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Biological Process (BP): macromolecule localization
(show info)
Gene Ontology (GO)
GO depicts three complementary biological concepts including Biological Process (BP), Molecular Function (MF) and Cellular Component (CC). The hierarchical structure of GO is organized as a directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental GO terms to the current GO term of interest ordered by their shortest distances to the current term. Also, only direct children GO terms of the current GO term are listed.
Structural Classification of Proteins (SCOP)
SCOP classifies evolutionary-related domains into Superfamily level and Family level. Accordingly, we have generated the domain-centric GO annotations for each of the three concepts at each of the two domain levels.
Structural Domain Functional Ontology (SDFO)
As domain-centric ontology, SDFO only refers to those GO terms which are the most informative to annotate SCOP domains.
GO annotations for SCOP domains
For details, please visit Documentation: GO annotations for SCOP domains. Therein, we provide several relevant files ( Data Availability) for the download. It includes two mapping results: Domain2GO supported by both, and Domain2GO supported only by all. For each mapping result, the ontology and annotation files are available. The annotation (i.e., Domain2GO_supported_by_both.txt) and the corresponding ontology (i.e., SDFO.both.txt) are suitable for small-scale studies (high-quality, and BROWSABLE BELOW), while the annotation (i.e., Domain2GO_supported_only_by_all.txt) and the corresponding ontology (i.e., SDFO.all.txt) for large-scale studies (high-coverage, like functional enrichment analysis).
Supra-domain Functional Ontology (SPFO)
As an extension, SPFO includes those GO terms which are the most informative to annotate supra-domains and individual SCOP domains at the Superfamily level.
GO annotations for Supra-domains
For details, please visit Documentation: GO annotations for Supra-domains. Therein, we provide several relevant files ( Data Availability) for the download, including a annotation file (i.e., SP2GO.txt) and an ontology (i.e., SPFO.txt). For the sake of being browsable, listed below are those supra-domains (single, dual, triple, quad).
Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]
Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)
Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this GO term
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Trees by TreeVector
A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this GO term (Not in SPFO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| PDZ domain-like | 0 | DIRECT |
| ARM repeat | 0 | DIRECT |
| WD40 repeat-like | 0 | DIRECT |
| Tim10-like | 7.735e-13 | DIRECT |
| Roadblock/LC7 domain | 1.431e-12 | DIRECT |
| Chitinase insertion domain | 2.312e-12 | DIRECT |
| Ubiquitin-like | 1.437e-10 | DIRECT |
| Preprotein translocase SecY subunit | 7.218e-10 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 7.411e-10 | DIRECT |
| Nucleoporin domain | 2.543e-09 | DIRECT |
| Apolipoprotein A-I | 3.216e-09 | DIRECT |
| 14-3-3 protein | 4.907e-09 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 1.15e-08 | DIRECT |
| SRP19 | 1.338e-08 | DIRECT |
| Nucleoplasmin-like core domain | 1.743e-08 | DIRECT |
| C-terminal autoproteolytic domain of nucleoporin nup98 | 2.153e-08 | DIRECT |
| dsRNA-binding domain-like | 4.253e-08 | DIRECT |
| Spectrin repeat | 6.517e-08 | DIRECT |
| Clathrin adaptor appendage domain | 1.17e-07 | DIRECT |
| Transcription factor STAT-4 N-domain | 1.656e-07 | DIRECT |
| Ribosomal protein S2 | 1.656e-07 | DIRECT |
| Domain of the SRP/SRP receptor G-proteins | 1.86e-07 | DIRECT |
| Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain | 2.06e-07 | DIRECT |
| EB1 dimerisation domain-like | 2.06e-07 | DIRECT |
| Cap-Gly domain | 2.423e-07 | DIRECT |
| TNF-like | 5.329e-07 | DIRECT |
| Lamin A/C globular tail domain | 6.309e-07 | DIRECT |
| Second domain of FERM | 1.029e-06 | DIRECT |
| TPR-like | 1.642e-06 | DIRECT |
| Apolipoprotein | 1.769e-06 | DIRECT |
| GAS2 domain-like | 2.677e-06 | DIRECT |
| RNase III domain-like | 3.11e-06 | DIRECT |
| Suppressor of Fused, N-terminal domain | 3.58e-06 | DIRECT |
| Helical scaffold and wing domains of SecA | 4.731e-06 | DIRECT |
| Acetyl-CoA synthetase-like | 5.084e-06 | DIRECT |
| Class II MHC-associated invariant chain ectoplasmic trimerization domain | 6.307e-06 | DIRECT |
| Signal peptide-binding domain | 1.062e-05 | DIRECT |
| Fzo-like conserved region | 1.143e-05 | DIRECT |
| Pre-protein crosslinking domain of SecA | 1.144e-05 | DIRECT |
| MIT domain | 1.378e-05 | DIRECT |
| Moesin tail domain | 1.56e-05 | DIRECT |
| LexA/Signal peptidase | 1.56e-05 | DIRECT |
| STAT | 1.992e-05 | DIRECT |
| PH domain-like | 4.023e-05 | DIRECT |
| Mitochondrial import receptor subunit Tom20 | 4.359e-05 | DIRECT |
| beta-N-acetylhexosaminidase-like domain | 4.433e-05 | DIRECT |
| Glycolipid transfer protein, GLTP | 4.433e-05 | DIRECT |
| Preprotein translocase SecE subunit | 4.433e-05 | DIRECT |
| P-loop containing nucleoside triphosphate hydrolases | 5.264e-05 | DIRECT |
| Head domain of nucleotide exchange factor GrpE | 5.449e-05 | DIRECT |
| Acyl-CoA binding protein | 7.027e-05 | DIRECT |
| Coiled-coil domain of nucleotide exchange factor GrpE | 7.167e-05 | DIRECT |
| GLA-domain | 9.441e-05 | DIRECT |
| Calponin-homology domain, CH-domain | 0.0001138 | DIRECT |
| KA1-like | 0.0001173 | DIRECT |
| DNA mismatch repair protein MutL | 0.0001189 | DIRECT |
| CAD & PB1 domains | 0.0001258 | DIRECT |
| Ganglioside M2 (gm2) activator | 0.0001568 | DIRECT |
| Oxysterol-binding protein-like | 0.0001668 | DIRECT |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0.0001687 | DIRECT |
| Polo-box domain | 0.0002014 | DIRECT |
| L27 domain | 0.0002306 | DIRECT |
| Rap/Ran-GAP | 0.0002306 | DIRECT |
| Cryptochrome/photolyase FAD-binding domain | 0.0002399 | DIRECT |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 0.00027 | DIRECT |
| EspE N-terminal domain-like | 0.0002878 | DIRECT |
| NTF2-like | 0.0002949 | DIRECT |
| Subdomain of clathrin and coatomer appendage domain | 0.0003414 | DIRECT |
| Hect, E3 ligase catalytic domain | 0.0004405 | DIRECT |
| Apolipoprotein A-II | 0.0004849 | DIRECT |
| p53 tetramerization domain | 0.0004878 | DIRECT |
| SNARE-like | 0.0005706 | DIRECT |
| alpha-catenin/vinculin-like | 0.0006168 | DIRECT |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0008359 | DIRECT |
| alpha/beta-Hydrolases | 1 | INHERITED FROM: postsynaptic density protein 95 clustering || gephyrin clustering || cholesterol transport || protein localization to synapse || neurexin clustering |
| SAM/Pointed domain | 0.6621 | INHERITED FROM: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering || cytokine secretion || receptor clustering || neurotransmitter-gated ion channel clustering || protein localization to synapse |
| Supernatant protein factor (SPF), C-terminal domain | 0.07518 | INHERITED FROM: establishment of protein localization to membrane || protein localization to plasma membrane || protein targeting to plasma membrane || protein localization to membrane || establishment of protein localization to plasma membrane || protein targeting to membrane |
| DNase I-like | 0.24 | INHERITED FROM: establishment of protein localization to membrane || protein localization to plasma membrane || protein targeting to plasma membrane || protein localization to membrane || establishment of protein localization to plasma membrane || protein targeting to membrane |
| DEATH domain | 0.1236 | INHERITED FROM: establishment of protein localization to membrane || protein localization to plasma membrane || protein targeting to plasma membrane || protein localization to membrane || cytoskeletal anchoring at plasma membrane || protein secretion || interleukin-1 secretion |
| Concanavalin A-like lectins/glucanases | 0.2003 | INHERITED FROM: establishment of protein localization to membrane || interferon-gamma secretion || protein targeting to plasma membrane || protein localization to membrane || postsynaptic density protein 95 clustering || neuroligin clustering || protein localization || establishment of protein localization to plasma membrane || gephyrin clustering || protein localization to synapse || protein targeting to membrane || protein localization to paranode region of axon || apical protein localization |
| EF-hand | 0.3922 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein targeting to plasma membrane || establishment of protein localization to endoplasmic reticulum || callose localization || protein localization to membrane || protein localization to endoplasmic reticulum || protein localization || posttranslational protein targeting to membrane || protein targeting to ER || establishment of protein localization to plasma membrane || microtubule anchoring at microtubule organizing center || protein targeting to membrane |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0.0919 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
| Sec1/munc18-like (SM) proteins | 0.3804 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
| JAB1/MPN domain | 0.4642 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
| Band 7/SPFH domain | 0.1154 | INHERITED FROM: protein localization to plasma membrane |
| Nucleoside diphosphate kinase, NDK | 0.113 | INHERITED FROM: protein localization to membrane || ciliary receptor clustering involved in smoothened signaling pathway || receptor clustering |
| SEA domain | 0.0162 | INHERITED FROM: protein localization to membrane || receptor clustering |
| TIMP-like | 0.1618 | INHERITED FROM: protein localization to membrane || receptor clustering |
| Kazal-type serine protease inhibitors | 0.9344 | INHERITED FROM: protein localization to membrane || receptor clustering |
| Voltage-gated potassium channels | 1 | INHERITED FROM: protein localization to membrane || receptor clustering |
| Immunoglobulin | 1 | INHERITED FROM: interferon-gamma secretion || receptor clustering || protein localization to juxtaparanode region of axon || protein localization to paranode region of axon |
| Family A G protein-coupled receptor-like | 1 | INHERITED FROM: interferon-gamma secretion || protein secretion || cytokine secretion || STAT protein import into nucleus || interleukin-1 beta secretion || long-chain fatty acid transport || chemokine secretion |
| (Trans)glycosidases | 0.2883 | INHERITED FROM: interleukin-8 secretion || lipid storage || protein secretion || cytokine secretion || lipid localization |
| Fibronectin type III | 1 | INHERITED FROM: protein localization to juxtaparanode region of axon || protein localization to synapse || protein localization to paranode region of axon |
| PapD-like | 0.007503 | INHERITED FROM: protein localization to endoplasmic reticulum || cellular protein localization || protein localization |
| Calpain large subunit, middle domain (domain III) | 0.001571 | INHERITED FROM: cellular macromolecule localization || protein localization to membrane || cellular protein localization || protein localization |
| Homeodomain-like | 1 | INHERITED FROM: protein localization to chromosome, telomeric region || immunoglobulin secretion involved in immune response || immunoglobulin secretion |
| RING/U-box | 0.7322 | INHERITED FROM: intracellular protein transmembrane transport || establishment of protein localization to peroxisome || protein targeting to peroxisome || protein import || protein import into peroxisome matrix || intracellular protein transmembrane import || protein transmembrane transport || dsRNA transport || protein localization to peroxisome |
| Actin-like ATPase domain | 0.193 | INHERITED FROM: intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein targeting to ER || protein complex localization || protein transmembrane transport || spindle localization || SRP-dependent cotranslational protein targeting to membrane, translocation |
| SH3-domain | 0.3124 | INHERITED FROM: protein localization to lysosome || protein localization to adherens junction || establishment of protein localization to peroxisome || alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering || protein targeting to peroxisome || protein import into peroxisome matrix, docking || protein import into peroxisome matrix || protein localization || neurotransmitter-gated ion channel clustering || protein localization to synapse |
| NagB/RpiA/CoA transferase-like | 0.5429 | INHERITED FROM: intracellular mRNA localization involved in anterior/posterior axis specification || intracellular mRNA localization involved in pattern specification process || intracellular mRNA localization || RNA localization || pole plasm oskar mRNA localization || pole plasm mRNA localization |
| Cytochrome P450 | 1 | INHERITED FROM: callose localization || defense response by callose deposition in cell wall || defense response by callose deposition || callose deposition in cell wall || polysaccharide localization |
| SRF-like | 0.2608 | INHERITED FROM: callose localization || callose deposition in cell wall || polysaccharide localization |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | INHERITED FROM: callose localization || polysaccharide localization |
| WRKY DNA-binding domain | 0.009387 | INHERITED FROM: callose localization || protein targeting || polysaccharide localization || intracellular protein transport || protein targeting to membrane |
| FYVE/PHD zinc finger | 0.02009 | INHERITED FROM: establishment of meiotic spindle localization || protein localization to plasma membrane || protein complex localization |
| Myosin rod fragments | 0.06682 | INHERITED FROM: establishment of spindle localization || establishment of meiotic spindle localization || protein complex localization || spindle localization |
| Formin homology 2 domain (FH2 domain) | 0.1739 | INHERITED FROM: establishment of spindle localization || protein insertion into membrane || protein insertion into ER membrane || tail-anchored membrane protein insertion into ER membrane |
| Cysteine-rich domain | 0.6667 | INHERITED FROM: establishment of spindle localization || asymmetric protein localization involved in cell fate determination || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || asymmetric protein localization || protein localization || protein complex localization || spindle localization || cortical protein anchoring || maintenance of protein location in cell |
| BRCT domain | 0.00715 | INHERITED FROM: establishment of spindle localization || protein localization to organelle || protein localization to cytoskeleton || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || protein localization to centrosome || protein complex localization || establishment of spindle orientation |
| G protein-binding domain | 0.1025 | INHERITED FROM: cytoplasmic sequestering of protein || maintenance of protein location || cortical protein anchoring || maintenance of protein location in cell |
| Bcl-2 inhibitors of programmed cell death | 0.944 | INHERITED FROM: protein insertion into membrane || protein localization to mitochondrion || establishment of protein localization to mitochondrion || establishment of protein localization to organelle || protein insertion into mitochondrial membrane involved in apoptotic signaling pathway || protein insertion into mitochondrial membrane |
| RNA-binding domain, RBD | 0.005306 | INHERITED FROM: mRNA transport || intracellular mRNA localization involved in anterior/posterior axis specification || RNA transport || poly(A)+ mRNA export from nucleus || intracellular mRNA localization involved in pattern specification process || intracellular mRNA localization || RNA localization || establishment of RNA localization || pole plasm oskar mRNA localization || snRNA export from nucleus || snRNA transport || pole plasm mRNA localization || RNA export from nucleus |
| Clavaminate synthase-like | 0.217 | INHERITED FROM: mRNA transport || mRNA export from nucleus || RNA transport || establishment of RNA localization || RNA export from nucleus |
| UBA-like | 0.002774 | INHERITED FROM: mRNA transport || mRNA export from nucleus || RNA transport || poly(A)+ mRNA export from nucleus || RNA localization || establishment of RNA localization || RNA export from nucleus |
| L domain-like | 0.006135 | INHERITED FROM: mRNA transport || mRNA export from nucleus || gamma-tubulin complex localization || RNA transport || poly(A)+ mRNA export from nucleus || establishment of protein localization to chromatin || protein secretion by the type III secretion system || establishment of protein localization to chromosome || protein targeting || establishment of RNA localization || protein targeting to membrane || protein localization to chromatin |
| RNI-like | 1 | INHERITED FROM: interleukin-1 secretion |
| Saposin | 0.03402 | INHERITED FROM: RNA transport || establishment of RNA localization || dsRNA transport |
| PAZ domain | 0.2341 | INHERITED FROM: RNA transport || RNA localization || establishment of RNA localization |
| Small-conductance potassium channel | 0.863 | INHERITED FROM: phospholipid translocation || lipid translocation || phospholipid transport || lipid localization |
| Calcium ATPase, transduction domain A | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
| Metal cation-transporting ATPase, ATP-binding domain N | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
| HAD-like | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
| Calcium ATPase, transmembrane domain M | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
| Protein kinase-like (PK-like) | 0.1417 | INHERITED FROM: asymmetric protein localization involved in cell fate determination || cellular macromolecule localization || protein localization to chromosome || pole plasm RNA localization || asymmetric protein localization || protein localization || pole plasm oskar mRNA localization || protein localization to medial cortex || pole plasm protein localization || maintenance of protein location || cortical protein anchoring || protein export from nucleus || sterol transmembrane transport || protein targeting to membrane |
| TRAF domain-like | 0.9441 | INHERITED FROM: asymmetric protein localization involved in cell fate determination || asymmetric protein localization |
| SIS domain | 0.4921 | INHERITED FROM: protein targeting to nucleus || protein import into nucleus, translocation || protein import into nucleus |
| Hook domain | 0.9846 | INHERITED FROM: protein localization to cytoskeleton || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || microtubule anchoring || protein localization to centrosome || protein complex localization || spindle localization || microtubule anchoring at microtubule organizing center || maintenance of protein location in cell || establishment of spindle orientation |
| WW domain | 0.001376 | INHERITED FROM: protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multi || cellular macromolecule localization || protein localization to membrane || cellular protein localization || protein targeting || establishment of protein localization to vacuole || establishment of protein localization to organelle || receptor clustering || protein targeting to vacuole || protein localization to vacuole |
| C-type lectin-like | 1 | INHERITED FROM: receptor clustering || protein localization to synapse |
| Thioredoxin-like | 1 | INHERITED FROM: cytoplasmic sequestering of transcription factor || cytoplasmic sequestering of protein || maintenance of protein localization in endoplasmic reticulum || protein retention in ER lumen |
| Leucine zipper domain | 0.906 | INHERITED FROM: cytoplasmic sequestering of transcription factor || cytoplasmic sequestering of protein |
| Actin depolymerizing proteins | 0.6922 | INHERITED FROM: sequestering of actin monomers || maintenance of protein location |
| Profilin (actin-binding protein) | 0.003335 | INHERITED FROM: sequestering of actin monomers || protein localization || maintenance of protein location |
| Frizzled cysteine-rich domain | 0.001443 | INHERITED FROM: progesterone secretion |
| Eukaryotic type KH-domain (KH-domain type I) | 0.3634 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || rRNA transport || intracellular mRNA localization || RNA localization |
| Ribonuclease PH domain 2-like | 0.02184 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || establishment of RNA localization |
| Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
| Translational machinery components | 0.2684 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
| Rhodanese/Cell cycle control phosphatase | 0.7557 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
| Ribosomal protein S5 domain 2-like | 0.2406 | INHERITED FROM: RNA import into mitochondrion || rRNA transport || establishment of protein localization to organelle |
| TB module/8-cys domain | 0.181 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || maintenance of protein location |
| GFP-like | 0.01652 | INHERITED FROM: protein localization to synapse |
| PLC-like phosphodiesterases | 0.9679 | INHERITED FROM: protein localization to synapse |
| Wiscott-Aldrich syndrome protein, WASP, C-terminal domain | 0.01453 | INHERITED FROM: cellular protein complex localization || cellular protein localization || protein localization || protein complex localization || spindle localization |
| Intermediate filament protein, coiled coil region | 0.2361 | INHERITED FROM: cellular protein complex localization || protein localization to nucleus || nuclear pore distribution || protein import || protein targeting to nucleus || nuclear pore localization || sterol regulatory element binding protein import into nucleus |
| Sialidases | 0.0919 | INHERITED FROM: cellular protein localization || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
| FAT domain of focal adhesion kinase | 0.003189 | INHERITED FROM: cellular protein localization || cytoskeletal anchoring at plasma membrane || protein localization || maintenance of protein location || maintenance of protein location in cell |
| NAD(P)-linked oxidoreductase | 0.7866 | INHERITED FROM: protein localization to nucleus || protein targeting to nucleus || protein import into nucleus, translocation || protein import into nucleus |
| Orange domain-like | 0.1214 | INHERITED FROM: protein localization to nucleus || protein import || protein targeting to nucleus || STAT protein import into nucleus || protein import into nucleus |
| 4-helical cytokines | 0.6868 | INHERITED FROM: protein localization to nucleus || protein import || protein targeting to nucleus || STAT protein import into nucleus || protein import into nucleus |
| DNA-binding domain | 0.03443 | INHERITED FROM: protein localization to nucleus || protein import || protein targeting || lipid storage || transcription factor import into nucleus |
| Hedgehog/DD-peptidase | 0.1441 | INHERITED FROM: protein localization to nucleus |
| Hedgehog/intein (Hint) domain | 0.2453 | INHERITED FROM: protein localization to nucleus |
| Chromo domain-like | 0.5321 | INHERITED FROM: protein localization to chromosome |
| ADP-ribosylation | 0.5323 | INHERITED FROM: protein localization to chromosome |
| Histone-fold | 1 | INHERITED FROM: protein localization to chromosome |
| PRC-barrel domain | 0.07716 | INHERITED FROM: microtubule anchoring || maintenance of protein location || maintenance of protein location in cell |
| DUSP-like | 0.05932 | INHERITED FROM: protein localization to cell surface |
| beta-sandwich domain of Sec23/24 | 0.2203 | INHERITED FROM: protein localization to cell surface |
| Cysteine proteinases | 1 | INHERITED FROM: protein localization to cell surface |
| vWA-like | 1 | INHERITED FROM: protein localization to cell surface |
| Translation proteins SH3-like domain | 0.09902 | INHERITED FROM: protein localization to organelle || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein targeting to membrane |
| RL5-like | 0.004696 | INHERITED FROM: protein localization to organelle || cellular macromolecule localization || protein localization to nucleus || cellular protein localization || protein localization |
| SH2 domain | 1 | INHERITED FROM: protein localization to organelle || NFAT protein import into nucleus || protein localization to nucleus || protein import || lipid storage || protein targeting to nucleus || protein import into nucleus |
| HMG-box | 0.6724 | INHERITED FROM: protein localization to organelle || catenin import into nucleus || protein localization to nucleus || protein import || protein targeting || protein targeting to nucleus || protein import into nucleus |
| Nop domain | 0.07933 | INHERITED FROM: protein localization to organelle || protein localization to nucleus || protein import || protein targeting || protein targeting to nucleus || protein import into nucleus || snRNP protein import into nucleus |
| Ran binding protein zinc finger-like | 0.03273 | INHERITED FROM: protein localization to organelle || protein import || protein targeting || establishment of protein localization to vacuole || SMAD protein import into nucleus || NLS-bearing substrate import into nucleus || establishment of protein localization |
| Cystine-knot cytokines | 0.06218 | INHERITED FROM: protein localization to organelle || lipid transport || protein localization to nucleus || protein import || cellular protein localization || protein targeting || SMAD protein import into nucleus || protein targeting to nucleus || protein import into nucleus, translocation || progesterone secretion || protein export from nucleus || lipid localization || protein import into nucleus |
| IP3 receptor type 1 binding core, domain 2 | 1 | INHERITED FROM: protein localization to organelle |
| SMAD/FHA domain | 0.6345 | INHERITED FROM: protein complex localization || establishment of spindle orientation |
| FKBP-like | 0.9344 | INHERITED FROM: protein complex localization |
| "Winged helix" DNA-binding domain | 0.988 | INHERITED FROM: proteasome localization || skeletal muscle acetylcholine-gated channel clustering || protein localization to microtubule cytoskeleton || protein localization to chromatin |
| Cdc48 domain 2-like | 0.03402 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || establishment of protein localization to peroxisome || protein targeting to peroxisome || protein import into peroxisome matrix || intracellular protein transmembrane import || protein localization || protein localization to peroxisome || establishment of protein localization |
| Rhomboid-like | 0.07247 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || intracellular protein transport || establishment of protein localization |
| ADC-like | 0.08826 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport |
| CBS-domain pair | 1 | INHERITED FROM: sequestering of triglyceride || lipid storage || lipid localization |
| (Phosphotyrosine protein) phosphatases II | 1 | INHERITED FROM: lipid storage || protein localization to synapse |
| Snake toxin-like | 0.911 | INHERITED FROM: lipid storage || lipid localization |
| Activating enzymes of the ubiquitin-like proteins | 0.6159 | INHERITED FROM: lipid storage |
| UBC-like | 0.9958 | INHERITED FROM: protein import into peroxisome matrix || protein localization to peroxisome |
| EGF/Laminin | 0.4473 | INHERITED FROM: sterol transport || establishment of protein localization to membrane || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || lipoprotein transport || protein targeting to plasma membrane || intracellular sterol transport || interleukin-4 secretion || protein localization to extracellular region || protein localization to membrane || intracellular lipid transport || STAT protein import into nucleus || establishment of protein localization to plasma membrane || protein targeting to lysosome || protein localization to paranode region of axon |
| Growth factor receptor domain | 0.2384 | INHERITED FROM: sterol transport || establishment of protein localization to membrane || sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein targeting to plasma membrane || interleukin-4 secretion || protein localization to extracellular region || protein localization to membrane || STAT protein import into nucleus || establishment of protein localization to plasma membrane || apical protein localization |
| LDL receptor-like module | 0.3885 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || lipid transport || intracellular lipid transport || protein targeting to lysosome || lipid localization |
| YWTD domain | 0.002542 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || lipid transport || protein import || establishment of protein localization to vacuole || intracellular lipid transport || STAT protein import into nucleus || protein targeting to lysosome || lipid localization || protein localization to synapse |
| E set domains | 0.6177 | INHERITED FROM: sterol transport || lipoprotein transport || cholesterol efflux || interleukin-4 secretion || lipid transport || protein localization to cell surface || cytoplasmic sequestering of protein || receptor clustering || intracellular lipid transport || intracellular cholesterol transport || lipid localization |
| Undecaprenyl diphosphate synthase | 0.02157 | INHERITED FROM: sterol transport || intracellular sterol transport || lipid transport || intracellular lipid transport || intracellular cholesterol transport || lipid localization || cholesterol transport |
| Dimerization cofactor of HNF-1 alpha | 0.01868 | INHERITED FROM: sterol transport || fatty acid transport || lipid transport || protein localization || reverse cholesterol transport || lipid localization || cholesterol transport |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.02282 | INHERITED FROM: sterol transport || lipid transport || lipid localization || cholesterol transport |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3679 | INHERITED FROM: sterol transport || lipid transport || protein secretion || lipid localization || cholesterol transport |
| PR-1-like | 0.6598 | INHERITED FROM: sterol transport |
| ABC transporter transmembrane region | 1 | INHERITED FROM: peroxisomal long-chain fatty acid import || lipid transport || lipid localization || cholesterol transport |
| CoA-dependent acyltransferases | 0.0313 | INHERITED FROM: fatty acid transport || fatty acid transmembrane transport || lipid transport || carnitine shuttle || intracellular lipid transport || lipid localization |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9408 | INHERITED FROM: fatty acid transport || interferon-gamma secretion || interleukin-4 secretion || maintenance of protein location in nucleus || cytoskeletal anchoring at plasma membrane || maintenance of protein location || maintenance of protein location in cell || maintenance of protein localization in organelle |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | INHERITED FROM: fatty acid transport || protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multi || arachidonic acid secretion || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole || long-chain fatty acid transport || protein localization to synapse |
| Porins | 1 | INHERITED FROM: fatty acid transport || lipid localization || long-chain fatty acid transport |
| Nuclear receptor ligand-binding domain | 0.283 | INHERITED FROM: fatty acid transport || lipid transport || maintenance of protein location in nucleus || lipid localization || maintenance of protein localization in organelle |
| Annexin | 0.2533 | INHERITED FROM: fatty acid transport || lipid transport || arachidonic acid secretion || lipid localization || long-chain fatty acid transport |
| FabD/lysophospholipase-like | 0.3984 | INHERITED FROM: fatty acid transport || lipid transport || arachidonic acid secretion || lipid localization || long-chain fatty acid transport |
| GAT-like domain | 0.007669 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein localization || protein targeting to vacuole || protein localization to vacuole || establishment of protein localization |
| PX domain | 0.007124 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein localization || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome || establishment of protein localization |
| Transferrin receptor-like dimerisation domain | 0.04528 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
| AN1-like Zinc finger | 0.02276 | INHERITED FROM: protein transport || establishment of protein localization to peroxisome || protein targeting to peroxisome || protein targeting || protein localization to peroxisome || establishment of protein localization |
| BAR/IMD domain-like | 0.507 | INHERITED FROM: protein transport || protein localization to membrane || protein localization |
| DNA-binding protein LAG-1 (CSL) | 0.001471 | INHERITED FROM: protein transport || interleukin-4 secretion || protein secretion || protein localization || cytokine secretion || establishment of protein localization |
| Notch domain | 0.002629 | INHERITED FROM: protein transport || interleukin-4 secretion || protein secretion || protein localization || establishment of protein localization |
| Plakin repeat | 0.001408 | INHERITED FROM: protein transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || protein localization || posttranslational protein targeting to membrane || protein targeting to ER || protein targeting to membrane || establishment of protein localization |
| Mannose 6-phosphate receptor domain | 0.06743 | INHERITED FROM: protein transport || protein localization to endoplasmic reticulum || establishment of protein localization to vacuole || protein localization || maintenance of protein location in cell || maintenance of protein localization in endoplasmic reticulum || protein retention in ER lumen || maintenance of protein localization in organelle |
| ERP29 C domain-like | 0.01416 | INHERITED FROM: protein transport || cellular macromolecule localization || cellular protein localization || protein localization || intracellular protein transport |
| t-snare proteins | 1 | INHERITED FROM: protein transport || callose localization || establishment of protein localization to vacuole || callose deposition in cell wall || protein targeting to vacuole || protein localization to vacuole || polysaccharide localization |
| SNARE fusion complex | 1 | INHERITED FROM: protein transport || cellular protein localization || establishment of protein localization to vacuole || protein localization to vacuole || Golgi to plasma membrane protein transport |
| Zn-finger domain of Sec23/24 | 0.04199 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
| Helical domain of Sec23/24 | 0.06743 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.3002 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
| Endosomal sorting complex assembly domain | 0.04089 | INHERITED FROM: protein transport || cellular protein localization || protein targeting || establishment of protein localization to vacuole || establishment of protein localization to organelle || protein localization || protein targeting to vacuole || protein localization to vacuole |
| VPS28 C-terminal domain-like | 0.007071 | INHERITED FROM: protein transport || cellular protein localization || protein targeting || establishment of protein localization to vacuole || protein localization || protein targeting to vacuole || protein localization to vacuole || establishment of protein localization |
| p53-like transcription factors | 0.008092 | INHERITED FROM: protein transport || protein localization to organelle || interleukin-4 secretion || protein localization to nucleus || protein import || lipid storage || protein targeting to nucleus || protein import into nucleus, translocation || lipid localization || protein import into nucleus || establishment of protein localization |
| Signal recognition particle alu RNA binding heterodimer, SRP9/14 | 0.01868 | INHERITED FROM: protein transport || protein localization to organelle || cellular macromolecule localization || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || cellular protein localization || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || intracellular protein transport || protein targeting to membrane |
| Cryptochrome/photolyase, N-terminal domain | 0.00291 | INHERITED FROM: protein transport || protein localization to organelle || cellular macromolecule localization || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein targeting to nucleus || protein import into nucleus, translocation || intracellular protein transport || protein import into nucleus || establishment of protein localization |
| Metallothionein | 0.001921 | INHERITED FROM: protein transport || protein localization to organelle || cellular macromolecule localization || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein localization || protein targeting to nucleus || protein import into nucleus, translocation || intracellular protein transport || protein import into nucleus || establishment of protein localization |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01994 | INHERITED FROM: protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
| PA domain | 0.04624 | INHERITED FROM: protein transport || protein localization to organelle || protein targeting || establishment of protein localization to vacuole || establishment of protein localization to organelle || protein targeting to vacuole || protein localization to vacuole || establishment of protein localization |
| ENTH/VHS domain | 0.1314 | INHERITED FROM: protein transport || storage protein import into fat body || establishment of protein localization to vacuole || intracellular protein transmembrane import || protein localization || protein targeting to vacuole || protein localization to vacuole || establishment of protein localization |
| Pili subunits | 0.008442 | INHERITED FROM: protein transport || protein secretion || establishment of protein localization |
| BEACH domain | 0.1474 | INHERITED FROM: protein transport || protein secretion || protein localization || secretion of lysosomal enzymes |
| Protein prenylyltransferase | 0.01404 | INHERITED FROM: protein transport || protein targeting to membrane || establishment of protein localization |
| ArfGap/RecO-like zinc finger | 0.08003 | INHERITED FROM: protein transport || protein import into nucleus, translocation || establishment of protein localization |
| beta-beta-alpha zinc fingers | 1 | INHERITED FROM: mRNA localization resulting in posttranscriptional regulation of gene expression |
| lambda repressor-like DNA-binding domains | 1 | INHERITED FROM: protein secretion || reverse cholesterol transport || immunoglobulin secretion involved in immune response || immunoglobulin secretion || cholesterol transport |
| HlyD-like secretion proteins | 0.09604 | INHERITED FROM: protein secretion || protein localization |
| Outer membrane efflux proteins (OEP) | 0.8133 | INHERITED FROM: protein secretion |
| Ribonuclease H-like | 1 | INHERITED FROM: intracellular mRNA localization || RNA localization |
| Tropomyosin | 0.007409 | INHERITED FROM: intracellular mRNA localization |
| Tudor/PWWP/MBT | 0.8658 | INHERITED FROM: intracellular mRNA localization |
| DBL homology domain (DH-domain) | 0.6539 | INHERITED FROM: asymmetric protein localization |
| GTPase activation domain, GAP | 0.9662 | INHERITED FROM: asymmetric protein localization |
| Inhibitor of apoptosis (IAP) repeat | 0.001491 | INHERITED FROM: protein localization || protein complex localization |
| HLH, helix-loop-helix DNA-binding domain | 1 | INHERITED FROM: STAT protein import into nucleus |
| Ankyrin repeat | 0.003942 | INHERITED FROM: cytoplasmic sequestering of NF-kappaB || chaperone-mediated protein transport || establishment of protein localization to membrane || cellular macromolecule localization || alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering || cytoplasmic sequestering of transcription factor || interleukin-4 secretion || cytoskeletal anchoring at plasma membrane || protein localization || cytokine secretion || cytoplasmic sequestering of protein || neurotransmitter-gated ion channel clustering || protein import into nucleus, translocation || maintenance of protein location || maintenance of protein location in cell |
| Nucleotide-diphospho-sugar transferases | 1 | INHERITED FROM: endocytosed protein transport to vacuole |
| Cadherin-like | 0.9867 | INHERITED FROM: cytoskeletal anchoring at plasma membrane || maintenance of protein location || maintenance of protein location in cell || apical protein localization |
| I/LWEQ domain | 0.6322 | INHERITED FROM: cytoskeletal anchoring at plasma membrane || maintenance of protein location || maintenance of protein location in cell |
| Phospholipase A2, PLA2 | 0.09783 | INHERITED FROM: lipid transport || arachidonic acid secretion || lipid localization || long-chain fatty acid transport |
| Lipocalins | 0.03994 | INHERITED FROM: lipid transport || isoprenoid transport || retinol transport || reverse cholesterol transport || lipid localization || cholesterol transport |
| Bet v1-like | 0.0718 | INHERITED FROM: lipid transport || ceramide transport || phospholipid transport || intracellular lipid transport || lipid localization |
| CRAL/TRIO N-terminal domain | 0.2357 | INHERITED FROM: lipid transport || phospholipid transport || lipid localization || Golgi to plasma membrane protein transport |
| CRAL/TRIO domain | 0.6275 | INHERITED FROM: lipid transport || phospholipid transport || lipid localization || Golgi to plasma membrane protein transport |
| Kelch motif | 0.02227 | INHERITED FROM: lipid transport || lipid localization |
| Bactericidal permeability-increasing protein, BPI | 0.8133 | INHERITED FROM: lipid transport || lipid localization |
| F-box domain | 1 | INHERITED FROM: lipid transport |
| HD-domain/PDEase-like | 1 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion || establishment of protein localization to organelle |
| GroEL-intermediate domain like | 0.5908 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
| GroEL apical domain-like | 0.7471 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
| GST C-terminal domain-like | 0.9377 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
| GroEL equatorial domain-like | 0.9814 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
| GAF domain-like | 0.08857 | INHERITED FROM: protein targeting to mitochondrion || protein localization to organelle || protein localization to mitochondrion || establishment of protein localization to mitochondrion || protein targeting || establishment of protein localization to organelle || intracellular protein transport |
| Chaperone J-domain | 0.4725 | INHERITED FROM: protein targeting to mitochondrion || protein import into mitochondrial matrix || intracellular protein transmembrane transport || protein localization to mitochondrion || intracellular protein transmembrane import || establishment of protein localization to organelle || protein transmembrane transport |
| LuxS/MPP-like metallohydrolase | 0.02878 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || protein localization to mitochondrion || establishment of protein localization to mitochondrion || protein targeting || establishment of protein localization to organelle || intracellular protein transport || protein processing involved in protein targeting to mitochondrion || establishment of protein localization |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
| Acid proteases | 1 | INHERITED FROM: protein targeting to peroxisome || protein import into peroxisome matrix || intracellular protein transmembrane import || protein localization to peroxisome |
| Zn-dependent exopeptidases | 1 | INHERITED FROM: protein targeting to vacuole |
| Translation proteins | 1 | INHERITED FROM: cotranslational protein targeting to membrane || SRP-dependent cotranslational protein targeting to membrane |
| Formate/glycerate dehydrogenase catalytic domain-like | 0.9991 | INHERITED FROM: protein export from nucleus |
| Mog1p/PsbP-like | 0.04528 | INHERITED FROM: protein targeting |
| Nucleic acid-binding proteins | 0.6352 | INHERITED FROM: rRNA export from nucleus || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
| HRDC-like | 0.3012 | INHERITED FROM: RNA localization |
| Fibrinogen C-terminal domain-like | 0.1206 | INHERITED FROM: protein localization to paranode region of axon |
| Galactose-binding domain-like | 1 | INHERITED FROM: protein localization to paranode region of axon |
| Cytokine | 0.1908 | INHERITED FROM: MAPK import into nucleus || protein localization to plasma membrane || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein targeting to nucleus || protein import into nucleus |
| Tubulin C-terminal domain-like | 0.9083 | INHERITED FROM: establishment of mitotic spindle orientation || protein complex localization || establishment of spindle orientation |
| Tubulin nucleotide-binding domain-like | 1 | INHERITED FROM: establishment of mitotic spindle orientation || protein complex localization || establishment of spindle orientation |
| POZ domain | 1 | INHERITED FROM: protein import into nucleus, translocation |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| PDZ domain-like | 0 | Direct |
| ARM repeat | 0 | Direct |
| WD40 repeat-like | 0 | Direct |
| Tim10-like | 7.735e-13 | Direct |
| Roadblock/LC7 domain | 1.431e-12 | Direct |
| Chitinase insertion domain | 2.312e-12 | Direct |
| Ubiquitin-like | 1.437e-10 | Direct |
| Preprotein translocase SecY subunit | 7.218e-10 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 7.411e-10 | Direct |
| Nucleoporin domain | 2.543e-09 | Direct |
| Apolipoprotein A-I | 3.216e-09 | Direct |
| 14-3-3 protein | 4.907e-09 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 1.15e-08 | Direct |
| SRP19 | 1.338e-08 | Direct |
| Nucleoplasmin-like core domain | 1.743e-08 | Direct |
| C-terminal autoproteolytic domain of nucleoporin nup98 | 2.153e-08 | Direct |
| dsRNA-binding domain-like | 4.253e-08 | Direct |
| Spectrin repeat | 6.517e-08 | Direct |
| Clathrin adaptor appendage domain | 1.17e-07 | Direct |
| Transcription factor STAT-4 N-domain | 1.656e-07 | Direct |
| Ribosomal protein S2 | 1.656e-07 | Direct |
| Domain of the SRP/SRP receptor G-proteins | 1.86e-07 | Direct |
| Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain | 2.06e-07 | Direct |
| EB1 dimerisation domain-like | 2.06e-07 | Direct |
| Cap-Gly domain | 2.423e-07 | Direct |
| TNF-like | 5.329e-07 | Direct |
| Lamin A/C globular tail domain | 6.309e-07 | Direct |
| Second domain of FERM | 1.029e-06 | Direct |
| TPR-like | 1.642e-06 | Direct |
| Apolipoprotein | 1.769e-06 | Direct |
| GAS2 domain-like | 2.677e-06 | Direct |
| RNase III domain-like | 3.11e-06 | Direct |
| Suppressor of Fused, N-terminal domain | 3.58e-06 | Direct |
| Helical scaffold and wing domains of SecA | 4.731e-06 | Direct |
| Acetyl-CoA synthetase-like | 5.084e-06 | Direct |
| Class II MHC-associated invariant chain ectoplasmic trimerization domain | 6.307e-06 | Direct |
| Signal peptide-binding domain | 1.062e-05 | Direct |
| Fzo-like conserved region | 1.143e-05 | Direct |
| Pre-protein crosslinking domain of SecA | 1.144e-05 | Direct |
| MIT domain | 1.378e-05 | Direct |
| Moesin tail domain | 1.56e-05 | Direct |
| LexA/Signal peptidase | 1.56e-05 | Direct |
| STAT | 1.992e-05 | Direct |
| PH domain-like | 4.023e-05 | Direct |
| Mitochondrial import receptor subunit Tom20 | 4.359e-05 | Direct |
| beta-N-acetylhexosaminidase-like domain | 4.433e-05 | Direct |
| Glycolipid transfer protein, GLTP | 4.433e-05 | Direct |
| Preprotein translocase SecE subunit | 4.433e-05 | Direct |
| P-loop containing nucleoside triphosphate hydrolases | 5.264e-05 | Direct |
| Head domain of nucleotide exchange factor GrpE | 5.449e-05 | Direct |
| Acyl-CoA binding protein | 7.027e-05 | Direct |
| Coiled-coil domain of nucleotide exchange factor GrpE | 7.167e-05 | Direct |
| GLA-domain | 9.441e-05 | Direct |
| Calponin-homology domain, CH-domain | 0.0001138 | Direct |
| KA1-like | 0.0001173 | Direct |
| DNA mismatch repair protein MutL | 0.0001189 | Direct |
| CAD & PB1 domains | 0.0001258 | Direct |
| Ganglioside M2 (gm2) activator | 0.0001568 | Direct |
| Oxysterol-binding protein-like | 0.0001668 | Direct |
| Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain | 0.0001687 | Direct |
| Polo-box domain | 0.0002014 | Direct |
| L27 domain | 0.0002306 | Direct |
| Rap/Ran-GAP | 0.0002306 | Direct |
| Cryptochrome/photolyase FAD-binding domain | 0.0002399 | Direct |
| Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin | 0.00027 | Direct |
| EspE N-terminal domain-like | 0.0002878 | Direct |
| NTF2-like | 0.0002949 | Direct |
| Subdomain of clathrin and coatomer appendage domain | 0.0003414 | Direct |
| Hect, E3 ligase catalytic domain | 0.0004405 | Direct |
| Apolipoprotein A-II | 0.0004849 | Direct |
| p53 tetramerization domain | 0.0004878 | Direct |
| SNARE-like | 0.0005706 | Direct |
| alpha-catenin/vinculin-like | 0.0006168 | Direct |
| Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0008359 | Direct |
| alpha/beta-Hydrolases | 1 | Inherited |
| SAM/Pointed domain | 0.6621 | Inherited |
| Supernatant protein factor (SPF), C-terminal domain | 0.07518 | Inherited |
| DNase I-like | 0.24 | Inherited |
| DEATH domain | 0.1236 | Inherited |
| Concanavalin A-like lectins/glucanases | 0.2003 | Inherited |
| EF-hand | 0.3922 | Inherited |
| Oligoxyloglucan reducing end-specific cellobiohydrolase | 0.0919 | Inherited |
| Sec1/munc18-like (SM) proteins | 0.3804 | Inherited |
| JAB1/MPN domain | 0.4642 | Inherited |
| Band 7/SPFH domain | 0.1154 | Inherited |
| Nucleoside diphosphate kinase, NDK | 0.113 | Inherited |
| SEA domain | 0.0162 | Inherited |
| TIMP-like | 0.1618 | Inherited |
| Kazal-type serine protease inhibitors | 0.9344 | Inherited |
| Voltage-gated potassium channels | 1 | Inherited |
| Immunoglobulin | 1 | Inherited |
| Family A G protein-coupled receptor-like | 1 | Inherited |
| (Trans)glycosidases | 0.2883 | Inherited |
| Fibronectin type III | 1 | Inherited |
| PapD-like | 0.007503 | Inherited |
| Calpain large subunit, middle domain (domain III) | 0.001571 | Inherited |
| Homeodomain-like | 1 | Inherited |
| RING/U-box | 0.7322 | Inherited |
| Actin-like ATPase domain | 0.193 | Inherited |
| SH3-domain | 0.3124 | Inherited |
| NagB/RpiA/CoA transferase-like | 0.5429 | Inherited |
| Cytochrome P450 | 1 | Inherited |
| SRF-like | 0.2608 | Inherited |
| UDP-Glycosyltransferase/glycogen phosphorylase | 1 | Inherited |
| WRKY DNA-binding domain | 0.009387 | Inherited |
| FYVE/PHD zinc finger | 0.02009 | Inherited |
| Myosin rod fragments | 0.06682 | Inherited |
| Formin homology 2 domain (FH2 domain) | 0.1739 | Inherited |
| Cysteine-rich domain | 0.6667 | Inherited |
| BRCT domain | 0.00715 | Inherited |
| G protein-binding domain | 0.1025 | Inherited |
| Bcl-2 inhibitors of programmed cell death | 0.944 | Inherited |
| RNA-binding domain, RBD | 0.005306 | Inherited |
| Clavaminate synthase-like | 0.217 | Inherited |
| UBA-like | 0.002774 | Inherited |
| L domain-like | 0.006135 | Inherited |
| RNI-like | 1 | Inherited |
| Saposin | 0.03402 | Inherited |
| PAZ domain | 0.2341 | Inherited |
| Small-conductance potassium channel | 0.863 | Inherited |
| Calcium ATPase, transduction domain A | 1 | Inherited |
| Metal cation-transporting ATPase, ATP-binding domain N | 1 | Inherited |
| HAD-like | 1 | Inherited |
| Calcium ATPase, transmembrane domain M | 1 | Inherited |
| Protein kinase-like (PK-like) | 0.1417 | Inherited |
| TRAF domain-like | 0.9441 | Inherited |
| SIS domain | 0.4921 | Inherited |
| Hook domain | 0.9846 | Inherited |
| WW domain | 0.001376 | Inherited |
| C-type lectin-like | 1 | Inherited |
| Thioredoxin-like | 1 | Inherited |
| Leucine zipper domain | 0.906 | Inherited |
| Actin depolymerizing proteins | 0.6922 | Inherited |
| Profilin (actin-binding protein) | 0.003335 | Inherited |
| Frizzled cysteine-rich domain | 0.001443 | Inherited |
| Eukaryotic type KH-domain (KH-domain type I) | 0.3634 | Inherited |
| Ribonuclease PH domain 2-like | 0.02184 | Inherited |
| Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | Inherited |
| Translational machinery components | 0.2684 | Inherited |
| Rhodanese/Cell cycle control phosphatase | 0.7557 | Inherited |
| Ribosomal protein S5 domain 2-like | 0.2406 | Inherited |
| TB module/8-cys domain | 0.181 | Inherited |
| GFP-like | 0.01652 | Inherited |
| PLC-like phosphodiesterases | 0.9679 | Inherited |
| Wiscott-Aldrich syndrome protein, WASP, C-terminal domain | 0.01453 | Inherited |
| Intermediate filament protein, coiled coil region | 0.2361 | Inherited |
| Sialidases | 0.0919 | Inherited |
| FAT domain of focal adhesion kinase | 0.003189 | Inherited |
| NAD(P)-linked oxidoreductase | 0.7866 | Inherited |
| Orange domain-like | 0.1214 | Inherited |
| 4-helical cytokines | 0.6868 | Inherited |
| DNA-binding domain | 0.03443 | Inherited |
| Hedgehog/DD-peptidase | 0.1441 | Inherited |
| Hedgehog/intein (Hint) domain | 0.2453 | Inherited |
| Chromo domain-like | 0.5321 | Inherited |
| ADP-ribosylation | 0.5323 | Inherited |
| Histone-fold | 1 | Inherited |
| PRC-barrel domain | 0.07716 | Inherited |
| DUSP-like | 0.05932 | Inherited |
| beta-sandwich domain of Sec23/24 | 0.2203 | Inherited |
| Cysteine proteinases | 1 | Inherited |
| vWA-like | 1 | Inherited |
| Translation proteins SH3-like domain | 0.09902 | Inherited |
| RL5-like | 0.004696 | Inherited |
| SH2 domain | 1 | Inherited |
| HMG-box | 0.6724 | Inherited |
| Nop domain | 0.07933 | Inherited |
| Ran binding protein zinc finger-like | 0.03273 | Inherited |
| Cystine-knot cytokines | 0.06218 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 1 | Inherited |
| SMAD/FHA domain | 0.6345 | Inherited |
| FKBP-like | 0.9344 | Inherited |
| "Winged helix" DNA-binding domain | 0.988 | Inherited |
| Cdc48 domain 2-like | 0.03402 | Inherited |
| Rhomboid-like | 0.07247 | Inherited |
| ADC-like | 0.08826 | Inherited |
| CBS-domain pair | 1 | Inherited |
| (Phosphotyrosine protein) phosphatases II | 1 | Inherited |
| Snake toxin-like | 0.911 | Inherited |
| Activating enzymes of the ubiquitin-like proteins | 0.6159 | Inherited |
| UBC-like | 0.9958 | Inherited |
| EGF/Laminin | 0.4473 | Inherited |
| Growth factor receptor domain | 0.2384 | Inherited |
| LDL receptor-like module | 0.3885 | Inherited |
| YWTD domain | 0.002542 | Inherited |
| E set domains | 0.6177 | Inherited |
| Undecaprenyl diphosphate synthase | 0.02157 | Inherited |
| Dimerization cofactor of HNF-1 alpha | 0.01868 | Inherited |
| Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.02282 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.3679 | Inherited |
| PR-1-like | 0.6598 | Inherited |
| ABC transporter transmembrane region | 1 | Inherited |
| CoA-dependent acyltransferases | 0.0313 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.9408 | Inherited |
| C2 domain (Calcium/lipid-binding domain, CaLB) | 1 | Inherited |
| Porins | 1 | Inherited |
| Nuclear receptor ligand-binding domain | 0.283 | Inherited |
| Annexin | 0.2533 | Inherited |
| FabD/lysophospholipase-like | 0.3984 | Inherited |
| GAT-like domain | 0.007669 | Inherited |
| PX domain | 0.007124 | Inherited |
| Transferrin receptor-like dimerisation domain | 0.04528 | Inherited |
| AN1-like Zinc finger | 0.02276 | Inherited |
| BAR/IMD domain-like | 0.507 | Inherited |
| DNA-binding protein LAG-1 (CSL) | 0.001471 | Inherited |
| Notch domain | 0.002629 | Inherited |
| Plakin repeat | 0.001408 | Inherited |
| Mannose 6-phosphate receptor domain | 0.06743 | Inherited |
| ERP29 C domain-like | 0.01416 | Inherited |
| t-snare proteins | 1 | Inherited |
| SNARE fusion complex | 1 | Inherited |
| Zn-finger domain of Sec23/24 | 0.04199 | Inherited |
| Helical domain of Sec23/24 | 0.06743 | Inherited |
| C-terminal, gelsolin-like domain of Sec23/24 | 0.3002 | Inherited |
| Endosomal sorting complex assembly domain | 0.04089 | Inherited |
| VPS28 C-terminal domain-like | 0.007071 | Inherited |
| p53-like transcription factors | 0.008092 | Inherited |
| Signal recognition particle alu RNA binding heterodimer, SRP9/14 | 0.01868 | Inherited |
| Cryptochrome/photolyase, N-terminal domain | 0.00291 | Inherited |
| Metallothionein | 0.001921 | Inherited |
| Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01994 | Inherited |
| PA domain | 0.04624 | Inherited |
| ENTH/VHS domain | 0.1314 | Inherited |
| Pili subunits | 0.008442 | Inherited |
| BEACH domain | 0.1474 | Inherited |
| Protein prenylyltransferase | 0.01404 | Inherited |
| ArfGap/RecO-like zinc finger | 0.08003 | Inherited |
| beta-beta-alpha zinc fingers | 1 | Inherited |
| lambda repressor-like DNA-binding domains | 1 | Inherited |
| HlyD-like secretion proteins | 0.09604 | Inherited |
| Outer membrane efflux proteins (OEP) | 0.8133 | Inherited |
| Ribonuclease H-like | 1 | Inherited |
| Tropomyosin | 0.007409 | Inherited |
| Tudor/PWWP/MBT | 0.8658 | Inherited |
| DBL homology domain (DH-domain) | 0.6539 | Inherited |
| GTPase activation domain, GAP | 0.9662 | Inherited |
| Inhibitor of apoptosis (IAP) repeat | 0.001491 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 1 | Inherited |
| Ankyrin repeat | 0.003942 | Inherited |
| Nucleotide-diphospho-sugar transferases | 1 | Inherited |
| Cadherin-like | 0.9867 | Inherited |
| I/LWEQ domain | 0.6322 | Inherited |
| Phospholipase A2, PLA2 | 0.09783 | Inherited |
| Lipocalins | 0.03994 | Inherited |
| Bet v1-like | 0.0718 | Inherited |
| CRAL/TRIO N-terminal domain | 0.2357 | Inherited |
| CRAL/TRIO domain | 0.6275 | Inherited |
| Kelch motif | 0.02227 | Inherited |
| Bactericidal permeability-increasing protein, BPI | 0.8133 | Inherited |
| F-box domain | 1 | Inherited |
| HD-domain/PDEase-like | 1 | Inherited |
| GroEL-intermediate domain like | 0.5908 | Inherited |
| GroEL apical domain-like | 0.7471 | Inherited |
| GST C-terminal domain-like | 0.9377 | Inherited |
| GroEL equatorial domain-like | 0.9814 | Inherited |
| GAF domain-like | 0.08857 | Inherited |
| Chaperone J-domain | 0.4725 | Inherited |
| LuxS/MPP-like metallohydrolase | 0.02878 | Inherited |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | Inherited |
| Acid proteases | 1 | Inherited |
| Zn-dependent exopeptidases | 1 | Inherited |
| Translation proteins | 1 | Inherited |
| Formate/glycerate dehydrogenase catalytic domain-like | 0.9991 | Inherited |
| Mog1p/PsbP-like | 0.04528 | Inherited |
| Nucleic acid-binding proteins | 0.6352 | Inherited |
| HRDC-like | 0.3012 | Inherited |
| Fibrinogen C-terminal domain-like | 0.1206 | Inherited |
| Galactose-binding domain-like | 1 | Inherited |
| Cytokine | 0.1908 | Inherited |
| Tubulin C-terminal domain-like | 0.9083 | Inherited |
| Tubulin nucleotide-binding domain-like | 1 | Inherited |
| POZ domain | 1 | Inherited |
(show details)
Supra-domains annotated to this GO term (Not in SPFO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | DIRECT |
53697,53697
53697 - SIS domain
53697 - SIS domain | 0 | DIRECT |
103652,50729
103652 - G protein-binding domain
50729 - PH domain-like | 0 | DIRECT |
57302,56112
57302 - Snake toxin-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
46966,75399
46966 - Spectrin repeat
75399 - Plakin repeat | 0 | DIRECT |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 1.24e-15 | DIRECT |
52058,54427
52058 - L domain-like
54427 - NTF2-like | 5.665e-14 | DIRECT |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 2.312e-12 | DIRECT |
54427,46934
54427 - NTF2-like
46934 - UBA-like | 2.319e-12 | DIRECT |
54928,52058
54928 - RNA-binding domain, RBD
52058 - L domain-like | 3.413e-11 | DIRECT |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 5.606e-10 | DIRECT |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 1.729e-09 | DIRECT |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 6.1e-09 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 7.426e-09 | DIRECT |
50729,90209
50729 - PH domain-like
90209 - Ran binding protein zinc finger-like | 1.338e-08 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 5.746e-08 | DIRECT |
81383,117281
81383 - F-box domain
117281 - Kelch motif | 6.751e-08 | DIRECT |
48403,74924
48403 - Ankyrin repeat
74924 - Cap-Gly domain | 8.069e-08 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 1.022e-07 | DIRECT |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 1.28e-07 | DIRECT |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 1.555e-07 | DIRECT |
47364,52540
47364 - Domain of the SRP/SRP receptor G-proteins
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.86e-07 | DIRECT |
47576,140612
47576 - Calponin-homology domain, CH-domain
140612 - EB1 dimerisation domain-like | 2.06e-07 | DIRECT |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 2.74e-07 | DIRECT |
51045,51045
51045 - WW domain
51045 - WW domain | 3.693e-07 | DIRECT |
48403,56112
48403 - Ankyrin repeat
56112 - Protein kinase-like (PK-like) | 4.306e-07 | DIRECT |
57196,56496
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like | 5.471e-07 | DIRECT |
56496,49899
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | DIRECT |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 1.02e-06 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 1.282e-06 | DIRECT |
57196,48726
57196 - EGF/Laminin
48726 - Immunoglobulin | 1.516e-06 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 1.595e-06 | DIRECT |
68906,57850
68906 - SAP domain
57850 - RING/U-box | 1.769e-06 | DIRECT |
109925,50978
109925 - Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain
50978 - WD40 repeat-like | 1.939e-06 | DIRECT |
54277,57889
54277 - CAD & PB1 domains
57889 - Cysteine-rich domain | 1.939e-06 | DIRECT |
47473,143575
47473 - EF-hand
143575 - GAS2 domain-like | 2.677e-06 | DIRECT |
52540,81886
52540 - P-loop containing nucleoside triphosphate hydrolases
81886 - Helical scaffold and wing domains of SecA | 4.731e-06 | DIRECT |
50242,100895
50242 - TIMP-like
100895 - Kazal-type serine protease inhibitors | 6.307e-06 | DIRECT |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 9.683e-06 | DIRECT |
52540,47446
52540 - P-loop containing nucleoside triphosphate hydrolases
47446 - Signal peptide-binding domain | 1.062e-05 | DIRECT |
81767,52540
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.144e-05 | DIRECT |
52540,81767
52540 - P-loop containing nucleoside triphosphate hydrolases
81767 - Pre-protein crosslinking domain of SecA | 1.144e-05 | DIRECT |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 1.344e-05 | DIRECT |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 1.534e-05 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 1.564e-05 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 1.992e-05 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 1.992e-05 | DIRECT |
57997,57997
57997 - Tropomyosin
57997 - Tropomyosin | 2.359e-05 | DIRECT |
54919,54919
54919 - Nucleoside diphosphate kinase, NDK
54919 - Nucleoside diphosphate kinase, NDK | 2.359e-05 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 2.681e-05 | DIRECT |
57903,53335
57903 - FYVE/PHD zinc finger
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 2.736e-05 | DIRECT |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 3.003e-05 | DIRECT |
55545,51445
55545 - beta-N-acetylhexosaminidase-like domain
51445 - (Trans)glycosidases | 4.433e-05 | DIRECT |
58014,51064
58014 - Coiled-coil domain of nucleotide exchange factor GrpE
51064 - Head domain of nucleotide exchange factor GrpE | 5.449e-05 | DIRECT |
50729,82185
50729 - PH domain-like
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 7.369e-05 | DIRECT |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 9.137e-05 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.0001133 | DIRECT |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0001366 | DIRECT |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0.0001687 | DIRECT |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0.0002062 | DIRECT |
48726,49899
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases | 0.0002873 | DIRECT |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0.0003486 | DIRECT |
50156,103657
50156 - PDZ domain-like
103657 - BAR/IMD domain-like | 0.0003486 | DIRECT |
55666,54791
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0003732 | DIRECT |
54791,50249
54791 - Eukaryotic type KH-domain (KH-domain type I)
50249 - Nucleic acid-binding proteins | 0.0003732 | DIRECT |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0.0004685 | DIRECT |
52540,50729
52540 - P-loop containing nucleoside triphosphate hydrolases
50729 - PH domain-like | 0.0004849 | DIRECT |
63825,57184
63825 - YWTD domain
57184 - Growth factor receptor domain | 0.0005129 | DIRECT |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.0005915 | DIRECT |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.0006168 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0008734 | DIRECT |
110217,81296
110217 - DNA-binding protein LAG-1 (CSL)
81296 - E set domains | 0.0009016 | DIRECT |
48371,52540
48371 - ARM repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0009016 | DIRECT |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0009083 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.02806 | INHERITED FROM: establishment of protein localization to membrane || protein targeting to plasma membrane || protein localization to membrane || protein localization || establishment of protein localization to plasma membrane || protein targeting to membrane |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.01968 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein targeting to plasma membrane || protein localization to membrane || protein targeting || protein localization || establishment of protein localization to plasma membrane || protein targeting to membrane || establishment of protein localization |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.004696 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein localization to plasma membrane || cellular macromolecule localization || protein targeting to plasma membrane || protein localization to membrane || cellular protein localization || protein targeting || establishment of protein localization to plasma membrane || intracellular protein transport || protein targeting to membrane || establishment of protein localization |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02292 | INHERITED FROM: establishment of protein localization to membrane || protein transport || sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein targeting to plasma membrane || interleukin-4 secretion || protein localization to extracellular region || protein targeting || protein localization || cytokine secretion || STAT protein import into nucleus || establishment of protein localization to plasma membrane || establishment of protein localization |
47661,58038
47661 - t-snare proteins
58038 - SNARE fusion complex | 0.9083 | INHERITED FROM: establishment of protein localization to vacuole || protein localization to vacuole |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0.3011 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0.04671 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.1931 | INHERITED FROM: protein localization to plasma membrane || protein localization to membrane |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.007135 | INHERITED FROM: protein localization to membrane || receptor clustering |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.01572 | INHERITED FROM: protein localization to membrane || receptor clustering |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0.004696 | INHERITED FROM: protein localization to membrane || cellular protein localization || protein localization || receptor clustering |
81296,81296
81296 - E set domains
81296 - E set domains | 0.1889 | INHERITED FROM: protein localization to membrane || protein localization to cell surface || protein localization || cytoplasmic sequestering of protein || receptor clustering || maintenance of protein location || maintenance of protein location in cell |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: interferon-gamma secretion || protein localization to membrane || receptor clustering || protein localization to juxtaparanode region of axon || protein localization to paranode region of axon |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.6658 | INHERITED FROM: interferon-gamma secretion || interleukin-4 secretion || cytoskeletal anchoring at plasma membrane || cytokine secretion || maintenance of protein location || maintenance of protein location in cell |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0.002146 | INHERITED FROM: cellular macromolecule localization || cellular protein localization || protein localization || protein targeting to membrane |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.01815 | INHERITED FROM: intracellular protein transmembrane transport || cellular protein localization || protein transmembrane transport |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.2602 | INHERITED FROM: intracellular mRNA localization involved in anterior/posterior axis specification || RNA transport || intracellular mRNA localization involved in pattern specification process || intracellular mRNA localization || RNA localization || establishment of RNA localization || pole plasm oskar mRNA localization |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.05085 | INHERITED FROM: establishment of spindle localization || establishment of meiotic spindle localization || protein localization || protein complex localization || spindle localization |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | INHERITED FROM: establishment of spindle localization || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || spindle localization || protein localization to juxtaparanode region of axon || establishment of spindle orientation || protein localization to synapse || protein localization to paranode region of axon |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.7045 | INHERITED FROM: establishment of spindle localization || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || spindle localization || protein localization to synapse |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0.05134 | INHERITED FROM: cytoplasmic sequestering of protein || maintenance of protein location || cortical protein anchoring || maintenance of protein location in cell |
47862,47862
47862 - Saposin
47862 - Saposin | 0.01644 | INHERITED FROM: RNA transport || RNA localization || establishment of RNA localization || dsRNA transport |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 1 | INHERITED FROM: RNA transport || RNA localization |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0.2046 | INHERITED FROM: maintenance of protein location || maintenance of protein location in cell |
49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.04334 | INHERITED FROM: asymmetric protein localization involved in cell fate determination || asymmetric protein localization |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0.8798 | INHERITED FROM: sequestering of actin monomers || maintenance of protein location |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.01928 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || establishment of RNA localization |
46915,54211
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
55666,46915
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
52821,52821
52821 - Rhodanese/Cell cycle control phosphatase
52821 - Rhodanese/Cell cycle control phosphatase | 0.002506 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 1 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || cytokine secretion || STAT protein import into nucleus || apical protein localization |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0222 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || protein localization || STAT protein import into nucleus || protein import into nucleus |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0.004696 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.004696 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.1327 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.1327 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.0565 | INHERITED FROM: protein localization to synapse |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.668 | INHERITED FROM: protein localization to synapse |
50729,47912
50729 - PH domain-like
47912 - Wiscott-Aldrich syndrome protein, WASP, C-terminal domain | 0.01868 | INHERITED FROM: cellular protein complex localization || cellular protein localization || protein localization || protein complex localization || spindle localization |
64356,58038
64356 - SNARE-like
58038 - SNARE fusion complex | 0.5085 | INHERITED FROM: cellular protein localization |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 1 | INHERITED FROM: protein localization to nucleus || protein targeting to nucleus || STAT protein import into nucleus || protein import into nucleus |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1101 | INHERITED FROM: protein localization to nucleus || protein import || protein targeting to nucleus || STAT protein import into nucleus || protein import into nucleus |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0.1742 | INHERITED FROM: protein localization to nucleus || protein import || protein targeting to nucleus || protein import into nucleus, translocation || protein import into nucleus |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.07752 | INHERITED FROM: protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein targeting to ER || protein complex localization || protein transmembrane transport || spindle localization || SRP-dependent cotranslational protein targeting to membrane, translocation |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.06927 | INHERITED FROM: protein localization to organelle || protein localization to nucleus || protein import || protein targeting || protein targeting to nucleus || STAT protein import into nucleus || protein import into nucleus |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.2582 | INHERITED FROM: protein localization to organelle || protein localization to nucleus || protein import || protein targeting || protein targeting to nucleus || protein import into nucleus |
55166,51294
55166 - Hedgehog/DD-peptidase
51294 - Hedgehog/intein (Hint) domain | 0.1025 | INHERITED FROM: protein localization to organelle || protein localization to nucleus |
82109,82109
82109 - MIR domain
82109 - MIR domain | 1 | INHERITED FROM: protein localization to organelle |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0.04007 | INHERITED FROM: protein complex localization |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0.06174 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || protein localization |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || protein localization |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08005 | INHERITED FROM: retrograde protein transport, ER to cytosol || mRNA export from nucleus || intracellular protein transmembrane transport || establishment of protein localization to peroxisome || protein targeting to peroxisome || poly(A)+ mRNA export from nucleus || protein import || intracellular protein transmembrane import || protein transmembrane transport || protein localization to peroxisome |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1931 | INHERITED FROM: lipid storage || lipid localization |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.03194 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || intracellular sterol transport || lipid transport || establishment of protein localization to vacuole || intracellular lipid transport || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome || lipid localization |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.0919 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || intracellular sterol transport || lipid transport || intracellular lipid transport || intracellular cholesterol transport || lipid localization || cholesterol transport |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2981 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || lipid transport || establishment of protein localization to vacuole || intracellular lipid transport || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome || lipid localization |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.244 | INHERITED FROM: sterol transport || fatty acid transport || protein secretion || reverse cholesterol transport || immunoglobulin secretion involved in immune response || immunoglobulin secretion || cholesterol transport |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.004571 | INHERITED FROM: sterol transport || lipid transport || protein localization to nucleus || protein import || protein targeting to nucleus || STAT protein import into nucleus || lipid localization || protein import into nucleus |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.01106 | INHERITED FROM: sterol transport || lipid transport || lipid localization || cholesterol transport |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1454 | INHERITED FROM: sterol transport || lipid transport || lipid localization || cholesterol transport |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | INHERITED FROM: peroxisomal long-chain fatty acid import || lipid transport || lipid localization || cholesterol transport |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.005454 | INHERITED FROM: fatty acid transport || fatty acid transmembrane transport || lipid transport || carnitine shuttle || intracellular lipid transport || lipid localization |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.4412 | INHERITED FROM: fatty acid transport || lipid transport || lipid localization |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.01372 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein localization || protein targeting to vacuole || protein localization to vacuole || establishment of protein localization |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0.01868 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0.02985 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.01868 | INHERITED FROM: protein transport || interleukin-4 secretion || protein secretion || cytokine secretion || establishment of protein localization |
49417,110217
49417 - p53-like transcription factors
110217 - DNA-binding protein LAG-1 (CSL) | 0.001471 | INHERITED FROM: protein transport || interleukin-4 secretion || protein secretion || protein localization || cytokine secretion || establishment of protein localization |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0.001408 | INHERITED FROM: protein transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || protein localization || posttranslational protein targeting to membrane || protein targeting to ER || protein targeting to membrane || establishment of protein localization |
52833,47933
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0.01416 | INHERITED FROM: protein transport || cellular macromolecule localization || cellular protein localization || protein localization || intracellular protein transport |
46565,158702
46565 - Chaperone J-domain
158702 - Sec63 N-terminal domain-like | 0.01416 | INHERITED FROM: protein transport || cellular macromolecule localization || cellular protein localization || protein targeting || intracellular protein transport |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.007071 | INHERITED FROM: protein transport || cellular macromolecule localization || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein targeting to nucleus || STAT protein import into nucleus || intracellular protein transport || protein import into nucleus || establishment of protein localization |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.01266 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.02538 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0.04199 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.06743 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0.0283 | INHERITED FROM: protein transport || cellular protein localization || protein localization || establishment of protein localization |
140111,140427
140111 - Endosomal sorting complex assembly domain
140427 - VPS28 C-terminal domain-like | 0.01868 | INHERITED FROM: protein transport || cellular protein localization || protein targeting || establishment of protein localization to vacuole || protein localization || protein targeting to vacuole || protein localization to vacuole |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0.002506 | INHERITED FROM: protein transport || protein localization to organelle || cellular macromolecule localization || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein localization || protein targeting to nucleus || protein import into nucleus, translocation || intracellular protein transport || protein import into nucleus || establishment of protein localization |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01643 | INHERITED FROM: protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0.181 | INHERITED FROM: protein transport || secretion of lysosomal enzymes |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0.007071 | INHERITED FROM: protein transport || protein localization || intracellular protein transport |
48371,49348
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain | 0.07518 | INHERITED FROM: protein transport || protein localization |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 1 | INHERITED FROM: lipid localization |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | INHERITED FROM: mRNA localization resulting in posttranscriptional regulation of gene expression |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05223 | INHERITED FROM: protein secretion || interleukin-1 secretion |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.4387 | INHERITED FROM: intracellular mRNA localization || RNA localization |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0.01815 | INHERITED FROM: asymmetric protein localization || protein localization |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04771 | INHERITED FROM: protein localization || receptor clustering || protein localization to paranode region of axon || apical protein localization |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0.244 | INHERITED FROM: protein localization || protein localization to paranode region of axon |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.001234 | INHERITED FROM: protein localization |
101288,101288
101288 - L27 domain
101288 - L27 domain | 0.08583 | INHERITED FROM: protein localization |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.05932 | INHERITED FROM: cytoplasmic sequestering of NF-kappaB || cytoplasmic sequestering of transcription factor || cytoplasmic sequestering of protein || maintenance of protein location in cell |
116846,52540
116846 - MIT domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001408 | INHERITED FROM: lipid transport || cellular protein localization || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole || cholesterol transport |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0.2234 | INHERITED FROM: lipid transport || phospholipid transport || lipid localization |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0.05542 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion || establishment of protein localization to organelle |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.5716 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.8648 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.9874 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0.002209 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || cellular macromolecule localization || protein localization to mitochondrion || establishment of protein localization to mitochondrion || cellular protein localization || protein targeting || establishment of protein localization to organelle || protein localization || intracellular protein transport || establishment of protein localization |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.04463 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || protein localization to mitochondrion || establishment of protein localization to mitochondrion || protein targeting || establishment of protein localization to organelle || intracellular protein transport || protein processing involved in protein targeting to mitochondrion |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
52200,52540
52200 - Toll/Interleukin receptor TIR domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0195 | INHERITED FROM: protein targeting to membrane |
52047,52058
52047 - RNI-like
52058 - L domain-like | 0.05783 | INHERITED FROM: protein targeting to membrane |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0.2777 | INHERITED FROM: protein targeting to membrane |
52058,56112
52058 - L domain-like
56112 - Protein kinase-like (PK-like) | 0.5128 | INHERITED FROM: protein targeting to membrane |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.002685 | INHERITED FROM: protein targeting || protein localization |
56112,47473
56112 - Protein kinase-like (PK-like)
47473 - EF-hand | 0.03126 | INHERITED FROM: protein targeting || intracellular protein transport || protein targeting to membrane |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.07158 | INHERITED FROM: RNA localization |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.9083 | INHERITED FROM: establishment of mitotic spindle orientation || protein complex localization || establishment of spindle orientation |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0 | Direct |
53697,53697
53697 - SIS domain
53697 - SIS domain | 0 | Direct |
103652,50729
103652 - G protein-binding domain
50729 - PH domain-like | 0 | Direct |
57302,56112
57302 - Snake toxin-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
46966,75399
46966 - Spectrin repeat
75399 - Plakin repeat | 0 | Direct |
51045,50156
51045 - WW domain
50156 - PDZ domain-like | 1.24e-15 | Direct |
52058,54427
52058 - L domain-like
54427 - NTF2-like | 5.665e-14 | Direct |
51445,54556
51445 - (Trans)glycosidases
54556 - Chitinase insertion domain | 2.312e-12 | Direct |
54427,46934
54427 - NTF2-like
46934 - UBA-like | 2.319e-12 | Direct |
54928,52058
54928 - RNA-binding domain, RBD
52058 - L domain-like | 3.413e-11 | Direct |
64593,74853
64593 - Intermediate filament protein, coiled coil region
74853 - Lamin A/C globular tail domain | 5.606e-10 | Direct |
52540,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 1.729e-09 | Direct |
47031,50729
47031 - Second domain of FERM
50729 - PH domain-like | 6.1e-09 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 7.426e-09 | Direct |
50729,90209
50729 - PH domain-like
90209 - Ran binding protein zinc finger-like | 1.338e-08 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 5.746e-08 | Direct |
81383,117281
81383 - F-box domain
117281 - Kelch motif | 6.751e-08 | Direct |
48403,74924
48403 - Ankyrin repeat
74924 - Cap-Gly domain | 8.069e-08 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 1.022e-07 | Direct |
54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 1.28e-07 | Direct |
56112,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain | 1.555e-07 | Direct |
47364,52540
47364 - Domain of the SRP/SRP receptor G-proteins
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.86e-07 | Direct |
47576,140612
47576 - Calponin-homology domain, CH-domain
140612 - EB1 dimerisation domain-like | 2.06e-07 | Direct |
50044,50156
50044 - SH3-domain
50156 - PDZ domain-like | 2.74e-07 | Direct |
51045,51045
51045 - WW domain
51045 - WW domain | 3.693e-07 | Direct |
48403,56112
48403 - Ankyrin repeat
56112 - Protein kinase-like (PK-like) | 4.306e-07 | Direct |
57196,56496
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like | 5.471e-07 | Direct |
56496,49899
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | Direct |
46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat | 1.02e-06 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 1.282e-06 | Direct |
57196,48726
57196 - EGF/Laminin
48726 - Immunoglobulin | 1.516e-06 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 1.595e-06 | Direct |
68906,57850
68906 - SAP domain
57850 - RING/U-box | 1.769e-06 | Direct |
109925,50978
109925 - Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain
50978 - WD40 repeat-like | 1.939e-06 | Direct |
54277,57889
54277 - CAD & PB1 domains
57889 - Cysteine-rich domain | 1.939e-06 | Direct |
47473,143575
47473 - EF-hand
143575 - GAS2 domain-like | 2.677e-06 | Direct |
52540,81886
52540 - P-loop containing nucleoside triphosphate hydrolases
81886 - Helical scaffold and wing domains of SecA | 4.731e-06 | Direct |
50242,100895
50242 - TIMP-like
100895 - Kazal-type serine protease inhibitors | 6.307e-06 | Direct |
54631,54631
54631 - CBS-domain pair
54631 - CBS-domain pair | 9.683e-06 | Direct |
52540,47446
52540 - P-loop containing nucleoside triphosphate hydrolases
47446 - Signal peptide-binding domain | 1.062e-05 | Direct |
81767,52540
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.144e-05 | Direct |
52540,81767
52540 - P-loop containing nucleoside triphosphate hydrolases
81767 - Pre-protein crosslinking domain of SecA | 1.144e-05 | Direct |
82615,82615
82615 - Polo-box domain
82615 - Polo-box domain | 1.344e-05 | Direct |
48431,56968
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 1.534e-05 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 1.564e-05 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 1.992e-05 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 1.992e-05 | Direct |
57997,57997
57997 - Tropomyosin
57997 - Tropomyosin | 2.359e-05 | Direct |
54919,54919
54919 - Nucleoside diphosphate kinase, NDK
54919 - Nucleoside diphosphate kinase, NDK | 2.359e-05 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 2.681e-05 | Direct |
57903,53335
57903 - FYVE/PHD zinc finger
53335 - S-adenosyl-L-methionine-dependent methyltransferases | 2.736e-05 | Direct |
57581,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 3.003e-05 | Direct |
55545,51445
55545 - beta-N-acetylhexosaminidase-like domain
51445 - (Trans)glycosidases | 4.433e-05 | Direct |
58014,51064
58014 - Coiled-coil domain of nucleotide exchange factor GrpE
51064 - Head domain of nucleotide exchange factor GrpE | 5.449e-05 | Direct |
50729,82185
50729 - PH domain-like
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 7.369e-05 | Direct |
51045,56204
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 9.137e-05 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0.0001133 | Direct |
64356,49447
64356 - SNARE-like
49447 - Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor | 0.0001366 | Direct |
57630,57184
57630 - GLA-domain
57184 - Growth factor receptor domain | 0.0001687 | Direct |
49348,55711
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0.0002062 | Direct |
48726,49899
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases | 0.0002873 | Direct |
49417,47719
49417 - p53-like transcription factors
47719 - p53 tetramerization domain | 0.0003486 | Direct |
50156,103657
50156 - PDZ domain-like
103657 - BAR/IMD domain-like | 0.0003486 | Direct |
55666,54791
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0003732 | Direct |
54791,50249
54791 - Eukaryotic type KH-domain (KH-domain type I)
50249 - Nucleic acid-binding proteins | 0.0003732 | Direct |
74924,74924
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0.0004685 | Direct |
52540,50729
52540 - P-loop containing nucleoside triphosphate hydrolases
50729 - PH domain-like | 0.0004849 | Direct |
63825,57184
63825 - YWTD domain
57184 - Growth factor receptor domain | 0.0005129 | Direct |
55781,109604
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.0005915 | Direct |
47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.0006168 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.0008734 | Direct |
110217,81296
110217 - DNA-binding protein LAG-1 (CSL)
81296 - E set domains | 0.0009016 | Direct |
48371,52540
48371 - ARM repeat
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0009016 | Direct |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.0009083 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.02806 | Inherited |
57184,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.01968 | Inherited |
57630,57196
57630 - GLA-domain
57196 - EGF/Laminin | 0.004696 | Inherited |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.02292 | Inherited |
47661,58038
47661 - t-snare proteins
58038 - SNARE fusion complex | 0.9083 | Inherited |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0.3011 | Inherited |
52025,53187
52025 - PA domain
53187 - Zn-dependent exopeptidases | 0.04671 | Inherited |
48403,48403
48403 - Ankyrin repeat
48403 - Ankyrin repeat | 0.1931 | Inherited |
50156,52540
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.007135 | Inherited |
100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.01572 | Inherited |
57196,100895
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0.004696 | Inherited |
81296,81296
81296 - E set domains
81296 - E set domains | 0.1889 | Inherited |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.6658 | Inherited |
64268,50044
64268 - PX domain
50044 - SH3-domain | 0.002146 | Inherited |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0.01815 | Inherited |
54928,54928
54928 - RNA-binding domain, RBD
54928 - RNA-binding domain, RBD | 0.2602 | Inherited |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.05085 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.7045 | Inherited |
50729,57889
50729 - PH domain-like
57889 - Cysteine-rich domain | 0.05134 | Inherited |
47862,47862
47862 - Saposin
47862 - Saposin | 0.01644 | Inherited |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 1 | Inherited |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 1 | Inherited |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 1 | Inherited |
57889,48350
57889 - Cysteine-rich domain
48350 - GTPase activation domain, GAP | 0.2046 | Inherited |
49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.04334 | Inherited |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0.8798 | Inherited |
54211,55666
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.01928 | Inherited |
46915,54211
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like | 0.001115 | Inherited |
55666,46915
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | Inherited |
52821,52821
52821 - Rhodanese/Cell cycle control phosphatase
52821 - Rhodanese/Cell cycle control phosphatase | 0.002506 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 1 | Inherited |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.0222 | Inherited |
57581,57581
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 0.004696 | Inherited |
57184,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.004696 | Inherited |
57581,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.1327 | Inherited |
57196,57581
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.1327 | Inherited |
52799,52799
52799 - (Phosphotyrosine protein) phosphatases II
52799 - (Phosphotyrosine protein) phosphatases II | 0.0565 | Inherited |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0.668 | Inherited |
50729,47912
50729 - PH domain-like
47912 - Wiscott-Aldrich syndrome protein, WASP, C-terminal domain | 0.01868 | Inherited |
64356,58038
64356 - SNARE-like
58038 - SNARE fusion complex | 0.5085 | Inherited |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 1 | Inherited |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0.1101 | Inherited |
57863,48403
57863 - ArfGap/RecO-like zinc finger
48403 - Ankyrin repeat | 0.1742 | Inherited |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0.07752 | Inherited |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.06927 | Inherited |
90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.2582 | Inherited |
55166,51294
55166 - Hedgehog/DD-peptidase
51294 - Hedgehog/intein (Hint) domain | 0.1025 | Inherited |
82109,82109
82109 - MIR domain
82109 - MIR domain | 1 | Inherited |
54534,54534
54534 - FKBP-like
54534 - FKBP-like | 0.04007 | Inherited |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0.06174 | Inherited |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | Inherited |
52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.08005 | Inherited |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0.1931 | Inherited |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0.03194 | Inherited |
57196,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.0919 | Inherited |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.2981 | Inherited |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0.244 | Inherited |
57184,63825
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.004571 | Inherited |
53474,49723
53474 - alpha/beta-Hydrolases
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain) | 0.01106 | Inherited |
57424,57184
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1454 | Inherited |
90123,52540
90123 - ABC transporter transmembrane region
52540 - P-loop containing nucleoside triphosphate hydrolases | 1 | Inherited |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0.005454 | Inherited |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0.4412 | Inherited |
48464,89009
48464 - ENTH/VHS domain
89009 - GAT-like domain | 0.01372 | Inherited |
53187,47672
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0.01868 | Inherited |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0.02985 | Inherited |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0.01868 | Inherited |
49417,110217
49417 - p53-like transcription factors
110217 - DNA-binding protein LAG-1 (CSL) | 0.001471 | Inherited |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0.001408 | Inherited |
52833,47933
52833 - Thioredoxin-like
47933 - ERP29 C domain-like | 0.01416 | Inherited |
46565,158702
46565 - Chaperone J-domain
158702 - Sec63 N-terminal domain-like | 0.01416 | Inherited |
50729,55550
50729 - PH domain-like
55550 - SH2 domain | 0.007071 | Inherited |
53300,81995
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.01266 | Inherited |
81995,81811
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.02538 | Inherited |
82919,53300
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like | 0.04199 | Inherited |
81811,82754
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.06743 | Inherited |
64268,103657
64268 - PX domain
103657 - BAR/IMD domain-like | 0.0283 | Inherited |
140111,140427
140111 - Endosomal sorting complex assembly domain
140427 - VPS28 C-terminal domain-like | 0.01868 | Inherited |
52425,48173
52425 - Cryptochrome/photolyase, N-terminal domain
48173 - Cryptochrome/photolyase FAD-binding domain | 0.002506 | Inherited |
100920,100934
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01643 | Inherited |
50729,81837
50729 - PH domain-like
81837 - BEACH domain | 0.181 | Inherited |
50729,50156
50729 - PH domain-like
50156 - PDZ domain-like | 0.007071 | Inherited |
48371,49348
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain | 0.07518 | Inherited |
103473,100895
103473 - MFS general substrate transporter
100895 - Kazal-type serine protease inhibitors | 1 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 1 | Inherited |
47986,52540
47986 - DEATH domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.05223 | Inherited |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.4387 | Inherited |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0.01815 | Inherited |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.04771 | Inherited |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0.244 | Inherited |
52113,52113
52113 - BRCT domain
52113 - BRCT domain | 0.001234 | Inherited |
101288,101288
101288 - L27 domain
101288 - L27 domain | 0.08583 | Inherited |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0.05932 | Inherited |
116846,52540
116846 - MIT domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.001408 | Inherited |
46938,52087
46938 - CRAL/TRIO N-terminal domain
52087 - CRAL/TRIO domain | 0.2234 | Inherited |
54534,48452
54534 - FKBP-like
48452 - TPR-like | 0.05542 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.5716 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.8648 | Inherited |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0.9874 | Inherited |
55781,55781
55781 - GAF domain-like
55781 - GAF domain-like | 0.002209 | Inherited |
63411,63411
63411 - LuxS/MPP-like metallohydrolase
63411 - LuxS/MPP-like metallohydrolase | 0.04463 | Inherited |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | Inherited |
52200,52540
52200 - Toll/Interleukin receptor TIR domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0195 | Inherited |
52047,52058
52047 - RNI-like
52058 - L domain-like | 0.05783 | Inherited |
52058,52047
52058 - L domain-like
52047 - RNI-like | 0.2777 | Inherited |
52058,56112
52058 - L domain-like
56112 - Protein kinase-like (PK-like) | 0.5128 | Inherited |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0.002685 | Inherited |
56112,47473
56112 - Protein kinase-like (PK-like)
47473 - EF-hand | 0.03126 | Inherited |
101690,53098
101690 - PAZ domain
53098 - Ribonuclease H-like | 0.07158 | Inherited |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0.9083 | Inherited |
(show details)
Supra-domains annotated to this GO term (Not in SPFO)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46966,75399,75399
46966 - Spectrin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
57184,57184,63825
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | DIRECT |
63825,57184,57184
63825 - YWTD domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57196,100895
57196 - EGF/Laminin
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | DIRECT |
48403,74924,74924
48403 - Ankyrin repeat
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | DIRECT |
51045,51045,50156
51045 - WW domain
51045 - WW domain
50156 - PDZ domain-like | 0 | DIRECT |
103652,50729,57889
103652 - G protein-binding domain
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | DIRECT |
57630,57196,57184
57630 - GLA-domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
54928,52058,54427
54928 - RNA-binding domain, RBD
52058 - L domain-like
54427 - NTF2-like | 3.413e-11 | DIRECT |
52058,54427,46934
52058 - L domain-like
54427 - NTF2-like
46934 - UBA-like | 4.823e-10 | DIRECT |
50156,50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 6.311e-10 | DIRECT |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 1.002e-09 | DIRECT |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 6.946e-09 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 2.787e-08 | DIRECT |
49785,49899,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 4.222e-08 | DIRECT |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 7.157e-08 | DIRECT |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 1.555e-07 | DIRECT |
57196,57196,48726
57196 - EGF/Laminin
57196 - EGF/Laminin
48726 - Immunoglobulin | 2.929e-07 | DIRECT |
57196,48726,48726
57196 - EGF/Laminin
48726 - Immunoglobulin
48726 - Immunoglobulin | 2.929e-07 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 3.994e-07 | DIRECT |
49899,57196,56496
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like | 5.471e-07 | DIRECT |
57196,56496,49899
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | DIRECT |
56496,49899,49899
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | DIRECT |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 8.874e-07 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 1.282e-06 | DIRECT |
81767,52540,81886
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases
81886 - Helical scaffold and wing domains of SecA | 4.731e-06 | DIRECT |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 5.949e-06 | DIRECT |
57630,57184,57196
57630 - GLA-domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 6.307e-06 | DIRECT |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 1.062e-05 | DIRECT |
52540,81767,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.144e-05 | DIRECT |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 1.144e-05 | DIRECT |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 1.534e-05 | DIRECT |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 1.56e-05 | DIRECT |
57196,57184,63825
57196 - EGF/Laminin
57184 - Growth factor receptor domain
63825 - YWTD domain | 2.736e-05 | DIRECT |
48726,49899,57196
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 2.909e-05 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 3.063e-05 | DIRECT |
57581,57184,57196
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 4.359e-05 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 4.818e-05 | DIRECT |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 6.347e-05 | DIRECT |
50729,82185,82185
50729 - PH domain-like
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 7.369e-05 | DIRECT |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 7.426e-05 | DIRECT |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 9.137e-05 | DIRECT |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.0002639 | DIRECT |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.000283 | DIRECT |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.0002878 | DIRECT |
47031,50729,55550
47031 - Second domain of FERM
50729 - PH domain-like
55550 - SH2 domain | 0.0002892 | DIRECT |
54211,55666,54791
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0003732 | DIRECT |
55666,54791,50249
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I)
50249 - Nucleic acid-binding proteins | 0.0003732 | DIRECT |
57581,57581,57184
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0.0004849 | DIRECT |
48371,52540,52540
48371 - ARM repeat
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0006866 | DIRECT |
57581,57196,57184
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0007551 | DIRECT |
57184,57196,57581
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0007551 | DIRECT |
49417,110217,81296
49417 - p53-like transcription factors
110217 - DNA-binding protein LAG-1 (CSL)
81296 - E set domains | 0.0009016 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.001408 | INHERITED FROM: establishment of protein localization to membrane || protein targeting to plasma membrane || protein localization to membrane || protein localization || establishment of protein localization to plasma membrane || protein targeting to membrane |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.09604 | INHERITED FROM: establishment of protein localization to membrane || protein localization to membrane || postsynaptic density protein 95 clustering || neuroligin clustering || protein localization || establishment of protein localization to plasma membrane || gephyrin clustering |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.4351 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein targeting to plasma membrane || protein localization to membrane || protein targeting || establishment of protein localization to plasma membrane || intracellular protein transport || protein targeting to membrane || establishment of protein localization |
57630,57184,49899
57630 - GLA-domain
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.004696 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein localization to plasma membrane || protein targeting to plasma membrane || protein localization to membrane || cellular protein localization || protein targeting || protein localization || establishment of protein localization to plasma membrane || intracellular protein transport || protein targeting to membrane || establishment of protein localization |
57184,57196,49899
57184 - Growth factor receptor domain
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.01416 | INHERITED FROM: establishment of protein localization to membrane || protein transport || protein localization to plasma membrane || cellular macromolecule localization || protein targeting to plasma membrane || protein localization to membrane || cellular protein localization || protein targeting || protein localization || establishment of protein localization to plasma membrane || intracellular protein transport || protein targeting to membrane || establishment of protein localization |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.04089 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.2019 | INHERITED FROM: establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.007398 | INHERITED FROM: protein localization to membrane || cellular protein localization || receptor clustering |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.219 | INHERITED FROM: protein localization to membrane || protein localization to cell surface || protein localization || cytoplasmic sequestering of protein || receptor clustering || maintenance of protein location || maintenance of protein location in cell |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | INHERITED FROM: interferon-gamma secretion || protein localization to membrane || establishment of mitotic spindle orientation || receptor clustering || protein localization to juxtaparanode region of axon || protein localization to paranode region of axon |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9096 | INHERITED FROM: interleukin-4 secretion || protein secretion || cytokine secretion |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.108 | INHERITED FROM: interleukin-4 secretion || protein localization |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0.002149 | INHERITED FROM: cellular macromolecule localization || protein localization to membrane || cellular protein localization || receptor clustering |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.003189 | INHERITED FROM: cellular macromolecule localization || cellular protein localization || cytoskeletal anchoring at plasma membrane || protein localization || maintenance of protein location || maintenance of protein location in cell |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0.001555 | INHERITED FROM: cellular macromolecule localization || cellular protein localization || protein targeting || protein localization || protein targeting to membrane |
63882,53218,63867
63882 - MoeA N-terminal region -like
53218 - Molybdenum cofactor biosynthesis proteins
63867 - MoeA C-terminal domain-like | 0.004676 | INHERITED FROM: cellular macromolecule localization || cellular protein localization |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04923 | INHERITED FROM: establishment of spindle localization || protein localization to plasma membrane || protein localization to membrane || establishment of mitotic spindle localization || protein localization || protein complex localization || spindle localization |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | INHERITED FROM: establishment of spindle localization || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || protein complex localization || spindle localization || protein localization to juxtaparanode region of axon || establishment of spindle orientation || protein localization to paranode region of axon |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.02149 | INHERITED FROM: establishment of spindle localization || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || protein complex localization || spindle localization || establishment of spindle orientation || protein localization to synapse |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3581 | INHERITED FROM: establishment of spindle localization || establishment of mitotic spindle orientation || establishment of mitotic spindle localization || protein complex localization || spindle localization |
47862,47862,47862
47862 - Saposin
47862 - Saposin
47862 - Saposin | 0.01926 | INHERITED FROM: RNA transport || RNA localization || establishment of RNA localization || dsRNA transport |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 1 | INHERITED FROM: phospholipid translocation || lipid translocation || lipid transport || phospholipid transport || aminophospholipid transport || lipid localization |
49599,49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.002751 | INHERITED FROM: asymmetric protein localization involved in cell fate determination || asymmetric protein localization |
55666,46915,54211
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
46915,54211,55666
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
54211,55666,46915
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | INHERITED FROM: rRNA import into mitochondrion || RNA import into mitochondrion || RNA transport || rRNA transport || RNA localization || establishment of RNA localization |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2083 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || protein secretion || maintenance of protein location |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01287 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || protein secretion || protein localization || cytokine secretion |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02985 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || protein secretion || protein localization |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.01815 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || interleukin-4 secretion || protein localization to extracellular region || protein localization || cytokine secretion |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.01416 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || maintenance of protein location |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.01416 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || maintenance of protein location |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.07143 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || maintenance of protein location |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3582 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || maintenance of protein location |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05932 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.05932 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0919 | INHERITED FROM: sequestering of TGFbeta in extracellular matrix || maintenance of protein location in extracellular region || protein localization to extracellular region || protein localization || maintenance of protein location |
90209,90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.04807 | INHERITED FROM: protein localization to organelle || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein localization || protein targeting to nucleus || protein import into nucleus |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || protein localization |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | INHERITED FROM: retrograde protein transport, ER to cytosol || protein transport || protein localization |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.0919 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || intracellular sterol transport || lipid transport || intracellular lipid transport || intracellular cholesterol transport || lipid localization || cholesterol transport |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.0919 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || intracellular sterol transport || lipid transport || intracellular lipid transport || intracellular cholesterol transport || lipid localization || cholesterol transport |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1927 | INHERITED FROM: sterol transport || receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport || lipid transport || establishment of protein localization to vacuole || intracellular lipid transport || protein targeting to vacuole || protein localization to vacuole || protein targeting to lysosome || lipid localization |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1454 | INHERITED FROM: sterol transport || lipid transport || lipid localization || cholesterol transport |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1454 | INHERITED FROM: sterol transport || lipid transport || lipid localization || cholesterol transport |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0.01868 | INHERITED FROM: protein transport || establishment of protein localization to vacuole || protein targeting to vacuole || protein localization to vacuole |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0.01868 | INHERITED FROM: protein transport || interleukin-4 secretion || protein secretion || protein localization || cytokine secretion || establishment of protein localization |
82919,53300,81995
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.007936 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.02538 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.02538 | INHERITED FROM: protein transport || cellular protein localization || protein localization to cell surface || protein localization |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.001834 | INHERITED FROM: protein transport || protein localization to organelle || cellular macromolecule localization || protein localization to nucleus || protein import || cellular protein localization || protein targeting || protein localization || protein targeting to nucleus || STAT protein import into nucleus || intracellular protein transport || protein import into nucleus || establishment of protein localization |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01643 | INHERITED FROM: protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.007071 | INHERITED FROM: protein transport || protein localization || intracellular protein transport |
48371,49348,55711
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0.3483 | INHERITED FROM: protein transport || protein localization |
57424,57424,57196
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0.8278 | INHERITED FROM: protein transport |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.07933 | INHERITED FROM: intracellular mRNA localization || RNA localization |
49899,49899,57196
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.003153 | INHERITED FROM: protein localization || protein localization to paranode region of axon || apical protein localization |
48726,48726,49899
48726 - Immunoglobulin
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases | 0.001294 | INHERITED FROM: protein localization |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0.003381 | INHERITED FROM: protein localization |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.03489 | INHERITED FROM: protein localization |
101288,101288,50156
101288 - L27 domain
101288 - L27 domain
50156 - PDZ domain-like | 0.08583 | INHERITED FROM: protein localization |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.0919 | INHERITED FROM: protein localization |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1374 | INHERITED FROM: cytoskeletal anchoring at plasma membrane || maintenance of protein location || maintenance of protein location in cell |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.8513 | INHERITED FROM: protein targeting to mitochondrion || protein localization to mitochondrion || establishment of protein localization to mitochondrion |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | INHERITED FROM: protein targeting to mitochondrion || protein transport || protein localization to organelle || intracellular protein transmembrane transport || establishment of protein localization to endoplasmic reticulum || protein localization to endoplasmic reticulum || protein targeting || establishment of protein localization to organelle || cotranslational protein targeting to membrane || protein localization || protein targeting to ER || SRP-dependent cotranslational protein targeting to membrane || protein transmembrane transport || SRP-dependent cotranslational protein targeting to membrane, translocation || establishment of protein localization |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.009387 | INHERITED FROM: mRNA export from nucleus || RNA transport || RNA localization || establishment of RNA localization |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
46966,75399,75399
46966 - Spectrin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
57184,57184,63825
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
63825 - YWTD domain | 0 | Direct |
63825,57184,57184
63825 - YWTD domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
57196,57196,100895
57196 - EGF/Laminin
57196 - EGF/Laminin
100895 - Kazal-type serine protease inhibitors | 0 | Direct |
48403,74924,74924
48403 - Ankyrin repeat
74924 - Cap-Gly domain
74924 - Cap-Gly domain | 0 | Direct |
51045,51045,50156
51045 - WW domain
51045 - WW domain
50156 - PDZ domain-like | 0 | Direct |
103652,50729,57889
103652 - G protein-binding domain
50729 - PH domain-like
57889 - Cysteine-rich domain | 0 | Direct |
57630,57196,57184
57630 - GLA-domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
54928,52058,54427
54928 - RNA-binding domain, RBD
52058 - L domain-like
54427 - NTF2-like | 3.413e-11 | Direct |
52058,54427,46934
52058 - L domain-like
54427 - NTF2-like
46934 - UBA-like | 4.823e-10 | Direct |
50156,50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 6.311e-10 | Direct |
52540,51045,51045
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain
51045 - WW domain | 1.002e-09 | Direct |
54768,54768,54768
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like
54768 - dsRNA-binding domain-like | 6.946e-09 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 2.787e-08 | Direct |
49785,49899,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 4.222e-08 | Direct |
55781,55781,55781
55781 - GAF domain-like
55781 - GAF domain-like
55781 - GAF domain-like | 7.157e-08 | Direct |
56112,82615,82615
56112 - Protein kinase-like (PK-like)
82615 - Polo-box domain
82615 - Polo-box domain | 1.555e-07 | Direct |
57196,57196,48726
57196 - EGF/Laminin
57196 - EGF/Laminin
48726 - Immunoglobulin | 2.929e-07 | Direct |
57196,48726,48726
57196 - EGF/Laminin
48726 - Immunoglobulin
48726 - Immunoglobulin | 2.929e-07 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 3.994e-07 | Direct |
49899,57196,56496
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like | 5.471e-07 | Direct |
57196,56496,49899
57196 - EGF/Laminin
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | Direct |
56496,49899,49899
56496 - Fibrinogen C-terminal domain-like
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 5.471e-07 | Direct |
46966,46966,46966
46966 - Spectrin repeat
46966 - Spectrin repeat
46966 - Spectrin repeat | 8.874e-07 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 1.282e-06 | Direct |
81767,52540,81886
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases
81886 - Helical scaffold and wing domains of SecA | 4.731e-06 | Direct |
49899,57196,49899
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 5.949e-06 | Direct |
57630,57184,57196
57630 - GLA-domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 6.307e-06 | Direct |
57196,57581,57184
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 1.062e-05 | Direct |
52540,81767,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
81767 - Pre-protein crosslinking domain of SecA
52540 - P-loop containing nucleoside triphosphate hydrolases | 1.144e-05 | Direct |
57581,57184,57184
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 1.144e-05 | Direct |
56968,48431,56968
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions | 1.534e-05 | Direct |
57184,49899,49899
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 1.56e-05 | Direct |
57196,57184,63825
57196 - EGF/Laminin
57184 - Growth factor receptor domain
63825 - YWTD domain | 2.736e-05 | Direct |
48726,49899,57196
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 2.909e-05 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 3.063e-05 | Direct |
57581,57184,57196
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 4.359e-05 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 4.818e-05 | Direct |
57196,57581,57196
57196 - EGF/Laminin
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 6.347e-05 | Direct |
50729,82185,82185
50729 - PH domain-like
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
82185 - Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | 7.369e-05 | Direct |
57184,57581,57581
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain | 7.426e-05 | Direct |
51045,51045,56204
51045 - WW domain
51045 - WW domain
56204 - Hect, E3 ligase catalytic domain | 9.137e-05 | Direct |
57581,57184,57581
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.0002639 | Direct |
55781,55781,109604
55781 - GAF domain-like
55781 - GAF domain-like
109604 - HD-domain/PDEase-like | 0.000283 | Direct |
55550,56112,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0.0002878 | Direct |
47031,50729,55550
47031 - Second domain of FERM
50729 - PH domain-like
55550 - SH2 domain | 0.0002892 | Direct |
54211,55666,54791
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.0003732 | Direct |
55666,54791,50249
55666 - Ribonuclease PH domain 2-like
54791 - Eukaryotic type KH-domain (KH-domain type I)
50249 - Nucleic acid-binding proteins | 0.0003732 | Direct |
57581,57581,57184
57581 - TB module/8-cys domain
57581 - TB module/8-cys domain
57184 - Growth factor receptor domain | 0.0004849 | Direct |
48371,52540,52540
48371 - ARM repeat
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.0006866 | Direct |
57581,57196,57184
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.0007551 | Direct |
57184,57196,57581
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0007551 | Direct |
49417,110217,81296
49417 - p53-like transcription factors
110217 - DNA-binding protein LAG-1 (CSL)
81296 - E set domains | 0.0009016 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.001408 | Inherited |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0.09604 | Inherited |
57196,57184,49899
57196 - EGF/Laminin
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.4351 | Inherited |
57630,57184,49899
57630 - GLA-domain
57184 - Growth factor receptor domain
49899 - Concanavalin A-like lectins/glucanases | 0.004696 | Inherited |
57184,57196,49899
57184 - Growth factor receptor domain
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0.01416 | Inherited |
63825,57196,63825
63825 - YWTD domain
57196 - EGF/Laminin
63825 - YWTD domain | 0.04089 | Inherited |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0.2019 | Inherited |
100895,100895,100895
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors
100895 - Kazal-type serine protease inhibitors | 0.007398 | Inherited |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0.219 | Inherited |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 1 | Inherited |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.9096 | Inherited |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.108 | Inherited |
50156,52540,51045
50156 - PDZ domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
51045 - WW domain | 0.002149 | Inherited |
47220,47220,47220
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like
47220 - alpha-catenin/vinculin-like | 0.003189 | Inherited |
64268,50044,50044
64268 - PX domain
50044 - SH3-domain
50044 - SH3-domain | 0.001555 | Inherited |
63882,53218,63867
63882 - MoeA N-terminal region -like
53218 - Molybdenum cofactor biosynthesis proteins
63867 - MoeA C-terminal domain-like | 0.004676 | Inherited |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.04923 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 1 | Inherited |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.02149 | Inherited |
49265,49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.3581 | Inherited |
47862,47862,47862
47862 - Saposin
47862 - Saposin
47862 - Saposin | 0.01926 | Inherited |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 1 | Inherited |
49599,49599,49599
49599 - TRAF domain-like
49599 - TRAF domain-like
49599 - TRAF domain-like | 0.002751 | Inherited |
55666,46915,54211
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like | 0.001115 | Inherited |
46915,54211,55666
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like | 0.001115 | Inherited |
54211,55666,46915
54211 - Ribosomal protein S5 domain 2-like
55666 - Ribonuclease PH domain 2-like
46915 - Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.001115 | Inherited |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.2083 | Inherited |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.01287 | Inherited |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.02985 | Inherited |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0.01815 | Inherited |
57184,57581,57196
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain
57196 - EGF/Laminin | 0.01416 | Inherited |
57184,57184,57581
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57581 - TB module/8-cys domain | 0.01416 | Inherited |
57184,57196,57184
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0.07143 | Inherited |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0.3582 | Inherited |
57581,57196,57196
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.05932 | Inherited |
57196,57196,57581
57196 - EGF/Laminin
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.05932 | Inherited |
57581,57196,57581
57581 - TB module/8-cys domain
57196 - EGF/Laminin
57581 - TB module/8-cys domain | 0.0919 | Inherited |
90209,90209,90209
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like
90209 - Ran binding protein zinc finger-like | 0.04807 | Inherited |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | Inherited |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0.1327 | Inherited |
57196,57424,57424
57196 - EGF/Laminin
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.0919 | Inherited |
63825,57196,57424
63825 - YWTD domain
57196 - EGF/Laminin
57424 - LDL receptor-like module | 0.0919 | Inherited |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0.1927 | Inherited |
57424,57184,63825
57424 - LDL receptor-like module
57184 - Growth factor receptor domain
63825 - YWTD domain | 0.1454 | Inherited |
57424,57424,57184
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57184 - Growth factor receptor domain | 0.1454 | Inherited |
52025,53187,47672
52025 - PA domain
53187 - Zn-dependent exopeptidases
47672 - Transferrin receptor-like dimerisation domain | 0.01868 | Inherited |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0.01868 | Inherited |
82919,53300,81995
82919 - Zn-finger domain of Sec23/24
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24 | 0.007936 | Inherited |
81995,81811,82754
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24
82754 - C-terminal, gelsolin-like domain of Sec23/24 | 0.02538 | Inherited |
53300,81995,81811
53300 - vWA-like
81995 - beta-sandwich domain of Sec23/24
81811 - Helical domain of Sec23/24 | 0.02538 | Inherited |
50729,55550,56112
50729 - PH domain-like
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0.001834 | Inherited |
53067,100920,100934
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.01643 | Inherited |
50729,50156,50156
50729 - PH domain-like
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.007071 | Inherited |
48371,49348,55711
48371 - ARM repeat
49348 - Clathrin adaptor appendage domain
55711 - Subdomain of clathrin and coatomer appendage domain | 0.3483 | Inherited |
57424,57424,57196
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57196 - EGF/Laminin | 0.8278 | Inherited |
54791,54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0.07933 | Inherited |
49899,49899,57196
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.003153 | Inherited |
48726,48726,49899
48726 - Immunoglobulin
48726 - Immunoglobulin
49899 - Concanavalin A-like lectins/glucanases | 0.001294 | Inherited |
101288,50156,50044
101288 - L27 domain
50156 - PDZ domain-like
50044 - SH3-domain | 0.003381 | Inherited |
57196,49899,57196
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0.03489 | Inherited |
101288,101288,50156
101288 - L27 domain
101288 - L27 domain
50156 - PDZ domain-like | 0.08583 | Inherited |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0.0919 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1374 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.8513 | Inherited |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0.004198 | Inherited |
48371,48371,48371
48371 - ARM repeat
48371 - ARM repeat
48371 - ARM repeat | 0.009387 | Inherited |
Plot distribution on phylogenetic tree for Individual Supra-domains annotated by this GO term
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A presence/absence matrix is generated using protein domains and supradomains
for all genomes in SUPERFAMILY. The RAxML
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
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