SUPERFAMILY 1.75 HMM library and genome assignments server

Disease Ontology (DO): disease by infectious agent

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease by infectious agent [DOID:0050117] <4>(37|51) (39|23|11)
- 1:   viral infectious disease [DOID:934] <80>(11|17) (14|9|3)
- 1:   fungal infectious disease [DOID:1564] <4>(4|2) (4|0|0)
- 1:   parasitic infectious disease [DOID:1398] <4>(10|9) (10|0|0)
- 1:   bacterial infectious disease [DOID:104] <3>(13|18) (14|7|1)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Integrin beta tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Defensin-like0Direct
Interleukin 8-like chemokines0.00000001566Direct
4-helical cytokines0.00000002315Direct
DEATH domain0.0000005281Direct
MHC antigen-recognition domain0.00000189Direct
Toll/Interleukin receptor TIR domain0.000002619Direct
Integrin domains0.000003077Direct
TNF receptor-like0.000005555Direct
Immunoglobulin0.00004077Direct
SH2 domain0.00008216Direct
SMAD/FHA domain0.0002052Direct
Heme-dependent peroxidases0.0006874Direct
PGBD-like0.0007809Direct
Triple coiled coil domain of C-type lectins0.002233Inherited
C-type lectin-like0.002832Inherited
SOCS box-like0.004564Inherited
Bcl-2 inhibitors of programmed cell death0.004564Inherited
p53-like transcription factors0.004768Inherited
Nuclear receptor ligand-binding domain0.005027Inherited
dsRNA-binding domain-like0.005962Inherited
TNF-like0.008762Inherited
Hemopexin-like domain0.01514Inherited
STAT0.01825Inherited
Transcription factor STAT-4 N-domain0.01825Inherited
Flavoproteins0.08315Inherited
Protein kinase-like (PK-like)0.1124Inherited
SRCR-like0.1322Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1848Inherited
Riboflavin synthase domain-like0.1848Inherited
ABC transporter transmembrane region0.2554Inherited
Cytokine0.4037Inherited
Bromodomain0.421Inherited
Fibronectin type III0.6269Inherited
L domain-like0.7066Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Defensin0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0Direct
2'-5'-oligoadenylate synthetase 1, OAS1, second domain0Direct
p53 tetramerization domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Integrin beta tail domain0Direct
C5 cytosine-specific DNA methylase, DCM0Direct
Integrin beta EGF-like domains0Direct
p53 DNA-binding domain-like0Direct
Interleukin 8-like chemokines0.00000001932Direct
Short-chain cytokines0.0000002808Direct
Toll/Interleukin receptor TIR domain0.0000007368Direct
MHC antigen-recognition domain0.000002038Direct
TNF receptor-like0.000002504Direct
Integrin domains0.000002847Direct
C1 set domains (antibody constant domain-like)0.00001296Direct
SH2 domain0.0001097Direct
Interferon regulatory factor 3 (IRF3), transactivation domain0.0001107Direct
C2 set domains0.0001525Direct
Interferon regulatory factor0.0001525Direct
Pyrin domain, PYD0.0004462Direct
Histone deacetylase, HDAC0.0005101Direct
Myeloperoxidase-like0.0005567Direct
MMP N-terminal domain0.0006828Direct
Integrin A (or I) domain0.0007513Direct
Caspase catalytic domain0.0009514Direct
Integrin alpha N-terminal domain0.0009514Direct
C-type lectin domain0.001212Inherited
Triple coiled coil domain of C-type lectins0.001736Inherited
Bcl-2 inhibitors of programmed cell death0.003838Inherited
SOCS box-like0.003838Inherited
Double-stranded RNA-binding domain (dsRBD)0.003838Inherited
Matrix metalloproteases, catalytic domain0.003861Inherited
Nuclear receptor ligand-binding domain0.005102Inherited
Cytochrome p450 reductase N-terminal domain-like0.006594Inherited
TNF-like0.008187Inherited
Interferons/interleukin-10 (IL-10)0.008689Inherited
Nuclear receptor0.009517Inherited
Hemopexin-like domain0.01358Inherited
STAT DNA-binding domain0.01534Inherited
STAT0.01534Inherited
Transcription factor STAT-4 N-domain0.01534Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.02067Inherited
NADPH-cytochrome p450 reductase-like0.02067Inherited
I set domains0.03565Inherited
Interleukin-1 (IL-1)0.07389Inherited
ABC transporter transmembrane region0.1534Inherited
Protein kinases, catalytic subunit0.2178Inherited
Bromodomain0.4122Inherited
ABC transporter ATPase domain-like0.4852Inherited
Fibronectin type III0.664Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Defensin-like0Direct
Integrin beta tail domain0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
p53 tetramerization domain0Direct
Interleukin 8-like chemokines0.000000007101Direct
4-helical cytokines0.00000001064Direct
DEATH domain0.0000002611Direct
MHC antigen-recognition domain0.0000009666Direct
Toll/Interleukin receptor TIR domain0.000001352Direct
Integrin domains0.000001591Direct
TNF receptor-like0.000002921Direct
Immunoglobulin0.00002292Direct
SH2 domain0.00004673Direct
SMAD/FHA domain0.0001173Direct
Heme-dependent peroxidases0.0004116Direct
PGBD-like0.0004703Direct
Integrin alpha N-terminal domain0.0006888Direct
Triple coiled coil domain of C-type lectins0.00143Inherited
C-type lectin-like0.001824Inherited
SOCS box-like0.003004Inherited
Bcl-2 inhibitors of programmed cell death0.003004Inherited
p53-like transcription factors0.003157Inherited
Nuclear receptor ligand-binding domain0.003332Inherited
dsRNA-binding domain-like0.003982Inherited
TNF-like0.005848Inherited
Hemopexin-like domain0.01049Inherited
Transcription factor STAT-4 N-domain0.01282Inherited
STAT0.01282Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.05826Inherited
Flavoproteins0.06459Inherited
Protein kinase-like (PK-like)0.08877Inherited
SRCR-like0.106Inherited
Ferredoxin reductase-like, C-terminal NADP-linked domain0.1505Inherited
Riboflavin synthase domain-like0.1505Inherited
ABC transporter transmembrane region0.2126Inherited
Cytokine0.3473Inherited
Bromodomain0.3637Inherited
Fibronectin type III0.5596Inherited
L domain-like0.6357Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63763,57903
  • 63763 - SAND domain-like
  • 57903 - FYVE/PHD zinc finger
  • 0Direct
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0Direct
    49562,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 0Direct
    53300,69179
  • 53300 - vWA-like
  • 69179 - Integrin domains
  • 0Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.000004827Direct
    57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.000005177Direct
    47986,47986
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 0.00007959Direct
    55550,158235
  • 55550 - SH2 domain
  • 158235 - SOCS box-like
  • 0.00007959Direct
    69318,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 0.0002891Direct
    69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0002891Direct
    54768,54768
  • 54768 - dsRNA-binding domain-like
  • 54768 - dsRNA-binding domain-like
  • 0.0003384Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004116Direct
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.0004703Direct
    57944,56436
  • 57944 - Triple coiled coil domain of C-type lectins
  • 56436 - C-type lectin-like
  • 0.00143Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.002645Inherited
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.003899Inherited
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 0.01282Inherited
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01282Inherited
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01282Inherited
    55486,50923
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.02519Inherited
    56487,50494
  • 56487 - SRCR-like
  • 50494 - Trypsin-like serine proteases
  • 0.09829Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2126Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    47986,47986,52129
  • 47986 - DEATH domain
  • 47986 - DEATH domain
  • 52129 - Caspase-like
  • 0Direct
    49562,57889,57889
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0Direct
    63763,57903,47370
  • 63763 - SAND domain-like
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0Direct
    57586,57586,57586
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 57586 - TNF receptor-like
  • 0.00007959Direct
    69318,69179,69179
  • 69318 - Integrin alpha N-terminal domain
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0002891Direct
    69179,69179,69179
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 69179 - Integrin domains
  • 0.0003659Direct
    47090,55486,50923
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 50923 - Hemopexin-like domain
  • 0.0104Inherited
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 0.01282Inherited
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 0.01282Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1468Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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