SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of the eye

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of the eye [HP:0000478] <2>(26|34) (33|29|20)
- 1:   Abnormal eye physiology [HP:0012373] <9>(5|10) (8|16|13)
- 1:   Abnormal eye morphology [HP:0012372] <7>(19|27) (24|23|19)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PX domain0Direct
4Fe-4S ferredoxins0Direct
Restriction endonuclease-like0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
Prefoldin0Direct
gamma-Crystallin-like0Direct
FKBP-like0Direct
Terpenoid synthases0Direct
Doublecortin (DC)0Direct
CalX-like0Direct
Smc hinge domain0Direct
TPR-like0.001921Inherited
Intermediate filament protein, coiled coil region0.04403Inherited
Nucleotide-diphospho-sugar transferases0.04855Inherited
TB module/8-cys domain0.08985Inherited
GroEL equatorial domain-like0.08985Inherited
GAF domain-like0.1457Inherited
(Trans)glycosidases0.1596Inherited
cAMP-binding domain-like0.1767Inherited
C-type lectin-like0.2046Inherited
Concanavalin A-like lectins/glucanases0.2631Inherited
FnI-like domain0.2973Inherited
EGF/Laminin0.3113Inherited
Homeodomain-like0.3999Inherited
RING/U-box0.6319Inherited
TSP-1 type 1 repeat0.7491Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Prefoldin0Direct
Tetratricopeptide repeat (TPR)0Direct
Smc hinge domain0Direct
CalX-beta domain0Direct
Doublecortin (DC)0Direct
FKBP immunophilin/proline isomerase0Direct
Ferredoxin domains from multidomain proteins0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
Crystallins/Ca-binding development proteins0Direct
PX domain0Direct
beta-glycanases0Direct
VWC domain0Direct
XPF/Rad1/Mus81 nuclease0Direct
Extended AAA-ATPase domain0.01322Inherited
Laminin-type module0.01722Inherited
Laminin G-like module0.02816Inherited
Intermediate filament protein, coiled coil region0.02969Inherited
Histone lysine methyltransferases0.03992Inherited
Noncollagenous (NC1) domain of collagen IV0.03992Inherited
YWTD domain0.03992Inherited
Reprolysin-like0.03992Inherited
TB module/8-cys domain0.06814Inherited
Actin/HSP700.06814Inherited
GAF domain0.1156Inherited
PDEase0.1706Inherited
EGF-type module0.1789Inherited
Homeodomain0.292Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4269Inherited
Nicotinic receptor ligand binding domain-like0.4269Inherited
PDZ domain0.5371Inherited
Protein kinases, catalytic subunit0.6699Inherited
TSP-1 type 1 repeat0.7075Inherited
I set domains0.817Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
CalX-like0Direct
Smc hinge domain0Direct
PX domain0Direct
A DNA-binding domain in eukaryotic transcription factors0Direct
Terpenoid synthases0Direct
gamma-Crystallin-like0Direct
4Fe-4S ferredoxins0Direct
FKBP-like0Direct
Doublecortin (DC)0Direct
Restriction endonuclease-like0Direct
Prefoldin0Direct
TPR-like0.00113Inherited
WD40 repeat-like0.004191Inherited
SET domain0.02498Inherited
Intermediate filament protein, coiled coil region0.03366Inherited
Nucleotide-diphospho-sugar transferases0.03744Inherited
YWTD domain0.04258Inherited
GroEL equatorial domain-like0.07255Inherited
TB module/8-cys domain0.07255Inherited
GAF domain-like0.122Inherited
(Trans)glycosidases0.1346Inherited
cAMP-binding domain-like0.1501Inherited
C-type lectin-like0.1762Inherited
Concanavalin A-like lectins/glucanases0.2314Inherited
FnI-like domain0.2644Inherited
EGF/Laminin0.2781Inherited
Glycosyl hydrolase domain0.3037Inherited
Homeodomain-like0.3652Inherited
Nicotinic receptor ligand binding domain-like0.4417Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4417Inherited
RING/U-box0.5975Inherited
Metalloproteases ("zincins"), catalytic domain0.6941Inherited
TSP-1 type 1 repeat0.7169Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    89837,89837
  • 89837 - Doublecortin (DC)
  • 89837 - Doublecortin (DC)
  • 0Direct
    46579,64593
  • 46579 - Prefoldin
  • 64593 - Intermediate filament protein, coiled coil region
  • 0Direct
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0Direct
    63825,57196
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.008087Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.04855Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.04855Inherited
    49899,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.04855Inherited
    55486,82895
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 82895 - TSP-1 type 1 repeat
  • 0.07255Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.07255Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.07255Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.07651Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.08904Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.09751Inherited
    55781,109604
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.122Inherited
    55781,55781
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 0.122Inherited
    82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.1501Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.2432Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.2692Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.3037Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4417Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.8204Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57196,63825,57196
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 57196 - EGF/Laminin
  • 0Direct
    57196,57196,57581
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57581,57184
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57196,57581,57196
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.01427Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.02498Inherited
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07255Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.07255Inherited
    82895,82895,82895
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 82895 - TSP-1 type 1 repeat
  • 0.07651Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.07653Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1033Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.1181Inherited
    55781,55781,109604
  • 55781 - GAF domain-like
  • 55781 - GAF domain-like
  • 109604 - HD-domain/PDEase-like
  • 0.122Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.122Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)