SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the endocrine system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the endocrine system [HP:0000818] <12>(9|13) (12|4|3)
- 1:   Abnormality of circulating hormone level [HP:0003117] <15>(1|1) (1|3|1)
- 1:   Puberty and gonadal disorders [HP:0008373] <13>(5|5) (5|0|0)
- 1:   Neoplasm of the endocrine system [HP:0100568] <8>(0|0) (0|0|0)
- 1:   Diabetes mellitus [HP:0000819] <6>(2|2) (3|2|3)
- 1:   Abnormality of renin-angiotensin system [HP:0000847] <4>(0|0) (0|0|0)
- 1:   Abnormality of the adrenal glands [HP:0000834] <2>(0|1) (0|0|0)
- 1:   Abnormality of the hypothalamus-pituitary axis [HP:0000864] <2>(1|1) (4|0|0)
- 1:   Abnormality of the parathyroid gland [HP:0000828] <2>(0|0) (0|0|0)
- 1:   Abnormality of the pineal gland [HP:0012680] <2>(0|0) (0|0|0)
- 1:   Abnormality of the thyroid gland [HP:0000820] <2>(0|1) (0|0|0)
- 1:   Diabetes insipidus [HP:0000873] <2>(1|0) (2|0|0)
- 1:   Abnormality of urine hormone level [HP:0012029] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.00008956Direct
Glucocorticoid receptor-like (DNA-binding domain)0.000785Direct
GAF domain-like0.01238Inherited
GroEL equatorial domain-like0.03438Inherited
GLA-domain0.1015Inherited
Homeodomain-like0.2007Inherited
Cytochrome P4500.2185Inherited
L domain-like0.247Inherited
Trypsin-like serine proteases0.611Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Gonadodropin/Follitropin0Direct
Nuclear receptor0.00001578Direct
Nuclear receptor ligand-binding domain0.0000556Direct
Tandem AAA-ATPase domain0.0003677Direct
PDEase0.0006364Direct
PHD domain0.007439Inherited
GAF domain0.008976Inherited
Tyrosine-dependent oxidoreductases0.01326Inherited
Ngr ectodomain-like0.01801Inherited
GLA-domain0.08607Inherited
Cytochrome P4500.1996Inherited
Homeodomain0.256Inherited
Eukaryotic proteases0.528Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nuclear receptor ligand-binding domain0.0000428Direct
Glucocorticoid receptor-like (DNA-binding domain)0.0004242Direct
Family A G protein-coupled receptor-like0.00099Direct
GAF domain-like0.008466Inherited
GroEL equatorial domain-like0.02575Inherited
WD40 repeat-like0.03086Inherited
p53-like transcription factors0.06957Inherited
GLA-domain0.08275Inherited
Homeodomain-like0.1723Inherited
Cytochrome P4500.1894Inherited
L domain-like0.2161Inherited
Trypsin-like serine proteases0.5762Inherited

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Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0006439Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.008466Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.008466Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.1613Inherited

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    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.008466Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.08275Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08275Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)