SUPERFAMILY 1.75 HMM library and genome assignments server

Disease Ontology (DO): syndrome

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   syndrome [DOID:225] <51>(16|23) (16|13|10)
- 1:   ARC syndrome [DOID:0050763](0|0) (0|0|0)
- 1:   Aagenaes syndrome [DOID:6691](0|0) (0|0|0)
- 1:   Achard syndrome [DOID:6686](0|0) (0|0|0)
- 1:   Adie syndrome [DOID:11549](0|0) (0|0|0)
- 1:   Aicardi syndrome [DOID:8461](0|0) (0|0|0)
- 1:   Armfield syndrome [DOID:0050764](0|0) (0|0|0)
- 1:   Barre-Lieou syndrome [DOID:6692](0|0) (0|0|0)
- 1:   Beemer-Langer syndrome [DOID:9249](0|0) (0|0|0)
- 1:   CHARGE syndrome [DOID:0050834](0|0) (0|0|0)
- 1:   CREST syndrome [DOID:0060218](0|0) (0|0|0)
- 1:   Dubowitz Syndrome [DOID:14796](0|0) (0|0|0)
- 1:   Felty's syndrome [DOID:11042](0|0) (0|0|0)
- 1:   Fuchs' heterochromic uveitis [DOID:9375](0|0) (0|0|0)
- 1:   Goldenhar syndrome [DOID:2907](0|0) (0|0|0)
- 1:   Gorham's disease [DOID:4837](0|0) (0|0|0)
- 1:   Hallermann-Streiff syndrome [DOID:4534](0|0) (0|0|0)
- 1:   IMAGe syndrome [DOID:0050885](0|0) (0|0|0)
- 1:   Jensen syndrome [DOID:0050867](0|0) (0|0|0)
- 1:   KBG syndrome [DOID:14780](0|0) (0|0|0)
- 1:   Klippel-Trenaunay syndrome [DOID:2926](0|0) (0|0|0)
- 1:   Koolen de Vries syndrome [DOID:0050880](0|0) (0|0|0)
- 1:   Lown-Ganong-Levine syndrome [DOID:13087](0|0) (0|0|0)
- 1:   Marshall-Smith syndrome [DOID:0050858](0|0) (0|0|0)
- 1:   N syndrome [DOID:0050769](0|0) (0|0|0)
- 1:   Ollier disease [DOID:4624](0|0) (0|0|0)
- 1:   Partington syndrome [DOID:14744](0|0) (0|0|0)
- 1:   Qazi Markouizos syndrome [DOID:0050740](0|0) (0|0|0)
- 1:   Reye syndrome [DOID:14525](0|0) (0|0|0)
- 1:   SAPHO syndrome [DOID:13677](0|0) (0|0|0)
- 1:   Saldino-Noonan syndrome [DOID:0050549](0|0) (0|0|0)
- 1:   Takayasu's arteritis [DOID:2508](0|0) (0|0|0)
- 1:   VACTERL association [DOID:14679](0|0) (0|0|0)
- 1:   Wissler's syndrome [DOID:3047](0|0) (0|0|0)
- 1:   Zollinger-Ellison Syndrome [DOID:0050782](0|0) (0|0|0)
- 1:   acrocallosal syndrome [DOID:9250](0|0) (0|0|0)
- 1:   chronic fatigue syndrome [DOID:8544](0|0) (0|0|0)
- 1:   diffuse infiltrative lymphocytosis syndrome [DOID:6677](0|0) (0|0|0)
- 1:   fibrogenesis imperfecta ossium [DOID:0080040](0|0) (0|0|0)
- 1:   inclusion body myopathy with Paget disease of bone and frontotemporal dementia [DOID:0050881](0|0) (0|0|0)
- 1:   irritable bowel syndrome [DOID:9778](2|1) (2|0|0)
- 1:   multicentric reticulohistiocytosis [DOID:11824](0|0) (0|0|0)
- 1:   multiple chemical sensitivity [DOID:4661](0|0) (0|0|0)
- 1:   palindromic rheumatism [DOID:1166](0|0) (0|0|0)
- 1:   persian gulf syndrome [DOID:4491](0|0) (0|0|0)
- 1:   polycystic ovary syndrome [DOID:11612](1|4) (1|0|0)
- 1:   primary hypertrophic osteoarthropathy [DOID:14283](0|0) (0|0|0)
- 1:   psoriatic arthritis [DOID:9008](1|4) (1|1|0)
- 1:   subclavian steal syndrome [DOID:13002](0|0) (0|0|0)
- 1:   sudden infant death syndrome [DOID:9007](1|0) (1|0|0)
- 1:   tooth and nail syndrome [DOID:6678](0|0) (0|0|0)
- 1:   yellow nail syndrome [DOID:0050468](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
2Fe-2S ferredoxin-like0Direct
Composite domain of metallo-dependent hydrolases0Direct
Apolipoprotein A-I0Direct
HRDC-like0Direct
CalX-like0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
GTF2I-like repeat0Direct
4-helical cytokines0.0001887Direct
Complement control module/SCR domain0.0006892Direct
GLA-domain0.0008591Direct
Kringle-like0.0009169Direct
Insulin-like0.005695Inherited
Voltage-gated potassium channels0.03423Inherited
DEATH domain0.04052Inherited
MHC antigen-recognition domain0.1945Inherited
RNI-like0.28Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
CalX-beta domain0Direct
NADPH-cytochrome p450 reductase FAD-binding domain-like0Direct
AAT-like0Direct
GTF2I-like repeat0Direct
Noncollagenous (NC1) domain of collagen IV0Direct
NADPH-cytochrome p450 reductase-like0Direct
Hydantoinase (dihydropyrimidinase)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0Direct
Cytochrome p450 reductase N-terminal domain-like0Direct
Hydantoinase (dihydropyrimidinase), catalytic domain0Direct
Long-chain cytokines0.0002582Direct
Complement control module/SCR domain0.0006232Direct
GLA-domain0.0006467Direct
Cytoplasmic domain of inward rectifier potassium channel0.0006467Direct
Insulin-like0.00429Inherited
Retinol binding protein-like0.03377Inherited
C1 set domains (antibody constant domain-like)0.09715Inherited
Interleukin-1 (IL-1)0.1312Inherited
MHC antigen-recognition domain0.1817Inherited
S100 proteins0.393Inherited
Caspase recruitment domain, CARD0.4764Inherited
Phosphotyrosine-binding domain (PTB)0.5379Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
GTF2I-like repeat0Direct
Composite domain of metallo-dependent hydrolases0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0Direct
HRDC-like0Direct
2Fe-2S ferredoxin-like0Direct
CalX-like0Direct
4-helical cytokines0.0001075Direct
Complement control module/SCR domain0.0004127Direct
GLA-domain0.000519Direct
Kringle-like0.0005586Direct
Insulin-like0.003795Inherited
Voltage-gated potassium channels0.02513Inherited
DEATH domain0.02996Inherited
MHC antigen-recognition domain0.1589Inherited
RNI-like0.2349Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
57196,50494
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct
    57581,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57630,57196
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 0Direct
    51556,51338
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    51338,51556
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 0Direct
    57581,57581
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57184,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00002666Direct
    57440,50494
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.000519Direct
    81324,81296
  • 81324 - Voltage-gated potassium channels
  • 81296 - E set domains
  • 0.000519Direct
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.0008844Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.1702Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    57184,57581,57196
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57196 - EGF/Laminin
  • 0Direct
    51338,51556,51338
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 51556 - Metallo-dependent hydrolases
  • 51338 - Composite domain of metallo-dependent hydrolases
  • 0Direct
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    57581,57184,57184
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57581,57184,57581
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57581,57184
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57184 - Growth factor receptor domain
  • 0Direct
    57184,57581,57581
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    57184,57184,57581
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57581 - TB module/8-cys domain
  • 0Direct
    141072,141072,141072
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 141072 - CalX-like
  • 0Direct
    57630,57196,50494
  • 57630 - GLA-domain
  • 57196 - EGF/Laminin
  • 50494 - Trypsin-like serine proteases
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)