SUPERFAMILY 1.75 HMM library and genome assignments server

Biological Process (BP): cellular macromolecule biosynthetic process

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Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
+ + + + 4:   biological_process [GO:0008150] <20>
+ + + 3:   cellular process [GO:0009987] <5>(361|480) (1111|1264|669)
+ + + 3:   metabolic process [GO:0008152] <11>(287|407) (960|984|456)
+ + + 3:   organic substance metabolic process [GO:0071704] <41>(270|377) (918|927|423)
+ + 2:   biosynthetic process [GO:0009058] <11>(151|181) (572|388|164)
+ + 2:   cellular metabolic process [GO:0044237] <40>(268|368) (920|894|397)
+ + 2:   macromolecule metabolic process [GO:0043170] <27>(172|225) (687|679|308)
+ + 2:   organic substance biosynthetic process [GO:1901576] <33>(145|172) (551|374|161)
+ 1:   cellular biosynthetic process [GO:0044249] <45>(141|166) (547|375|160)
+ 1:   cellular macromolecule metabolic process [GO:0044260] <12>(159|201) (646|599|254)
+ 1:   macromolecule biosynthetic process [GO:0009059] <30>(65|75) (309|194|81)
0:   cellular macromolecule biosynthetic process [GO:0034645] <15>(61|68) (300|190|80)
- 1:   transcription, DNA-dependent [GO:0006351] <19>(12|12) (81|57|21)
- 1:   cellular polysaccharide biosynthetic process [GO:0033692] <18>(8|7) (25|12|4)
- 1:   glycoprotein biosynthetic process [GO:0009101] <8>(6|7) (46|28|15)
- 1:   translation [GO:0006412] <8>(30|33) (103|65|32)
- 1:   translational elongation [GO:0006414] <6>(1|0) (13|11|6)
- 1:   DNA replication [GO:0006260] <4>(5|7) (47|24|6)
- 1:   lipoprotein biosynthetic process [GO:0042158] <4>(3|3) (22|6|3)
- 1:   DNA biosynthetic process [GO:0071897] <3>(0|0) (11|8|3)
- 1:   cellular component macromolecule biosynthetic process [GO:0070589] <2>(4|2) (25|11|2)
- 1:   acyl-carrier-protein biosynthetic process [GO:0042967] <1>(0|0) (0|0|0)
- 1:   poly-gamma-glutamate biosynthetic process [GO:0070501] <1>(0|0) (0|0|0)
- 1:   ferredoxin biosynthetic process [GO:0043172](0|0) (0|0|0)
- 1:   glutaredoxin biosynthetic process [GO:0042965](0|0) (0|0|0)
- 1:   hemoglobin biosynthetic process [GO:0042541](0|0) (3|2|1)
- 1:   thioredoxin biosynthetic process [GO:0042964](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
Apolipoprotein03.995e-06Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase00Direct
eIF4e-like4.194e-061.214e-06Direct
HRDC-like1.399e-136.471e-06Direct
L28p-like7.062e-054.446e-06Direct
Mediator hinge subcomplex-like5.338e-063.143e-07Direct
NagB/RpiA/CoA transferase-like6.015e-078.462e-13Direct
Nucleic acid-binding proteins00Direct
Nucleotide-diphospho-sugar transferases00Direct
Oligosaccharyltransferase subunit ost4p1.767e-141.285e-12Direct
RBP11-like subunits of RNA polymerase1.203e-110Direct
Release factor3.931e-062.611e-06Direct
Ribosomal protein L10.00069050.000119Direct
Ribosomal protein L130.0003431.33e-07Direct
Ribosomal protein L143.931e-061.057e-06Direct
Ribosomal protein L30p/L7e7.968e-084.993e-08Direct
Ribosomal protein L31e1.077e-081.243e-07Direct
Ribosomal protein L32e2.718e-083.078e-07Direct
Ribosomal protein S101.958e-052.059e-06Direct
Ribosomal protein S190.0003437.243e-05Direct
Ribosomal protein S22.718e-080Direct
Ribosomal protein S61.681e-061.465e-05Direct
Ribosomal protein S71.177e-090Direct
Ribosomal protein S83.931e-061.852e-05Direct
Ribosomal proteins L15p and L18e5.338e-061.771e-10Direct
Ribosomal proteins S24e, L23 and L15e1.736e-125.5e-12Direct
RL5-like2.419e-064.446e-06Direct
RNA polymerase subunit RPB108.776e-101.062e-08Direct
RNA polymerase subunits4.464e-113.369e-09Direct
RNase A-like1.024e-082.005e-07Direct
RPB6/omega subunit-like1.706e-096.808e-08Direct
SIS domain0.00039953.32e-07Direct
Translation proteins1.958e-050Direct
Translation proteins SH3-like domain5.287e-080Direct
Translational machinery components9.573e-058.968e-12Direct
UDP-Glycosyltransferase/glycogen phosphorylase4.975e-122.837e-11Direct
Zn-binding ribosomal proteins02.003e-13Direct
beta-lactamase/transpeptidase-like0.0046172.034e-13Inherited
Family A G protein-coupled receptor-like11Inherited
Cupredoxins0.078051Inherited
RmlC-like cupins0.014120.04661Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
Trimeric LpxA-like enzymes0.019891.558e-05Inherited
HAD-like0.80231Inherited
Metallo-dependent phosphatases0.049721Inherited
TPR-like11Inherited
ADP-ribosylation0.061087.715e-08Inherited
P-loop containing nucleoside triphosphate hydrolases0.52860Inherited
Nucleotidylyl transferase0.13620Inherited
"Winged helix" DNA-binding domain0.0025540Inherited
Alpha-L RNA-binding motif0.0029010.005913Inherited
eIF1-like0.00033380.004183Inherited
Ribosomal protein S169.684e-050.001551Inherited
Ribosomal protein S5 domain 2-like0.0033481.603e-11Inherited
S-adenosyl-L-methionine-dependent methyltransferases11Inherited
Histone-fold0.10755.317e-13Inherited
p53-like transcription factors0.0027194.032e-14Inherited
DNA/RNA polymerases0.0023990Inherited
Ribonuclease H-like0.33115.563e-06Inherited
UBC-like11Inherited
Ferritin-like0.0047350.1382Inherited


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Family

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SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
ADP-heptose LPS heptosyltransferase II00Direct
Apolipoprotein03.596e-08Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain1.135e-070Direct
Cold shock DNA-binding domain-like06.365e-15Direct
dTDP-sugar isomerase6.844e-124.827e-12Direct
FucT-like4.199e-132.019e-12Direct
glucose-1-phosphate thymidylyltransferase5.25e-091.632e-09Direct
Glycosyl transferases group 11.537e-087.031e-07Direct
IF2B-like5.61e-120Direct
L15e8.912e-050.0003556Direct
L23p2.973e-066.182e-06Direct
mono-SIS domain2.541e-051.722e-07Direct
Mycolic acid cyclopropane synthase1.385e-050.0005178Direct
Oligosaccharyltransferase subunit ost4p4.342e-141.977e-12Direct
Probable phosphatase YrbI1.791e-074.998e-06Direct
RBP11/RpoL4.354e-085.078e-07Direct
RBP12 subunit of RNA polymerase II1.591e-081.48e-07Direct
Release factor2.973e-062.107e-06Direct
Ribonuclease A-like7.201e-091.599e-07Direct
Ribosomal protein L10.00070279.351e-05Direct
Ribosomal protein L10-like0.00038146.038e-10Direct
Ribosomal protein L130.00025941.068e-07Direct
Ribosomal protein L142.973e-068.566e-07Direct
Ribosomal protein L18 and S117.481e-051.365e-08Direct
Ribosomal protein L30p/L7e1.079e-073.989e-08Direct
Ribosomal protein L31e1.591e-081.48e-07Direct
Ribosomal protein L32e4.011e-083.666e-07Direct
Ribosomal protein L35ae5.888e-074.998e-06Direct
Ribosomal protein L53.629e-063.613e-06Direct
Ribosomal protein S101.511e-051.665e-06Direct
Ribosomal protein S148.306e-052.764e-07Direct
Ribosomal protein S190.00040578.839e-05Direct
Ribosomal protein S24.011e-080Direct
Ribosomal protein S24e1.511e-056.357e-05Direct
Ribosomal protein S62.115e-061.659e-05Direct
Ribosomal protein S72.292e-091.682e-15Direct
Ribosomal protein S82.973e-061.52e-05Direct
Ribosomal proteins L15p and L18e7.357e-061.4e-10Direct
Ribosomal proteins L24p and L21e7.607e-051.52e-05Direct
RNA polymerase II subunit RBP4 (RpoF)2.457e-130Direct
RNA polymerase subunit RBP83.351e-072.894e-06Direct
RNA polymerase subunit RPB101.304e-091.266e-08Direct
RNA-polymerase beta3.576e-144.844e-15Direct
RNA-polymerase beta-prime0.00012338.762e-13Direct
RPB61.19e-105.226e-09Direct
Rps19E-like1.511e-056.357e-05Direct
TBP-associated factors, TAFs0.00036350Direct
Translation initiation factor eIF4e6.518e-061.189e-06Direct
Translational machinery components0.00012330Direct
beta-Lactamase/D-ala carboxypeptidase0.0017020Inherited
beta 1,4 galactosyltransferase (b4GalT1)0.0096417.55e-05Inherited
Rhodopsin-like11Inherited
Tyrosine-dependent oxidoreductases0.95691Inherited
1,3-glucuronyltransferase0.0017251.665e-06Inherited
Tetratricopeptide repeat (TPR)0.76291Inherited
G proteins0.72680Inherited
WD40-repeat0.12780.9524Inherited
eIF1-like0.00042680.003398Inherited
Ribosomal protein L37e00.00131Inherited
Ribosomal protein S167.607e-050.00131Inherited
Ribosomal protein S27e0.00039560.00131Inherited
UBC-related11Inherited
Nucleotide and nucleoside kinases0.13380.739Inherited
Ribonucleotide reductase-like9.506e-070.005508Inherited
DnaQ-like 3'-5' exonuclease0.19474.432e-09Inherited
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0.2240.1625Inherited
Ribonuclease H0.0033710.005482Inherited
Single strand DNA-binding domain, SSB0.0019451.94e-06Inherited


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Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Class II aaRS and biotin synthetases0Direct
Nucleic acid-binding proteins0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Cyclin-like0Direct
post-AAA+ oligomerization domain-like0Direct
tRNA-binding arm0Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0Direct
DNA/RNA polymerases0Direct
Nucleotidylyl transferase0Direct
Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain0Direct
EF-G C-terminal domain-like0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)0Direct
"Winged helix" DNA-binding domain0Direct
Translation proteins SH3-like domain0Direct
Nucleotide-diphospho-sugar transferases0Direct
Translation proteins0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
Zinc beta-ribbon0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Ribosomal protein S70Direct
RBP11-like subunits of RNA polymerase0Direct
GINS helical bundle-like0Direct
N-terminal, heterodimerisation domain of RBP7 (RpoE)0Direct
Ribosomal protein S20Direct
Nuclear receptor ligand-binding domain0Direct
ThrRS/AlaRS common domain0Direct
ValRS/IleRS/LeuRS editing domain3.599e-15Direct
p53-like transcription factors2.478e-14Direct
Ricin B-like lectins2.804e-14Direct
Sigma2 domain of RNA polymerase sigma factors1.022e-13Direct
Zinc finger domain of DNA polymerase-alpha1.062e-13Direct
Zn-binding ribosomal proteins1.245e-13Direct
beta-lactamase/transpeptidase-like1.265e-13Direct
PriA/YqbF domain2.266e-13Direct
Rps17e-like3.127e-13Direct
Histone-fold3.339e-13Direct
NagB/RpiA/CoA transferase-like5.332e-13Direct
HLH, helix-loop-helix DNA-binding domain6.555e-13Direct
Oligosaccharyltransferase subunit ost4p8.1e-13Direct
Eukaryotic RPB5 N-terminal domain1.022e-12Direct
RPB5-like RNA polymerase subunit1.022e-12Direct
TATA-box binding protein-like1.44e-12Direct
Leucine zipper domain2.46e-12Direct
Class II aaRS ABD-related2.81e-12Direct
Ribosomal proteins S24e, L23 and L15e3.492e-12Direct
Initiation factor IF2/eIF5b, domain 34.591e-12Direct
Translational machinery components5.688e-12Direct
Ribosomal protein S5 domain 2-like1.016e-11Direct
UDP-Glycosyltransferase/glycogen phosphorylase1.802e-11Direct
DNA clamp2.035e-11Direct
Rap30/74 interaction domains3.204e-11Direct
Sigma3 and sigma4 domains of RNA polymerase sigma factors5.154e-11Direct
Transcription factor IIA (TFIIA), beta-barrel domain5.604e-11Direct
MIR domain5.915e-11Direct
Ribosomal proteins L15p and L18e1.135e-10Direct
Putative DNA-binding domain1.849e-10Direct
MurE/MurF N-terminal domain3.45e-10Direct
Ribosomal protein L62.113e-09Direct
RNA polymerase subunits2.181e-09Direct
Ribosomal protein S182.181e-09Direct
eEF-1beta-like2.574e-09Direct
Insert subdomain of RNA polymerase alpha subunit3.813e-09Direct
RNA polymerase subunit RPB106.918e-09Direct
Ribosomal protein L7/12, oligomerisation (N-terminal) domain7.409e-09Direct
Transcription factor IIA (TFIIA), alpha-helical domain1.011e-08Direct
E2F-DP heterodimerization region1.16e-08Direct
Ribosomal protein L30p/L7e3.287e-08Direct
Ribosomal protein L25-like3.9e-08Direct
Ribosomal protein L10-like3.926e-08Direct
RPB6/omega subunit-like4.496e-08Direct
ADP-ribosylation5.103e-08Direct
Ribosomal protein L31e8.241e-08Direct
An anticodon-binding domain of class I aminoacyl-tRNA synthetases8.241e-08Direct
Ribosomal protein L138.828e-08Direct
Ribosomal protein L48.828e-08Direct
STAT1.164e-07Direct
RNase A-like1.335e-07Direct
Methionyl-tRNA synthetase (MetRS), Zn-domain1.477e-07Direct
Ribosomal protein L16p/L10e1.673e-07Direct
Ribosomal protein L32e2.061e-07Direct
DNA primase core2.061e-07Direct
Mediator hinge subcomplex-like2.104e-07Direct
SIS domain2.222e-07Direct
occludin/ELL-like3.111e-07Direct
Homeodomain-like3.301e-07Direct
GreA transcript cleavage protein, N-terminal domain4.225e-07Direct
Zinc-binding domain of translation initiation factor 2 beta7.101e-07Direct
Translation initiation factor 2 beta, aIF2beta, N-terminal domain7.101e-07Direct
Ribosomal protein L147.101e-07Direct
Taf5 N-terminal domain-like7.101e-07Direct
Transcription factor STAT-4 N-domain7.569e-07Direct
eIF4e-like8.173e-07Direct
Conserved domain common to transcription factors TFIIS, elongin A, CRSP708.173e-07Direct
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF18.964e-07Direct
Ribosomal protein L361.191e-06Direct
Ribosomal protein S101.39e-06Direct
Release factor1.765e-06Direct
Ribosomal protein L11, C-terminal domain1.765e-06Direct
Apolipoprotein2.711e-06Direct
Penicillin binding protein dimerisation domain2.877e-06Direct
L28p-like3.018e-06Direct
Anticodon-binding domain of PheRS3.018e-06Direct
RL5-like3.018e-06Direct
Ribonuclease H-like3.789e-06Direct
HRDC-like4.42e-06Direct
Ribosomal L11/L12e N-terminal domain6.507e-06Direct
Rho N-terminal domain-like8.439e-06Direct
A DNA-binding domain in eukaryotic transcription factors9.777e-06Direct
Ribosomal protein S61.01e-05Direct
Peptidyl-tRNA hydrolase domain-like1.01e-05Direct
Trimeric LpxA-like enzymes1.075e-05Direct
Ribosomal protein S81.279e-05Direct
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain1.279e-05Direct
HAND domain of the nucleosome remodeling ATPase ISWI1.279e-05Direct
Ribosomal protein L29 (L29p)1.279e-05Direct
S15/NS1 RNA-binding domain1.442e-05Direct
Ribosomal protein L222.111e-05Direct
TAFH domain-like2.285e-05Direct
Ribosomal protein S195.084e-05Direct
Prokaryotic ribosomal protein L175.391e-05Direct
Prim-pol domain5.391e-05Direct
Penicillin-binding protein associated domain5.391e-05Direct
eEF1-gamma domain6.19e-05Direct
Lesion bypass DNA polymerase (Y-family), little finger domain7.522e-05Direct
eIF-2-alpha, C-terminal domain8.083e-05Direct
Ribosomal protein L18.4e-05Direct
N-utilization substance G protein NusG, N-terminal domain9.784e-05Direct
L9 N-domain-like0.0001559Direct
ClpS-like0.0001597Direct
Translation initiation factor IF3, C-terminal domain0.000226Direct
eIF2alpha middle domain-like0.0003047Direct
C-terminal domain of ProRS0.0003829Direct
Phosphoglucomutase, first 3 domains0.0005284Direct
Phosphoglucomutase, C-terminal domain0.0007801Direct
MurD-like peptide ligases, peptide-binding domain0.0008894Direct
MurD-like peptide ligases, catalytic domain0.0008894Direct
L21p-like0.0009469Direct
GAD domain-like0.0009469Direct
MurCD N-terminal domain0.0009469Direct
Ribosome recycling factor, RRF0.0009469Direct
Zinc domain conserved in yeast copper-regulated transcription factors0.0009945Direct
Alanine racemase C-terminal domain-like0.656Inherited
PLP-binding barrel0.8245Inherited
PreATP-grasp domain1Inherited
Lysozyme-like0.004527Inherited
Ankyrin repeat1Inherited
SAM/Pointed domain1Inherited
HMA, heavy metal-associated domain0.03819Inherited
Calcium ATPase, transduction domain A1Inherited
Calcium ATPase, transmembrane domain M1Inherited
C-type lectin-like1Inherited
Complement control module/SCR domain1Inherited
Insulin-like0.01103Inherited
Ran binding protein zinc finger-like1Inherited
BRCA2 tower domain0.1437Inherited
BRCA2 helical domain0.1437Inherited
NAC domain0.5202Inherited
Pectin lyase-like1Inherited
Ribokinase-like0.9998Inherited
WD40 repeat-like0.7813Inherited
Family A G protein-coupled receptor-like1Inherited
PLP-dependent transferases1Inherited
Cystine-knot cytokines0.01359Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.001572Inherited
Apolipoprotein A-I0.002561Inherited
Lipovitellin-phosvitin complex, superhelical domain0.008671Inherited
Activating enzymes of the ubiquitin-like proteins1Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like0.189Inherited
HCP-like0.1228Inherited
Cupredoxins0.9069Inherited
NAD(P)-binding Rossmann-fold domains1Inherited
RmlC-like cupins0.03638Inherited
Aldolase1Inherited
CBS-domain pair0.9567Inherited
Mog1p/PsbP-like0.06192Inherited
E set domains0.4968Inherited
(Trans)glycosidases0.8879Inherited
Glycosyl hydrolase domain0.002875Inherited
Fe,Mn superoxide dismutase (SOD), C-terminal domain0.03914Inherited
RNase III domain-like1Inherited
RNI-like1Inherited
Immunoglobulin1Inherited
Apyrase0.002806Inherited
Cdc48 domain 2-like0.004415Inherited
ADC-like0.01556Inherited
Outer membrane efflux proteins (OEP)0.0351Inherited
Cap-Gly domain0.7781Inherited
L,D-transpeptidase catalytic domain-like0.08477Inherited
EGF/Laminin1Inherited
Glutathione synthetase ATP-binding domain-like1Inherited
Thioredoxin-like1Inherited
HAD-like1Inherited
RING/U-box1Inherited
Acid proteases1Inherited
L domain-like1Inherited
Protein kinase-like (PK-like)1Inherited
Acyl-CoA N-acyltransferases (Nat)1Inherited
PAP/OAS1 substrate-binding domain1Inherited
Nucleotidyltransferase1Inherited
BAG domain0.1273Inherited
HSP20-like chaperones1Inherited
Alkaline phosphatase-like0.4282Inherited
Trm112p-like0.02109Inherited
LmbE-like0.02247Inherited
Metallo-dependent phosphatases1Inherited
SEA domain0.006214Inherited
Serine protease inhibitors0.2235Inherited
TPR-like1Inherited
UBC-like1Inherited
Rhomboid-like0.8529Inherited
Mannose 6-phosphate receptor domain0.007286Inherited
Galactose mutarotase-like0.01799Inherited
Seven-hairpin glycosidases0.09195Inherited
Families 57/38 glycoside transferase middle domain0.002542Inherited
Helical domain of Sec23/240.01029Inherited
beta-sandwich domain of Sec23/240.03008Inherited
Zn-finger domain of Sec23/240.08477Inherited
C-terminal, gelsolin-like domain of Sec23/240.1072Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.5375Inherited
Undecaprenyl diphosphate synthase0.0257Inherited
Glycoside hydrolase/deacetylase0.2263Inherited
DHS-like NAD/FAD-binding domain0.7972Inherited
Domain of poly(ADP-ribose) polymerase0.01084Inherited
WGR domain-like0.08621Inherited
BRCT domain0.6613Inherited
YbaK/ProRS associated domain0.008671Inherited
PheT/TilS domain0.06192Inherited
ARM repeat0.7093Inherited
eIF1-like0.003101Inherited
Tricorn protease domain 20.009712Inherited
DPP6 N-terminal domain-like0.02307Inherited
FMT C-terminal domain-like0.09221Inherited
Formyltransferase0.2638Inherited
Translation initiation factor IF3, N-terminal domain0.003947Inherited
Alpha-L RNA-binding motif0.004413Inherited
TGS-like0.006308Inherited
L30e-like0.002875Inherited
GST C-terminal domain-like0.01001Inherited
Elongation factor Ts (EF-Ts), dimerisation domain0.004793Inherited
Ribosomal protein S160.001134Inherited
Ribosomal protein L19 (L19e)0.001134Inherited
RplX-like0.002062Inherited
Ribosomal protein S3 C-terminal domain0.02758Inherited
GatB/YqeY motif0.03121Inherited
S13-like H2TH domain0.1087Inherited
S-adenosyl-L-methionine-dependent methyltransferases1Inherited
HMG-box0.2562Inherited
RuvA domain 2-like0.07273Inherited
RNA-binding domain, RBD0.9563Inherited
ENTH/VHS domain0.7964Inherited
Sm-like ribonucleoproteins1Inherited
Metallo-hydrolase/oxidoreductase1Inherited
Creatinase/aminopeptidase0.1934Inherited
PYP-like sensor domain (PAS domain)0.006098Inherited
Elongation factor TFIIS domain 20.01674Inherited
Notch domain0.008671Inherited
BSD domain-like0.001572Inherited
Tex N-terminal region-like0.00253Inherited
Soluble quinoprotein glucose dehydrogenase0.01018Inherited
SAND domain-like0.01025Inherited
SRF-like0.0226Inherited
TAF(II)230 TBP-binding fragment0.03369Inherited
alpha/beta-Hydrolases1Inherited
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)0.09887Inherited
p53 tetramerization domain0.1667Inherited
GntR ligand-binding domain-like0.01324Inherited
IHF-like DNA-binding proteins0.1676Inherited
lambda repressor-like DNA-binding domains0.2887Inherited
Zn2/Cys6 DNA-binding domain0.343Inherited
Bromodomain0.5145Inherited
beta-beta-alpha zinc fingers1Inherited
SH2 domain1Inherited
FYVE/PHD zinc finger1Inherited
vWA-like0.6957Inherited
PUA domain-like1Inherited
Pseudouridine synthase1Inherited
ATP-dependent DNA ligase DNA-binding domain0.02501Inherited
Rad51 N-terminal domain-like0.01412Inherited
GIY-YIG endonuclease0.01823Inherited
DNA repair protein MutS, domain I0.6175Inherited
Smc hinge domain1Inherited
DNA repair protein MutS, domain III1Inherited
Ferritin-like0.1115Inherited
5' to 3' exonuclease, C-terminal subdomain0.003836Inherited
PHP domain-like0.00992Inherited
dUTPase-like0.01674Inherited
DNA ligase/mRNA capping enzyme, catalytic domain0.01966Inherited
CCHHC domain0.03369Inherited
PIN domain-like0.1014Inherited
Chaperone J-domain0.7249Inherited
R1 subunit of ribonucleotide reductase, N-terminal domain0.7822Inherited
PFL-like glycyl radical enzymes0.9217Inherited
Retrovirus zinc finger-like domains1Inherited
Concanavalin A-like lectins/glucanases1Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)1Inherited
Heat shock protein 70kD (HSP70), peptide-binding domain1Inherited
Actin-like ATPase domain1Inherited
Heat shock protein 70kD (HSP70), C-terminal subdomain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    88798,50249
  • 88798 - N-terminal, heterodimerisation domain of RBP7 (RpoE)
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    55681,101353
  • 55681 - Class II aaRS and biotin synthetases
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    64484,64484
  • 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase
  • 64484 - beta and beta-prime subunits of DNA dependent RNA-polymerase
  • 0Direct
    101353,50447
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 0Direct
    57716,48508
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 48508 - Nuclear receptor ligand-binding domain
  • 0Direct
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0Direct
    50447,55186
  • 50447 - Translation proteins
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    53448,50370
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 50370 - Ricin B-like lectins
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    57783,47954
  • 57783 - Zinc beta-ribbon
  • 47954 - Cyclin-like
  • 0Direct
    55945,55945
  • 55945 - TATA-box binding protein-like
  • 55945 - TATA-box binding protein-like
  • 0Direct
    53697,54631
  • 53697 - SIS domain
  • 54631 - CBS-domain pair
  • 0Direct
    46589,55681
  • 46589 - tRNA-binding arm
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    101489,48371
  • 101489 - Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain
  • 48371 - ARM repeat
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 3.599e-15Direct
    88946,88659
  • 88946 - Sigma2 domain of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 6.162e-13Direct
    53036,55287
  • 53036 - Eukaryotic RPB5 N-terminal domain
  • 55287 - RPB5-like RNA polymerase subunit
  • 1.022e-12Direct
    56672,90234
  • 56672 - DNA/RNA polymerases
  • 90234 - Zinc finger domain of DNA polymerase-alpha
  • 2.303e-12Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 2.768e-12Direct
    52156,50447
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 1.907e-11Direct
    88659,88659
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 2.752e-11Direct
    55979,55979
  • 55979 - DNA clamp
  • 55979 - DNA clamp
  • 3.599e-11Direct
    63418,53623
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 3.45e-10Direct
    160059,158573
  • 160059 - PriA/YqbF domain
  • 158573 - GINS helical bundle-like
  • 6.589e-10Direct
    55729,55729
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 55729 - Acyl-CoA N-acyltransferases (Nat)
  • 2.113e-09Direct
    50249,50104
  • 50249 - Nucleic acid-binding proteins
  • 50104 - Translation proteins SH3-like domain
  • 2.181e-09Direct
    53756,53756
  • 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
  • 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
  • 2.202e-09Direct
    46785,144074
  • 46785 - "Winged helix" DNA-binding domain
  • 144074 - E2F-DP heterodimerization region
  • 5.046e-09Direct
    48300,54736
  • 48300 - Ribosomal protein L7/12, oligomerisation (N-terminal) domain
  • 54736 - ClpS-like
  • 7.409e-09Direct
    47459,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 9.366e-09Direct
    49417,55550
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 1.039e-08Direct
    50916,46785
  • 50916 - Rap30/74 interaction domains
  • 46785 - "Winged helix" DNA-binding domain
  • 2.078e-08Direct
    50978,50952
  • 50978 - WD40 repeat-like
  • 50952 - Soluble quinoprotein glucose dehydrogenase
  • 2.078e-08Direct
    56731,52540
  • 56731 - DNA primase core
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 2.078e-08Direct
    56553,55257
  • 56553 - Insert subdomain of RNA polymerase alpha subunit
  • 55257 - RBP11-like subunits of RNA polymerase
  • 3.018e-08Direct
    50447,52156
  • 50447 - Translation proteins
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 3.9e-08Direct
    56053,56053
  • 56053 - Ribosomal protein L6
  • 56053 - Ribosomal protein L6
  • 3.9e-08Direct
    53448,51161
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51161 - Trimeric LpxA-like enzymes
  • 3.905e-08Direct
    46955,55681
  • 46955 - Putative DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 8.241e-08Direct
    52374,48163
  • 52374 - Nucleotidylyl transferase
  • 48163 - An anticodon-binding domain of class I aminoacyl-tRNA synthetases
  • 8.241e-08Direct
    47655,49417
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 1.164e-07Direct
    48092,47655
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 1.164e-07Direct
    48403,74924
  • 48403 - Ankyrin repeat
  • 74924 - Cap-Gly domain
  • 1.249e-07Direct
    57770,52374
  • 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
  • 52374 - Nucleotidylyl transferase
  • 1.477e-07Direct
    49417,81296
  • 49417 - p53-like transcription factors
  • 81296 - E set domains
  • 1.567e-07Direct
    52374,50715
  • 52374 - Nucleotidylyl transferase
  • 50715 - Ribosomal protein L25-like
  • 1.673e-07Direct
    47396,50784
  • 47396 - Transcription factor IIA (TFIIA), alpha-helical domain
  • 50784 - Transcription factor IIA (TFIIA), beta-barrel domain
  • 2.061e-07Direct
    46557,54534
  • 46557 - GreA transcript cleavage protein, N-terminal domain
  • 54534 - FKBP-like
  • 4.225e-07Direct
    140383,140383
  • 140383 - BSD domain-like
  • 140383 - BSD domain-like
  • 4.425e-07Direct
    100966,75689
  • 100966 - Translation initiation factor 2 beta, aIF2beta, N-terminal domain
  • 75689 - Zinc-binding domain of translation initiation factor 2 beta
  • 7.101e-07Direct
    48371,46785
  • 48371 - ARM repeat
  • 46785 - "Winged helix" DNA-binding domain
  • 7.101e-07Direct
    55481,53137
  • 55481 - N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
  • 53137 - Translational machinery components
  • 8.964e-07Direct
    158573,160059
  • 158573 - GINS helical bundle-like
  • 160059 - PriA/YqbF domain
  • 8.964e-07Direct
    46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 1.135e-06Direct
    81296,51445
  • 81296 - E set domains
  • 51445 - (Trans)glycosidases
  • 1.84e-06Direct
    47769,56399
  • 47769 - SAM/Pointed domain
  • 56399 - ADP-ribosylation
  • 2.174e-06Direct
    50729,140383
  • 50729 - PH domain-like
  • 140383 - BSD domain-like
  • 2.711e-06Direct
    54928,69322
  • 54928 - RNA-binding domain, RBD
  • 69322 - Tricorn protease domain 2
  • 2.711e-06Direct
    56519,56601
  • 56519 - Penicillin binding protein dimerisation domain
  • 56601 - beta-lactamase/transpeptidase-like
  • 2.877e-06Direct
    55681,54991
  • 55681 - Class II aaRS and biotin synthetases
  • 54991 - Anticodon-binding domain of PheRS
  • 3.018e-06Direct
    54747,46906
  • 54747 - Ribosomal L11/L12e N-terminal domain
  • 46906 - Ribosomal protein L11, C-terminal domain
  • 6.507e-06Direct
    47616,54984
  • 47616 - GST C-terminal domain-like
  • 54984 - eEF-1beta-like
  • 6.773e-06Direct
    82679,50104
  • 82679 - N-utilization substance G protein NusG, N-terminal domain
  • 50104 - Translation proteins SH3-like domain
  • 8.439e-06Direct
    47060,47060
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 8.439e-06Direct
    48452,48403
  • 48452 - TPR-like
  • 48403 - Ankyrin repeat
  • 1.01e-05Direct
    75689,48371
  • 75689 - Zinc-binding domain of translation initiation factor 2 beta
  • 48371 - ARM repeat
  • 1.01e-05Direct
    48371,52540
  • 48371 - ARM repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1.154e-05Direct
    55008,55008
  • 55008 - HMA, heavy metal-associated domain
  • 55008 - HMA, heavy metal-associated domain
  • 1.254e-05Direct
    53137,55315
  • 53137 - Translational machinery components
  • 55315 - L30e-like
  • 1.279e-05Direct
    52540,52156
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 1.279e-05Direct
    55190,52374
  • 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
  • 52374 - Nucleotidylyl transferase
  • 1.279e-05Direct
    101224,46689
  • 101224 - HAND domain of the nucleosome remodeling ATPase ISWI
  • 46689 - Homeodomain-like
  • 1.279e-05Direct
    52540,101224
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 101224 - HAND domain of the nucleosome remodeling ATPase ISWI
  • 1.279e-05Direct
    51984,53623
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 3.357e-05Direct
    53955,56601
  • 53955 - Lysozyme-like
  • 56601 - beta-lactamase/transpeptidase-like
  • 3.357e-05Direct
    52374,55174
  • 52374 - Nucleotidylyl transferase
  • 55174 - Alpha-L RNA-binding motif
  • 5.391e-05Direct
    56601,69189
  • 56601 - beta-lactamase/transpeptidase-like
  • 69189 - Penicillin-binding protein associated domain
  • 5.391e-05Direct
    47454,57959
  • 47454 - A DNA-binding domain in eukaryotic transcription factors
  • 57959 - Leucine zipper domain
  • 6.008e-05Direct
    47616,89942
  • 47616 - GST C-terminal domain-like
  • 89942 - eEF1-gamma domain
  • 6.19e-05Direct
    56672,100879
  • 56672 - DNA/RNA polymerases
  • 100879 - Lesion bypass DNA polymerase (Y-family), little finger domain
  • 7.522e-05Direct
    51161,48371
  • 51161 - Trimeric LpxA-like enzymes
  • 48371 - ARM repeat
  • 8.083e-05Direct
    55781,52540
  • 55781 - GAF domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 9.784e-05Direct
    47323,47060
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 47060 - S15/NS1 RNA-binding domain
  • 9.784e-05Direct
    81271,55186
  • 81271 - TGS-like
  • 55186 - ThrRS/AlaRS common domain
  • 0.0001468Direct
    53623,53244
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0.0001597Direct
    55186,55681
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0001875Direct
    56037,46955
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 0.0002078Direct
    56235,53697
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 53697 - SIS domain
  • 0.000226Direct
    54768,54211
  • 54768 - dsRNA-binding domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0.0002949Direct
    57783,57783
  • 57783 - Zinc beta-ribbon
  • 57783 - Zinc beta-ribbon
  • 0.0002949Direct
    50104,50249
  • 50104 - Translation proteins SH3-like domain
  • 50249 - Nucleic acid-binding proteins
  • 0.0002949Direct
    50249,116742
  • 50249 - Nucleic acid-binding proteins
  • 116742 - eIF2alpha middle domain-like
  • 0.0003047Direct
    116742,110993
  • 116742 - eIF2alpha middle domain-like
  • 110993 - eIF-2-alpha, C-terminal domain
  • 0.0003047Direct
    54862,52540
  • 54862 - 4Fe-4S ferredoxins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003829Direct
    52954,64586
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0.0003829Direct
    46942,57783
  • 46942 - Elongation factor TFIIS domain 2
  • 57783 - Zinc beta-ribbon
  • 0.000523Direct
    53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0.0005284Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0005337Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.0008939Direct
    81631,81301
  • 81631 - PAP/OAS1 substrate-binding domain
  • 81301 - Nucleotidyltransferase
  • 0.0009469Direct
    47616,52374
  • 47616 - GST C-terminal domain-like
  • 52374 - Nucleotidylyl transferase
  • 0.0009469Direct
    55681,55261
  • 55681 - Class II aaRS and biotin synthetases
  • 55261 - GAD domain-like
  • 0.0009469Direct
    47113,48371
  • 47113 - Histone-fold
  • 48371 - ARM repeat
  • 0.0009469Direct
    54713,54713
  • 54713 - Elongation factor Ts (EF-Ts), dimerisation domain
  • 54713 - Elongation factor Ts (EF-Ts), dimerisation domain
  • 0.0009945Direct
    51419,50621
  • 51419 - PLP-binding barrel
  • 50621 - Alanine racemase C-terminal domain-like
  • 0.604Inherited
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 1Inherited
    48403,48403
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 0.6446Inherited
    48403,47769
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 0.9415Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 1Inherited
    56436,57535
  • 56436 - C-type lectin-like
  • 57535 - Complement control module/SCR domain
  • 0.0188Inherited
    48726,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 0.02588Inherited
    56436,56436
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.3295Inherited
    50249,81878
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 0.1437Inherited
    81872,50249
  • 81872 - BRCA2 helical domain
  • 50249 - Nucleic acid-binding proteins
  • 0.1437Inherited
    81878,50249
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 0.1437Inherited
    55785,55785
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.006865Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.007468Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.189Inherited
    49785,51445
  • 49785 - Galactose-binding domain-like
  • 51445 - (Trans)glycosidases
  • 0.01457Inherited
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0.4765Inherited
    51445,51011
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.01254Inherited
    53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0.001974Inherited
    53335,53335
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 53335 - S-adenosyl-L-methionine-dependent methyltransferases
  • 1Inherited
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0.001304Inherited
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002498Inherited
    74924,74924
  • 74924 - Cap-Gly domain
  • 74924 - Cap-Gly domain
  • 0.01493Inherited
    81296,81296
  • 81296 - E set domains
  • 81296 - E set domains
  • 0.9071Inherited
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 1Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.06076Inherited
    57567,57567
  • 57567 - Serine protease inhibitors
  • 57567 - Serine protease inhibitors
  • 0.001572Inherited
    53300,81995
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 0.05866Inherited
    81995,81811
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.05866Inherited
    74650,51445
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 0.08621Inherited
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.01029Inherited
    81995,82919
  • 81995 - beta-sandwich domain of Sec23/24
  • 82919 - Zn-finger domain of Sec23/24
  • 0.02109Inherited
    88713,88688
  • 88713 - Glycoside hydrolase/deacetylase
  • 88688 - Families 57/38 glycoside transferase middle domain
  • 0.02247Inherited
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.05645Inherited
    47587,56399
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.01084Inherited
    142921,47587
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0.08621Inherited
    52113,142921
  • 52113 - BRCT domain
  • 142921 - WGR domain-like
  • 0.112Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 1Inherited
    54364,55200
  • 54364 - Translation initiation factor IF3, N-terminal domain
  • 55200 - Translation initiation factor IF3, C-terminal domain
  • 0.003947Inherited
    47060,55681
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0.03962Inherited
    55931,89095
  • 55931 - Glutamine synthetase/guanido kinase
  • 89095 - GatB/YqeY motif
  • 0.003947Inherited
    54814,54821
  • 54814 - Prokaryotic type KH domain (KH-domain type II)
  • 54821 - Ribosomal protein S3 C-terminal domain
  • 0.02109Inherited
    54980,54980
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0.02588Inherited
    53328,50486
  • 53328 - Formyltransferase
  • 50486 - FMT C-terminal domain-like
  • 0.06192Inherited
    47095,47095
  • 47095 - HMG-box
  • 47095 - HMG-box
  • 0.1162Inherited
    57184,57184
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.9326Inherited
    47676,46942
  • 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
  • 46942 - Elongation factor TFIIS domain 2
  • 0.002062Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.09678Inherited
    90193,90193
  • 90193 - Notch domain
  • 90193 - Notch domain
  • 0.01324Inherited
    57196,90193
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.02109Inherited
    158832,53098
  • 158832 - Tex N-terminal region-like
  • 53098 - Ribonuclease H-like
  • 0.00253Inherited
    53098,47781
  • 53098 - Ribonuclease H-like
  • 47781 - RuvA domain 2-like
  • 0.00253Inherited
    57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.005149Inherited
    57850,46689
  • 57850 - RING/U-box
  • 46689 - Homeodomain-like
  • 0.03962Inherited
    47370,47370
  • 47370 - Bromodomain
  • 47370 - Bromodomain
  • 0.117Inherited
    51045,51045
  • 51045 - WW domain
  • 51045 - WW domain
  • 1Inherited
    50249,52540
  • 50249 - Nucleic acid-binding proteins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.004121Inherited
    57184,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.922Inherited
    57196,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.9424Inherited
    47212,56112
  • 47212 - FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
  • 56112 - Protein kinase-like (PK-like)
  • 0.09887Inherited
    49417,47719
  • 49417 - p53-like transcription factors
  • 47719 - p53 tetramerization domain
  • 0.2618Inherited
    46785,53850
  • 46785 - "Winged helix" DNA-binding domain
  • 53850 - Periplasmic binding protein-like II
  • 0.005443Inherited
    52540,46689
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46689 - Homeodomain-like
  • 0.007673Inherited
    46785,48008
  • 46785 - "Winged helix" DNA-binding domain
  • 48008 - GntR ligand-binding domain-like
  • 0.01324Inherited
    47413,46689
  • 47413 - lambda repressor-like DNA-binding domains
  • 46689 - Homeodomain-like
  • 0.02009Inherited
    47413,53822
  • 47413 - lambda repressor-like DNA-binding domains
  • 53822 - Periplasmic binding protein-like I
  • 0.0351Inherited
    57903,47370
  • 57903 - FYVE/PHD zinc finger
  • 47370 - Bromodomain
  • 0.2265Inherited
    57667,57667
  • 57667 - beta-beta-alpha zinc fingers
  • 57667 - beta-beta-alpha zinc fingers
  • 1Inherited
    55120,88697
  • 55120 - Pseudouridine synthase
  • 88697 - PUA domain-like
  • 0.4317Inherited
    47794,52540
  • 47794 - Rad51 N-terminal domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05244Inherited
    57850,52540
  • 57850 - RING/U-box
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.04051Inherited
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited
    88723,47807
  • 88723 - PIN domain-like
  • 47807 - 5' to 3' exonuclease, C-terminal subdomain
  • 0.00315Inherited
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0.01432Inherited
    48168,51998
  • 48168 - R1 subunit of ribonucleotide reductase, N-terminal domain
  • 51998 - PFL-like glycyl radical enzymes
  • 0.7822Inherited
    54928,54928
  • 54928 - RNA-binding domain, RBD
  • 54928 - RNA-binding domain, RBD
  • 1Inherited
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.9915Inherited
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 1Inherited
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    81296,81296,51445
  • 81296 - E set domains
  • 81296 - E set domains
  • 51445 - (Trans)glycosidases
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    48403,48403,47769
  • 48403 - Ankyrin repeat
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 0Direct
    48403,74924,74924
  • 48403 - Ankyrin repeat
  • 74924 - Cap-Gly domain
  • 74924 - Cap-Gly domain
  • 0Direct
    101353,50447,55186
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 55186 - ThrRS/AlaRS common domain
  • 0Direct
    55681,101353,50447
  • 55681 - Class II aaRS and biotin synthetases
  • 101353 - Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)
  • 50447 - Translation proteins
  • 0Direct
    57783,47954,47954
  • 57783 - Zinc beta-ribbon
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0Direct
    48403,47769,56399
  • 48403 - Ankyrin repeat
  • 47769 - SAM/Pointed domain
  • 56399 - ADP-ribosylation
  • 0Direct
    50447,54980,54211
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    53098,56672,90234
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 90234 - Zinc finger domain of DNA polymerase-alpha
  • 2.303e-12Direct
    88946,88659,88659
  • 88946 - Sigma2 domain of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 88659 - Sigma3 and sigma4 domains of RNA polymerase sigma factors
  • 3.402e-10Direct
    63418,53623,53244
  • 63418 - MurE/MurF N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 3.45e-10Direct
    55008,55008,55008
  • 55008 - HMA, heavy metal-associated domain
  • 55008 - HMA, heavy metal-associated domain
  • 55008 - HMA, heavy metal-associated domain
  • 5.416e-09Direct
    48452,48452,48403
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48403 - Ankyrin repeat
  • 2.078e-08Direct
    47655,49417,55550
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 55550 - SH2 domain
  • 3.284e-08Direct
    50447,52156,50447
  • 50447 - Translation proteins
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 3.9e-08Direct
    57770,52374,47323
  • 57770 - Methionyl-tRNA synthetase (MetRS), Zn-domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 7.48e-08Direct
    48092,47655,49417
  • 48092 - Transcription factor STAT-4 N-domain
  • 47655 - STAT
  • 49417 - p53-like transcription factors
  • 1.164e-07Direct
    52540,50447,52156
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 1.673e-07Direct
    50729,140383,140383
  • 50729 - PH domain-like
  • 140383 - BSD domain-like
  • 140383 - BSD domain-like
  • 4.425e-07Direct
    55481,53137,55315
  • 55481 - N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
  • 53137 - Translational machinery components
  • 55315 - L30e-like
  • 8.964e-07Direct
    81301,81631,81301
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 81301 - Nucleotidyltransferase
  • 6.773e-06Direct
    48371,52540,52540
  • 48371 - ARM repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 7.544e-06Direct
    47060,47060,47060
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 47060 - S15/NS1 RNA-binding domain
  • 8.439e-06Direct
    100966,75689,48371
  • 100966 - Translation initiation factor 2 beta, aIF2beta, N-terminal domain
  • 75689 - Zinc-binding domain of translation initiation factor 2 beta
  • 48371 - ARM repeat
  • 1.01e-05Direct
    52540,101224,46689
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 101224 - HAND domain of the nucleosome remodeling ATPase ISWI
  • 46689 - Homeodomain-like
  • 1.279e-05Direct
    52540,52540,101224
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 101224 - HAND domain of the nucleosome remodeling ATPase ISWI
  • 1.279e-05Direct
    52540,52156,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52156 - Initiation factor IF2/eIF5b, domain 3
  • 50447 - Translation proteins
  • 1.279e-05Direct
    50677,52374,47323
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 1.279e-05Direct
    101224,46689,46689
  • 101224 - HAND domain of the nucleosome remodeling ATPase ISWI
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 1.279e-05Direct
    55190,52374,47323
  • 55190 - Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 1.279e-05Direct
    81296,51445,51011
  • 81296 - E set domains
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 2.36e-05Direct
    51984,53623,53244
  • 51984 - MurCD N-terminal domain
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 3.357e-05Direct
    52374,47323,47060
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 47060 - S15/NS1 RNA-binding domain
  • 3.647e-05Direct
    52833,47616,89942
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 89942 - eEF1-gamma domain
  • 6.19e-05Direct
    81271,55186,55681
  • 81271 - TGS-like
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 6.505e-05Direct
    53448,51161,48371
  • 53448 - Nucleotide-diphospho-sugar transferases
  • 51161 - Trimeric LpxA-like enzymes
  • 48371 - ARM repeat
  • 8.083e-05Direct
    55781,52540,46689
  • 55781 - GAF domain-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 46689 - Homeodomain-like
  • 9.784e-05Direct
    55186,55681,52954
  • 55186 - ThrRS/AlaRS common domain
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.0001135Direct
    55681,52954,64586
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 64586 - C-terminal domain of ProRS
  • 0.0002078Direct
    47060,55681,52954
  • 47060 - S15/NS1 RNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0.0002078Direct
    56037,46955,55681
  • 56037 - PheT/TilS domain
  • 46955 - Putative DNA-binding domain
  • 55681 - Class II aaRS and biotin synthetases
  • 0.0002078Direct
    50249,116742,110993
  • 50249 - Nucleic acid-binding proteins
  • 116742 - eIF2alpha middle domain-like
  • 110993 - eIF-2-alpha, C-terminal domain
  • 0.0003047Direct
    54862,52540,52540
  • 54862 - 4Fe-4S ferredoxins
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003829Direct
    53738,53738,53738
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 0.0005284Direct
    47459,55785,55785
  • 47459 - HLH, helix-loop-helix DNA-binding domain
  • 55785 - PYP-like sensor domain (PAS domain)
  • 55785 - PYP-like sensor domain (PAS domain)
  • 0.0008488Direct
    81631,81301,81631
  • 81631 - PAP/OAS1 substrate-binding domain
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0.0009469Direct
    47616,52374,50715
  • 47616 - GST C-terminal domain-like
  • 52374 - Nucleotidylyl transferase
  • 50715 - Ribosomal protein L25-like
  • 0.0009469Direct
    50249,55681,55261
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 55261 - GAD domain-like
  • 0.0009469Direct
    47676,46942,57783
  • 47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
  • 46942 - Elongation factor TFIIS domain 2
  • 57783 - Zinc beta-ribbon
  • 0.0009945Direct
    48726,56436,56436
  • 48726 - Immunoglobulin
  • 56436 - C-type lectin-like
  • 56436 - C-type lectin-like
  • 0.02588Inherited
    81872,50249,81878
  • 81872 - BRCA2 helical domain
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 0.1437Inherited
    50249,81878,50249
  • 50249 - Nucleic acid-binding proteins
  • 81878 - BRCA2 tower domain
  • 50249 - Nucleic acid-binding proteins
  • 0.1437Inherited
    53738,53738,55957
  • 53738 - Phosphoglucomutase, first 3 domains
  • 53738 - Phosphoglucomutase, first 3 domains
  • 55957 - Phosphoglucomutase, C-terminal domain
  • 0.001974Inherited
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.001304Inherited
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.002498Inherited
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.1115Inherited
    53300,81995,81811
  • 53300 - vWA-like
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 0.05341Inherited
    81995,81811,82754
  • 81995 - beta-sandwich domain of Sec23/24
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0.05866Inherited
    81995,82919,53300
  • 81995 - beta-sandwich domain of Sec23/24
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0.02109Inherited
    74650,51445,51011
  • 74650 - Galactose mutarotase-like
  • 51445 - (Trans)glycosidases
  • 51011 - Glycosyl hydrolase domain
  • 0.1252Inherited
    142921,47587,56399
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 56399 - ADP-ribosylation
  • 0.08621Inherited
    52113,142921,47587
  • 52113 - BRCT domain
  • 142921 - WGR domain-like
  • 47587 - Domain of poly(ADP-ribose) polymerase
  • 0.112Inherited
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.1934Inherited
    50447,54980,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54980 - EF-G C-terminal domain-like
  • 0.03927Inherited
    46689,46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0.04375Inherited
    57196,57196,90193
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 90193 - Notch domain
  • 0.01111Inherited
    57184,57196,57184
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.06989Inherited
    158832,53098,47781
  • 158832 - Tex N-terminal region-like
  • 53098 - Ribonuclease H-like
  • 47781 - RuvA domain 2-like
  • 0.00253Inherited
    57196,57184,57184
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 0.26Inherited
    57184,57184,57196
  • 57184 - Growth factor receptor domain
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.2903Inherited
    57196,57184,57196
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 0.4667Inherited
    57184,57196,57196
  • 57184 - Growth factor receptor domain
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.5169Inherited
    57196,57196,57184
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57184 - Growth factor receptor domain
  • 0.5547Inherited
    57196,57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.98Inherited
    50249,50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0.004832Inherited
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 1Inherited
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 1Inherited


    Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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