SUPERFAMILY 1.75 HMM library and genome assignments server

Molecular Function (MF): molecular_function

(show info)

Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Root: GO Hierarchy Containing Three Sub-Ontologies (BP, MF, CC)

Shortest distance to current term (+ for parents, - for children) GO term [GO ID] <#Children> #High-quality
(SF|FA)
#Supra-domain
(Single|Duplex|Triple)
0:   molecular_function [GO:0003674] <21>
- 1:   binding [GO:0005488] <48>(210|240) (789|832|477)
- 1:   catalytic activity [GO:0003824] <29>(270|402) (787|868|410)
- 1:   enzyme regulator activity [GO:0030234] <21>(39|36) (155|123|67)
- 1:   structural molecule activity [GO:0005198] <20>(30|31) (119|62|54)
- 1:   transporter activity [GO:0005215] <15>(40|39) (166|97|41)
- 1:   antioxidant activity [GO:0016209] <7>(6|7) (18|9|2)
- 1:   electron carrier activity [GO:0009055] <7>(11|8) (32|18|4)
- 1:   receptor activity [GO:0004872] <7>(12|13) (98|112|83)
- 1:   channel regulator activity [GO:0016247] <5>(3|4) (30|11|4)
- 1:   receptor regulator activity [GO:0030545] <3>(2|2) (18|13|6)
- 1:   translation regulator activity [GO:0045182] <3>(0|0) (7|4|0)
- 1:   metallochaperone activity [GO:0016530] <2>(1|1) (8|3|1)
- 1:   molecular transducer activity [GO:0060089] <2>(15|15) (99|107|71)
- 1:   nucleic acid binding transcription factor activity [GO:0001071] <2>(11|13) (62|53|11)
- 1:   protein binding transcription factor activity [GO:0000988] <2>(6|6) (81|51|21)
- 1:   D-alanyl carrier activity [GO:0036370](0|0) (0|0|0)
- 1:   chemoattractant activity [GO:0042056](1|1) (5|1|0)
- 1:   chemorepellent activity [GO:0045499](0|0) (10|10|4)
- 1:   morphogen activity [GO:0016015](0|0) (3|1|0)
- 1:   nutrient reservoir activity [GO:0045735](0|0) (2|0|0)
- 1:   protein tag [GO:0031386](1|1) (3|2|1)


Jump to [ Top · GO Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
"Winged helix" DNA-binding domain0.000024060.00000000001264Direct
all-alpha NTP pyrophosphatases0.00028510.00001998Direct
Ankyrin repeat0.0000063140Direct
Aquaporin-like0.00028080.00001742Direct
BB1717-like00Direct
BB2672-like00Direct
BC4932-like00Direct
BolA-like0.000022480.000007945Direct
Bowman-Birk inhibitor, BBI00Direct
Calcium-dependent phosphotriesterase0.00038230.000002732Direct
Caspase-like0.00013830.00003588Direct
CcmK-like00Direct
Cell division protein ZapA-like00Direct
CheC-like00.0004336Direct
CheW-like00.0000005296Direct
Chondroitin AC/alginate lyase00Direct
Chromo domain-like00.0000006042Direct
Class I glutamine amidotransferase-like0.00000000076960.000000002472Direct
CNF1/YfiH-like putative cysteine hydrolases0.00015260.00003836Direct
Coproporphyrinogen III oxidase00Direct
Dimeric alpha+beta barrel00Direct
DinB/YfiT-like putative metalloenzymes0.0000029580.00003974Direct
DR1885-like metal-binding protein00Direct
DsrC, the gamma subunit of dissimilatory sulfite reductase00Direct
DsrEFH-like0.00083780.0001604Direct
EAL domain-like0.00049580.00002141Direct
Elafin-like00.0001237Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain00Direct
Fic-like00Direct
FlaG-like00Direct
Flagellar export chaperone FliS00Direct
FlgN-like00Direct
Fumarate reductase respiratory complex transmembrane subunits0.00035470.000011Direct
GINS helical bundle-like00.00001571Direct
GlnB-like0.00013030.00009159Direct
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase0.0000033020.00002208Direct
gpW/gp25-like00Direct
Hypothetical protein TT172500Direct
Hypothetical protein VC042400Direct
Hypothetical protein YjbJ00Direct
ICP-like00Direct
Immunoglobulin0.0000037330Direct
Indolic compounds 2,3-dioxygenase-like0.0000000000015420.0000002189Direct
Insect pheromone/odorant-binding proteins00Direct
Invertebrate chitin-binding proteins00.0002276Direct
IscX-like00Direct
ITPase-like0.0000000015350.00000000006012Direct
L,D-transpeptidase catalytic domain-like00.000002452Direct
LemA-like00Direct
Leucine zipper domain00.000006955Direct
Lipocalins0.00006860.0000004939Direct
LysM domain00.00002086Direct
Metallothionein0.00000000026230.00000000006245Direct
MFS general substrate transporter00Direct
Molybdenum cofactor-binding domain00.0003698Direct
MTH1187/YkoF-like00Direct
NAC domain00Direct
NTF2-like0.000000033350.000000001563Direct
Nucleotide-diphospho-sugar transferases0.00000007140.000000004967Direct
OMPA-like0.00000022220.0000000000004393Direct
OmpH-like00Direct
OsmC-like0.00040940.0005769Direct
PAP/OAS1 substrate-binding domain00.0001037Direct
Peptide deformylase00Direct
Periplasmic binding protein-like I0.00013350Direct
Periplasmic binding protein-like II0.00000000003820Direct
Phosphofructokinase0.00073520.00000001453Direct
PhoU-like0.000016220.000008117Direct
PilZ domain-like00.00001137Direct
Porins0.000000004560.00000000006301Direct
PR-1-like0.000007290.000009427Direct
PRC-barrel domain00.000581Direct
PSTPO5379-like00Direct
Putative cyclase0.000000017570.000000000534Direct
Regulator of G-protein signaling, RGS0.00083780.000000000000003078Direct
Rhodanese/Cell cycle control phosphatase0.0000047250.00001782Direct
RNase A-like0.0000034520.0001468Direct
Roadblock/LC7 domain0.0000013280.00000003271Direct
Sialidases0.00070840.0001069Direct
SirA-like0.000046950.00001137Direct
SMc04008-like00Direct
SMI1/KNR4-like00.00001676Direct
SP0830-like00Direct
Stabilizer of iron transporter SufD00Direct
Thioesterase/thiol ester dehydrase-isomerase0.000000030830.00000001869Direct
TM1631-like00Direct
TolA/TonB C-terminal domain00.00001137Direct
Transcription factor STAT-4 N-domain00.000005609Direct
Tropomyosin0.00000014770.00000005399Direct
TrpR-like00Direct
Tsx-like channel00Direct
TT1751-like00Direct
TTP0101/SSO1404-like00Direct
UraD-Like00Direct
VPA0735-like00Direct
XCC0632-like00Direct
YacF-like00Direct
YaeB-like00Direct
YcfC-like00Direct
YcgL-like00Direct
YdhG-like00Direct
YebC-like00.00003439Direct
YehU-like00Direct
YgaC/TfoX-N like00Direct
YggU-like00.00097Direct
YheA/YmcA-like00Direct
YjbQ-like0.00022690.0002329Direct
YjbR-like00Direct
YlxR-like00Direct
YutG-like00Direct
Cytokine10.9335Inherited
Cystine-knot cytokines0.93450.3764Inherited
alpha/beta knot0.034160.05383Inherited
TIMP-like0.0096270.2048Inherited
Kazal-type serine protease inhibitors0.085190.01311Inherited
STI-like0.24690.1235Inherited
Calponin-homology domain, CH-domain0.31890.00004411Inherited
SGNH hydrolase11Inherited
FabD/lysophospholipase-like0.01051Inherited
YbaK/ProRS associated domain0.0098530.0188Inherited
Clavaminate synthase-like11Inherited
4Fe-4S ferredoxins0.028510.04996Inherited
HesB-like domain0.0060440.04016Inherited
SH2 domain0.015360Inherited
RmlC-like cupins0.0000035120.008301Inherited
Aromatic compound dioxygenase11Inherited
Lipoxigenase0.65530.03283Inherited
ACP-like0.0069621Inherited
GroES-like11Inherited
HSP20-like chaperones11Inherited
ARM repeat0.98290.5104Inherited
NAD(P)-binding Rossmann-fold domains11Inherited
Dihydrofolate reductase-like0.036350.06376Inherited
Subunits of heterodimeric actin filament capping protein Capz11Inherited
Nudix0.064211Inherited
dUTPase-like0.6610.7798Inherited
Starch-binding domain-like01Inherited
Thioredoxin-like0.9580.8556Inherited
Bcl-2 inhibitors of programmed cell death0.063970.01894Inherited
Apolipoprotein A-II0.05430.05333Inherited
PRTase-like0.0064180.1455Inherited
2Fe-2S ferredoxin-like0.00015260.006478Inherited
Tim10-like11Inherited
HD-domain/PDEase-like0.061150.00001193Inherited
Inhibitor of apoptosis (IAP) repeat0.13020.5643Inherited
Cysteine alpha-hairpin motif0.15630.1485Inherited
Chelatase0.0098530.004525Inherited
Arabinanase/levansucrase/invertase11Inherited
NAD(P)-linked oxidoreductase10.7811Inherited
Cytochrome c0.01020.000002387Inherited
Acid phosphatase/Vanadium-dependent haloperoxidase0.00740.003603Inherited
UBC-like0.4111Inherited
Oxysterol-binding protein-like0.33251Inherited
Cu,Zn superoxide dismutase-like0.020310.003082Inherited
beta-carbonic anhydrase, cab0.97280.991Inherited
HAD-like11Inherited
Mss4-like11Inherited
CYTH-like phosphatases0.0010870.1859Inherited
Metalloproteases ("zincins"), catalytic domain0.46930.02091Inherited
Metallo-dependent phosphatases0.85150.4633Inherited
Metallo-dependent hydrolases11Inherited
Synuclein0.060720.05585Inherited
HMA, heavy metal-associated domain0.68821Inherited
Ferritin-like0.047810.01302Inherited
Isocitrate/Isopropylmalate dehydrogenase-like0.97521Inherited
LanC-like0.28130.274Inherited
PEBP-like0.22870.2038Inherited
Profilin (actin-binding protein)0.34510.2449Inherited
Flavoproteins0.050911Inherited
Preprotein translocase SecY subunit11Inherited
F1F0 ATP synthase subunit C11Inherited
Apyrase00.3868Inherited
ABC transporter involved in vitamin B12 uptake, BtuC0.013190.006108Inherited
"Helical backbone" metal receptor0.37680.4836Inherited
Transthyretin (synonym: prealbumin)0.097040.1303Inherited
NAP-like0.16540.01064Inherited
Family A G protein-coupled receptor-like10Inherited
MHC antigen-recognition domain0.92580.000000003112Inherited
PH domain-like0.076230Inherited
PX domain0.42480.3691Inherited
Transducin (heterotrimeric G protein), gamma chain0.042390.001134Inherited
Mog1p/PsbP-like0.052580.5447Inherited
Protein prenylyltransferase0.019490.002357Inherited
Terpenoid cyclases/Protein prenyltransferases0.0026470.0008472Inherited
Snake toxin-like10.045Inherited
Molybdopterin synthase subunit MoaE0.18840.01454Inherited
MoaD/ThiS0.11630.1485Inherited
Carbohydrate phosphatase0.10070.1804Inherited
Galactose-binding domain-like0.17351Inherited
C-type lectin-like0.78231Inherited
DBL homology domain (DH-domain)0.28910.01436Inherited
Plant invertase/pectin methylesterase inhibitor11Inherited
SH3-domain0.94430.000000000001407Inherited
Sema domain01Inherited
Glycolipid transfer protein, GLTP0.61590.2549Inherited
Vacuolar ATP synthase subunit C0.61590.3571Inherited
Voltage-gated potassium channels0.68820Inherited
Phoshotransferase/anion transport protein0.36290.3378Inherited
AtpF-like0.36290.3654Inherited
Proton glutamate symport protein0.001720.00001571Inherited
CalX-like00.5788Inherited
Nicotinic receptor ligand binding domain-like0.058910Inherited
Apolipoprotein00.5593Inherited
Ammonium transporter0.19560.07206Inherited
Preprotein translocase SecE subunit0.470.4009Inherited
Cytochrome c oxidase subunit h0.94880.9375Inherited
Mitochondrial cytochrome c oxidase subunit IV11Inherited
Cytochrome c oxidase subunit I-like10.9662Inherited
Globin-like0.099480.3889Inherited
Outer membrane efflux proteins (OEP)0.67780.8338Inherited
Probable bacterial effector-binding domain0.00083780.04212Inherited
14-3-3 protein0.015730.1015Inherited
PTPA-like0.92281Inherited
Histidine-containing phosphotransfer domain, HPT domain0.32690.02185Inherited
Protein kinase-like (PK-like)0.99450.445Inherited
Mob1/phocein0.7450.5253Inherited
Cyclin-like0.037920.3439Inherited
Casein kinase II beta subunit0.12210.2358Inherited
UDP-Glycosyltransferase/glycogen phosphorylase0.057240.07815Inherited
Ubiquitin-like0.22540.0000000006017Inherited
Cytidine deaminase-like11Inherited
Glycoside hydrolase/deacetylase0.90350.9512Inherited
Macro domain-like0.25160.02442Inherited
Myosin phosphatase inhibitor 17kDa protein, CPI-1700.05333Inherited
Mitochondrial carrier0.57540.08643Inherited
PHP domain-like0.5470.6962Inherited
Class II aaRS and biotin synthetases0.075790.0003766Inherited
Nucleotidylyl transferase0.10070.7839Inherited
Hypothetical protein PH16020.024360.03203Inherited
RING/U-box11Inherited
CoaB-like0.03690.003052Inherited
Glutathione synthetase ATP-binding domain-like0.03290.3583Inherited
Acetyl-CoA synthetase-like11Inherited
Hect, E3 ligase catalytic domain0.5470.008219Inherited
L-aspartase-like11Inherited
Six-hairpin glycosidases11Inherited
Galactose mutarotase-like11Inherited
ADC synthase0.091290.3035Inherited
MAPEG domain-like0.00098810.001115Inherited
Cyclophilin-like11Inherited
NagB/RpiA/CoA transferase-like0.041670.6106Inherited
RbsD-like0.36290.3654Inherited
Chorismate mutase II0.03690.0006497Inherited
ClpP/crotonase11Inherited
Tautomerase/MIF0.0070060.01074Inherited
SIS domain0.75450.9568Inherited
FKBP-like0.082080.002952Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.00000027140.01233Inherited
Diaminopimelate epimerase-like0.470.2347Inherited
Pseudouridine synthase0.91051Inherited
Xylose isomerase-like0.0016090.01574Inherited
CoA-transferase family III (CaiB/BaiF)0.99371Inherited
Phosphoglycerate mutase-like0.038181Inherited
Triosephosphate isomerase (TIM)0.85150.6487Inherited
Ribulose-phoshate binding barrel0.011280.05383Inherited
Nucleotide cyclase0.11780.00000000000001188Inherited
Dehydroquinate synthase-like10.955Inherited
Aconitase iron-sulfur domain0.83461Inherited
LeuD/IlvD-like0.13621Inherited
AttH-like0.26720.3774Inherited
Terpenoid synthases0.018710.000001695Inherited
Carbonic anhydrase0.37960.1195Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.62241Inherited
UROD/MetE-like0.60620.8378Inherited
S-adenosylmethionine decarboxylase0.40320.347Inherited
2-methylcitrate dehydratase PrpD11Inherited
Acylphosphatase/BLUF domain-like0.16540.591Inherited
Pentein10.7293Inherited
Arginase/deacetylase0.39820.0003592Inherited
DHS-like NAD/FAD-binding domain0.33871Inherited
Glutaminase/Asparaginase0.54650.1044Inherited
N-acetylmuramoyl-L-alanine amidase-like0.058910.02163Inherited
Amidase signature (AS) enzymes11Inherited
Heme-dependent catalase-like0.075790.03652Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)11Inherited
LmbE-like0.12860.003115Inherited
Uracil-DNA glycosylase-like0.000046950.001872Inherited
Nucleoside hydrolase0.13610.2358Inherited
Ribosome inactivating proteins (RIP)00.03585Inherited
N-(deoxy)ribosyltransferase-like0.00033560.005391Inherited
Purine and uridine phosphorylases0.84011Inherited
DNA-glycosylase0.0024331Inherited
ADP-ribosylglycohydrolase0.078630.05585Inherited
Phosphotyrosine protein phosphatases I0.0069620.03203Inherited
DNase I-like0.17610.06575Inherited
Pectin lyase-like10.9526Inherited
FAH11Inherited
DLC0.28130.347Inherited
Inorganic pyrophosphatase0.36660.1401Inherited
ATP synthase (F1-ATPase), gamma subunit11Inherited
Alkaline phosphatase-like0.014880.9103Inherited
Carbon-nitrogen hydrolase11Inherited
Metallo-hydrolase/oxidoreductase11Inherited
HIT-like0.37230.1845Inherited
Phospholipase D/nuclease00.1687Inherited
Isochorismatase-like hydrolases11Inherited
PLC-like phosphodiesterases0.71681Inherited
Hemopexin-like domain01Inherited
Trypsin-like serine proteases0.000042470.1029Inherited
(Phosphotyrosine protein) phosphatases II0.26570.000005965Inherited
(Trans)glycosidases11Inherited
Seven-hairpin glycosidases0.03691Inherited
Ribonuclease Rh-like0.71681Inherited
RelE-like0.0096270.008452Inherited
Acid proteases0.57231Inherited
LexA/Signal peptidase0.97281Inherited
Lysozyme-like0.2140.004742Inherited
Radical SAM enzymes0.95661Inherited
Activating enzymes of the ubiquitin-like proteins0.0013050.0001892Inherited
4'-phosphopantetheinyl transferase0.11780.7495Inherited
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK00.0698Inherited
DNA/RNA polymerases11Inherited
Actin-like ATPase domain0.016380.000000000000004577Inherited
beta and beta-prime subunits of DNA dependent RNA-polymerase0.90530.4256Inherited
RBP11-like subunits of RNA polymerase0.060721Inherited
RNA polymerase subunit RPB100.44770.6605Inherited
RPB6/omega subunit-like0.86480.9788Inherited
Carbamate kinase-like0.31770.006207Inherited
HRDC-like0.03690.8637Inherited
HPr-like0.24690.646Inherited
Undecaprenyl diphosphate synthase0.072641Inherited
GST C-terminal domain-like0.63020.1673Inherited
EPT/RTPC-like0.7581Inherited
ADP-ribosylation0.000110.01957Inherited
tRNA-guanine transglycosylase0.03690.001163Inherited
Zn-dependent exopeptidases0.021151Inherited
Malate synthase G0.20740.1582Inherited
Citrate synthase0.81630.1481Inherited
Trimeric LpxA-like enzymes11Inherited
Gamma-glutamyl cyclotransferase-like0.055530.008716Inherited
CoA-dependent acyltransferases0.18371Inherited
Acyl-CoA N-acyltransferases (Nat)11Inherited
Glycerol-3-phosphate (1)-acyltransferase11Inherited
Cysteine proteinases10.4506Inherited
Thiolase-like0.88041Inherited
Formyltransferase0.36291Inherited
Cytochrome b5-like heme/steroid binding domain11Inherited
FAD/NAD(P)-binding domain0.89771Inherited
ERO1-like0.28910.4789Inherited
Peptide methionine sulfoxide reductase0.77620.4105Inherited
FMN-dependent nitroreductase-like0.65531Inherited
FMN-linked oxidoreductases11Inherited
Thiamin diphosphate-binding fold (THDP-binding)0.26721Inherited
SET domain0.26720.0000002843Inherited
omega toxin-like0.03690.02407Inherited
Scorpion toxin-like0.056690.1221Inherited
Chlorophyll a-b binding protein11Inherited
Bet v1-like0.4471Inherited
Stathmin0.96910.536Inherited
MetI-like0.032370.0000505Inherited
Multiheme cytochromes0.73070.05859Inherited
Rubredoxin-like0.24691Inherited
Transmembrane di-heme cytochromes0.035610.3902Inherited
GckA/TtuD-like0.078290.07407Inherited
Aldolase0.0000012180.01354Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.83460.9809Inherited
YrdC/RibB0.10520.4349Inherited
SNARE-like11Inherited
SNF-like0.001510.0004519Inherited
alpha/beta-Hydrolases11Inherited
Creatinase/aminopeptidase0.38641Inherited
Homocysteine S-methyltransferase0.09960.02406Inherited
beta-lactamase/transpeptidase-like0.033020.0184Inherited
HLH, helix-loop-helix DNA-binding domain0.75880.04531Inherited
FMN-binding split barrel11Inherited
Transcription factor IIA (TFIIA), alpha-helical domain00.08307Inherited
Actin-crosslinking proteins00.001848Inherited
Spectrin repeat0.17310.0000002892Inherited
Actin depolymerizing proteins11Inherited
Arp2/3 complex 21 kDa subunit ARPC30.31430.3033Inherited
Proteasome activator0.64030.3868Inherited
Interleukin 8-like chemokines0.042370.0001569Inherited
Cullin repeat-like0.25820.9039Inherited
PDZ domain-like0.43120.0000000001805Inherited
gp120 core00.03585Inherited
SMAD/FHA domain0.22760.007027Inherited
TRADD, N-terminal domain00.07935Inherited
Insulin-like11Inherited
DEATH domain0.027310.00008618Inherited
SNARE fusion complex0.73670.9502Inherited
Sec1/munc18-like (SM) proteins0.0093250.0002928Inherited
CAD & PB1 domains0.42480.3228Inherited
Cell cycle regulatory proteins0.5470.4747Inherited
TRAF domain-like01Inherited
Annexin11Inherited
EF-hand11Inherited
Concanavalin A-like lectins/glucanases0.27571Inherited
Phospholipase A2, PLA20.006590.0008379Inherited
Cupredoxins11Inherited
TPR-like0.4920.0003146Inherited
Multidrug resistance efflux transporter EmrE0.0060440Inherited
Pili subunits0.098470.2347Inherited
Blood coagulation inhibitor (disintegrin)0.28910.00000002517Inherited
4-helical cytokines0.99771Inherited
RCC1/BLIP-II0.29230.5588Inherited
Ras GEF0.0034980.00001066Inherited
GTPase activation domain, GAP0.5470.00002119Inherited
BAR/IMD domain-like0.0052620.0000334Inherited
Tubby C-terminal domain-like0.54640.7049Inherited
Fibronectin type III0.044070Inherited
BPTI-like0.48141Inherited
Serpins0.50240.7426Inherited
HemD-like0.003540.1438Inherited
Tetrapyrrole methylase0.078630.8838Inherited
RNI-like0.24970.2638Inherited
Thymidylate synthase/dCMP hydroxymethylase0.09960.1438Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.00091391Inherited
PP2C-like0.96570.7579Inherited
SAICAR synthase-like11Inherited
Adenine nucleotide alpha hydrolases-like0.87140.01733Inherited
Heme-dependent peroxidases11Inherited
Oligosaccharyltransferase subunit ost4p0.0098530.006247Inherited
Cell growth inhibitor/plasmid maintenance toxic component0.61590.759Inherited
L domain-like0.092980.9819Inherited
Quinoprotein alcohol dehydrogenase-like0.39290.002728Inherited
Phospholipase C/P1 nuclease0.54460.1313Inherited
Restriction endonuclease-like0.0024940.007531Inherited
PIN domain-like11Inherited
Cytochrome P45011Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.17310.001362Inherited
Bacterial luciferase-like0.93371Inherited
FAD-linked oxidoreductase0.09961Inherited
Ribokinase-like0.17690.6807Inherited
Phosphoenolpyruvate/pyruvate domain11Inherited
PLP-dependent transferases11Inherited
Dihydropteroate synthetase-like00.002501Inherited
Tetrahydrobiopterin biosynthesis enzymes-like0.060120.09619Inherited
Chorismate synthase, AroC0.11780.4571Inherited
P-loop containing nucleoside triphosphate hydrolases0.014521Inherited
ACT-like00.008362Inherited
HydA/Nqo6-like0.94880.9375Inherited
Nqo5-like0.84970.9069Inherited
HydB/Nqo4-like10.9472Inherited
Inosine monophosphate dehydrogenase (IMPDH)11Inherited
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III00.09897Inherited
L28p-like0.24690.8705Inherited
Ribosomal protein L111Inherited
Ribosomal protein L130.80031Inherited
Ribosomal protein L140.99641Inherited
Ribosomal protein L30p/L7e0.73861Inherited
Ribosomal protein L31e0.80030.83Inherited
Ribosomal protein S100.68820.2358Inherited
Ribosomal protein S160.025050.2239Inherited
Ribosomal protein S1911Inherited
Ribosomal protein S5 domain 2-like10.8161Inherited
Ribosomal protein S60.42480.7385Inherited
Ribosomal protein S811Inherited
Ribosomal proteins L15p and L18e11Inherited
RL5-like11Inherited
Translation proteins11Inherited
Zn-binding ribosomal proteins11Inherited
Nucleotidyltransferase0.017420.0001906Inherited
Alpha-L RNA-binding motif0.60231Inherited
Ribosomal proteins S24e, L23 and L15e11Inherited
Translation proteins SH3-like domain11Inherited
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.31430.02129Inherited
Ribbon-helix-helix0.012690.003895Inherited
SPOC domain-like0.18370.6092Inherited
eIF4e-like0.98410.8112Inherited
L30e-like0.98891Inherited
Ribonuclease H-like0.68431Inherited
EndoU-like00.001452Inherited
Nuclear receptor ligand-binding domain0.0011950Inherited
POZ domain0.16020.00003049Inherited
Sm-like ribonucleoproteins0.17720.02818Inherited
RNA-binding domain, RBD11Inherited
eIF1-like0.86480.6487Inherited
Release factor11Inherited
Ribosomal protein S710.8042Inherited
Translational machinery components0.85821Inherited
Translin0.43120.3654Inherited
ssDNA-binding transcriptional regulator domain0.98820.6164Inherited
Histone-fold11Inherited
p53-like transcription factors0.16540.000000000006836Inherited
HMG-box0.044070.000000000000006053Inherited
Nucleic acid-binding proteins11Inherited
beta-beta-alpha zinc fingers0.62781Inherited
Homeodomain-like0.46460.8267Inherited
IHF-like DNA-binding proteins00.02407Inherited
lambda repressor-like DNA-binding domains11Inherited
Cystatin/monellin0.10940.3646Inherited
NAD kinase/diacylglycerol kinase-like0.089270.1502Inherited
Phosphoglycerate kinase0.017270.03629Inherited
Nucleoside diphosphate kinase, NDK0.97870.7595Inherited
E set domains0.97970.002192Inherited
Prefoldin11Inherited
Mediator hinge subcomplex-like0.0052440.4266Inherited
Putative DNA-binding domain0.60231Inherited
WD40 repeat-like10.0000000811Inherited
CheY-like0.035480.001485Inherited
Myosin S1 fragment, N-terminal domain10.3399Inherited
ALDH-like11Inherited
Acyl-CoA binding protein11Inherited


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Family

(show details)
SCOP termFDR (singleton)FDR (all)Annotation (direct or inherited)
2'-5'-oligoadenylate synthetase 1, OAS1, second domain00.00000002073Direct
3-demethylubiquinone-9 3-methyltransferase00Direct
4HBT-like0.000032030.0004044Direct
A novel bacterial esterase00Direct
ADP-ribosylating toxins00.0002057Direct
All0351-like00Direct
Ankyrin repeat0.00000087980Direct
Apolipoprotein00Direct
Aquaporin-like0.00003080.000001696Direct
Arginine methyltransferase00Direct
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A00.0003443Direct
Atu0120-like00Direct
Atu1531-like00Direct
Atu1826-like00Direct
Bacterial tryptophan 2,3-dioxygenase0.0000000000028130.000000000002364Direct
BB1717-like00Direct
BB2672-like00Direct
BC3264-like00Direct
BC4932-like00Direct
Biotin biosynthesis protein BioH00Direct
BolA-like0.0000093940.000004387Direct
Bowman-Birk inhibitor, BBI00Direct
Caspase catalytic domain0.000011160.000000002928Direct
CcmK-like00Direct
Cell division protein ZapA-like00Direct
CheC-like00Direct
CheD-like00Direct
CheW-like00.0000009916Direct
Chromo domain00.00000002033Direct
Class I aldolase0.00000000018580.0000001748Direct
Coproporphyrinogen III oxidase00Direct
DEATH effector domain, DED00.000007115Direct
Diaminopimelate epimerase00Direct
Divergent polysaccharide deacetylase00Direct
DJ-1/PfpI0.000000042390.00000004217Direct
DR1885-like metal-binding protein00Direct
DsrC, the gamma subunit of dissimilatory sulfite reductase00Direct
dTDP-sugar isomerase00Direct
EAL domain00.00008263Direct
Ecto-ART00Direct
Elafin-like00.00007404Direct
Eukaryotic proteases0.0000019590.00000005395Direct
Ferredoxin thioredoxin reductase (FTR), catalytic beta chain00Direct
Fic-like00Direct
First domain of FERM00.0000000001904Direct
FlaG-like00Direct
Flagellar export chaperone FliS00Direct
Fucose binding lectin00Direct
Galactosyltransferase LgtC00Direct
GrpB-like00Direct
HI0395-like00Direct
Histidine kinase00.0000194Direct
Histidinol phosphatase-like0.00023640.0001081Direct
HxlR-like00Direct
Hypothetical protein MJ088200Direct
Hypothetical protein TT172500Direct
Hypothetical protein Yhr087W00Direct
Hypothetical protein YjbJ00Direct
hypothetical RNA methyltransferase00.0001589Direct
ICP-like00Direct
Inositol polyphosphate 5-phosphatase (IPP5)00.00004135Direct
Insect pheromone/odorant-binding proteins00Direct
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain00.0009188Direct
Iojap/YbeB-like00.00006452Direct
IolI-like00Direct
IscX-like00Direct
KRAB domain (Kruppel-associated box)0.00071980.0001813Direct
L,D-transpeptidase catalytic domain-like00.0000003009Direct
LemA-like00Direct
Leucine zipper domain00.000001309Direct
LPG0085-like00Direct
LPG1296-like00Direct
Maf-like0.00078370.00004894Direct
Metallothionein0.000000000071150.00000000002765Direct
MLTA-like00Direct
modified HD domain00.000007348Direct
Molybdenum cofactor biosynthesis protein MoeB0.0000093490.00001742Direct
Molybdenum cofactor-binding domain00.0002234Direct
MTH1187-like00Direct
MutT-like0.00034880.0002427Direct
NAC domain00Direct
NE135400Direct
NifU C-terminal domain-like00.0003038Direct
Nuclear receptor ligand-binding domain0.00073620Direct
Ohr/OsmC resistance proteins0.00070830.0007145Direct
OmpH-like00Direct
Outer membrane enzyme PagP00Direct
Oxygen-independent coproporphyrinogen III oxidase HemN0.000025590.0002748Direct
p53 DNA-binding domain-like00.000000005447Direct
PA0094-like00Direct
PA3566-like00Direct
PA5104-like00Direct
PAPS sulfotransferase0.0000032620.00000001273Direct
Pectin lyase00Direct
Peptide deformylase00Direct
PG130-like00Direct
Phosphate binding protein-like0.0000034440Direct
Phosphofructokinase0.00070830.00000001063Direct
PhoU-like0.000046250.00004469Direct
PhyH-like0.00046930.0004716Direct
PilZ domain00Direct
Pirin-like0.00036850.00002322Direct
PR-1-like0.00000026590.000001625Direct
PSTPO5379-like00Direct
Putative cyclase0.0000000089110.0000001404Direct
Regulator of G-protein signaling, RGS0.00050620.000000000000001877Direct
Rel/Dorsal transcription factors, DNA-binding domain00.00001331Direct
Reprolysin-like00.00000001117Direct
Retinol binding protein-like0.00000025630.00000003288Direct
Ribonuclease A-like0.0000012390.0000821Direct
Roadblock/LC7 domain0.000003030.0000001039Direct
Sden0562-like00Direct
Short-chain scorpion toxins00Direct
Sialidases (neuraminidases)00.00008954Direct
SirA-like0.00003890.00001115Direct
SMc04008-like00Direct
SNF-like0.00077330.000356Direct
SoxZ-like00Direct
SP0830-like00Direct
Stabilizer of iron transporter SufD00Direct
Succinate dehydrogenase/Fumarate reductase transmembrane subunits (SdhC/FrdC and SdhD/FrdD)0.00070830.0004716Direct
SVA-like00Direct
Thiopurine S-methyltransferase00Direct
Thyroglobulin type-1 domain00.0007118Direct
TM1631-like00Direct
Transcription factor STAT-4 N-domain00.000002843Direct
Transcriptional regulator Rrf200Direct
Tropomyosin0.00000023110.00000006958Direct
Truncated hemoglobin00Direct
Tsx-like channel00Direct
TTP0101/SSO1404-like00Direct
UraD-like00Direct
V set domains (antibody variable domain-like)0.0000038060.0006248Direct
VPA0057-like00Direct
VPA0735-like00Direct
XCC0632-like00Direct
YacF-like00Direct
YaeB-like00Direct
YaeQ-like00Direct
YbcJ-like00Direct
YbeA-like00Direct
YcfC-like00Direct
YcgL-like00Direct
YciI-like0.00070830.0004716Direct
YdhA-like00Direct
YdjC-like00Direct
YebC-like00.00002141Direct
YehU-like00Direct
YgdI/YgdR-like00Direct
YgfB-like00Direct
YggU-like00.0007145Direct
YhfA-like00Direct
YhiQ-like00Direct
YiiL-like00Direct
YjbQ-like0.00013510.0001589Direct
YjbR-like00Direct
YjjX-like00.0000000000005404Direct
YkgG-like00Direct
YlbA-like00Direct
YlxR-like00Direct
YoeB/Txe-like00Direct
YutG-like00Direct
Fibroblast growth factors (FGF)11Inherited
Platelet-derived growth factor-like0.57890.4771Inherited
Rhodopsin-like10.00000003361Inherited
Cytidylytransferase0.066690.6108Inherited
EMG1/NEP1-like0.49130.6534Inherited
Ovomucoid domain III-like0.018640.08296Inherited
Kunitz (STI) inhibitors0.28220.2924Inherited
Calponin-homology domain, CH-domain0.32290.00001823Inherited
Glycosyl hydrolases family 160.41361Inherited
YbaK/ProRS associated domain0.0068350.007364Inherited
AlkB-like0.014040.7027Inherited
MoCo biosynthesis proteins0.90641Inherited
HesB-like domain0.0063320.04217Inherited
Ferredoxin domains from multidomain proteins0.1110.1004Inherited
SH2 domain0.010160Inherited
Penicillin synthase-like11Inherited
Aromatic compound dioxygenase11Inherited
Animal lipoxigenases0.14730.01671Inherited
Indoleamine 2,3-dioxygenase-like0.0056110.7795Inherited
3-hydroxyanthranilic acid dioxygenase-like0.87130.6025Inherited
Acyl-carrier protein (ACP)0.28220.9538Inherited
GroES0.71420.6076Inherited
HSP2011Inherited
Phosphotyrosine-binding domain (PTB)0.028920.00002989Inherited
Tyrosine-dependent oxidoreductases11Inherited
Capz beta-1 subunit0.18590.1498Inherited
ITPase (Ham1)0.52870.543Inherited
dUTPase-like0.57890.7013Inherited
Starch-binding domain00.714Inherited
Bcl-2 inhibitors of programmed cell death0.036820.01195Inherited
Hypoxia-inducible factor HIF ihhibitor (FIH1)0.0047410.00002424Inherited
Apolipoprotein A-II0.043650.04467Inherited
Phosphoribosyltransferases (PRTases)0.0031790.02466Inherited
Nuclease00.008598Inherited
S100 proteins0.46760.5428Inherited
Neurolysin-like00.03015Inherited
Tim10/DDP0.89870.9941Inherited
Inhibitor of apoptosis (IAP) repeat0.10110.4771Inherited
alpha-L-arabinanase-like11Inherited
Aldo-keto reductases (NADP)0.87670.5964Inherited
monodomain cytochrome c0.01520.00787Inherited
UBC-related0.43511Inherited
Enolase-phosphatase E10.1110.2506Inherited
Fatty acid binding protein-like0.49480.4621Inherited
Oxysterol-binding protein0.2190.9538Inherited
HpcH/HpaI aldolase11Inherited
2Fe-2S ferredoxin-related0.00070830.5844Inherited
RabGEF Mss40.15250.1569Inherited
Ferritin0.66520.5516Inherited
Cu,Zn superoxide dismutase-like0.012040.001886Inherited
Glyoxalase I (lactoylglutathione lyase)00.09418Inherited
beta-carbonic anhydrase, cab0.93940.9465Inherited
Alkaline phosphatase0.15380.7239Inherited
Purple acid phosphatase-like0.057060.6133Inherited
Germin/Seed storage 7S protein11Inherited
MioX-like0.028540.1696Inherited
COX17-like0.20970.2155Inherited
Multidomain cupredoxins01Inherited
SelR domain0.68170.37Inherited
Adenosine/AMP deaminase0.10110.1956Inherited
Cytidine deaminase0.63131Inherited
Glycine N-methyltransferase0.31280.2506Inherited
HMGL-like0.41490.9918Inherited
Predicted hydrolases Cof0.054060.1638Inherited
NagD-like0.60550.5036Inherited
CYTH domain00.02494Inherited
glucose-1-phosphate thymidylyltransferase0.1110.1182Inherited
Renal dipeptidase0.025180.4181Inherited
Synuclein0.044630.04454Inherited
HMA, heavy metal-associated domain0.61471Inherited
5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)0.002260.0185Inherited
Dimeric isocitrate & isopropylmalate dehydrogenases0.9581Inherited
LanC-like0.40610.4181Inherited
Phosphatidylethanolamine binding protein0.54750.2612Inherited
Profilin (actin-binding protein)0.27480.2011Inherited
D-aminoacid aminotransferase-like PLP-dependent enzymes0.66760.845Inherited
Preprotein translocase SecY subunit11Inherited
F1F0 ATP synthase subunit C11Inherited
Apyrase00.3401Inherited
ABC transporter involved in vitamin B12 uptake, BtuC0.014010.006839Inherited
Protein serine/threonine phosphatase0.41090.01178Inherited
Transthyretin (synonym: prealbumin)0.072460.1056Inherited
NAP-like0.13080.006978Inherited
Armadillo repeat10.5071Inherited
MHC antigen-recognition domain0.86190.00000000053Inherited
Trehalose-6-phosphate synthase, OtsA0.99421Inherited
Glycogenin0.96971Inherited
beta 1,4 galactosyltransferase (b4GalT1)0.00031020.01011Inherited
PX domain0.35560.1644Inherited
Phoshoinositide 3-kinase (PI3K), catalytic domain0.71660.01243Inherited
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.35030.0001795Inherited
Ubiquitin activating enzymes (UBA)0.52930.3456Inherited
G proteins11Inherited
Transducin (heterotrimeric G protein), gamma chain0.027960.004128Inherited
Ran-binding protein mog1p0.20970.08121Inherited
Protein prenylyltransferase0.020030.002554Inherited
NTF2-like0.4150.2654Inherited
Protein prenyltransferases0.0047510.009617Inherited
Pectate lyase-like11Inherited
Laminin G-like module0.20970.8054Inherited
Snake venom toxins0.028920.02963Inherited
Molybdopterin synthase subunit MoaE0.14820.01069Inherited
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0.075520.1678Inherited
Galectin (animal S-lectin)0.023390.06361Inherited
C-type lectin domain0.57311Inherited
Legume lectins0.30191Inherited
HEAT repeat0.019060.00005995Inherited
DBL homology domain (DH-domain)0.24370.005822Inherited
B56-like0.65690.5036Inherited
Ornithine decarboxylase antizyme-like0.0084390.004522Inherited
RhoGDI-like11Inherited
Plant invertase/pectin methylesterase inhibitor0.961Inherited
SH3-domain0.88460.00000000000002339Inherited
Sema domain01Inherited
STAR domain11Inherited
Glycolipid transfer protein, GLTP0.54410.2138Inherited
Vacuolar ATP synthase subunit C0.54410.3072Inherited
LacY-like proton/sugar symporter00.02374Inherited
IIA domain of mannitol-specific and ntr phosphotransferase EII0.15250.3682Inherited
AtpF-like0.31280.3228Inherited
Proton glutamate symport protein0.001310.00001142Inherited
CalX-beta domain00.57Inherited
Nicotinic receptor ligand binding domain-like0.040480Inherited
Ammonium transporter0.097760.03568Inherited
Preprotein translocase SecE subunit0.41090.3511Inherited
Phoshatidylinositol transfer protein, PITP0.6680.6209Inherited
Mitochondrial cytochrome c oxidase subunit IV11Inherited
Cytochrome c oxidase subunit I-like0.9840.9184Inherited
Globins0.067690.4151Inherited
Outer membrane efflux proteins (OEP)0.79830.8372Inherited
Porin0.10820.1097Inherited
SOUL heme-binding protein0.057060.3511Inherited
14-3-3 protein0.0089640.07372Inherited
PTPA-like0.87131Inherited
Phosphorelay protein-like0.70920.6534Inherited
Protein kinases, catalytic subunit0.06620.0001222Inherited
Mob1/phocein0.65690.4531Inherited
Casein kinase II beta subunit0.092870.1941Inherited
UDPGT-like0.024760.0274Inherited
Ubiquitin-related0.012980.3252Inherited
Deoxycytidylate deaminase-like11Inherited
Macro domain0.077560.0000821Inherited
NodB-like polysaccharide deacetylase11Inherited
Myosin phosphatase inhibitor 17kDa protein, CPI-1700.04467Inherited
Nucleotide and nucleoside kinases0.002380.00001994Inherited
MaoC-like0.00073620.08702Inherited
Clp protease, ClpP subunit0.9251Inherited
Mitochondrial carrier0.22110.04141Inherited
Branched-chain alpha-keto acid dehydrogenase PP module0.28220.845Inherited
Actin/HSP700.013790.605Inherited
Nitrogenase iron protein-like0.10730.05047Inherited
Hypothetical protein PH16020.017190.02494Inherited
Biotin dependent carboxylase carboxyltransferase domain0.24370.2661Inherited
Methenyltetrahydrofolate synthetase0.54411Inherited
RING finger domain, C3HC40.77491Inherited
UFC1-like0.079880.08121Inherited
Eukaryotic glutathione synthetase ATP-binding domain00.4216Inherited
N-type ATP pyrophosphatases0.00070830.1972Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.88951Inherited
Cyclin A/CDK2-associated p19, Skp20.56490.5766Inherited
CoaB-like0.028920.002255Inherited
Pantothenate synthetase (Pantoate-beta-alanine ligase, PanC)0.043650.1569Inherited
Acetyl-CoA synthetase-like11Inherited
Hect, E3 ligase catalytic domain0.56490.008175Inherited
ADC synthase0.066690.2501Inherited
beta-Phosphoglucomutase-like0.96441Inherited
D-ribulose-5-phosphate 3-epimerase0.060230.04454Inherited
MAPEG domain0.0012830.001962Inherited
Cyclophilin (peptidylprolyl isomerase)0.97781Inherited
RbsD-like0.31280.3228Inherited
NagB-like0.28280.5622Inherited
Cofactor-dependent phosphoglycerate mutase0.2930.2289Inherited
Pseudouridine synthase I TruA0.14730.1624Inherited
Pseudouridine synthase RsuA/RluD0.8221Inherited
HAL/PAL-like00.0185Inherited
IPP isomerase-like0.40610.9144Inherited
Crotonase-like11Inherited
MIF-related0.060230.04454Inherited
FKBP immunophilin/proline isomerase0.093290.001658Inherited
N-acylglucosamine (NAG) epimerase0.0084390.008598Inherited
UDP-N-acetylglucosamine 2-epimerase00.001084Inherited
Aldose 1-epimerase (mutarotase)11Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.000000063140.006528Inherited
CoA-transferase family III (CaiB/BaiF)0.931Inherited
Thioltransferase0.91720.966Inherited
Tryptophan biosynthesis enzymes0.14340.6884Inherited
Triosephosphate isomerase (TIM)0.77340.5763Inherited
Methylmalonyl-CoA epimerase0.49130.5105Inherited
mono-SIS domain0.060230.5677Inherited
Adenylyl and guanylyl cyclase catalytic domain0.22060.0000000000001109Inherited
Cystathionine synthase-like11Inherited
6-pyruvoyl tetrahydropterin synthase0.1110.1132Inherited
Dehydroquinate synthase, DHQS0.22060.8548Inherited
Aconitase iron-sulfur domain0.77720.8807Inherited
gamma-carbonic anhydrase-like0.95490.9539Inherited
LeuD-like0.1110.5756Inherited
Aristolochene/pentalenene synthase0.56490.3682Inherited
Carbonic anhydrase0.2930.08351Inherited
Class II FBP aldolase11Inherited
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0.55371Inherited
S-adenosylmethionine decarboxylase0.56490.5731Inherited
Uroporphyrinogen decarboxylase, UROD0.18820.5731Inherited
2-methylcitrate dehydratase PrpD11Inherited
FAH0.96971Inherited
RecA protein-like (ATPase-domain)0.50370.5121Inherited
ATP synthase (F1-ATPase), gamma subunit11Inherited
Arginase-like amidino hydrolases0.76141Inherited
Dimethylarginine dimethylaminohydrolase DDAH0.1110.1132Inherited
Sir2 family of transcriptional regulators0.26640.03741Inherited
Glutaminase/Asparaginase0.48870.08375Inherited
N-acetylmuramoyl-L-alanine amidase-like0.044330.01564Inherited
Amidase signature (AS) enzymes11Inherited
(Glycosyl)asparaginase0.0036950.2597Inherited
AstE/AspA-like0.057060.05787Inherited
Histone deacetylase, HDAC0.066690.0000000001237Inherited
Heme-dependent catalases0.05040.03127Inherited
Glutaminase00.7795Inherited
LmbE-like0.17520.006019Inherited
Carbamilase0.87131Inherited
Nitrilase11Inherited
Epoxide hydrolase11Inherited
Mug-like0.0084390.06004Inherited
Uracil-DNA glycosylase00.02374Inherited
N-deoxyribosyltransferase0.028920.1132Inherited
Nucleoside hydrolase0.10820.2302Inherited
Plant cytotoxins00.04467Inherited
DNA repair glycosylase, 2 C-terminal domains0.14731Inherited
Purine and uridine phosphorylases0.86981Inherited
ADP-ribosylglycohydrolase0.059180.04454Inherited
PaaI/YdiI-like0.022030.01931Inherited
Serine carboxypeptidase-like0.48871Inherited
Hydroxynitrile lyase-like00.002479Inherited
Cutinase-like0.47030.5351Inherited
Pectin methylesterase0.7861Inherited
Acetylcholinesterase-like0.28220.9306Inherited
Carboxylesterase11Inherited
Fungal lipases10.8956Inherited
Serum paraoxonase/arylesterase 1, PON10.057060.1879Inherited
GlpX-like bacterial fructose-1,6-bisphosphatase0.098660.1015Inherited
Cell cycle control phosphatase, catalytic domain00.03607Inherited
Higher-molecular-weight phosphotyrosine protein phosphatases0.25360.00002811Inherited
Low-molecular-weight phosphotyrosine protein phosphatases0.0047410.02494Inherited
PDEase00.02667Inherited
Xylanase/endoglucanase 11/1211Inherited
Ribonuclease H0.96971Inherited
Galacturonase10.9662Inherited
Extended AAA-ATPase domain0.16271Inherited
DLC0.22970.299Inherited
Inorganic pyrophosphatase0.30190.1115Inherited
Motor proteins0.0047410.0005761Inherited
Acylphosphatase-like0.33070.2338Inherited
Glyoxalase II (hydroxyacylglutathione hydrolase)0.98191Inherited
Hypothetical esterase YJL068C0.017190.01716Inherited
Bacterial lipase0.079880.006839Inherited
Patatin0.0097870.006088Inherited
Family 1 of glycosyl hydrolase0.84091Inherited
ABC transporter ATPase domain-like0.36320.6254Inherited
Glycerophosphoryl diester phosphodiesterase0.61471Inherited
Histidine acid phosphatase0.002850.9681Inherited
5'(3')-deoxyribonucleotidase (dNT-2)0.28220.2924Inherited
Astacin11Inherited
Hemopexin-like domain01Inherited
Adenain-like0.56490.0009489Inherited
Ubiquitin thiolesterase protein OTUB2 (Otubain-2)0.8220.7382Inherited
Ubiquitin carboxyl-terminal hydrolase UCH-L0.48150.009056Inherited
Dual specificity phosphatase-like0.1420.02754Inherited
Gastric lipase0.36670.5254Inherited
Type II chitinase11Inherited
beta-glycanases11Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.028921Inherited
beta-Galactosidase/glucuronidase, N-terminal domain01Inherited
HIT (HINT, histidine triad) family of protein kinase-interacting proteins0.27110.5066Inherited
Kid/PemK0.28210.2884Inherited
Ribonuclease Rh-like0.65131Inherited
Pepsin-like0.70381Inherited
Proteasome subunits11Inherited
Dihydroorotase0.065720.06749Inherited
Arylsulfatase0.084830.9123Inherited
C-type lysozyme0.0054930.002826Inherited
Carbon-carbon bond hydrolase0.15250.1132Inherited
Phosphonoacetate hydrolase0.098660.9855Inherited
CoA transferase alpha subunit-like0.28220.4071Inherited
CoA transferase beta subunit-like0.49130.5677Inherited
Biotin synthase0.028540.08176Inherited
Holo-(acyl carrier protein) synthase ACPS0.14730.8903Inherited
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK00.05787Inherited
Inositol polyphosphate kinase (IPK)0.39651Inherited
Phosphoribulokinase/pantothenate kinase0.89390.9538Inherited
RNA-polymerase beta-prime0.040480.04217Inherited
Lesion bypass DNA polymerase (Y-family), catalytic domain0.040480.01056Inherited
RBP11/RpoL0.0097870.00985Inherited
RNA polymerase subunit RPB100.39650.6025Inherited
RNA-polymerase beta10.93Inherited
RPB60.88690.9855Inherited
Hexokinase0.028920.3422Inherited
RNA polymerase II subunit RBP4 (RpoF)0.028920.07783Inherited
Thiamin biosynthesis kinases0.15250.366Inherited
Pleckstrin-homology domain (PH domain)0.29330.0000000003093Inherited
Diacylglycerol kinase-like0.020030.01931Inherited
Shikimate kinase (AroK)00.8014Inherited
Adenylyltransferase0.0089320.007897Inherited
APH phosphotransferases0.019160.005676Inherited
HPr-like0.20970.5862Inherited
Squalene synthase00.05577Inherited
Undecaprenyl diphosphate synthase0.079881Inherited
Glutathione S-transferase (GST), N-terminal domain0.065720.0005012Inherited
Enolpyruvate transferase, EPT0.079880.6905Inherited
tRNA-guanine transglycosylase0.028920.0007693Inherited
Gtf glycosyltransferase0.31281Inherited
Glycosyl transferases group 10.79840.9199Inherited
FucT-like0.043260.03271Inherited
Spore coat polysaccharide biosynthesis protein SpsA0.065720.3228Inherited
alpha-1,3-galactosyltransferase-like0.14341Inherited
Oligosaccharyltransferase subunit ost4p0.0068350.004726Inherited
Malate synthase G0.16690.1319Inherited
Citrate synthase0.73690.1083Inherited
LplA-like0.033580.2366Inherited
Glutaminyl-peptide cyclotransferase-like0.49130.4817Inherited
Gamma-glutamyl cyclotransferase-like0.052430.06068Inherited
Galactoside acetyltransferase-like11Inherited
N-acetyl transferase, NAT11Inherited
Arylamine N-acetyltransferase0.9250.9144Inherited
O-acetyltransferase0.15250.2165Inherited
Thiolase-related0.71661Inherited
SpoU-like RNA 2'-O ribose methyltransferase0.49131Inherited
Leucine carboxy methyltransferase Ppm10.39650.7357Inherited
RNA methyltransferase FtsJ0.95350.8127Inherited
rRNA adenine dimethylase-like0.75750.4864Inherited
Formyltransferase0.31281Inherited
Ketopantoate hydroxymethyltransferase PanB0.1110.08121Inherited
ADP-heptose LPS heptosyltransferase II0.28220.2924Inherited
Tpt1/KptA0.14730.1015Inherited
Cytochrome b50.99421Inherited
Acireductone dioxygenase0.0097870.1498Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.012380.2032Inherited
ERO1-like0.24370.424Inherited
Peptide methionine sulfoxide reductase0.70920.3582Inherited
Quinone reductase0.0089320.02494Inherited
NADH:FMN oxidoreductase-like0.1441Inherited
FMN-linked oxidoreductases11Inherited
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0.31281Inherited
NADH oxidase/flavin reductase0.68170.9827Inherited
Pancreatic lipase, N-terminal domain11Inherited
Spider toxins0.043650.04467Inherited
Long-chain scorpion toxins0.017190.01716Inherited
COMT-like11Inherited
Stathmin0.90640.4688Inherited
MetI-like0.022620.000302Inherited
NQO2-like0.31280.7193Inherited
Flavodoxin-related00.9593Inherited
Rubredoxin0.14730.3511Inherited
Isochorismatase-like hydrolases11Inherited
GckA/TtuD-like0.020030.02024Inherited
Mycolic acid cyclopropane synthase0.028540.04746Inherited
Cellulases catalytic domain0.96971Inherited
Guanidinoacetate methyltransferase0.14730.6025Inherited
N5-glutamine methyltransferase, HemK0.10820.2165Inherited
Arylamine N-methyltransferase0.040480.04094Inherited
tRNA(1-methyladenosine) methyltransferase-like0.14730.1569Inherited
3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB0.098660.1132Inherited
Clathrin coat assembly domain11Inherited
Glycerol-3-phosphate transporter0.72910.5158Inherited
1,3-glucuronyltransferase0.014010.0004995Inherited
Class I glutamine amidotransferases (GAT)0.0067020.003351Inherited
AAT-like11Inherited
PfkB-like kinase0.95350.9407Inherited
Carboxylesterase/thioesterase 111Inherited
Thioesterases0.55420.5148Inherited
AD-003 protein-like0.060230.06061Inherited
Protein-L-isoaspartyl O-methyltransferase0.0010750.001137Inherited
Creatinase/aminopeptidase0.33071Inherited
TrmB-like0.0068350.006839Inherited
Homocysteine S-methyltransferase0.079880.0185Inherited
Tetrapyrrole methylase0.059180.8019Inherited
beta-Lactamase/D-ala carboxypeptidase0.050890.00363Inherited
Dihydrofolate reductases0.018640.007897Inherited
HLH, helix-loop-helix DNA-binding domain0.66210.01171Inherited
PNP-oxidase like11Inherited
Transcription factor IIA (TFIIA), alpha-helical domain00.06615Inherited
Capz alpha-1 subunit11Inherited
p25-alpha0.0037010.003749Inherited
Cofilin-like11Inherited
Spectrin repeat0.14730.000001538Inherited
Arp2/3 complex 21 kDa subunit ARPC30.25360.2573Inherited
L-arabinose binding protein-like0.0015810Inherited
Proteasome activator0.57890.3401Inherited
Interleukin 8-like chemokines0.021350.00006637Inherited
Papain-like11Inherited
Cullin repeat0.079880.1146Inherited
PDZ domain0.14820.000000000000001257Inherited
Heat shock protein 90, HSP90, N-terminal domain0.065720.489Inherited
Enabled/VASP homology 1 domain (EVH1 domain)0.098660.0000005212Inherited
gp120 core00.02963Inherited
Plakophilin 1 helical region0.065720.9284Inherited
TRADD, N-terminal domain00.06749Inherited
Insulin-like0.99950.9473Inherited
Ephrin ectodomain0.57890.5092Inherited
Long-chain cytokines0.97361Inherited
Interleukin 17F, IL-17F0.48870.1879Inherited
SNARE fusion complex0.64670.8413Inherited
Sec1/munc18-like (SM) proteins0.0014040.00003792Inherited
Arrestin/Vps26-like0.28220.1601Inherited
BAR domain0.0032760.004757Inherited
Cell cycle regulatory proteins0.48530.4223Inherited
Annexin0.99781Inherited
Penta-EF-hand proteins0.060230.000007826Inherited
Translationally controlled tumor protein TCTP (histamine-releasing factor)0.22110.223Inherited
SGL-like0.0063320.003418Inherited
Phosphoserine phosphatase00.3582Inherited
Calmodulin-like11Inherited
Vertebrate phospholipase A20.013490.01068Inherited
Tetratricopeptide repeat (TPR)0.38090.002026Inherited
Ligand-gated protein channel0.49130.06004Inherited
Multidrug resistance efflux transporter EmrE0.023690.0001557Inherited
Pilin0.031730.04746Inherited
Tissue inhibitor of metalloproteinases, TIMP0.043260.02487Inherited
Blood coagulation inhibitor (disintegrin)0.24370.000000008464Inherited
Interleukin-1 (IL-1)0.54410.03491Inherited
Short-chain cytokines0.0067020.1004Inherited
Interferons/interleukin-10 (IL-10)11Inherited
Gonadodropin/Follitropin0.53580.5519Inherited
Regulator of chromosome condensation RCC10.63130.9049Inherited
Ras GEF0.16270.0000364Inherited
BCR-homology GTPase activation domain (BH-domain)0.65130.00013Inherited
I set domains0.15250.0000000000005621Inherited
Transcriptional factor tubby, C-terminal domain00.3285Inherited
Fibronectin type III0.03250Inherited
Small Kunitz-type inhibitors & BPTI-like toxins0.41361Inherited
Serpins0.33250.6051Inherited
HemD-like0.0084390.2884Inherited
Thymidylate synthase/dCMP hydroxymethylase0.079880.1182Inherited
Spermidine synthase0.24330.37Inherited
Ribonucleotide reductase-like0.025180.01452Inherited
NLI interacting factor-like phosphatase0.86761Inherited
PP2C-like0.90370.4887Inherited
SAICAR synthase0.043650.1017Inherited
PAPS reductase-like0.20970.08176Inherited
Glutathione peroxidase-like0.92681Inherited
CCP-like11Inherited
Decarboxylase0.16690.1439Inherited
RNase Z-like0.57891Inherited
CAF1-like ribonuclease0.033580.0517Inherited
P1 nuclease0.71660.3228Inherited
Cytochrome P45011Inherited
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains0.14730.0009222Inherited
Methylenetetrahydrofolate reductase00.5763Inherited
Ribokinase-like0.2110.8717Inherited
Phosphoenolpyruvate mutase/Isocitrate lyase-like11Inherited
Bee venom hyaluronidase0.018640.0005224Inherited
Pyridoxal-dependent decarboxylase0.16691Inherited
L-aspartase/fumarase11Inherited
Ferrochelatase0.3770.09273Inherited
Isoprenyl diphosphate synthases0.010140.000007893Inherited
Dihydropteroate synthetase00.02887Inherited
DHN aldolase/epimerase0.28220.9172Inherited
Chorismate synthase, AroC0.098660.4097Inherited
Choline kinase0.70920.2929Inherited
Iron-containing alcohol dehydrogenase10.8158Inherited
Adenosine-5'phosphosulfate kinase (APS kinase)0.1110.1624Inherited
GABA-aminotransferase-like11Inherited
Nq06-like0.71420.7382Inherited
Nqo5-like0.7860.8903Inherited
Nqo4-like0.95860.895Inherited
Inosine monophosphate dehydrogenase (IMPDH)11Inherited
C5 cytosine-specific DNA methylase, DCM0.098660.4388Inherited
Class I DAHP synthetase0.88950.9004Inherited
Pyruvate oxidase and decarboxylase Pyr module0.098661Inherited
L-histidinol dehydrogenase HisD0.098660.1132Inherited
Amylase, catalytic domain0.098660.9206Inherited
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III00.04094Inherited
L15e0.8220.8537Inherited
L23p11Inherited
Ribosomal protein L111Inherited
Ribosomal protein L130.57891Inherited
Ribosomal protein L140.94471Inherited
Ribosomal protein L30p/L7e0.67730.7282Inherited
Ribosomal protein L31e0.73740.7664Inherited
Ribosomal protein L33p0.77720.8537Inherited
Ribosomal protein L35ae11Inherited
Ribosomal protein L511Inherited
Ribosomal protein S100.61470.1941Inherited
Ribosomal protein S160.019160.1921Inherited
Ribosomal protein S190.96971Inherited
Ribosomal protein S27e0.73740.7664Inherited
Ribosomal protein S40.3771Inherited
Ribosomal protein S60.3770.6758Inherited
Ribosomal protein S811Inherited
Ribosomal proteins L15p and L18e11Inherited
Ribosomal proteins L24p and L21e0.7860.8259Inherited
Rps19E-like0.98690.9855Inherited
Translational machinery components10.8084Inherited
Tandem AAA-ATPase domain11Inherited
IF2B-like0.0089320.03564Inherited
Translation initiation factor eIF4e0.87130.7418Inherited
L30e/L7ae ribosomal proteins0.99620.828Inherited
Pseudouridine synthase II TruB0.77720.7367Inherited
DnaQ-like 3'-5' exonuclease0.54261Inherited
DNase I-like0.21250.8158Inherited
Eukaryotic EndoU ribonuclease00.002479Inherited
BTB/POZ domain0.1130.00007585Inherited
Pumilio repeat0.88691Inherited
Canonical RBD11Inherited
eIF1-like0.79830.6884Inherited
Release factor11Inherited
Ribosomal protein S70.99280.7282Inherited
Ribosomal protein L18 and S110.77490.907Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.36150.4778Inherited
Translin0.41520.366Inherited
Cold shock DNA-binding domain-like11Inherited
DNA gyrase/MutL, N-terminal domain0.57890.1764Inherited
Homeodomain0.80490.671Inherited
HMG-box0.0097870Inherited
Single strand DNA-binding domain, SSB0.90640.02466Inherited
Prokaryotic DNA-bending protein00.02963Inherited
Nucleosome core histones11Inherited
Classic zinc finger, C2H20.41470.9533Inherited
2'-5'-oligoadenylate synthetase 1, OAS1, N-terminal domain0.20970.000000145Inherited
Interferon regulatory factor0.098660.2643Inherited
ets domain00.02677Inherited
Forkhead DNA-binding domain0.065720.0000192Inherited
TBP-associated factors, TAFs0.0075340.01044Inherited
Cystatins0.089670.1323Inherited
NAD kinase-like00.4688Inherited
Phosphoglycerate kinase0.010940.02716Inherited
Nucleoside diphosphate kinase, NDK0.90850.668Inherited
PP1699/LP2961-like11Inherited
ML domain0.48150.4959Inherited
Prefoldin11Inherited
DNA-binding N-terminal domain of transcription activators0.56490.5618Inherited
MarR-like transcriptional regulators0.1110.273Inherited
WD40-repeat10.003031Inherited
CheY-related0.0039840.002392Inherited
Myosin S1 fragment, N-terminal domain0.96970.2842Inherited
ALDH-like11Inherited
Acyl-CoA binding protein0.96971Inherited


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Supra-domain (including individual superfamily)

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