain-like0Direct
FKBP-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Smc hinge domain0Direct
Saposin0Direct
Nucleotide-diphospho-sugar transferases0.001368Inherited
TPR-like0.01258Inherited
Cystine-knot cytokines0.03597Inherited
SET domain0.04173Inherited
p53-like transcription factors0.05258Inherited
WD40 repeat-like0.0528Inherited
Tudor/PWWP/MBT0.07733Inherited
Alkaline phosphatase-like0.07734Inherited
FnI-like domain0.07734Inherited
Prefoldin0.1041Inherited
(Trans)glycosidases0.1091Inherited
Actin-like ATPase domain0.1527Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1527Inherited
Bromodomain0.1527Inherited
Nicotinic receptor ligand binding domain-like0.1527Inherited
ARID-like0.1633Inherited
GLA-domain0.1649Inherited
Growth factor receptor domain0.2065Inherited
Hemopexin-like domain0.2351Inherited
FYVE/PHD zinc finger0.2888Inherited
Troponin coil-coiled subunits0.3327Inherited
PGBD-like0.3327Inherited
Protein kinase-like (PK-like)0.3464Inherited
RNI-like0.3773Inherited
TNF receptor-like0.408Inherited
RING/U-box0.4424Inherited
Galactose-binding domain-like0.4481Inherited
TSP-1 type 1 repeat0.4611Inherited
Tropomyosin0.5157Inherited
Fibronectin type III0.5572Inherited
E set domains0.5768Inherited
Intermediate filament protein, coiled coil region0.5768Inherited
Concanavalin A-like lectins/glucanases0.5841Inherited
vWA-like0.6422Inherited
Immunoglobulin0.6583Inherited
CBS-domain pair0.7499Inherited
Cysteine-rich domain0.7499Inherited
HLH, helix-loop-helix DNA-binding domain0.7862Inherited
DEATH domain0.8291Inherited
Trypsin-like serine proteases0.9599Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Tubulin, C-terminal domain0Direct
Clathrin coat assembly domain0Direct
Prefoldin0Direct
Tetratricopeptide repeat (TPR)0Direct
Clathrin adaptor core protein0Direct
Smc hinge domain0Direct
Filamin repeat (rod domain)0Direct
ZZ domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
BRK domain-like0Direct
Myotubularin-like phosphatases0Direct
Fibroblast growth factors (FGF)0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
FKBP immunophilin/proline isomerase0Direct
Erythroid transcription factor GATA-10Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Neutral endopeptidase (neprilysin)0Direct
Tubulin, GTPase domain0Direct
PX domain0Direct
Plakin repeat0Direct
Elongation factors0Direct
TB module/8-cys domain0Direct
FHA domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Transforming growth factor (TGF)-beta0.001973Inherited
WD40-repeat0.02303Inherited
Tandem AAA-ATPase domain0.03797Inherited
Histone lysine methyltransferases0.04958Inherited
VWC domain0.04958Inherited
G proteins0.06359Inherited
Extended AAA-ATPase domain0.08865Inherited
Arylsulfatase0.08865Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1218Inherited
Nicotinic receptor ligand binding domain-like0.1218Inherited
Bromodomain0.1218Inherited
ARID domain0.1333Inherited
beta-glycanases0.1333Inherited
GLA-domain0.1337Inherited
T-box0.173Inherited
Hemopexin-like domain0.1987Inherited
Reprolysin-like0.1987Inherited
Laminin-type module0.2045Inherited
PHD domain0.23Inherited
BCR-homology GTPase activation domain (BH-domain)0.2423Inherited
28-residue LRR0.29Inherited
Pyrin domain, PYD0.29Inherited
MMP N-terminal domain0.29Inherited
Matrix metalloproteases, catalytic domain0.29Inherited
Classic zinc finger, C2H20.3392Inherited
Integrin A (or I) domain0.4129Inherited
TSP-1 type 1 repeat0.4129Inherited
Protein kinases, catalytic subunit0.4503Inherited
Tropomyosin0.4704Inherited
Fibronectin type III0.5014Inherited
Intermediate filament protein, coiled coil region0.528Inherited
I set domains0.531Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.7147Inherited
CBS-domain pair0.7147Inherited
HLH, helix-loop-helix DNA-binding domain0.7498Inherited
Eukaryotic proteases0.9494Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plakin repeat0Direct
Tubulin nucleotide-binding domain-like0Direct
Tubulin C-terminal domain-like0Direct
SNARE-like0Direct
RuvA domain 2-like0Direct
RCC1/BLIP-II0Direct
Smc hinge domain0Direct
PX domain0Direct
Saposin0Direct
GroEL equatorial domain-like0Direct
FKBP-like0Direct
TB module/8-cys domain0Direct
BRK domain-like0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Nucleotide-diphospho-sugar transferases0.0007767Direct
TPR-like0.008621Inherited
Cystine-knot cytokines0.02704Inherited
SET domain0.03166Inherited
p53-like transcription factors0.04072Inherited
WD40 repeat-like0.04091Inherited
Tudor/PWWP/MBT0.06178Inherited
FnI-like domain0.0618Inherited
Alkaline phosphatase-like0.0618Inherited
Prefoldin0.08512Inherited
(Trans)glycosidases0.08924Inherited
Snake toxin-like0.09333Inherited
Nicotinic receptor ligand binding domain-like0.1283Inherited
Actin-like ATPase domain0.1283Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.1283Inherited
Bromodomain0.1283Inherited
ARID-like0.1377Inherited
GLA-domain0.1392Inherited
Growth factor receptor domain0.1781Inherited
Hemopexin-like domain0.205Inherited
FYVE/PHD zinc finger0.2562Inherited
PGBD-like0.2987Inherited
Troponin coil-coiled subunits0.2987Inherited
Protein kinase-like (PK-like)0.312Inherited
RNI-like0.3428Inherited
TNF receptor-like0.3731Inherited
RING/U-box0.407Inherited
Galactose-binding domain-like0.413Inherited
TSP-1 type 1 repeat0.4261Inherited
Tropomyosin0.4802Inherited
Fibronectin type III0.522Inherited
Intermediate filament protein, coiled coil region0.5419Inherited
E set domains0.5419Inherited
Concanavalin A-like lectins/glucanases0.5489Inherited
vWA-like0.608Inherited
Immunoglobulin0.6245Inherited
CBS-domain pair0.7179Inherited
Cysteine-rich domain0.7179Inherited
HLH, helix-loop-helix DNA-binding domain0.7553Inherited
DEATH domain0.8Inherited
Trypsin-like serine proteases0.9374Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    103473,100895
  • 103473 - MFS general substrate transporter
  • 100895 - Kazal-type serine protease inhibitors
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    50729,50729
  • 50729 - PH domain-like
  • 50729 - PH domain-like
  • 0Direct
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.01116Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.04036Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.08512Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.08512Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08581Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1283Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.1283Inherited
    47986,52540
  • 47986 - DEATH domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1377Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.1377Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.1377Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1804Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.1804Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.1804Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.2809Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.2987Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.3934Inherited
    49265,49265
  • 49265 - Fibronectin type III
  • 49265 - Fibronectin type III
  • 0.5456Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.6028Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.03166Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.09333Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1283Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1377Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1377Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.2516Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.487Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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