SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the nervous system

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the nervous system [HP:0000707] <2>(68|71) (74|39|13)
- 1:   Abnormality of nervous system physiology [HP:0012638] <24>(47|49) (48|31|9)
- 1:   Abnormality of nervous system morphology [HP:0012639] <6>(33|37) (40|21|7)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
CoA-dependent acyltransferases0Direct
Riboflavin synthase domain-like0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
MIR domain0Direct
4Fe-4S ferredoxins0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
SAND domain-like0Direct
Restriction endonuclease-like0Direct
dsRNA-binding domain-like0Direct
Tubulin C-terminal domain-like0Direct
SNF-like0Direct
L-aspartase-like0Direct
GroEL-intermediate domain like0Direct
RCC1/BLIP-II0Direct
Alkaline phosphatase-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
BRK domain-like0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
RuvA domain 2-like0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
GroEL equatorial domain-like0Direct
UBA-like0Direct
HD-domain/PDEase-like0Direct
Thiolase-like0Direct
HSP20-like chaperones0Direct
Chaperone J-domain0Direct
GAF domain-like0Direct
Arginase/deacetylase0Direct
IP3 receptor type 1 binding core, domain 20Direct
Terpenoid synthases0Direct
Doublecortin (DC)0Direct
Hect, E3 ligase catalytic domain0Direct
Tubulin nucleotide-binding domain-like0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
GroEL apical domain-like0Direct
CAD & PB1 domains0Direct
Class II aaRS ABD-related0Direct
Nicotinic receptor ligand binding domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0.06987Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.06987Inherited
Single hybrid motif0.09467Inherited
Glutathione synthetase ATP-binding domain-like0.09467Inherited
Voltage-gated potassium channels0.122Inherited
SET domain0.1262Inherited
Glycosyl hydrolase domain0.1262Inherited
PreATP-grasp domain0.1262Inherited
TPR-like0.1292Inherited
Actin-like ATPase domain0.1818Inherited
Bromodomain0.1818Inherited
beta-sandwich domain of Sec23/240.2268Inherited
cAMP-binding domain-like0.2297Inherited
PLP-dependent transferases0.2646Inherited
Ribosomal protein S5 domain 2-like0.2894Inherited
GTPase activation domain, GAP0.3195Inherited
GLA-domain0.3599Inherited
WD40 repeat-like0.4165Inherited
FAD/NAD(P)-binding domain0.5271Inherited
MHC antigen-recognition domain0.5459Inherited
MFS general substrate transporter0.5541Inherited
Adenine nucleotide alpha hydrolases-like0.733Inherited
Cysteine-rich domain0.7805Inherited
SH3-domain0.791Inherited
vWA-like0.8628Inherited
DEATH domain1Inherited
Immunoglobulin1Inherited
Homeodomain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Tubulin, C-terminal domain0Direct
GAF domain0Direct
Prefoldin0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
Cytoplasmic domain of inward rectifier potassium channel0Direct
Extended AAA-ATPase domain0Direct
Caspase recruitment domain, CARD0Direct
Clathrin adaptor core protein0Direct
L-aspartase/fumarase0Direct
Anticodon-binding domain of Class II aaRS0Direct
Nicotinic receptor ligand binding domain-like0Direct
Filamin repeat (rod domain)0Direct
ZZ domain0Direct
Hect, E3 ligase catalytic domain0Direct
Branched-chain alpha-keto acid dehydrogenase PP module0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
BRK domain-like0Direct
Branched-chain alpha-keto acid dehydrogenase Pyr module0Direct
CAT-like0Direct
Myotubularin-like phosphatases0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
SNF-like0Direct
Ubiquitin-related0Direct
Doublecortin (DC)0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0Direct
Erythroid transcription factor GATA-10Direct
Choline/Carnitine O-acyltransferase0Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
Ferredoxin domains from multidomain proteins0Direct
PDEase0Direct
MIR domain0Direct
Arylsulfatase0Direct
Cold shock DNA-binding domain-like0Direct
Tubulin, GTPase domain0Direct
beta-glycanases0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
p120GAP domain-like0Direct
FYVE, a phosphatidylinositol-3-phosphate binding domain0Direct
Amylase, catalytic domain0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
Crotonase-like0Direct
Elongation factors0Direct
Phosphate binding protein-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
FHA domain0Direct
Chaperone J-domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Reprolysin-like0Direct
Tetratricopeptide repeat (TPR)0.01909Inherited
Biotinyl/lipoyl-carrier proteins and domains0.07199Inherited
Medium chain acyl-CoA dehydrogenase-like, C-terminal domain0.07199Inherited
Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains0.07199Inherited
Tandem AAA-ATPase domain0.08783Inherited
Histone lysine methyltransferases0.1371Inherited
Voltage-gated potassium channels0.1463Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.1467Inherited
Bromodomain0.1467Inherited
BC N-terminal domain-like0.19Inherited
Tetramerization domain of potassium channels0.19Inherited
Actin/HSP700.19Inherited
BC ATP-binding domain-like0.19Inherited
Meta-cation ATPase, catalytic domain P0.1908Inherited
GLA-domain0.3126Inherited
Pleckstrin-homology domain (PH domain)0.4571Inherited
PDZ domain0.4879Inherited
MHC antigen-recognition domain0.5013Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.7447Inherited
SH3-domain0.7475Inherited
Tyrosine-dependent oxidoreductases0.8076Inherited
Integrin A (or I) domain0.9046Inherited
Homeodomain1Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MIR domain0Direct
GroEL apical domain-like0Direct
UBA-like0Direct
Hect, E3 ligase catalytic domain0Direct
Nicotinic receptor ligand binding domain-like0Direct
Thiolase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Tubulin C-terminal domain-like0Direct
Chaperone J-domain0Direct
CoA-dependent acyltransferases0Direct
GAF domain-like0Direct
Ferredoxin reductase-like, C-terminal NADP-linked domain0Direct
Class II aaRS ABD-related0Direct
Neurotransmitter-gated ion-channel transmembrane pore0Direct
CAD & PB1 domains0Direct
Multidrug efflux transporter AcrB transmembrane domain0Direct
RuvA domain 2-like0Direct
RCC1/BLIP-II0Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
SNF-like0Direct
GroEL-intermediate domain like0Direct
IP3 receptor type 1 binding core, domain 20Direct
Alkaline phosphatase-like0Direct
Terpenoid synthases0Direct
GroEL equatorial domain-like0Direct
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex0Direct
4Fe-4S ferredoxins0Direct
Thiamin diphosphate-binding fold (THDP-binding)0Direct
HD-domain/PDEase-like0Direct
L-aspartase-like0Direct
HSP20-like chaperones0Direct
BRK domain-like0Direct
Doublecortin (DC)0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Arginase/deacetylase0Direct
Acyl-CoA N-acyltransferases (Nat)0Direct
Riboflavin synthase domain-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
dsRNA-binding domain-like0Direct
Acyl-CoA dehydrogenase NM domain-like0.05544Inherited
Acyl-CoA dehydrogenase C-terminal domain-like0.05544Inherited
Glutathione synthetase ATP-binding domain-like0.0768Inherited
Single hybrid motif0.0768Inherited
Voltage-gated potassium channels0.1008Inherited
PreATP-grasp domain0.1046Inherited
Glycosyl hydrolase domain0.1046Inherited
SET domain0.1046Inherited
TPR-like0.1074Inherited
Class II aaRS and biotin synthetases0.1212Inherited
Nucleotide-diphospho-sugar transferases0.1407Inherited
Actin-like ATPase domain0.1547Inherited
Bromodomain0.1547Inherited
ARM repeat0.1672Inherited
SMAD/FHA domain0.1878Inherited
beta-sandwich domain of Sec23/240.197Inherited
cAMP-binding domain-like0.1998Inherited
RING/U-box0.2138Inherited
PLP-dependent transferases0.2328Inherited
Ribosomal protein S5 domain 2-like0.2567Inherited
GTPase activation domain, GAP0.2861Inherited
GLA-domain0.3252Inherited
WD40 repeat-like0.3817Inherited
FAD/NAD(P)-binding domain0.4914Inherited
MHC antigen-recognition domain0.5105Inherited
MFS general substrate transporter0.5188Inherited
PDZ domain-like0.6499Inherited
Adenine nucleotide alpha hydrolases-like0.7008Inherited
Cysteine-rich domain0.7494Inherited
SH3-domain0.7603Inherited
vWA-like0.8357Inherited
DEATH domain0.985Inherited
Immunoglobulin0.9913Inherited
Homeodomain-like0.9943Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
47005,52777
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0Direct
    49899,57196
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 0Direct
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    82109,100909
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0Direct
    82109,82109
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    52096,52096
  • 52096 - ClpP/crotonase
  • 52096 - ClpP/crotonase
  • 0Direct
    50729,56112
  • 50729 - PH domain-like
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    51230,47005
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0Direct
    56645,47203
  • 56645 - Acyl-CoA dehydrogenase NM domain-like
  • 47203 - Acyl-CoA dehydrogenase C-terminal domain-like
  • 0.05544Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.05544Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1046Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1074Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0.1436Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.197Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.197Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1998Inherited
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0.2704Inherited
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.5105Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.6534Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    51230,47005,52777
  • 51230 - Single hybrid motif
  • 47005 - Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    82109,82109,100909
  • 82109 - MIR domain
  • 82109 - MIR domain
  • 100909 - IP3 receptor type 1 binding core, domain 2
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.1046Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.7603Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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