SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Paramecium tetraurelia

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

  • For a list of unique full length architectures for this genome click here (can be slow).
Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

1043 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 37525
Growth factor receptor domain Growth factor receptor domain 285119
Voltage-gated potassium channels cAMP-binding domain-like 28510
Protein kinase-like (PK-like) EF-hand 23512
cAMP-binding domain-like cAMP-binding domain-like 22215
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 20149
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheY-like 19714
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 17310
Homodimeric domain of signal transducing histidine kinase CheY-like 1719
Homeodomain-like Homeodomain-like 16612
TPR-like TPR-like 16643
WD40 repeat-like WD40 repeat-like 11054
Calcium ATPase, transduction domain A HAD-like 1099
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 10810
HAD-like Calcium ATPase, transmembrane domain M 10711
Calcium ATPase, transmembrane domain M Metal cation-transporting ATPase, ATP-binding domain N 946
Metal cation-transporting ATPase, ATP-binding domain N HAD-like 924
Calcium ATPase, transduction domain A Metal cation-transporting ATPase, ATP-binding domain N 924
RING/U-box RING/U-box 9019
Ypt/Rab-GAP domain of gyp1p Ypt/Rab-GAP domain of gyp1p 8610
EF-hand EF-hand 7826
RNA-binding domain, RBD RNA-binding domain, RBD 7021
Pentapeptide repeat-like WD40 repeat-like 6744
Actin-like ATPase domain Actin-like ATPase domain 668
P-loop containing nucleoside triphosphate hydrolases ABC transporter transmembrane region 628
Voltage-gated potassium channels Voltage-gated potassium channels 568
SMAD/FHA domain RING/U-box 546
Cyclin-like Cyclin-like 495
Protein kinase-like (PK-like) PH domain-like 4810
WD40 repeat-like Quinoprotein alcohol dehydrogenase-like 4639
Protein kinase-like (PK-like) Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 4510
ABC transporter transmembrane region ABC transporter transmembrane region 454
CCCH zinc finger CCCH zinc finger 443
Thioredoxin-like Thioredoxin-like 4212
Nucleotide cyclase Nucleotide cyclase 4112
Thioredoxin-like GST C-terminal domain-like 396
DUSP-like Cysteine proteinases 399
ARM repeat ARM repeat 3813
cAMP-binding domain-like Protein kinase-like (PK-like) 375
P-loop containing nucleoside triphosphate hydrolases Translation proteins 3715
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 364
P-loop containing nucleoside triphosphate hydrolases WD40 repeat-like 3425
GroEL equatorial domain-like GroEL apical domain-like 334
GroEL equatorial domain-like GroEL-intermediate domain like 323
Nucleotidyltransferase PAP/OAS1 substrate-binding domain 316
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 316
GroEL-intermediate domain like GroEL apical domain-like 312
Ankyrin repeat Protein kinase-like (PK-like) 318
CRAL/TRIO N-terminal domain CRAL/TRIO domain 305
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 309
SMAD/FHA domain SMAD/FHA domain 299
C2 domain (Calcium/lipid-binding domain, CaLB) C2 domain (Calcium/lipid-binding domain, CaLB) 299
Pentapeptide repeat-like Quinoprotein alcohol dehydrogenase-like 2827
Protein prenylyltransferase TPR-like 2619
Calcium ATPase, transduction domain A Nucleotide cyclase 266
P-loop containing nucleoside triphosphate hydrolases Pentapeptide repeat-like 2622
PX domain PX domain 244
Growth factor receptor domain Pectin lyase-like 249
RING/U-box B-box zinc-binding domain 247
Protein kinase-like (PK-like) Protein kinase-like (PK-like) 2310
ARM repeat Protein kinase-like (PK-like) 2313
GroES-like NAD(P)-binding Rossmann-fold domains 233
RING/U-box TRAF domain-like 239
L domain-like Ankyrin repeat 233
C2 domain (Calcium/lipid-binding domain, CaLB) vWA-like 213
Kelch motif Kelch motif 218
PH domain-like BEACH domain 206
E set domains E set domains 2015
HIT/MYND zinc finger-like Protein kinase-like (PK-like) 202
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 209
FYVE/PHD zinc finger FYVE/PHD zinc finger 206
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 205
(Phosphotyrosine protein) phosphatases II C2 domain (Calcium/lipid-binding domain, CaLB) 203
MIR domain MIR domain 196
RNA-binding domain, RBD Retrovirus zinc finger-like domains 191
Globin-like Globin-like 193
Translation proteins EF-G C-terminal domain-like 199
IP3 receptor type 1 binding core, domain 2 IP3 receptor type 1 binding core, domain 2 184
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 188
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 175
DBL homology domain (DH-domain) PX domain 1710
Ribosomal protein S5 domain 2-like EF-G C-terminal domain-like 178
EF-G C-terminal domain-like EF-G C-terminal domain-like 177
PH domain-like Cysteine proteinases 172
Leukotriene A4 hydrolase N-terminal domain Metalloproteases ("zincins"), catalytic domain 174
BEACH domain WD40 repeat-like 176
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 175
PH domain-like Oxysterol-binding protein-like 177
Ubiquitin-like Ubiquitin-like 1713
WD40 repeat-like EF-hand 1613
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 164
RING/U-box RNI-like 165
RNI-like RNI-like 1610
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 164
SAM/Pointed domain SMAD/FHA domain 168
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 165
PX domain WD40 repeat-like 163
HAD-like Nucleotide cyclase 166
GAF domain-like GAF domain-like 151
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 155
Growth factor receptor domain gamma-Crystallin-like 151
PAZ domain Ribonuclease H-like 152
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 156
PH domain-like WD40 repeat-like 154
B-box zinc-binding domain RNI-like 153
Chaperone J-domain HSP40/DnaJ peptide-binding domain 155
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 156
vWA-like Protein kinase-like (PK-like) 153
SET domain RuBisCo LSMT C-terminal, substrate-binding domain 155
MIR domain IP3 receptor type 1 binding core, domain 2 155
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 154
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 145
TPR-like HCP-like 1410
"Winged helix" DNA-binding domain E2F-DP heterodimerization region 142
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 144
SNARE-like SNARE fusion complex 143
Acyl-CoA dehydrogenase C-terminal domain-like Acyl-CoA dehydrogenase C-terminal domain-like 143
Translation proteins Ribosomal protein S5 domain 2-like 146
P-loop containing nucleoside triphosphate hydrolases Quinoprotein alcohol dehydrogenase-like 1413
P-loop containing nucleoside triphosphate hydrolases Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain 143
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 145
Rhodanese/Cell cycle control phosphatase Rhodanese/Cell cycle control phosphatase 132
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 133
Ankyrin repeat Ankyrin repeat 136
Class II aaRS and biotin synthetases Class II aaRS ABD-related 136
EF-hand Cysteine proteinases 1310
(Trans)glycosidases Glycosyl hydrolase domain 134
Protein prenylyltransferase Protein prenylyltransferase 1311
Ribosomal protein S5 domain 2-like HSP90 C-terminal domain 135
Polo-box domain Polo-box domain 134
HCP-like HCP-like 134
Kelch motif POZ domain 136
Galactose oxidase, central domain Kelch motif 137
C2 domain (Calcium/lipid-binding domain, CaLB) EF-hand 138
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HSP90 C-terminal domain 135
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 125
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 123
Cullin homology domain "Winged helix" DNA-binding domain 123
Protein kinase-like (PK-like) Polo-box domain 123
Leukotriene A4 hydrolase N-terminal domain ARM repeat 122
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 126
Nucleic acid-binding proteins Translation proteins SH3-like domain 124
Nucleic acid-binding proteins Nucleic acid-binding proteins 124
Domain of poly(ADP-ribose) polymerase ADP-ribosylation 125
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 125
Metalloproteases ("zincins"), catalytic domain ARM repeat 122
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 122
Ubiquitin-like UBA-like 116
Quinoprotein alcohol dehydrogenase-like Quinoprotein alcohol dehydrogenase-like 1111
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Cysteine proteinases 112
WGR domain-like ADP-ribosylation 114
E set domains (Trans)glycosidases 115
Starch-binding domain-like (Phosphotyrosine protein) phosphatases II 113
Activating enzymes of the ubiquitin-like proteins Activating enzymes of the ubiquitin-like proteins 116
Zn-finger domain of Sec23/24 vWA-like 117
WGR domain-like Domain of poly(ADP-ribose) polymerase 114
Kelch motif Metallo-dependent phosphatases 101
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 103
beta-sandwich domain of Sec23/24 Zn-finger domain of Sec23/24 106
P-loop containing nucleoside triphosphate hydrolases vWA-like 103
Tropomyosin Tropomyosin 105
RCC1/BLIP-II RCC1/BLIP-II 105
Cullin repeat-like Cullin homology domain 101
Ubiquitin-like ARM repeat 104
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 103
Ubiquitin-like Cysteine proteinases 105
Pectin lyase-like Pectin lyase-like 106
Cullin repeat-like "Winged helix" DNA-binding domain 101
EF-hand PH domain-like 103
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 105
WD40 repeat-like RING/U-box 104
ThrRS/AlaRS common domain Class II aaRS and biotin synthetases 106
FKBP-like TPR-like 103
Tricorn protease domain 2 WD40 repeat-like 96
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 91
P-loop containing nucleoside triphosphate hydrolases HSP20-like chaperones 91
t-snare proteins SNARE fusion complex 92
SAM/Pointed domain RING/U-box 94
Voltage-gated potassium channels Nucleotide cyclase 91
SNARE-like Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor 91
F1F0 ATP synthase subunit C F1F0 ATP synthase subunit C 91
Ankyrin repeat PH domain-like 94
Agglutinin HPA-like gamma-Crystallin-like 93
Starch-binding domain-like Starch-binding domain-like 93
beta-beta-alpha zinc fingers beta-beta-alpha zinc fingers 95
Thiolase-like Thiolase-like 93
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 91
Ubiquitin-like Protein kinase-like (PK-like) 93
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 92
beta-sandwich domain of Sec23/24 vWA-like 95
Ankyrin repeat Bromodomain 93
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 92
TPR-like RING/U-box 92
P-loop containing nucleoside triphosphate hydrolases RCC1/BLIP-II 94
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 96
Bet v1-like Oxysterol-binding protein-like 85
CAD & PB1 domains RING/U-box 83
Zn-finger domain of Sec23/24 C-terminal, gelsolin-like domain of Sec23/24 84
SET domain SET domain 84
Protein kinase-like (PK-like) RNI-like 86
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 82
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 82
beta-sandwich domain of Sec23/24 C-terminal, gelsolin-like domain of Sec23/24 84
Protein kinase-like (PK-like) WD40 repeat-like 86
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit P-loop containing nucleoside triphosphate hydrolases 83
vWA-like C-terminal, gelsolin-like domain of Sec23/24 84
EF-hand SAICAR synthase-like 81
ARM repeat Clathrin adaptor appendage domain 84
EF-hand Quinoprotein alcohol dehydrogenase-like 87
B-box zinc-binding domain Kelch motif 84
Metallo-hydrolase/oxidoreductase Rhodanese/Cell cycle control phosphatase 81
Glycoside hydrolase/deacetylase Families 57/38 glycoside transferase middle domain 83
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 83
Nucleotide cyclase PH domain-like 84
GST C-terminal domain-like eEF1-gamma domain 83
P-loop containing nucleoside triphosphate hydrolases TGS-like 82
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 85
PH domain-like Bet v1-like 85
CBS-domain pair CBS-domain pair 81
ARM repeat Formin homology 2 domain (FH2 domain) 82
Cytochrome b5-like heme/steroid binding domain Ferredoxin reductase-like, C-terminal NADP-linked domain 83
Phospholipase D/nuclease Phospholipase D/nuclease 85
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 84
P-loop containing nucleoside triphosphate hydrolases TPR-like 72
Families 57/38 glycoside transferase middle domain Galactose mutarotase-like 72
P-loop containing nucleoside triphosphate hydrolases RING/U-box 72
RNA-binding domain, RBD PABC (PABP) domain 75
TPR-like Protein kinase-like (PK-like) 74
Galactose mutarotase-like Glycosyl hydrolase domain 71
PH domain-like P-loop containing nucleoside triphosphate hydrolases 73
Galactose mutarotase-like (Trans)glycosidases 71
Voltage-gated potassium channels NAD(P)-binding Rossmann-fold domains 72
P-loop containing nucleoside triphosphate hydrolases Phosphoglycerate mutase-like 71
Creatinase/aminopeptidase "Winged helix" DNA-binding domain 72
L domain-like EF-hand 73
Ribonuclease H-like DNA/RNA polymerases 73
FYVE/PHD zinc finger SET domain 74
WD40 repeat-like TPR-like 74
Glycoside hydrolase/deacetylase Galactose mutarotase-like 72
PEP carboxykinase N-terminal domain PEP carboxykinase-like 71
Single hybrid motif CoA-dependent acyltransferases 73
Thioredoxin-like eEF1-gamma domain 72
Eukaryotic type KH-domain (KH-domain type I) Eukaryotic type KH-domain (KH-domain type I) 74
UBC-like Activating enzymes of the ubiquitin-like proteins 74
Calcium ATPase, transmembrane domain M Nucleotide cyclase 73
Sec7 domain ARM repeat 74
BAH domain FYVE/PHD zinc finger 71
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 71
FYVE/PHD zinc finger P-loop containing nucleoside triphosphate hydrolases 75
RING/U-box Cysteine proteinases 74
PX domain Protein kinase-like (PK-like) 72
NAD(P)-binding Rossmann-fold domains P-loop containing nucleoside triphosphate hydrolases 73
GroEL apical domain-like SAICAR synthase-like 62
P-loop containing nucleoside triphosphate hydrolases Smc hinge domain 62
Sec63 N-terminal domain-like E set domains 64
HMG-box HMG-box 63
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 62
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 62
Staphylococcal nuclease Staphylococcal nuclease 64
UBA-like UBA-like 62
Metalloproteases ("zincins"), catalytic domain Growth factor receptor domain 62
RNase III domain-like RNase III domain-like 64
DUSP-like Hect, E3 ligase catalytic domain 61
EF-hand PLC-like phosphodiesterases 63
Flavoproteins Riboflavin synthase domain-like 62
Nucleotide cyclase P-loop containing nucleoside triphosphate hydrolases 62
FYVE/PHD zinc finger Ypt/Rab-GAP domain of gyp1p 62
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 64
Pentapeptide repeat-like DPP6 N-terminal domain-like 66
UBA-like UBC-like 63
Ankyrin repeat WGR domain-like 63
EF-hand ARM repeat 64
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 64
DPP6 N-terminal domain-like WD40 repeat-like 66
BAR/IMD domain-like Ypt/Rab-GAP domain of gyp1p 61
RING/U-box Concanavalin A-like lectins/glucanases 62
ADC-like Cdc48 domain 2-like 62
PLC-like phosphodiesterases C2 domain (Calcium/lipid-binding domain, CaLB) 63
P-loop containing nucleoside triphosphate hydrolases E set domains 65
C2 domain (Calcium/lipid-binding domain, CaLB) Protein kinase-like (PK-like) 62
Protein kinase-like (PK-like) Kelch motif 62
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 64
ADC-like P-loop containing nucleoside triphosphate hydrolases 62
Cdc48 domain 2-like P-loop containing nucleoside triphosphate hydrolases 62
Protein kinase-like (PK-like) KA1-like 62
Ankyrin repeat ADP-ribosylation 63
Flavoproteins Ferredoxin reductase-like, C-terminal NADP-linked domain 62
WD40 repeat-like ARM repeat 64
S-adenosyl-L-methionine-dependent methyltransferases RING/U-box 63
Dipeptidyl peptidase I (cathepsin C), exclusion domain Cysteine proteinases 62
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain SAM/Pointed domain 62
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 62
Voltage-gated potassium channels EF-hand 62
C2 domain (Calcium/lipid-binding domain, CaLB) ARM repeat 62
Guanido kinase N-terminal domain Glutamine synthetase/guanido kinase 62
Ankyrin repeat Domain of poly(ADP-ribose) polymerase 63
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 63
Chromo domain-like P-loop containing nucleoside triphosphate hydrolases 65
L domain-like L domain-like 65
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 62
Protein kinase-like (PK-like) Acyl-CoA dehydrogenase NM domain-like 51
Glutaminase/Asparaginase Ankyrin repeat 52
Translation proteins ThrRS/AlaRS common domain 53
PH domain-like PH domain-like 53
PK beta-barrel domain-like PK C-terminal domain-like 53
FYVE/PHD zinc finger GroEL apical domain-like 51
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 52
SAM/Pointed domain Protein kinase-like (PK-like) 51
Ubiquitin-like C2 domain (Calcium/lipid-binding domain, CaLB) 51
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 51
UBA-like Cysteine proteinases 53
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 53
Quinoprotein alcohol dehydrogenase-like DPP6 N-terminal domain-like 55
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 53
Saposin Metallo-dependent phosphatases 52
Voltage-gated potassium channels HD-domain/PDEase-like 51
BRCT domain BRCT domain 53
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 51
FYVE/PHD zinc finger Chromo domain-like 54
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Adenine nucleotide alpha hydrolases-like 52
Staphylococcal nuclease Tudor/PWWP/MBT 53
vWA-like SPOC domain-like 52
ThrRS/AlaRS common domain Class II aaRS ABD-related 53
P-loop containing nucleoside triphosphate hydrolases SMAD/FHA domain 53
E set domains Galactose-binding domain-like 55
E set domains Kelch motif 54
Metallo-hydrolase/oxidoreductase cAMP-binding domain-like 53
Thioesterase/thiol ester dehydrase-isomerase Thioesterase/thiol ester dehydrase-isomerase 52
FYVE/PHD zinc finger SAICAR synthase-like 51
Starch-binding domain-like UDP-Glycosyltransferase/glycogen phosphorylase 52
RNA-binding domain, RBD Eukaryotic type KH-domain (KH-domain type I) 54
PH domain-like PX domain 54
Protein kinase-like (PK-like) Acyl-CoA dehydrogenase C-terminal domain-like 51
Putative isomerase YbhE WD40 repeat-like 55
Ribosomal protein L6 Ribosomal protein L6 51
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 54
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 52
EGF/Laminin RING/U-box 51
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 53
Cysteine proteinases Calpain large subunit, middle domain (domain III) 54
FAD-binding/transporter-associated domain-like FAD-linked oxidases, C-terminal domain 52
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 51
Nucleotidylyl transferase Ribosomal protein L25-like 43
Ankyrin repeat Nucleotidyltransferase 42
YbaK/ProRS associated domain C-terminal domain of ProRS 41
P-loop containing nucleoside triphosphate hydrolases Glucocorticoid receptor-like (DNA-binding domain) 41
Zn-finger domain of Sec23/24 Helical domain of Sec23/24 43
Class II aaRS and biotin synthetases C-terminal domain of ProRS 41
"Winged helix" DNA-binding domain Sec63 N-terminal domain-like 43
Voltage-gated potassium channels Retrovirus zinc finger-like domains 41
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 41
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 42
vWA-like UBC-like 42
Metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 42
Protein kinase-like (PK-like) P-loop containing nucleoside triphosphate hydrolases 41
Aconitase iron-sulfur domain LeuD/IlvD-like 41
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 43
ISP domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 42
RING/U-box FYVE/PHD zinc finger 41
NagB/RpiA/CoA transferase-like NagB/RpiA/CoA transferase-like 41
beta-N-acetylhexosaminidase-like domain (Trans)glycosidases 41
PsbU/PolX domain-like Nucleotidyltransferase 42
Retrovirus zinc finger-like domains Retrovirus zinc finger-like domains 41
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 41
NHL repeat WD40 repeat-like 44
Acyl-CoA N-acyltransferases (Nat) Acyl-CoA N-acyltransferases (Nat) 42
Ubiquitin-like Ankyrin repeat 42
PR-1-like PR-1-like 42
YbaK/ProRS associated domain Class II aaRS and biotin synthetases 41
DNA clamp DNA clamp 41
Ankyrin repeat EF-hand 44
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 41
Cytochrome b5-like heme/steroid binding domain Cytochrome b5-like heme/steroid binding domain 41
Ubiquitin-like EF-hand 42
DBL homology domain (DH-domain) PH domain-like 43
Ubiquitin-like Zn-binding ribosomal proteins 41
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 41
beta-sandwich domain of Sec23/24 Helical domain of Sec23/24 43
RING/U-box Tudor/PWWP/MBT 42
MIR domain EF-hand 42
Nqo1 middle domain-like Nqo1C-terminal domain-like 41
Pentapeptide repeat-like YVTN repeat-like/Quinoprotein amine dehydrogenase 44
Acyl-CoA N-acyltransferases (Nat) Bromodomain 41
PLP-binding barrel Alanine racemase C-terminal domain-like 43
Quinoprotein alcohol dehydrogenase-like YVTN repeat-like/Quinoprotein amine dehydrogenase 44
P-loop containing nucleoside triphosphate hydrolases DPP6 N-terminal domain-like 44
ATP-dependent DNA ligase DNA-binding domain DNA ligase/mRNA capping enzyme, catalytic domain 42
Agglutinin HPA-like Agglutinin HPA-like 42
Nucleoside diphosphate kinase, NDK Nucleoside diphosphate kinase, NDK 41
P-loop containing nucleoside triphosphate hydrolases Sec63 N-terminal domain-like 43
DNA polymerase beta, N-terminal domain-like PsbU/PolX domain-like 42
TRAF domain-like TRAF domain-like 43
GTPase activation domain, GAP VPS9 domain 41
WD40 repeat-like Nucleoporin domain 44
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 43
P-loop containing nucleoside triphosphate hydrolases EF-hand 42
Calponin-homology domain, CH-domain EB1 dimerisation domain-like 42
2Fe-2S ferredoxin-like alpha-helical ferredoxin 42
TPR-like SET domain 42
ARM repeat Cysteine proteinases 42
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 41
P-loop containing nucleoside triphosphate hydrolases Tropomyosin 43
ISP domain FAD/NAD(P)-binding domain 42
TATA-box binding protein-like TATA-box binding protein-like 41
ATP-dependent DNA ligase DNA-binding domain Nucleic acid-binding proteins 42
GST C-terminal domain-like GST C-terminal domain-like 42
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 41
vWA-like Helical domain of Sec23/24 43
Helical domain of Sec23/24 C-terminal, gelsolin-like domain of Sec23/24 43
E set domains Galactose oxidase, central domain 43
Sec63 N-terminal domain-like Sec63 N-terminal domain-like 43
YVTN repeat-like/Quinoprotein amine dehydrogenase WD40 repeat-like 44
DNA polymerase beta, N-terminal domain-like Nucleotidyltransferase 42
Bromodomain FYVE/PHD zinc finger 44
Concanavalin A-like lectins/glucanases Growth factor receptor domain 44
Tryptophan synthase beta subunit-like PLP-dependent enzymes Tryptophan synthase beta subunit-like PLP-dependent enzymes 41
cAMP-binding domain-like Retrovirus zinc finger-like domains 41
Translational machinery components L30e-like 42
YbaK/ProRS associated domain Class II aaRS ABD-related 41
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 42
"Winged helix" DNA-binding domain E set domains 43
Outer arm dynein light chain 1 L domain-like 43
Class II aaRS ABD-related C-terminal domain of ProRS 41
Heat shock protein 70kD (HSP70), C-terminal subdomain Heat shock protein 70kD (HSP70), C-terminal subdomain 31
P-loop containing nucleoside triphosphate hydrolases Hypothetical protein YjiA, C-terminal domain 32
SPOC domain-like C-terminal domain of Ku80 31
P-loop containing nucleoside triphosphate hydrolases RNase III domain-like 33
(Phosphotyrosine protein) phosphatases II (Phosphotyrosine protein) phosphatases II 31
F-box domain RNI-like 32
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 32
NAD-binding domain of HMG-CoA reductase Substrate-binding domain of HMG-CoA reductase 33
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 Translational machinery components 31
RING/U-box Cysteine-rich domain 32
Bromodomain Chromo domain-like 33
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 32
RNA-binding domain, RBD RING/U-box 33
RING/U-box Homeodomain-like 32
Ubiquitin-like vWA-like 32
Ubiquitin-like PH domain-like 31
Galactose oxidase, central domain POZ domain 31
Protein kinase-like (PK-like) ENTH/VHS domain 31
Pentapeptide repeat-like Calcium-dependent phosphotriesterase 33
Class II aaRS and biotin synthetases Translation proteins 31
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 32
Chromo domain-like Chromo domain-like 33
B-box zinc-binding domain EF-hand 33
E set domains Glycosyl hydrolase domain 31
Ribonuclease H-like Ribonuclease H-like 33
WWE domain WWE domain 32
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 31
EF-hand Calpain large subunit, middle domain (domain III) 33
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 31
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 31
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 31
PriA/YqbF domain GINS helical bundle-like 31
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 32
AN1-like Zinc finger AN1-like Zinc finger 32
Aminoacid dehydrogenase-like, N-terminal domain Aminoacid dehydrogenase-like, N-terminal domain 31
Macro domain-like Macro domain-like 33
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 32
Nucleotidyltransferase PAP/Archaeal CCA-adding enzyme, C-terminal domain 33
Cystatin/monellin Cystatin/monellin 31
TPR-like Chaperone J-domain 32
CheY-like CheY-like 32
vWA-like C-terminal domain of Ku80 31
Domain of the SRP/SRP receptor G-proteins Signal peptide-binding domain 32
RING/U-box Chromo domain-like 33
Glutathione synthetase ATP-binding domain-like PreATP-grasp domain 32
NSFL1 (p97 ATPase) cofactor p47, SEP domain Ubiquitin-like 33
HAD-like MFS general substrate transporter 32
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 32
PUA domain-like Ribosomal protein S5 domain 2-like 31
Pentapeptide repeat-like Soluble quinoprotein glucose dehydrogenase 33
NAD(P)-binding Rossmann-fold domains SCP-like 31
Actin depolymerizing proteins (Phosphotyrosine protein) phosphatases II 33
Macro domain-like ADP-ribosylation 31
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 31
PH domain-like (Phosphotyrosine protein) phosphatases II 31
N-terminal, heterodimerisation domain of RBP7 (RpoE) Nucleic acid-binding proteins 32
FYVE/PHD zinc finger Elongation factor TFIIS domain 2 32
Cap-Gly domain Ubiquitin-like 32
Quinoprotein alcohol dehydrogenase-like Putative isomerase YbhE 33
RING/U-box Kelch motif 33
RCC1/BLIP-II Protein kinase-like (PK-like) 31
Alpha-L RNA-binding motif Pseudouridine synthase 31
TPR-like HSP20-like chaperones 32
TPR-like RuBisCo LSMT C-terminal, substrate-binding domain 31
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 32
PH domain-like CRAL/TRIO N-terminal domain 31
Nucleic acid-binding proteins Eukaryotic type KH-domain (KH-domain type I) 32
TRAF domain-like Cysteine-rich domain 32
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 31
TolB, C-terminal domain WD40 repeat-like 33
B-box zinc-binding domain Concanavalin A-like lectins/glucanases 31
ACT-like Aromatic aminoacid monoxygenases, catalytic and oligomerization domains 31
Quinoprotein alcohol dehydrogenase-like Nucleoporin domain 33
TPR-like vWA-like 32
UBA-like XPC-binding domain 31
Ubiquitin-like L domain-like 32
CheY-like Protein kinase-like (PK-like) 31
E set domains Pectin lyase-like 33
Cyclophilin-like Carbohydrate phosphatase 31
Bromodomain P-loop containing nucleoside triphosphate hydrolases 33
NHL repeat Quinoprotein alcohol dehydrogenase-like 33
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 31
Soluble quinoprotein glucose dehydrogenase WD40 repeat-like 33
Ubiquitin-like XPC-binding domain 31
Zinc hairpin stack RING/U-box 32
CHY zinc finger-like Zinc hairpin stack 32
Galactose-binding domain-like ARM repeat 31
PAP/OAS1 substrate-binding domain PAP/Archaeal CCA-adding enzyme, C-terminal domain 33
CHY zinc finger-like RING/U-box 32
Ypt/Rab-GAP domain of gyp1p EF-hand 33
Pseudouridine synthase PUA domain-like 31
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 31
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 31
PH domain-like CRAL/TRIO domain 31
Nucleotide cyclase MFS general substrate transporter 32
Chaperone J-domain Thioredoxin-like 31
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 31
Ypt/Rab-GAP domain of gyp1p Rhodanese/Cell cycle control phosphatase 33
Hypothetical protein SAV1430 Fe-S cluster assembly (FSCA) domain-like 31
N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 L30e-like 31
Cysteine proteinases Cysteine proteinases 32
WW domain RNA-binding domain, RBD 21
Nucleotidylyl transferase HD-domain/PDEase-like 21
PapD-like Calponin-homology domain, CH-domain 21
Galactose-binding domain-like Pectin lyase-like 22
UDP-Glycosyltransferase/glycogen phosphorylase HAD-like 21
Aldolase NAD(P)-binding Rossmann-fold domains 22
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 21
Radical SAM enzymes Acyl-CoA N-acyltransferases (Nat) 21
YbiA-like RNA-binding domain, RBD 21
UBC-like Endosomal sorting complex assembly domain 21
ADP-ribosylation Pentapeptide repeat-like 22
Acid proteases UBA-like 21
RNI-like Ubiquitin-like 21
Glutathione synthetase ATP-binding domain-like Phosphoglycerate mutase-like 21
DUSP-like HIT/MYND zinc finger-like 21
Kelch motif P-loop containing nucleoside triphosphate hydrolases 22
Ribonuclease H-like HRDC-like 21
Calponin-homology domain, CH-domain P-loop containing nucleoside triphosphate hydrolases 22
Starch-binding domain-like HAD-like 21
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 21
PreATP-grasp domain Rudiment single hybrid motif 21
Cytochrome P450 TPR-like 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Single hybrid motif Single hybrid motif 21
S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases 21
Ribosomal L27 protein-like Nucleic acid-binding proteins 22
RNI-like EF-hand 22
Chaperone J-domain Sec63 N-terminal domain-like 21
WD40 repeat-like RNI-like 22
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 21
WD40 repeat-like Ypt/Rab-GAP domain of gyp1p 21
BRCT domain DNA polymerase beta, N-terminal domain-like 21
PheT/TilS domain Class II aaRS and biotin synthetases 21
Outer arm dynein light chain 1 Protein kinase-like (PK-like) 21
ARM repeat Subdomain of clathrin and coatomer appendage domain 21
DPP6 N-terminal domain-like DPP6 N-terminal domain-like 22
WD40 repeat-like Bromodomain 22
Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain PX domain 21
SMAD/FHA domain RNA-binding domain, RBD 21
NAD(P)-binding Rossmann-fold domains Glycerol-3-phosphate (1)-acyltransferase 21
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 21
WD40 repeat-like Cyclophilin-like 22
Glycerol-3-phosphate (1)-acyltransferase Glycerol-3-phosphate (1)-acyltransferase 21
ClpP/crotonase ClpP/crotonase 21
Pentapeptide repeat-like TolB, C-terminal domain 22
6-phosphogluconate dehydrogenase C-terminal domain-like UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
Nucleotidylyl transferase Nucleotidylyl transferase 21
(Trans)glycosidases Beta-D-glucan exohydrolase, C-terminal domain 22
Putative DNA-binding domain Class II aaRS and biotin synthetases 21
EPT/RTPC-like P-loop containing nucleoside triphosphate hydrolases 22
RNI-like S-adenosyl-L-methionine-dependent methyltransferases 22
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 22
EPT/RTPC-like Aminoacid dehydrogenase-like, N-terminal domain 22
Metallo-hydrolase/oxidoreductase Metallo-hydrolase/oxidoreductase 22
P-loop containing nucleoside triphosphate hydrolases Aminoacid dehydrogenase-like, N-terminal domain 22
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 21
P-loop containing nucleoside triphosphate hydrolases Aldolase 22
Protein kinase-like (PK-like) SNARE-like 21
RING/U-box BRCT domain 21
Aldolase Aminoacid dehydrogenase-like, N-terminal domain 22
Thiolase-like NAD-binding domain of HMG-CoA reductase 22
HAD-like BRCT domain 21
FF domain FF domain 22
RNA-binding domain, RBD PWI domain 21
WW domain WW domain 22
Surp module (SWAP domain) Surp module (SWAP domain) 21
POZ domain Skp1 dimerisation domain-like 21
Trypsin-like serine proteases Trypsin-like serine proteases 22
SMAD/FHA domain PP2C-like 21
Ankyrin repeat TPR-like 21
B-box zinc-binding domain TRAF domain-like 21
BRCT domain post-AAA+ oligomerization domain-like 21
Calcium ATPase, transmembrane domain M MFS general substrate transporter 21
Calcium-dependent phosphotriesterase WD40 repeat-like 22
Alkaline phosphatase-like Translation proteins SH3-like domain 21
Nucleic acid-binding proteins BRCT domain 22
FKBP-like Cyclophilin-like 21
TolB, C-terminal domain Quinoprotein alcohol dehydrogenase-like 22
eIF2alpha middle domain-like eIF-2-alpha, C-terminal domain 21
RING/U-box UBA-like 21
DLC DLC 21
TPR-like "Winged helix" DNA-binding domain 21
TPR-like ARM repeat 21
Family A G protein-coupled receptor-like SAICAR synthase-like 21
vWA-like Cysteine-rich domain 22
Chaperone J-domain E set domains 21
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit Enolase C-terminal domain-like 21
HMG-box Chromo domain-like 21
PH domain-like Ypt/Rab-GAP domain of gyp1p 21
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 21
PapD-like WD40 repeat-like 22
Clavaminate synthase-like S-adenosyl-L-methionine-dependent methyltransferases 21
FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) Protein kinase-like (PK-like) 22
WW domain FF domain 22
Concanavalin A-like lectins/glucanases Activating enzymes of the ubiquitin-like proteins 22
RNA-binding domain, RBD Ran binding protein zinc finger-like 21
Calponin-homology domain, CH-domain Calponin-homology domain, CH-domain 22
WD40 repeat-like S-adenosyl-L-methionine-dependent methyltransferases 22
Histone-fold ARM repeat 22
Calpain large subunit, middle domain (domain III) Calpain large subunit, middle domain (domain III) 21
SAM/Pointed domain P-loop containing nucleoside triphosphate hydrolases 21
Cap-Gly domain RNI-like 21
UBA-like Ran binding protein zinc finger-like 22
TPR-like PH domain-like 21
Tropomyosin Protein kinase-like (PK-like) 22
Translation initiation factor 2 beta, aIF2beta, N-terminal domain Zinc-binding domain of translation initiation factor 2 beta 21
HIT/MYND zinc finger-like Cysteine proteinases 21
Chaperone J-domain RNA-binding domain, RBD 21
Calcium ATPase, transduction domain A MFS general substrate transporter 21
PLP-dependent transferases PLP-dependent transferases 21
Sec7 domain Ypt/Rab-GAP domain of gyp1p 21
Formate/glycerate dehydrogenase catalytic domain-like DHS-like NAD/FAD-binding domain 21
P-loop containing nucleoside triphosphate hydrolases Tricorn protease domain 2 22
Ubiquitin-like UBC-like 21
Concanavalin A-like lectins/glucanases UBC-like 22
Clathrin heavy-chain terminal domain ARM repeat 21
ARM repeat Hect, E3 ligase catalytic domain 21
Ubiquitin-like Chromo domain-like 21
Trypsin-like serine proteases PDZ domain-like 21
4Fe-4S ferredoxins P-loop containing nucleoside triphosphate hydrolases 21
Ribonuclease H-like Retrovirus zinc finger-like domains 22
Ubiquitin-like Acid proteases 21
ENTH/VHS domain GAT-like domain 21
ARM repeat P-loop containing nucleoside triphosphate hydrolases 22
YbiA-like SMAD/FHA domain 21
BRCT domain PsbU/PolX domain-like 21
MFS general substrate transporter MFS general substrate transporter 21
Concanavalin A-like lectins/glucanases UBA-like 22
Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain WD40 repeat-like 21
C2 domain (Calcium/lipid-binding domain, CaLB) alpha-D-mannose-specific plant lectins 21
Nucleic acid-binding proteins eIF2alpha middle domain-like 21
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 22
vWA-like vWA-like 21
PX domain Ubiquitin-like 22
PH domain-like Phospholipase D/nuclease 22
Rad51 N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 21
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 21
ALDH-like ALDH-like 21
Adenine nucleotide alpha hydrolases-like Adenine nucleotide alpha hydrolases-like 21
E set domains Six-hairpin glycosidases 21
Nucleic acid-binding proteins eIF-2-alpha, C-terminal domain 21
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 21
Adenine nucleotide alpha hydrolases-like DHS-like NAD/FAD-binding domain 21
Enolase N-terminal domain-like Enolase C-terminal domain-like 21
Doublecortin (DC) P-loop containing nucleoside triphosphate hydrolases 21
Protein kinase-like (PK-like) Globin-like 21
EPT/RTPC-like NAD(P)-binding Rossmann-fold domains 22
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 22
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain alpha-D-mannose-specific plant lectins 21
Cytochrome P450 HSP20-like chaperones 21
ADP-ribosylation WD40 repeat-like 22
P-loop containing nucleoside triphosphate hydrolases Cytidine deaminase-like 21
BRCT domain Nucleotidyltransferase 21
Anthrax protective antigen E set domains 22
(Trans)glycosidases Six-hairpin glycosidases 21
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 22
Sec7 domain PH domain-like 21
Putative DNA-binding domain PheT/TilS domain 21
Ricin B-like lectins Ricin B-like lectins 22
SET domain P-loop containing nucleoside triphosphate hydrolases 21
Hypothetical protein c14orf129, hspc210 TPR-like 22
NAD(P)-binding Rossmann-fold domains DHS-like NAD/FAD-binding domain 21
Clathrin adaptor appendage domain Subdomain of clathrin and coatomer appendage domain 21
PRTase-like PRTase-like 21
Putative DNA-binding domain Putative DNA-binding domain 21
Folate-binding domain Aminomethyltransferase beta-barrel domain 21
alpha/beta knot Nucleic acid-binding proteins 22
EPT/RTPC-like Aldolase 22
Quinoprotein alcohol dehydrogenase-like Tricorn protease domain 2 22
Pre-PUA domain PUA domain-like 21
P-loop containing nucleoside triphosphate hydrolases PX domain 21
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit EF-hand 21
DNA primase core P-loop containing nucleoside triphosphate hydrolases 21
Fumarylacetoacetate hydrolase, FAH, N-terminal domain FAH 21
Tropomyosin Myosin rod fragments 22
PX domain Second domain of FERM 21
Eukaryotic type KH-domain (KH-domain type I) RING/U-box 22
Actin depolymerizing proteins Actin depolymerizing proteins 22
FYSH domain Hypothetical protein AF0491, middle domain 21
P-loop containing nucleoside triphosphate hydrolases beta-beta-alpha zinc fingers 21
tRNA-binding arm Class II aaRS and biotin synthetases 21
NAD(P)-binding Rossmann-fold domains UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
Initiation factor IF2/eIF5b, domain 3 Translation proteins 22
Rudiment single hybrid motif Single hybrid motif 21
Tricorn protease domain 2 TPR-like 21
L domain-like HSP20-like chaperones 21
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment DNA breaking-rejoining enzymes 22
Pectin lyase-like Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 21
C2 domain (Calcium/lipid-binding domain, CaLB) Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 21
TPR-like Cyclophilin-like 21
Metallo-dependent phosphatases 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 22
P-loop containing nucleoside triphosphate hydrolases RNA-binding domain, RBD 21
Glutathione synthetase ATP-binding domain-like Single hybrid motif 21
Eukaryotic type KH-domain (KH-domain type I) Retrovirus zinc finger-like domains 21
PRP4-like WD40 repeat-like 22
Aldolase Aldolase 21
Pentapeptide repeat-like NHL repeat 22
Ran binding protein zinc finger-like Ran binding protein zinc finger-like 22
TPR-like Metallo-dependent phosphatases 21
PRP4-like Functional domain of the splicing factor Prp18 21
Elongation factor TFIIS domain 2 Zinc beta-ribbon 21
TROVE domain-like vWA-like 22
Arginase/deacetylase SAICAR synthase-like 21
RNA-binding domain, RBD Surp module (SWAP domain) 22
"Winged helix" DNA-binding domain Protein kinase-like (PK-like) 22
Eukaryotic RPB5 N-terminal domain RPB5-like RNA polymerase subunit 21
Mannose-binding lectins PX domain 21
Chaperone J-domain HSC20 (HSCB), C-terminal oligomerisation domain 22
BRCT domain P-loop containing nucleoside triphosphate hydrolases 21
UBA-like Activating enzymes of the ubiquitin-like proteins 22
R3H domain Ribonuclease H-like 21
DBL homology domain (DH-domain) Ubiquitin-like 22
EF-hand Chaperone J-domain 21
Aminopeptidase/glucanase lid domain Zn-dependent exopeptidases 21
EF-hand Putative isomerase YbhE 22
Growth factor receptor domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 21
DBL homology domain (DH-domain) Second domain of FERM 21
PreATP-grasp domain Single hybrid motif 21
RNI-like FabD/lysophospholipase-like 22
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 21
Tetrapyrrole methylase Tetrapyrrole methylase 21
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 22
Thiolase-like Substrate-binding domain of HMG-CoA reductase 22
Nucleic acid-binding proteins TPR-like 21
HMA, heavy metal-associated domain HAD-like 22
Homodimeric domain of signal transducing histidine kinase HAD-like 11
Ribosomal protein L19 (L19e) Translational machinery components 11
Nucleotide-binding domain FAD/NAD(P)-binding domain 11
Sm-like ribonucleoproteins SNARE fusion complex 11
alpha-helical ferredoxin 4Fe-4S ferredoxins 11
Protein kinase-like (PK-like) Cysteine proteinases 11
Galactose oxidase, central domain Galactose oxidase, central domain 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
UDP-Glycosyltransferase/glycogen phosphorylase E set domains 11
Ubiquitin-like ADP-ribosylation 11
Galactose oxidase, central domain EGF/Laminin 11
HIT-like beta-carbonic anhydrase, cab 11
YVTN repeat-like/Quinoprotein amine dehydrogenase YVTN repeat-like/Quinoprotein amine dehydrogenase 11
Pentapeptide repeat-like Tricorn protease domain 2 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
Chromo domain-like Acyl-CoA N-acyltransferases (Nat) 11
FYVE/PHD zinc finger EF-hand 11
Hook domain Protein kinase-like (PK-like) 11
P-loop containing nucleoside triphosphate hydrolases Calcium-dependent phosphotriesterase 11
NagB/RpiA/CoA transferase-like LmbE-like 11
CBD9-like Cytochrome b5-like heme/steroid binding domain 11
gamma-Crystallin-like gamma-Crystallin-like 11
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 11
Concanavalin A-like lectins/glucanases WD40 repeat-like 11
Thioredoxin-like RING/U-box 11
Protein kinase-like (PK-like) Ypt/Rab-GAP domain of gyp1p 11
Calcium-dependent phosphotriesterase YVTN repeat-like/Quinoprotein amine dehydrogenase 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
P-loop containing nucleoside triphosphate hydrolases Mannose 6-phosphate receptor domain 11
Terpenoid cyclases/Protein prenyltransferases Terpenoid cyclases/Protein prenyltransferases 11
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Ribosomal proteins L15p and L18e 11
Class II aaRS and biotin synthetases SufE/NifU 11
Quinoprotein alcohol dehydrogenase-like Calcium-dependent phosphotriesterase 11
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 11
ADP-ribosylation B-box zinc-binding domain 11
E set domains AMPKBI-like 11
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain PH domain-like 11
PH domain-like C2 domain (Calcium/lipid-binding domain, CaLB) 11
(Phosphotyrosine protein) phosphatases II P-loop containing nucleoside triphosphate hydrolases 11
Protein kinase-like (PK-like) Rhodanese/Cell cycle control phosphatase 11
Anthrax protective antigen Galactose-binding domain-like 11
WD40 repeat-like Nitrous oxide reductase, N-terminal domain 11
Mitochondrial carrier Thioredoxin-like 11
YVTN repeat-like/Quinoprotein amine dehydrogenase DPP6 N-terminal domain-like 11
Outer arm dynein light chain 1 Outer arm dynein light chain 1 11
vWA-like Cysteine proteinases 11
RNA-binding domain, RBD Ribosomal protein S5 domain 2-like 11
B-box zinc-binding domain WD40 repeat-like 11
ARM repeat PH domain-like 11
CBD9-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
HAD-like P-loop containing nucleoside triphosphate hydrolases 11
RNA-binding domain, RBD ENTH/VHS domain 11
Formate/glycerate dehydrogenase catalytic domain-like Formate/glycerate dehydrogenase catalytic domain-like 11
Translation proteins Translation proteins 11
Tex N-terminal region-like Ribonuclease H-like 11
Glucocorticoid receptor-like (DNA-binding domain) AN1-like Zinc finger 11
Tropomyosin vWA-like 11
Tropomyosin EF-hand 11
RING/U-box Cyclophilin-like 11
beta-sandwich domain of Sec23/24 Glutathione synthetase ATP-binding domain-like 11
Ran binding protein zinc finger-like Activating enzymes of the ubiquitin-like proteins 11
3-carboxy-cis,cis-mucoante lactonizing enzyme WD40 repeat-like 11
BAR/IMD domain-like (Phosphotyrosine protein) phosphatases II 11
FMN-linked oxidoreductases FMN-linked oxidoreductases 11
Ankyrin repeat Sec7 domain 11
Protein kinase-like (PK-like) Ribonuclease H-like 11
PH domain-like Wiscott-Aldrich syndrome protein, WASP, C-terminal domain 11
EF-hand alpha/beta-Hydrolases 11
PX domain RNI-like 11
Ankyrin repeat C2 domain (Calcium/lipid-binding domain, CaLB) 11
Insert subdomain of RNA polymerase alpha subunit 4Fe-4S ferredoxins 11
Growth factor receptor domain Ferredoxin reductase-like, C-terminal NADP-linked domain 11
FAD-linked reductases, C-terminal domain 4Fe-4S ferredoxins 11
Translation initiation factor 2 beta, aIF2beta, N-terminal domain ARM repeat 11
Dom34/Pelota N-terminal domain-like L30e-like 11
B-box zinc-binding domain FYVE/PHD zinc finger 11
ARM repeat FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 11
Carboxypeptidase regulatory domain-like WD40 repeat-like 11
Dehydroquinate synthase-like P-loop containing nucleoside triphosphate hydrolases 11
PYP-like sensor domain (PAS domain) CheY-like 11
Hedgehog/intein (Hint) domain ADP-ribosylation 11
RNI-like Glutathione synthetase ATP-binding domain-like 11
CCCH zinc finger WD40 repeat-like 11
L domain-like Protein kinase-like (PK-like) 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
Ribosomal L27 protein-like Eukaryotic type KH-domain (KH-domain type I) 11
Thioredoxin-like WD40 repeat-like 11
Dehydroquinate synthase-like EPT/RTPC-like 11
Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment WD40 repeat-like 11
Glutamine synthetase/guanido kinase beta-sandwich domain of Sec23/24 11
3-carboxy-cis,cis-mucoante lactonizing enzyme Quinoprotein alcohol dehydrogenase-like 11
CCCH zinc finger RING/U-box 11
Mitochondrial carrier GST C-terminal domain-like 11
TPR-like cAMP-binding domain-like 11
Cyclophilin-like RNA-binding domain, RBD 11
GST C-terminal domain-like Nucleotidylyl transferase 11
UBC-like Protein kinase-like (PK-like) 11
Acyl-CoA binding protein Ankyrin repeat 11
ACP-like Oligoxyloglucan reducing end-specific cellobiohydrolase 11
Anthrax protective antigen Pectin lyase-like 11
RNI-like TPR-like 11
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 11
Retrovirus zinc finger-like domains ARM repeat 11
PUG domain-like Ubiquitin-like 11
Homodimeric domain of signal transducing histidine kinase Rhodanese/Cell cycle control phosphatase 11
Nucleotide-binding domain FAD-linked reductases, C-terminal domain 11
Cysteine-rich domain NAD kinase/diacylglycerol kinase-like 11
Substrate-binding domain of HMG-CoA reductase Voltage-gated potassium channels 11
Substrate-binding domain of HMG-CoA reductase cAMP-binding domain-like 11
Pre-protein crosslinking domain of SecA TPR-like 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
TPR-like Nucleotide-diphospho-sugar transferases 11
alpha/beta-Hydrolases Clavaminate synthase-like 11
FMN-linked oxidoreductases 4Fe-4S ferredoxins 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
cAMP-binding domain-like WD40 repeat-like 11
Growth factor receptor domain Agglutinin HPA-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Chaperone J-domain 11
ARID-like ARM repeat 11
Dehydroquinate synthase-like NAD(P)-binding Rossmann-fold domains 11
E set domains Ankyrin repeat 11
ATP-dependent DNA ligase DNA-binding domain BRCT domain 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) HSC20 (HSCB), C-terminal oligomerisation domain 11
cAMP-binding domain-like Thiamin diphosphate-binding fold (THDP-binding) 11
FAD/NAD(P)-binding domain 4Fe-4S ferredoxins 11
Surp module (SWAP domain) ENTH/VHS domain 11
Ubiquitin-like Hedgehog/intein (Hint) domain 11
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Chaperone J-domain 11
EF-hand TolB, C-terminal domain 11
Peptidase/esterase 'gauge' domain alpha/beta-Hydrolases 11
RING/U-box PH domain-like 11
N-terminal domain of adenylylcyclase associated protein, CAP C-terminal domain of adenylylcyclase associated protein 11
SNARE fusion complex SNARE fusion complex 11
SH2 domain Retrovirus zinc finger-like domains 11
WD40 repeat-like HIT/MYND zinc finger-like 11
YVTN repeat-like/Quinoprotein amine dehydrogenase Tricorn protease domain 2 11
beta-sandwich domain of Sec23/24 WD40 repeat-like 11
Nucleotide-binding domain 4Fe-4S ferredoxins 11
Putative isomerase YbhE YVTN repeat-like/Quinoprotein amine dehydrogenase 11
Tubby C-terminal domain-like Tubby C-terminal domain-like 11
Calcium-dependent phosphotriesterase Soluble quinoprotein glucose dehydrogenase 11
Protein kinase-like (PK-like) Chaperone J-domain 11
ARM repeat alpha/beta knot 11
L domain-like C2 domain (Calcium/lipid-binding domain, CaLB) 11
RING/U-box Oxysterol-binding protein-like 11
Dcp2 domain-like Nudix 11
ENTH/VHS domain Ribosomal protein S5 domain 2-like 11
"Winged helix" DNA-binding domain RNA-binding domain, RBD 11
HIT/MYND zinc finger-like TPR-like 11
ADP-ribosylation Quinoprotein alcohol dehydrogenase-like 11
CheY-like HAD-like 11
Acid proteases Acid proteases 11
Dihydrofolate reductase-like Thymidylate synthase/dCMP hydroxymethylase 11
mRNA decapping enzyme DcpS N-terminal domain beta-carbonic anhydrase, cab 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
GST C-terminal domain-like Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Dehydroquinate synthase-like Aldolase 11
Homeodomain-like Protein kinase-like (PK-like) 11
SNARE-like P-loop containing nucleoside triphosphate hydrolases 11
Cysteine proteinases Glutathione synthetase ATP-binding domain-like 11
Thiolase-like cAMP-binding domain-like 11
RING/U-box ABC transporter transmembrane region 11
Methyl-accepting chemotaxis protein (MCP) signaling domain Tropomyosin 11
NHL repeat Nucleoporin domain 11
Ypt/Rab-GAP domain of gyp1p beta-sandwich domain of Sec23/24 11
Nucleotide-binding domain FMN-linked oxidoreductases 11
beta-Galactosidase/glucuronidase domain (Trans)glycosidases 11
(Phosphotyrosine protein) phosphatases II C-terminal, gelsolin-like domain of Sec23/24 11
Concanavalin A-like lectins/glucanases Ran binding protein zinc finger-like 11
Aquaporin-like PX domain 11
Chaperone J-domain beta-beta-alpha zinc fingers 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HAD-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
(Phosphotyrosine protein) phosphatases II Mannose 6-phosphate receptor domain 11
Ubiquitin-like Tropomyosin 11
ARM repeat beta-sandwich domain of Sec23/24 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
(Trans)glycosidases UDP-Glycosyltransferase/glycogen phosphorylase 11
UDP-Glycosyltransferase/glycogen phosphorylase Alanine racemase C-terminal domain-like 11
Mitochondrial carrier Mitochondrial carrier 11
L30e-like alpha/beta knot 11
Guanido kinase N-terminal domain beta-sandwich domain of Sec23/24 11
Metallo-dependent phosphatases PH domain-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
DNA polymerase beta, N-terminal domain-like Restriction endonuclease-like 11
ARM repeat "Winged helix" DNA-binding domain 11
P-loop containing nucleoside triphosphate hydrolases 3-carboxy-cis,cis-mucoante lactonizing enzyme 11
Actin depolymerizing proteins C-terminal, gelsolin-like domain of Sec23/24 11
Dehydroquinate synthase-like Aminoacid dehydrogenase-like, N-terminal domain 11
Pentapeptide repeat-like Nucleoporin domain 11
Pentapeptide repeat-like 3-carboxy-cis,cis-mucoante lactonizing enzyme 11
P-loop containing nucleoside triphosphate hydrolases Soluble quinoprotein glucose dehydrogenase 11
Fe-S cluster assembly (FSCA) domain-like P-loop containing nucleoside triphosphate hydrolases 11
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 11
Multidrug resistance efflux transporter EmrE TPR-like 11
Ran binding protein zinc finger-like Cyclin-like 11
Glutamine synthetase/guanido kinase Glutamine synthetase/guanido kinase 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
Thioredoxin-like Carboxypeptidase regulatory domain-like 11
RING/U-box Ubiquitin-like 11
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Tudor/PWWP/MBT Elongation factor TFIIS domain 2 11
PapD-like Rubredoxin-like 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Dom34/Pelota N-terminal domain-like Translational machinery components 11
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 11
RING/U-box DUSP-like 11
TPR-like RNA-binding domain, RBD 11
Tricorn protease domain 2 Pectin lyase-like 11
Succinyl-CoA synthetase domains Succinyl-CoA synthetase domains 11
Ran binding protein zinc finger-like UBC-like 11
mRNA decapping enzyme DcpS N-terminal domain HIT-like 11
Hect, E3 ligase catalytic domain Hect, E3 ligase catalytic domain 11
Carbonic anhydrase Carbonic anhydrase 11
Galactose oxidase, central domain RING/U-box 11
Nucleotidyltransferase Poly A polymerase C-terminal region-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
RING/U-box NAP-like 11
PurM N-terminal domain-like PurM C-terminal domain-like 11
Mediator hinge subcomplex-like B-box zinc-binding domain 11
beta-sandwich domain of Sec23/24 Nucleotide cyclase 11
Protein kinase-like (PK-like) Cyclin-like 11
Myosin rod fragments Myosin rod fragments 11
ThrRS/AlaRS common domain P-loop containing nucleoside triphosphate hydrolases 11
PapD-like beta-sandwich domain of Sec23/24 11
beta-Galactosidase/glucuronidase domain beta-Galactosidase/glucuronidase domain 11
Thiolase-like Voltage-gated potassium channels 11
RING/U-box Fe-only hydrogenase 11
14-3-3 protein 14-3-3 protein 11
CheY-like Rhodanese/Cell cycle control phosphatase 11
Multiheme cytochromes Pectin lyase-like 11
UBA-like PUG domain-like 11
Growth factor receptor domain Multiheme cytochromes 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
PX domain Phospholipase D/nuclease 11
EF-hand Mediator hinge subcomplex-like 11
NAD-binding domain of HMG-CoA reductase Voltage-gated potassium channels 11
PH domain-like PLC-like phosphodiesterases 11
Starch-binding domain-like DNase I-like 11
P-loop containing nucleoside triphosphate hydrolases NHL repeat 11
SNARE-like Domain of the SRP/SRP receptor G-proteins 11
RING/U-box DHS-like NAD/FAD-binding domain 11
Growth factor receptor domain Cytochrome b5-like heme/steroid binding domain 11
TPR-like Zn-binding ribosomal proteins 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Rhodanese/Cell cycle control phosphatase 11
Voltage-gated potassium channels WD40 repeat-like 11
Protein kinase-like (PK-like) HSP40/DnaJ peptide-binding domain 11
Tex N-terminal region-like Retrovirus zinc finger-like domains 11
Putative isomerase YbhE Calcium-dependent phosphotriesterase 11
Sm-like ribonucleoproteins SNARE-like 11
alpha-helical ferredoxin Nucleotide-binding domain 11
Pentapeptide repeat-like Putative isomerase YbhE 11
UBC-like RNI-like 11
RNase III domain-like dsRNA-binding domain-like 11
ARM repeat RING/U-box 11
EF-hand DPP6 N-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases YVTN repeat-like/Quinoprotein amine dehydrogenase 11
EF-hand NHL repeat 11
alpha-helical ferredoxin FMN-linked oxidoreductases 11
Concanavalin A-like lectins/glucanases PH domain-like 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
UBA-like SMR domain-like 11
Concanavalin A-like lectins/glucanases Agglutinin HPA-like 11
Concanavalin A-like lectins/glucanases BEACH domain 11
Thiamin pyrophosphokinase, catalytic domain Thiamin pyrophosphokinase, substrate-binding domain 11
Galactose-binding domain-like (Trans)glycosidases 11
Protein kinase-like (PK-like) Phospholipase C/P1 nuclease 11
Outer arm dynein light chain 1 Ankyrin repeat 11
Putative isomerase YbhE Putative isomerase YbhE 11
ARM repeat NSFL1 (p97 ATPase) cofactor p47, SEP domain 11
Cysteine-rich domain Cysteine-rich domain 11
Ribonuclease H-like SH2 domain 11
HCP-like Zn-binding ribosomal proteins 11
GST C-terminal domain-like Methionyl-tRNA synthetase (MetRS), Zn-domain 11
Surp module (SWAP domain) Ribosomal protein S5 domain 2-like 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Carbonic anhydrase SMAD/FHA domain 11
DNA breaking-rejoining enzymes WD40 repeat-like 11
Calponin-homology domain, CH-domain ARM repeat 11
Eukaryotic type KH-domain (KH-domain type I) DnaJ/Hsp40 cysteine-rich domain 11
UDP-Glycosyltransferase/glycogen phosphorylase PLP-binding barrel 11
Nucleotide-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
Macro domain-like Protein kinase-like (PK-like) 11
Galactose-binding domain-like beta-Galactosidase/glucuronidase domain 11
EF-hand DUSP-like 11
Class II aaRS and biotin synthetases P-loop containing nucleoside triphosphate hydrolases 11
Zn-dependent exopeptidases Cysteine proteinases 11
Mitochondrial carrier TPR-like 11
NAD(P)-binding Rossmann-fold domains CI-2 family of serine protease inhibitors 11
AlbA-like beta-sandwich domain of Sec23/24 11
Eukaryotic type KH-domain (KH-domain type I) Chaperone J-domain 11
Phosphofructokinase Phosphofructokinase 11
NAD-binding domain of HMG-CoA reductase cAMP-binding domain-like 11
Protein kinase-like (PK-like) DnaJ/Hsp40 cysteine-rich domain 11

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