SUPERFAMILY 1.75 HMM library and genome assignments server

Disease Ontology (DO): disease of mental health

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease of mental health [DOID:150] <12>(21|31) (21|20|8)
- 1:   personality disorder [DOID:1510] <10>(0|0) (0|0|0)
- 1:   sleep disorder [DOID:535] <7>(0|0) (0|0|0)
- 1:   impulse control disorder [DOID:10937] <6>(0|0) (0|0|0)
- 1:   somatoform disorder [DOID:4737] <6>(0|0) (0|0|0)
- 1:   cognitive disorder [DOID:1561] <5>(17|23) (17|12|6)
- 1:   sexual disorder [DOID:0060043] <5>(0|0) (0|0|0)
- 1:   dissociative disorder [DOID:10935] <3>(0|0) (0|0|0)
- 1:   substance-related disorder [DOID:303] <3>(7|10) (7|6|1)
- 1:   developmental disorder of mental health [DOID:0060037] <2>(7|8) (7|2|0)
- 1:   gender identity disorder [DOID:1234] <2>(0|0) (0|0|0)
- 1:   factitious disorder [DOID:1766] <1>(0|0) (0|0|0)
- 1:   adjustment disorder [DOID:507](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Proton glutamate symport protein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Synuclein0Direct
Nicotinic receptor ligand binding domain-like0.000000000007942Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000007942Direct
Periplasmic binding protein-like II0.00000000006428Direct
Periplasmic binding protein-like I0.000000008031Direct
Family A G protein-coupled receptor-like0.000002498Direct
Voltage-gated potassium channels0.00006935Direct
Flavoproteins0.0002164Direct
YWTD domain0.0008217Direct
14-3-3 protein0.003373Inherited
SNF-like0.02086Inherited
Tubulin nucleotide-binding domain-like0.0297Inherited
Tubulin C-terminal domain-like0.0297Inherited
Lipoxigenase0.03053Inherited
GroES-like0.09996Inherited
4-helical cytokines0.1846Inherited
HLH, helix-loop-helix DNA-binding domain0.3332Inherited
Hormone receptor domain0.4282Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Transferrin0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Proton glutamate symport protein0Direct
Synapsin domain0Direct
Synapsin C-terminal domain0Direct
Synuclein0Direct
p53 DNA-binding domain-like0Direct
Nicotinic receptor ligand binding domain-like0.000000000009215Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000009215Direct
Phosphate binding protein-like0.000000005868Direct
L-arabinose binding protein-like0.0000003523Direct
Rhodopsin-like0.000004409Direct
YWTD domain0.00066Direct
Pyridoxal-dependent decarboxylase0.002279Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.002279Inherited
Pentraxin (pentaxin)0.002279Inherited
NADPH-cytochrome p450 reductase-like0.002279Inherited
14-3-3 protein0.002639Inherited
Acetylcholinesterase-like0.005357Inherited
Cytochrome p450 reductase N-terminal domain-like0.008167Inherited
SNF-like0.01761Inherited
Neutral endopeptidase (neprilysin)0.02525Inherited
Animal lipoxigenases0.02525Inherited
Tubulin, C-terminal domain0.02531Inherited
Tubulin, GTPase domain0.02531Inherited
Alcohol dehydrogenase-like, C-terminal domain0.05962Inherited
Alcohol dehydrogenase-like, N-terminal domain0.05962Inherited
Voltage-gated potassium channels0.1006Inherited
HLH, helix-loop-helix DNA-binding domain0.3378Inherited
Hormone receptor domain0.4056Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Proton glutamate symport protein0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Synuclein0Direct
p53 tetramerization domain0Direct
Nicotinic receptor ligand binding domain-like0.000000000003455Direct
Neurotransmitter-gated ion-channel transmembrane pore0.000000000003455Direct
Periplasmic binding protein-like II0.00000000002817Direct
Periplasmic binding protein-like I0.000000003639Direct
Family A G protein-coupled receptor-like0.000001287Direct
Voltage-gated potassium channels0.00003965Direct
Flavoproteins0.0001238Direct
YWTD domain0.0004957Direct
14-3-3 protein0.002203Inherited
SNF-like0.01472Inherited
Tubulin nucleotide-binding domain-like0.02163Inherited
Tubulin C-terminal domain-like0.02163Inherited
Lipoxigenase0.02229Inherited
GroES-like0.07855Inherited
4-helical cytokines0.1503Inherited
HLH, helix-loop-helix DNA-binding domain0.2831Inherited
Hormone receptor domain0.3705Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50729,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    81324,53850
  • 81324 - Voltage-gated potassium channels
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0Direct
    57889,49562
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    53822,53850
  • 53822 - Periplasmic binding protein-like I
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    53850,53850
  • 53850 - Periplasmic binding protein-like II
  • 53850 - Periplasmic binding protein-like II
  • 0Direct
    63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.000000000003455Direct
    57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.001151Inherited
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.001932Inherited
    57184,63825
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.001937Inherited
    52058,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 0.001937Inherited
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.005818Inherited
    49785,49899
  • 49785 - Galactose-binding domain-like
  • 49899 - Concanavalin A-like lectins/glucanases
  • 0.007111Inherited
    51735,50129
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0.01686Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.02163Inherited
    49723,48484
  • 49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
  • 48484 - Lipoxigenase
  • 0.02229Inherited
    57424,57184
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.02229Inherited
    50129,51735
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 0.05196Inherited
    111418,81321
  • 111418 - Hormone receptor domain
  • 81321 - Family A G protein-coupled receptor-like
  • 0.3176Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52058,48726,48726
  • 52058 - L domain-like
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0Direct
    57184,52058,57184
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0Direct
    57889,57889,49562
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    50729,50156,50156
  • 50729 - PH domain-like
  • 50156 - PDZ domain-like
  • 50156 - PDZ domain-like
  • 0Direct
    57424,57424,57424
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 0.0004957Direct
    57424,57424,57184
  • 57424 - LDL receptor-like module
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 0.007111Inherited
    57424,57184,63825
  • 57424 - LDL receptor-like module
  • 57184 - Growth factor receptor domain
  • 63825 - YWTD domain
  • 0.007111Inherited
    50129,51735,50129
  • 50129 - GroES-like
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 50129 - GroES-like
  • 0.01686Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)