SUPERFAMILY 1.75 HMM library and genome assignments server

Disease Ontology (DO): disease of metabolism

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Root: DO Hierarchy (disease ontology from University of Maryland)

Shortest distance to current term (+ for parents, - for children) DO term [DO ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   disease [DOID:4] <8>
0:   disease of metabolism [DOID:0014667] <2>(23|34) (28|12|6)
- 1:   inherited metabolic disorder [DOID:655] <13>(12|14) (15|5|0)
- 1:   acquired metabolic disease [DOID:0060158] <8>(15|21) (18|10|6)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Rudiment single hybrid motif0Direct
Apolipoprotein A-I0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Calpain large subunit, middle domain (domain III)0Direct
Nuclear receptor ligand-binding domain0.0000002145Direct
(Trans)glycosidases0.0000003619Direct
MHC antigen-recognition domain0.00000626Direct
FabD/lysophospholipase-like0.00003178Direct
Single hybrid motif0.0001012Direct
Glycosyl hydrolase domain0.0001208Direct
4-helical cytokines0.0005596Direct
Integrin domains0.001029Inherited
Integrin beta tail domain0.001825Inherited
Insulin-like0.001825Inherited
Flavoproteins0.001899Inherited
MFS general substrate transporter0.002813Inherited
Alkaline phosphatase-like0.003054Inherited
TNF-like0.006053Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.02961Inherited
PGBD-like0.03899Inherited
Family A G protein-coupled receptor-like0.05781Inherited
Hemopexin-like domain0.08861Inherited
Voltage-gated potassium channels0.6866Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Biotin dependent carboxylase carboxyltransferase domain0Direct
AAT-like0Direct
Calpain large subunit, middle domain (domain III)0Direct
Nitric oxide (NO) synthase oxygenase domain0Direct
Calpain large subunit, catalytic domain (domain II)0Direct
BC C-terminal domain-like0Direct
alpha-Amylases, C-terminal beta-sheet domain0Direct
Exostosin0Direct
Apolipoprotein A-I0Direct
Nuclear receptor ligand-binding domain0.0000002043Direct
Nuclear receptor0.0000006242Direct
C1 set domains (antibody constant domain-like)0.0000007514Direct
MHC antigen-recognition domain0.000005392Direct
Biotinyl/lipoyl-carrier proteins and domains0.00007523Direct
L domain0.0003209Direct
Amylase, catalytic domain0.0003209Direct
Integrin domains0.0008122Direct
Insulin-like0.001332Inherited
NADPH-cytochrome p450 reductase FAD-binding domain-like0.001332Inherited
NADPH-cytochrome p450 reductase-like0.001332Inherited
Integrin beta tail domain0.001332Inherited
BC N-terminal domain-like0.001332Inherited
Integrin beta EGF-like domains0.001332Inherited
BC ATP-binding domain-like0.001332Inherited
Long-chain cytokines0.001844Inherited
TNF-like0.005094Inherited
beta-glycanases0.005342Inherited
Arylsulfatase0.005377Inherited
UDPGT-like0.02289Inherited
Fatty acid binding protein-like0.02407Inherited
MMP N-terminal domain0.03331Inherited
Rhodopsin-like0.03674Inherited
Matrix metalloproteases, catalytic domain0.07851Inherited
Hemopexin-like domain0.07851Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nitric oxide (NO) synthase oxygenase domain0Direct
Apolipoprotein A-I0Direct
Calpain large subunit, middle domain (domain III)0Direct
Rudiment single hybrid motif0Direct
Nuclear receptor ligand-binding domain0.0000001037Direct
(Trans)glycosidases0.0000001773Direct
MHC antigen-recognition domain0.000003309Direct
FabD/lysophospholipase-like0.00001765Direct
Single hybrid motif0.0000584Direct
Glycosyl hydrolase domain0.00006982Direct
4-helical cytokines0.0003328Direct
Integrin domains0.0006321Direct
Integrin beta tail domain0.001148Inherited
Insulin-like0.001148Inherited
Flavoproteins0.001202Inherited
MFS general substrate transporter0.00181Inherited
Alkaline phosphatase-like0.001972Inherited
TNF-like0.004049Inherited
Lipocalins0.007075Inherited
Lipase/lipooxygenase domain (PLAT/LH2 domain)0.02104Inherited
Glucocorticoid receptor-like (DNA-binding domain)0.02137Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.02156Inherited
Cytokine0.02511Inherited
Kringle-like0.02862Inherited
PGBD-like0.02871Inherited
Family A G protein-coupled receptor-like0.04385Inherited
Hemopexin-like domain0.06903Inherited
Voltage-gated potassium channels0.6166Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    49758,47473
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 47473 - EF-hand
  • 0Direct
    54452,48726
  • 54452 - MHC antigen-recognition domain
  • 48726 - Immunoglobulin
  • 0.0000002675Direct
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.00006982Direct
    57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.00007585Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0.0001743Direct
    52058,57184
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 0.0002586Direct
    57184,52058
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002586Direct
    57196,69687
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001148Inherited
    47090,55486
  • 47090 - PGBD-like
  • 55486 - Metalloproteases ("zincins"), catalytic domain
  • 0.02871Inherited
    57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3318Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    52058,57184,52058
  • 52058 - L domain-like
  • 57184 - Growth factor receptor domain
  • 52058 - L domain-like
  • 0.0002586Direct
    57196,57196,69687
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 69687 - Integrin beta tail domain
  • 0.001148Inherited
    57440,57440,57440
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 0.004425Inherited
    57440,57440,50494
  • 57440 - Kringle-like
  • 57440 - Kringle-like
  • 50494 - Trypsin-like serine proteases
  • 0.004425Inherited
    57535,57535,57535
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 57535 - Complement control module/SCR domain
  • 0.3562Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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