SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Thiomicrospira crunogena XCL-2

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

  • For a list of unique full length architectures for this genome click here (can be slow).
Adjacent domain pairs graph

Graph of adjacent domain pairs.


Add or remove domain pairs

The links below permit the addition or removal of specific sets of domain combination pairs.


Jump to [ Top of page · Add/remove domain pairs · Domain combination pairs ]

Add or remove genomes

Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.

Add or remove genomes:
Include genomes:
Exclude genomes:


Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes ]

Domain combination pairs

598 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 1810
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 1713
Nucleotide cyclase EAL domain-like 1710
PYP-like sensor domain (PAS domain) Nucleotide cyclase 1412
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 126
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 115
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 115
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 115
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 115
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 104
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 99
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 94
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheY-like 99
PYP-like sensor domain (PAS domain) EAL domain-like 87
Actin-like ATPase domain Actin-like ATPase domain 83
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 88
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 73
Homodimeric domain of signal transducing histidine kinase CheY-like 77
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 71
P-loop containing nucleoside triphosphate hydrolases Translation proteins 75
PYP-like sensor domain (PAS domain) PYP-like sensor domain (PAS domain) 77
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 73
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 64
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 66
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
CheY-like PYP-like sensor domain (PAS domain) 66
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 63
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 64
Calcium ATPase, transduction domain A HAD-like 64
HAD-like Calcium ATPase, transmembrane domain M 64
PreATP-grasp domain Rudiment single hybrid motif 52
Sensory domain-like Nucleotide cyclase 54
CheY-like Homeodomain-like 53
PYP-like sensor domain (PAS domain) Methyl-accepting chemotaxis protein (MCP) signaling domain 55
PurM N-terminal domain-like PurM C-terminal domain-like 52
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 52
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 53
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 53
Translation proteins EF-G C-terminal domain-like 43
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 43
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 44
PYP-like sensor domain (PAS domain) Sensory domain-like 44
CheY-like C-terminal effector domain of the bipartite response regulators 41
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 44
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 42
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 42
CheY-like P-loop containing nucleoside triphosphate hydrolases 42
Nucleic acid-binding proteins Nucleic acid-binding proteins 43
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 42
Cupredoxins Cupredoxins 43
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 41
Alpha-L RNA-binding motif Pseudouridine synthase 41
RuBisCO, large subunit, small (N-terminal) domain RuBisCo, C-terminal domain 31
Chaperone J-domain HSP40/DnaJ peptide-binding domain 32
Homodimeric domain of signal transducing histidine kinase Histidine-containing phosphotransfer domain, HPT domain 32
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 33
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 33
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
Sensory domain-like EAL domain-like 33
HAMP domain-like Methyl-accepting chemotaxis protein (MCP) signaling domain 33
Thioredoxin-like GST C-terminal domain-like 31
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 33
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 31
HD-domain/PDEase-like ACT-like 32
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
ACT-like ACT-like 33
Cytochrome c Cytochrome c 32
Cation efflux protein transmembrane domain-like Cation efflux protein cytoplasmic domain-like 31
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 32
Nucleotidyltransferase ACT-like 32
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 32
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 32
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 31
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 32
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 31
EF-G C-terminal domain-like EF-G C-terminal domain-like 32
HD-domain/PDEase-like Nucleotidyltransferase 32
PYP-like sensor domain (PAS domain) HAMP domain-like 33
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 32
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 32
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Histidine-containing phosphotransfer domain, HPT domain 32
EAL domain-like HD-domain/PDEase-like 31
Triger factor/SurA peptide-binding domain-like FKBP-like 33
Translation proteins SH3-like domain Nucleic acid-binding proteins 32
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
Thiolase-like Thiolase-like 31
Periplasmic binding protein-like II Periplasmic binding protein-like II 33
PLP-binding barrel Alanine racemase C-terminal domain-like 32
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 31
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 31
Composite domain of metallo-dependent hydrolases Metallo-dependent hydrolases 32
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
(Trans)glycosidases Glycosyl hydrolase domain 22
CBS-domain pair Nucleotide cyclase 22
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 22
CheY-like HD-domain/PDEase-like 21
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 22
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 21
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 21
tRNA-binding arm Class II aaRS and biotin synthetases 21
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 22
"Winged helix" DNA-binding domain Rhodanese/Cell cycle control phosphatase 21
EAL domain-like CBS-domain pair 22
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 22
CheY-like EAL domain-like 22
HAMP domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Nucleic acid-binding proteins RuvA domain 2-like 22
Nucleotidyltransferase Poly A polymerase C-terminal region-like 21
MgtE N-terminal domain-like MgtE membrane domain-like 22
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 21
Nucleotidyltransferase Nucleotidyltransferase substrate binding subunit/domain 22
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 22
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 22
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 22
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 22
Periplasmic binding protein-like II Nucleotide cyclase 22
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 21
Methyl-accepting chemotaxis protein (MCP) signaling domain Methyl-accepting chemotaxis protein (MCP) signaling domain 22
Thioredoxin-like TPR-like 21
CheY-like Nucleotide cyclase 22
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 22
PYP-like sensor domain (PAS domain) GAF domain-like 22
Periplasmic binding protein-like II PYP-like sensor domain (PAS domain) 22
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 21
Metal cation-transporting ATPase, ATP-binding domain N HAD-like 21
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 21
EspE N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 22
Nucleotidyltransferase TGS-like 21
6-phosphogluconate dehydrogenase C-terminal domain-like UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
CBS-domain pair FAD-binding/transporter-associated domain-like 21
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 22
Class II aaRS and biotin synthetases ThrRS/AlaRS common domain 22
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 22
HAMP domain-like Homodimeric domain of signal transducing histidine kinase 22
CheW-like CheY-like 21
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheW-like 21
HAMP domain-like Nucleotide cyclase 22
Rhodanese/Cell cycle control phosphatase Rhodanese/Cell cycle control phosphatase 21
Homodimeric domain of signal transducing histidine kinase CheW-like 21
GreA transcript cleavage protein, N-terminal domain FKBP-like 21
Phospholipase D/nuclease Phospholipase D/nuclease 22
MoeA N-terminal region -like MoeA C-terminal domain-like 21
PUA domain-like Ribosomal protein S5 domain 2-like 22
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 21
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 22
Carbamate kinase-like ACT-like 22
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 21
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
vWA-like TPR-like 22
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 22
"Winged helix" DNA-binding domain Dimeric alpha+beta barrel 21
Metal cation-transporting ATPase, ATP-binding domain N Calcium ATPase, transmembrane domain M 21
NAD(P)-binding Rossmann-fold domains ACT-like 22
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 22
MgtE N-terminal domain-like CBS-domain pair 22
CBS-domain pair MgtE membrane domain-like 22
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 21
Calcium ATPase, transduction domain A Metal cation-transporting ATPase, ATP-binding domain N 21
TGS-like ACT-like 21
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
NAD(P)-binding Rossmann-fold domains UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
HD-domain/PDEase-like TGS-like 21
Histidine-containing phosphotransfer domain, HPT domain CheW-like 21
HAMP domain-like EAL domain-like 22
GAF domain-like Nucleotide cyclase 22
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 22
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 21
Sensory domain-like HAMP domain-like 22
Sensory domain-like Methyl-accepting chemotaxis protein (MCP) signaling domain 22
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 21
ACT-like Formyltransferase 21
PurM C-terminal domain-like Class I glutamine amidotransferase-like 11
Glutamyl tRNA-reductase catalytic, N-terminal domain NAD(P)-binding Rossmann-fold domains 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
P-loop containing nucleoside triphosphate hydrolases HRDC-like 11
Nucleic acid-binding proteins S-adenosyl-L-methionine-dependent methyltransferases 11
FAD-binding/transporter-associated domain-like FAD-linked oxidases, C-terminal domain 11
PheT/TilS domain Putative DNA-binding domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Sensory domain-like CheY-like 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
Nudix Thiamin phosphate synthase 11
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III TK C-terminal domain-like 11
lambda repressor-like DNA-binding domains RmlC-like cupins 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
Aconitase B, N-terminal domain Aconitase iron-sulfur domain 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
Methionine synthase domain Methionine synthase activation domain-like 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
Putative DNA-binding domain Translation proteins 11
Rudiment single hybrid motif PH0987 N-terminal domain-like 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
Leukotriene A4 hydrolase N-terminal domain Metalloproteases ("zincins"), catalytic domain 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
RuvA domain 2-like BRCT domain 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
PreATP-grasp domain PreATP-grasp domain 11
Glycerol-3-phosphate (1)-acyltransferase Acyl-CoA N-acyltransferases (Nat) 11
Macro domain-like Zn-dependent exopeptidases 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
2Fe-2S ferredoxin-like CO dehydrogenase ISP C-domain like 11
alpha-helical ferredoxin Nucleotide-binding domain 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) FMN-linked oxidoreductases 11
Periplasmic binding protein-like II Lysozyme-like 11
HMA, heavy metal-associated domain HAD-like 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
Ribonuclease H-like DNA/RNA polymerases 11
TGS-like Class II aaRS and biotin synthetases 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
YajQ-like YajQ-like 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Formate dehydrogenase/DMSO reductase, domains 1-3 ADC-like 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Carbamate kinase-like PUA domain-like 11
TGS-like Class II aaRS ABD-related 11
Aldolase post-HMGL domain-like 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
GAF domain-like Homodimeric domain of signal transducing histidine kinase 11
Dihydropteroate synthetase-like Methionine synthase domain 11
YjeF N-terminal domain-like Ribokinase-like 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
Aldolase AFP III-like domain 11
Siroheme synthase middle domains-like Tetrapyrrole methylase 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain 11
Sensory domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
FAD/NAD(P)-binding domain Nitrite/Sulfite reductase N-terminal domain-like 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain ACT-like 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
Dihydropteroate synthetase-like Cobalamin (vitamin B12)-binding domain 11
MOP-like MOP-like 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
TolB, N-terminal domain Tricorn protease N-terminal domain 11
beta-lactamase/transpeptidase-like Penicillin-binding protein associated domain 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
Single hybrid motif CoA-dependent acyltransferases 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
PIN domain-like DNA/RNA polymerases 11
GAF domain-like HD-domain/PDEase-like 11
Nucleotidyltransferase substrate binding subunit/domain Nucleotidyltransferase substrate binding subunit/domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 11
Cyclophilin-like PH0987 N-terminal domain-like 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
Lysozyme-like beta-lactamase/transpeptidase-like 11
Homocysteine S-methyltransferase Dihydropteroate synthetase-like 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
Periplasmic binding protein-like II ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Translation proteins Translation proteins 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
FAD/NAD(P)-binding domain HI0933 insert domain-like 11
PurS-like PurM C-terminal domain-like 11
GroEL equatorial domain-like GroEL apical domain-like 11
UDP-Glycosyltransferase/glycogen phosphorylase HAD-like 11
DNA clamp DNA clamp 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Nucleic acid-binding proteins BRCT domain 11
PreATP-grasp domain Methylglyoxal synthase-like 11
Cyclophilin-like Single hybrid motif 11
N-terminal domain of MutM-like DNA repair proteins Glucocorticoid receptor-like (DNA-binding domain) 11
Ribosomal protein S5 domain 2-like HSP90 C-terminal domain 11
Nucleotidylyl transferase tRNA-binding arm 11
Homocysteine S-methyltransferase Methionine synthase activation domain-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
THUMP domain-like Rhodanese/Cell cycle control phosphatase 11
DNA-glycosylase Nudix 11
CBS-domain pair CBS-domain pair 11
PUA domain-like alpha/beta knot 11
FAD/NAD(P)-binding domain HydA/Nqo6-like 11
Carbamate kinase-like Acyl-CoA N-acyltransferases (Nat) 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
Nqo1 middle domain-like Nqo1C-terminal domain-like 11
Class II aaRS and biotin synthetases Translation proteins 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
PDZ domain-like PDZ domain-like 11
FliG FliG 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
TrmE connector domain P-loop containing nucleoside triphosphate hydrolases 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
FGAM synthase PurL, linker domain Class I glutamine amidotransferase-like 11
Homocysteine S-methyltransferase Cobalamin (vitamin B12)-binding domain 11
"Winged helix" DNA-binding domain Chorismate lyase-like 11
Translation proteins Ribosomal protein S5 domain 2-like 11
Homocysteine S-methyltransferase Methionine synthase domain 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Nqo1 FMN-binding domain-like alpha-helical ferredoxin 11
"Winged helix" DNA-binding domain GAF domain-like 11
Sensory domain-like Sensory domain-like 11
Glutathione synthetase ATP-binding domain-like Single hybrid motif 11
cAMP-binding domain-like "Winged helix" DNA-binding domain 11
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III Thiamin diphosphate-binding fold (THDP-binding) 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
MetI-like MetI-like 11
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 11
CheY-like Periplasmic binding protein-like I 11
Pili subunits beta-Roll 11
THUMP domain-like Adenine nucleotide alpha hydrolases-like 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
Nucleotidylyl transferase Ribosomal protein L25-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Nucleic acid-binding proteins PheT/TilS domain 11
Homeodomain-like Probable bacterial effector-binding domain 11
Acylphosphatase/BLUF domain-like YrdC/RibB 11
FGAM synthase PurL, linker domain PurM N-terminal domain-like 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
CBS-domain pair PYP-like sensor domain (PAS domain) 11
Trigger factor ribosome-binding domain FKBP-like 11
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 11
Periplasmic binding protein-like II ACT-like 11
Glutathione synthetase ATP-binding domain-like Cyclophilin-like 11
cAMP-binding domain-like CBS-domain pair 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
2Fe-2S ferredoxin-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
PH0987 N-terminal domain-like Single hybrid motif 11
Apolipoprotein A-I Cytochrome c 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
NusB-like S-adenosyl-L-methionine-dependent methyltransferases 11
CBS-domain pair Nucleotide-diphospho-sugar transferases 11
"Winged helix" DNA-binding domain Iron-dependent repressor protein, dimerization domain 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
FKBP-like FKBP-like 11
Protein kinase-like (PK-like) HCP-like 11
NAD(P)-binding Rossmann-fold domains Glutamyl tRNA-reductase dimerization domain 11
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 11
GAF domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
NAD-binding domain of HMG-CoA reductase Substrate-binding domain of HMG-CoA reductase 11
TSP type-3 repeat OmpA-like 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
Periplasmic binding protein-like II CheY-like 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
ClpP/crotonase NfeD domain-like 11
WD40 repeat-like MetI-like 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
2Fe-2S ferredoxin-like Riboflavin synthase domain-like 11
CheY-like Methylesterase CheB, C-terminal domain 11
Rhodanese/Cell cycle control phosphatase S-adenosyl-L-methionine-dependent methyltransferases 11
GAF domain-like CheY-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
CheY-like Histidine-containing phosphotransfer domain, HPT domain 11
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 11
Ribosomal protein L6 Ribosomal protein L6 11
Metallo-dependent phosphatases 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 11
Dihydropteroate synthetase-like Methionine synthase activation domain-like 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
CarD-like TRCF domain-like 11
DNA-binding domain DNA breaking-rejoining enzymes 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Alpha subunit of glutamate synthase, C-terminal domain 11
HlyD-like secretion proteins HlyD-like secretion proteins 11
Formyltransferase FMT C-terminal domain-like 11
Class II aaRS and biotin synthetases YbaK/ProRS associated domain 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
PPK N-terminal domain-like PHP14-like 11
Methionine synthase domain Cobalamin (vitamin B12)-binding domain 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Peptide methionine sulfoxide reductase Thioredoxin-like 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
Pili subunits GspK insert domain-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
PPK N-terminal domain-like Phospholipase D/nuclease 11
FAD/NAD(P)-binding domain Folate-binding domain 11
PhoU-like Protein kinase-like (PK-like) 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
Rudiment single hybrid motif Cyclophilin-like 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
Iron-dependent repressor protein, dimerization domain C-terminal domain of transcriptional repressors 11
NAD(P)-binding Rossmann-fold domains Tetrapyrrole methylase 11
lambda integrase-like, N-terminal domain DNA breaking-rejoining enzymes 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
Homeodomain-like Homeodomain-like 11
Chorismate mutase II Periplasmic binding protein-like II 11
Lysozyme-like PGBD-like 11
Thioredoxin-like Six-hairpin glycosidases 11
Sensory domain-like Homodimeric domain of signal transducing histidine kinase 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) Thioredoxin-like 11
Periplasmic binding protein-like II Homodimeric domain of signal transducing histidine kinase 11
CheY-like CheY-like 11
PurS-like Class I glutamine amidotransferase-like 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
P-loop containing nucleoside triphosphate hydrolases Acyl-CoA N-acyltransferases (Nat) 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
CorA soluble domain-like Magnesium transport protein CorA, transmembrane region 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Actin-like ATPase domain HD-domain/PDEase-like 11
Translation proteins PRC-barrel domain 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
FAD-binding/transporter-associated domain-like alpha-helical ferredoxin 11
RNase III domain-like dsRNA-binding domain-like 11
NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains 11
Thioredoxin-like Mss4-like 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
S13-like H2TH domain Glucocorticoid receptor-like (DNA-binding domain) 11
Glutamyl tRNA-reductase catalytic, N-terminal domain Glutamyl tRNA-reductase dimerization domain 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
FGAM synthase PurL, linker domain PurM C-terminal domain-like 11
TPR-like NTF2-like 11
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 11
Trypsin-like serine proteases PDZ domain-like 11
RuvA domain 2-like JAB1/MPN domain 11
Chemotaxis receptor methyltransferase CheR, N-terminal domain S-adenosyl-L-methionine-dependent methyltransferases 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
PDZ domain-like ClpP/crotonase 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
"Winged helix" DNA-binding domain MOP-like 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
Single hybrid motif FAD/NAD(P)-binding domain 11
GAF domain-like P-loop containing nucleoside triphosphate hydrolases 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
Multiheme cytochromes Multiheme cytochromes 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
Lysozyme-like LysM domain 11
PIN domain-like Ribonuclease H-like 11
Putative DNA-binding domain P-loop containing nucleoside triphosphate hydrolases 11
Aconitase B, N-terminal domain LeuD/IlvD-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
PreATP-grasp domain Single hybrid motif 11
Zn-dependent exopeptidases LysM domain 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
EAL domain-like Periplasmic binding protein-like I 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
Hsp33 domain HSP33 redox switch-like 11
Glycerol-3-phosphate (1)-acyltransferase Acetyl-CoA synthetase-like 11
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 11
Transmembrane di-heme cytochromes a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 11
E set domains (Trans)glycosidases 11
Metalloproteases ("zincins"), catalytic domain PDZ domain-like 11
Ribokinase-like Nucleotidylyl transferase 11
FMN-linked oxidoreductases Alpha subunit of glutamate synthase, C-terminal domain 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
post-HMGL domain-like 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
lambda repressor-like DNA-binding domains Cyanase C-terminal domain 11
Single hybrid motif FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
Rad51 N-terminal domain-like Rad51 N-terminal domain-like 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
Glutathione synthetase ATP-binding domain-like PH0987 N-terminal domain-like 11
Putative DNA-binding domain Initiation factor IF2/eIF5b, domain 3 11
Ribonuclease H-like HRDC-like 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
Ammonium transporter Nucleotide cyclase 11
Nucleotide-diphospho-sugar transferases RmlC-like cupins 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
GIY-YIG endonuclease RuvA domain 2-like 11
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
DNA methylase specificity domain DNA methylase specificity domain 11
Nucleotidylyl transferase Nucleic acid-binding proteins 11
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 11
L30e-like alpha/beta knot 11
Rudiment single hybrid motif Single hybrid motif 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
Chorismate mutase II ACT-like 11
Cobalamin (vitamin B12)-binding domain Methionine synthase activation domain-like 11
E set domains E set domains 11
S-adenosyl-L-methionine-dependent methyltransferases EreA/ChaN-like 11
YhbC-like, N-terminal domain YhbC-like, C-terminal domain 11
Zinc beta-ribbon DNA primase core 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
TrkA C-terminal domain-like TrkA C-terminal domain-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleic acid-binding proteins 11
PHP14-like Phospholipase D/nuclease 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases 11
Bacterial muramidases Lysozyme-like 11
C-type lectin-like S-adenosyl-L-methionine-dependent methyltransferases 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
LeuD/IlvD-like Aconitase iron-sulfur domain 11
Epsilon subunit of F1F0-ATP synthase N-terminal domain Epsilon subunit of F1F0-ATP synthase C-terminal domain 11
Ferritin-like HAD-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Nucleic acid-binding proteins 11
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Alkaline phosphatase-like 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
FAD/NAD(P)-binding domain Aminomethyltransferase beta-barrel domain 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Ribokinase-like ISP domain 11
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 11
P-loop containing nucleoside triphosphate hydrolases MOP-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11
Ferritin-like Calcium ATPase, transmembrane domain M 11
Nucleotidyltransferase Nucleotidyltransferase 11
Cyclophilin-like Cyclophilin-like 11
PurM N-terminal domain-like Class I glutamine amidotransferase-like 11
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HSP90 C-terminal domain 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
Adenine nucleotide alpha hydrolases-like Rhodanese/Cell cycle control phosphatase 11
PurS-like PurM N-terminal domain-like 11
GroEL-intermediate domain like GroEL apical domain-like 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
GAF domain-like Homeodomain-like 11
"Winged helix" DNA-binding domain C-terminal domain of transcriptional repressors 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
UROD/MetE-like UROD/MetE-like 11
YbaK/ProRS associated domain Class II aaRS ABD-related 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
Protein kinase-like (PK-like) P-loop containing nucleoside triphosphate hydrolases 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
LysM domain LysM domain 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
FAD-linked oxidases, C-terminal domain alpha-helical ferredoxin 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
Peptide methionine sulfoxide reductase Mss4-like 11
Ferritin-like Calcium ATPase, transduction domain A 11
RmlC-like cupins RmlC-like cupins 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 11
E set domains Glycosyl hydrolase domain 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
NAD(P)-binding Rossmann-fold domains Siroheme synthase middle domains-like 11
ParB/Sulfiredoxin KorB DNA-binding domain-like 11
Nucleotidyltransferase substrate binding subunit/domain ACT-like 11
Nucleic acid-binding proteins GAD domain-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Adenine nucleotide alpha hydrolases-like 11
PK beta-barrel domain-like PK C-terminal domain-like 11
PIN domain-like P-loop containing nucleoside triphosphate hydrolases 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
GAF domain-like EAL domain-like 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
alpha/beta-Hydrolases Thioredoxin-like 11
Translation proteins ThrRS/AlaRS common domain 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
PreATP-grasp domain PH0987 N-terminal domain-like 11
PurS-like FGAM synthase PurL, linker domain 11
PUA domain-like S-adenosyl-L-methionine-dependent methyltransferases 11
Oxidoreductase molybdopterin-binding domain E set domains 11
ABC transporter involved in vitamin B12 uptake, BtuC Iron-dependent repressor protein, dimerization domain 11
DsbC/DsbG N-terminal domain-like Thioredoxin-like 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
CheY-like PP2C-like 11
TGS-like ThrRS/AlaRS common domain 11
Nucleotidyltransferase substrate binding subunit/domain HD-domain/PDEase-like 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
Rubredoxin-like FAD/NAD(P)-binding domain 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
Fe-S cluster assembly (FSCA) domain-like P-loop containing nucleoside triphosphate hydrolases 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
FAD/NAD(P)-binding domain Nitrite and sulphite reductase 4Fe-4S domain-like 11
PreATP-grasp domain Cyclophilin-like 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
TPR-like TPR-like 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
CheC-like Surface presentation of antigens (SPOA) 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
YrdC/RibB RibA-like 11

Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes · Domain combination pairs ]