SUPERFAMILY 1.75 HMM library and genome assignments server

Phenotypic Abnormality (PA): Abnormality of head and neck

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Root: HP Hierarchy (human phenotype with 3 sub-ontologies PA, MI, ON)

Shortest distance to current term (+ for parents, - for children) HP term [HP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   Phenotypic abnormality [HP:0000118] <21>
0:   Abnormality of head and neck [HP:0000152] <2>(41|47) (50|25|17)
- 1:   Abnormality of the neck [HP:0000464] <12>(5|4) (5|2|0)
- 1:   Abnormality of the head [HP:0000234] <4>(38|46) (49|25|17)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
PX domain0Direct
Integrin beta tail domain0Direct
SAND domain-like0Direct
Plakin repeat0Direct
Restriction endonuclease-like0Direct
Tubulin C-terminal domain-like0Direct
BEACH domain0Direct
RCC1/BLIP-II0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
BRK domain-like0Direct
RuvA domain 2-like0Direct
FKBP-like0Direct
Cytokine0Direct
CalX-like0Direct
Tubulin nucleotide-binding domain-like0Direct
Smc hinge domain0Direct
Alkaline phosphatase-like0.02227Inherited
SET domain0.04128Inherited
Tudor/PWWP/MBT0.07612Inherited
Cystine-knot cytokines0.08119Inherited
TB module/8-cys domain0.1032Inherited
GroEL equatorial domain-like0.1032Inherited
p53-like transcription factors0.1204Inherited
Intermediate filament protein, coiled coil region0.1208Inherited
SMAD/FHA domain0.1356Inherited
Actin-like ATPase domain0.1512Inherited
Bromodomain0.1512Inherited
ARID-like0.1622Inherited
Glycosyl hydrolase domain0.1633Inherited
HLH, helix-loop-helix DNA-binding domain0.3268Inherited
MIR domain0.3307Inherited
TNF receptor-like0.4049Inherited
vWA-like0.4786Inherited
Tropomyosin0.5123Inherited
Cysteine-rich domain0.5123Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.5256Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5256Inherited
Nicotinic receptor ligand binding domain-like0.5256Inherited
Immunoglobulin0.7264Inherited
Kringle-like0.7295Inherited
Trypsin-like serine proteases0.9001Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Tubulin, C-terminal domain0Direct
Prefoldin0Direct
Clathrin adaptor core protein0Direct
Smc hinge domain0Direct
CalX-beta domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
BRK domain-like0Direct
Fibroblast growth factors (FGF)0Direct
FKBP immunophilin/proline isomerase0Direct
Inositol polyphosphate 5-phosphatase (IPP5)0Direct
Integrin beta EGF-like domains0Direct
Tubulin, GTPase domain0Direct
PX domain0Direct
beta-glycanases0Direct
Plakin repeat0Direct
BEACH domain0Direct
Elongation factors0Direct
XPF/Rad1/Mus81 nuclease0Direct
Integrin beta tail domain0Direct
Tetratricopeptide repeat (TPR)0.002138Inherited
Tandem AAA-ATPase domain0.01208Inherited
Transforming growth factor (TGF)-beta0.0163Inherited
Arylsulfatase0.01881Inherited
Histone lysine methyltransferases0.05114Inherited
VWC domain0.05114Inherited
TB module/8-cys domain0.0842Inherited
Laminin-type module0.08822Inherited
Intermediate filament protein, coiled coil region0.1008Inherited
Bromodomain0.1265Inherited
ARID domain0.1361Inherited
Amylase, catalytic domain0.1361Inherited
EGF-type module0.1731Inherited
BCR-homology GTPase activation domain (BH-domain)0.2484Inherited
Integrin A (or I) domain0.259Inherited
I set domains0.2884Inherited
HLH, helix-loop-helix DNA-binding domain0.2937Inherited
PWWP domain0.2954Inherited
MIR domain0.2954Inherited
Actin/HSP700.2954Inherited
ABC transporter ATPase domain-like0.4028Inherited
Pleckstrin-homology domain (PH domain)0.4028Inherited
Tropomyosin0.4782Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.4782Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4918Inherited
Nicotinic receptor ligand binding domain-like0.4918Inherited
Kringle modules0.6048Inherited
Eukaryotic proteases0.8008Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Plakin repeat0Direct
Tubulin nucleotide-binding domain-like0Direct
Tubulin C-terminal domain-like0Direct
Integrin beta tail domain0Direct
RuvA domain 2-like0Direct
RCC1/BLIP-II0Direct
CalX-like0Direct
BEACH domain0Direct
Smc hinge domain0Direct
PX domain0Direct
Cytokine0Direct
FKBP-like0Direct
BRK domain-like0Direct
Restriction endonuclease-like0Direct
SAND domain-like0Direct
Glycerol-3-phosphate (1)-acyltransferase0Direct
Nucleotide-diphospho-sugar transferases0.000747Direct
WD40 repeat-like0.001004Inherited
Alkaline phosphatase-like0.01601Inherited
SET domain0.03128Inherited
(Trans)glycosidases0.03725Inherited
Tudor/PWWP/MBT0.06076Inherited
Cystine-knot cytokines0.06507Inherited
GroEL equatorial domain-like0.08424Inherited
TB module/8-cys domain0.08424Inherited
p53-like transcription factors0.09937Inherited
Intermediate filament protein, coiled coil region0.09966Inherited
SMAD/FHA domain0.113Inherited
Actin-like ATPase domain0.1268Inherited
Bromodomain0.1268Inherited
ARID-like0.1368Inherited
Glycosyl hydrolase domain0.1377Inherited
HLH, helix-loop-helix DNA-binding domain0.2931Inherited
MIR domain0.2968Inherited
PH domain-like0.3005Inherited
GLA-domain0.34Inherited
TNF receptor-like0.3701Inherited
vWA-like0.4432Inherited
Growth factor receptor domain0.4474Inherited
Integrin domains0.477Inherited
Tropomyosin0.477Inherited
Cysteine-rich domain0.477Inherited
Nicotinic receptor ligand binding domain-like0.4899Inherited
Neurotransmitter-gated ion-channel transmembrane pore0.4899Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.4899Inherited
RING/U-box0.5362Inherited
DEATH domain0.6752Inherited
Immunoglobulin0.6941Inherited
Kringle-like0.6973Inherited
Trypsin-like serine proteases0.8747Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
75399,75399
  • 75399 - Plakin repeat
  • 75399 - Plakin repeat
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    50729,81837
  • 50729 - PH domain-like
  • 81837 - BEACH domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    64268,50044
  • 64268 - PX domain
  • 50044 - SH3-domain
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    52980,47781
  • 52980 - Restriction endonuclease-like
  • 47781 - RuvA domain 2-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.01094Inherited
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.06076Inherited
    57581,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0.08424Inherited
    53300,53300
  • 53300 - vWA-like
  • 53300 - vWA-like
  • 0.08424Inherited
    57196,57581
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.08424Inherited
    57196,63825
  • 57196 - EGF/Laminin
  • 63825 - YWTD domain
  • 0.1368Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1377Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.1783Inherited
    64593,64593
  • 64593 - Intermediate filament protein, coiled coil region
  • 64593 - Intermediate filament protein, coiled coil region
  • 0.1783Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.2849Inherited
    50156,50156
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0.2968Inherited
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.4899Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.7151Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    49899,57196,49899
  • 49899 - Concanavalin A-like lectins/glucanases
  • 57196 - EGF/Laminin
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0Direct
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57196,57196
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.08424Inherited
    57581,57196,57581
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 57581 - TB module/8-cys domain
  • 0.08424Inherited
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.09205Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.1368Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.2816Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.34Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.4819Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)