SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Ketogulonicigenium vulgare Y25

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

528 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 3911
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 261
"Winged helix" DNA-binding domain GntR ligand-binding domain-like 191
Composite domain of metallo-dependent hydrolases Metallo-dependent hydrolases 186
P-loop containing nucleoside triphosphate hydrolases MOP-like 151
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 144
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 148
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 124
lambda repressor-like DNA-binding domains Periplasmic binding protein-like I 121
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 111
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 101
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 103
"Winged helix" DNA-binding domain Dimeric alpha+beta barrel 91
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 91
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 92
Glutathione synthetase ATP-binding domain-like PreATP-grasp domain 95
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 92
Actin-like ATPase domain Actin-like ATPase domain 84
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 83
"Winged helix" DNA-binding domain GAF domain-like 82
MetI-like MetI-like 72
GroES-like NAD(P)-binding Rossmann-fold domains 72
P-loop containing nucleoside triphosphate hydrolases Translation proteins 76
Thioredoxin-like GST C-terminal domain-like 71
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 62
CheY-like C-terminal effector domain of the bipartite response regulators 61
CheY-like Homeodomain-like 52
lambda repressor-like DNA-binding domains RmlC-like cupins 51
CheY-like P-loop containing nucleoside triphosphate hydrolases 52
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 53
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 53
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 52
Ribosomal protein S5 domain 2-like P-loop containing nucleoside triphosphate hydrolases 44
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 44
PLP-binding barrel Alanine racemase C-terminal domain-like 42
Rhodanese/Cell cycle control phosphatase Rhodanese/Cell cycle control phosphatase 41
Cytochrome c Cytochrome c 43
Nucleic acid-binding proteins Nucleic acid-binding proteins 44
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 44
PreATP-grasp domain Rudiment single hybrid motif 42
MetI-like P-loop containing nucleoside triphosphate hydrolases 32
Triger factor/SurA peptide-binding domain-like FKBP-like 33
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 33
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 32
Phospholipase D/nuclease Phospholipase D/nuclease 33
Nucleotide-diphospho-sugar transferases UDP-Glycosyltransferase/glycogen phosphorylase 32
Translation proteins EF-G C-terminal domain-like 33
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
E set domains (Trans)glycosidases 33
Metallo-dependent phosphatases 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 32
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 31
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 32
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 31
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 32
Alpha-L RNA-binding motif Pseudouridine synthase 32
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 32
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 32
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 31
FAD-binding/transporter-associated domain-like FAD-linked oxidases, C-terminal domain 31
ABC transporter involved in vitamin B12 uptake, BtuC ABC transporter involved in vitamin B12 uptake, BtuC 31
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 31
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 32
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 32
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 32
EF-G C-terminal domain-like EF-G C-terminal domain-like 33
CBS-domain pair FAD-binding/transporter-associated domain-like 32
Homeodomain-like Homeodomain-like 33
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 33
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 32
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 32
2Fe-2S ferredoxin-like CO dehydrogenase ISP C-domain like 32
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 33
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
"Winged helix" DNA-binding domain Chorismate lyase-like 21
(Trans)glycosidases Beta-D-glucan exohydrolase, C-terminal domain 22
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 21
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
Rudiment single hybrid motif Single hybrid motif 22
Aspartate/glutamate racemase Aspartate/glutamate racemase 21
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 22
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 21
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 22
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 21
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 22
Nucleotide cyclase EAL domain-like 21
Glutathione synthetase ATP-binding domain-like Single hybrid motif 22
Sensory domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 22
LmbE-like Class I glutamine amidotransferase-like 22
Beta-D-glucan exohydrolase, C-terminal domain Anthrax protective antigen 22
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Alpha subunit of glutamate synthase, C-terminal domain 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 22
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 21
ThrRS/AlaRS common domain Class II aaRS and biotin synthetases 22
Lysozyme-like beta-lactamase/transpeptidase-like 22
ACT-like ACT-like 22
"Winged helix" DNA-binding domain Actin-like ATPase domain 21
beta-Roll beta-Roll 22
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
PYP-like sensor domain (PAS domain) PYP-like sensor domain (PAS domain) 22
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 22
Class I glutamine amidotransferase-like vWA-like 21
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Homeodomain-like SIS domain 21
(Trans)glycosidases Glycosyl hydrolase domain 22
DNA methylase specificity domain DNA methylase specificity domain 21
Sensory domain-like Homodimeric domain of signal transducing histidine kinase 22
DNA clamp DNA clamp 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheY-like 22
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 22
PurM N-terminal domain-like PurM C-terminal domain-like 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
PH0987 N-terminal domain-like Cyclophilin-like 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 21
Translation proteins SH3-like domain Nucleic acid-binding proteins 22
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 22
(Trans)glycosidases Anthrax protective antigen 22
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 22
FMN-linked oxidoreductases Alpha subunit of glutamate synthase, C-terminal domain 22
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 22
PGBD-like PGBD-like 22
Macro domain-like Zn-dependent exopeptidases 21
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 22
Methylated DNA-protein cysteine methyltransferase domain Methylated DNA-protein cysteine methyltransferase, C-terminal domain 22
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Chemotaxis receptor methyltransferase CheR, N-terminal domain S-adenosyl-L-methionine-dependent methyltransferases 22
NAD(P)-binding Rossmann-fold domains ACT-like 22
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 22
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 22
Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain 22
Porins OMPA-like 22
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 21
N-terminal nucleophile aminohydrolases (Ntn hydrolases) FMN-linked oxidoreductases 22
CheY-like CheY-like 22
PYP-like sensor domain (PAS domain) EAL domain-like 21
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 22
PDZ domain-like PDZ domain-like 22
PYP-like sensor domain (PAS domain) Nucleotide cyclase 21
FAD/NAD(P)-binding domain HI0933 insert domain-like 21
ParB/Sulfiredoxin KorB DNA-binding domain-like 21
E set domains Glycosyl hydrolase domain 22
Molybdenum cofactor-binding domain CO dehydrogenase molybdoprotein N-domain-like 22
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 22
Thiolase-like Thiolase-like 21
Fe-S cluster assembly (FSCA) domain-like P-loop containing nucleoside triphosphate hydrolases 11
Nucleic acid-binding proteins RuvA domain 2-like 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Chemotaxis receptor methyltransferase CheR, N-terminal domain PYP-like sensor domain (PAS domain) 11
PGBD-like L,D-transpeptidase catalytic domain-like 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Ada DNA repair protein, N-terminal domain (N-Ada 10) Methylated DNA-protein cysteine methyltransferase domain 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
Trypsin-like serine proteases PDZ domain-like 11
Xylose isomerase-like Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 11
FMT C-terminal domain-like FMT C-terminal domain-like 11
Methylesterase CheB, C-terminal domain S-adenosyl-L-methionine-dependent methyltransferases 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
alpha/beta-Hydrolases Galactose-binding domain-like 11
Nucleotidyltransferase Nucleotidyltransferase substrate binding subunit/domain 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
Prokaryotic type I DNA topoisomerase Zinc beta-ribbon 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
Nucleotide-diphospho-sugar transferases IpsF-like 11
HD-domain/PDEase-like TGS-like 11
P-loop containing nucleoside triphosphate hydrolases Hypothetical protein YjiA, C-terminal domain 11
Nucleic acid-binding proteins GAD domain-like 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
PHP14-like Phospholipase D/nuclease 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
ALDH-like ALDH-like 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Pyrimidine nucleoside phosphorylase C-terminal domain 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Cation efflux protein transmembrane domain-like Cation efflux protein cytoplasmic domain-like 11
Homodimeric domain of signal transducing histidine kinase CheW-like 11
HAMP domain-like PYP-like sensor domain (PAS domain) 11
Dihydropteroate synthetase-like Cobalamin (vitamin B12)-binding domain 11
TGS-like Class II aaRS and biotin synthetases 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
Single hybrid motif TK C-terminal domain-like 11
YhbC-like, N-terminal domain YhbC-like, C-terminal domain 11
NusB-like S-adenosyl-L-methionine-dependent methyltransferases 11
Translation proteins Translation proteins 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
Cytochrome c Quinoprotein alcohol dehydrogenase-like 11
Pheromone-binding domain of LuxR-like quorum-sensing transcription factors C-terminal effector domain of the bipartite response regulators 11
GroEL equatorial domain-like GroEL apical domain-like 11
Ada DNA repair protein, N-terminal domain (N-Ada 10) Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11
Periplasmic binding protein-like II ACT-like 11
Homocysteine S-methyltransferase Dihydropteroate synthetase-like 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 11
PA domain Zn-dependent exopeptidases 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
S-adenosyl-L-methionine-dependent methyltransferases PYP-like sensor domain (PAS domain) 11
Nucleotide-diphospho-sugar transferases RmlC-like cupins 11
Dihydropteroate synthetase-like Methionine synthase activation domain-like 11
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 11
Hypothetical protein SAV1430 Fe-S cluster assembly (FSCA) domain-like 11
L30e-like alpha/beta knot 11
Ribonuclease H-like HRDC-like 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Pyrimidine nucleoside phosphorylase C-terminal domain 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
Sigma3 and sigma4 domains of RNA polymerase sigma factors CheY-like 11
N-terminal domain of bifunctional PutA protein ALDH-like 11
HD-domain/PDEase-like Nucleotidyltransferase 11
Thioredoxin-like TPR-like 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 11
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 11
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
GAF domain-like Phosphoenolpyruvate/pyruvate domain 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
Actin-like ATPase domain CV3147-like 11
Galactose mutarotase-like E set domains 11
P-loop containing nucleoside triphosphate hydrolases HRDC-like 11
Homeodomain-like Methylated DNA-protein cysteine methyltransferase domain 11
HD-domain/PDEase-like ACT-like 11
HMA, heavy metal-associated domain HMA, heavy metal-associated domain 11
CBS-domain pair MgtE membrane domain-like 11
Single hybrid motif CoA-dependent acyltransferases 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
Homodimeric domain of signal transducing histidine kinase CheY-like 11
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
HMA, heavy metal-associated domain HAD-like 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
Methionine synthase domain Methionine synthase activation domain-like 11
CO dehydrogenase ISP C-domain like FAD-binding/transporter-associated domain-like 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
"Winged helix" DNA-binding domain HRDC-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Dihydropteroate synthetase-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
YrdC/RibB RibA-like 11
Acetyl-CoA synthetase-like alpha/beta-Hydrolases 11
Single hybrid motif Thiamin diphosphate-binding fold (THDP-binding) 11
Dihydropteroate synthetase-like Methionine synthase domain 11
Homocysteine S-methyltransferase Methionine synthase activation domain-like 11
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 11
HAMP domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
Aconitase iron-sulfur domain LeuD/IlvD-like 11
NAD(P)-binding Rossmann-fold domains Isocitrate/Isopropylmalate dehydrogenase-like 11
MgtE N-terminal domain-like MgtE membrane domain-like 11
Flavoproteins Riboflavin synthase domain-like 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 11
TolB, N-terminal domain Tricorn protease N-terminal domain 11
PDZ domain-like ClpP/crotonase 11
PUA domain-like alpha/beta knot 11
Rudiment single hybrid motif Aldolase 11
S-adenosyl-L-methionine-dependent methyltransferases P-loop containing nucleoside triphosphate hydrolases 11
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 11
TPR-like TPR-like 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Nucleotidylyl transferase tRNA-binding arm 11
PRC-barrel domain PRC-barrel domain 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
Ankyrin repeat Sigma2 domain of RNA polymerase sigma factors 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
Class II aaRS and biotin synthetases GAD domain-like 11
Translation proteins PRC-barrel domain 11
Aldolase post-HMGL domain-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
PreATP-grasp domain Methylglyoxal synthase-like 11
PreATP-grasp domain PreATP-grasp domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
N-terminal domain of MutM-like DNA repair proteins Glucocorticoid receptor-like (DNA-binding domain) 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheW-like 11
post-HMGL domain-like Single hybrid motif 11
Carbamate kinase-like ACT-like 11
ACT-like Formyltransferase 11
Histidine-containing phosphotransfer domain, HPT domain ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
Lysozyme-like PGBD-like 11
P-loop containing nucleoside triphosphate hydrolases Tropomyosin 11
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 11
FMN-binding split barrel GAF domain-like 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
HD-domain/PDEase-like P-loop containing nucleoside triphosphate hydrolases 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
Nucleotidyltransferase TGS-like 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
FAD-binding/transporter-associated domain-like CO dehydrogenase flavoprotein C-terminal domain-like 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Nucleic acid-binding proteins PheT/TilS domain 11
Nucleotidyltransferase ACT-like 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 11
LysM domain Duplicated hybrid motif 11
Homocysteine S-methyltransferase Methionine synthase domain 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
GroEL-intermediate domain like GroEL apical domain-like 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 11
CarD-like TRCF domain-like 11
Periplasmic binding protein-like II Periplasmic binding protein-like II 11
Carbamate kinase-like PUA domain-like 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
ACP-like alpha/beta-Hydrolases 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
HAD-like Calcium ATPase, transmembrane domain M 11
MgtE N-terminal domain-like CBS-domain pair 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
Ankyrin repeat Sigma3 and sigma4 domains of RNA polymerase sigma factors 11
all-alpha NTP pyrophosphatases all-alpha NTP pyrophosphatases 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
DeoB insert domain-like Alkaline phosphatase-like 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
S13-like H2TH domain Glucocorticoid receptor-like (DNA-binding domain) 11
TGS-like ThrRS/AlaRS common domain 11
TGS-like Class II aaRS ABD-related 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
RuvA domain 2-like JAB1/MPN domain 11
Cytidine deaminase-like Cytidine deaminase-like 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
Trigger factor ribosome-binding domain FKBP-like 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
Heme-dependent peroxidases Heme-dependent peroxidases 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
Class II aaRS and biotin synthetases Translation proteins 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
CoA-dependent acyltransferases CoA-dependent acyltransferases 11
PUA domain-like S-adenosyl-L-methionine-dependent methyltransferases 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
CheY-like Nucleotide cyclase 11
GIY-YIG endonuclease RuvA domain 2-like 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
RmlC-like cupins Homeodomain-like 11
YlxR-like L30e-like 11
Soluble quinoprotein glucose dehydrogenase Cytochrome c 11
HAMP domain-like Homodimeric domain of signal transducing histidine kinase 11
Quinoprotein alcohol dehydrogenase-like Quinoprotein alcohol dehydrogenase-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
alpha-helical ferredoxin Nucleotide-binding domain 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
Regulatory protein AraC Homeodomain-like 11
Nucleotide-binding domain FAD-linked reductases, C-terminal domain 11
2Fe-2S ferredoxin-like FAD-binding/transporter-associated domain-like 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Formate/glycerate dehydrogenase catalytic domain-like Serine metabolism enzymes domain 11
PPK N-terminal domain-like PHP14-like 11
Aminoacid dehydrogenase-like, N-terminal domain Isocitrate/Isopropylmalate dehydrogenase-like 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
MoeA N-terminal region -like MoeA C-terminal domain-like 11
Zinc beta-ribbon DNA primase core 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
Cobalamin (vitamin B12)-binding domain Methionine synthase activation domain-like 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Rudiment single hybrid motif post-HMGL domain-like 11
Bacterial muramidases Lysozyme-like 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Glutathione synthetase ATP-binding domain-like Aldolase 11
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase alpha/beta-Hydrolases 11
UDP-Glycosyltransferase/glycogen phosphorylase UDP-Glycosyltransferase/glycogen phosphorylase 11
Histidine-containing phosphotransfer domain, HPT domain CheW-like 11
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
GAF domain-like Phosphohistidine domain 11
FAD-linked oxidoreductase ALDH-like 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
"Winged helix" DNA-binding domain LexA/Signal peptidase 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
Adenine nucleotide alpha hydrolases-like DHS-like NAD/FAD-binding domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
PPK N-terminal domain-like Phospholipase D/nuclease 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 11
Serine metabolism enzymes domain ACT-like 11
TrmE connector domain P-loop containing nucleoside triphosphate hydrolases 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
CheY-like PYP-like sensor domain (PAS domain) 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
Putative DNA-binding domain ACP-like 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
Leukotriene A4 hydrolase N-terminal domain Metalloproteases ("zincins"), catalytic domain 11
Ribosomal protein L6 Ribosomal protein L6 11
Calcium ATPase, transduction domain A HAD-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
CO dehydrogenase ISP C-domain like CO dehydrogenase flavoprotein C-terminal domain-like 11
HlyD-like secretion proteins HlyD-like secretion proteins 11
Homeodomain-like Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 11
Glutathione synthetase ATP-binding domain-like post-HMGL domain-like 11
cAMP-binding domain-like "Winged helix" DNA-binding domain 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
lambda integrase-like, N-terminal domain DNA breaking-rejoining enzymes 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 11
Flavoproteins Ferredoxin reductase-like, C-terminal NADP-linked domain 11
P-loop containing nucleoside triphosphate hydrolases ACT-like 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain ACT-like 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Alkaline phosphatase-like 11
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
N-terminal domain of bifunctional PutA protein FAD-linked oxidoreductase 11
PreATP-grasp domain Single hybrid motif 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
dUTPase-like dUTPase-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
2Fe-2S ferredoxin-like CO dehydrogenase flavoprotein C-terminal domain-like 11
Methylesterase CheB, C-terminal domain PYP-like sensor domain (PAS domain) 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
Class I glutamine amidotransferase-like Homeodomain-like 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 11
GroES-like GroES-like 11
Translation proteins Ribosomal protein S5 domain 2-like 11
Aldolase Single hybrid motif 11
"Winged helix" DNA-binding domain NagB/RpiA/CoA transferase-like 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
HRDC-like HRDC-like 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
Homocysteine S-methyltransferase Cobalamin (vitamin B12)-binding domain 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
Myosin rod fragments OmpA-like 11
Heme-dependent catalase-like Class I glutamine amidotransferase-like 11
Dimeric alpha+beta barrel Dimeric alpha+beta barrel 11
Glycoside hydrolase/deacetylase UraD-Like 11
Nucleotidyltransferase Poly A polymerase C-terminal region-like 11
Hsp33 domain HSP33 redox switch-like 11
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
Methionine synthase domain Cobalamin (vitamin B12)-binding domain 11
NAD(P)-binding Rossmann-fold domains 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
Cyclophilin-like Cyclophilin-like 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Nqo1 middle domain-like Nqo1C-terminal domain-like 11
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
PLP-dependent transferases PLP-dependent transferases 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Ribonuclease H-like DNA/RNA polymerases 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Ribbon-helix-helix ACT-like 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
NAD(P)-binding Rossmann-fold domains Serine metabolism enzymes domain 11
Urease metallochaperone UreE, N-terminal domain Urease metallochaperone UreE, C-terminal domain 11
GAF domain-like Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 11
Formyltransferase FMT C-terminal domain-like 11
TGS-like ACT-like 11
PheT/TilS domain Putative DNA-binding domain 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
TerB-like Chaperone J-domain 11
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 11
RNase III domain-like dsRNA-binding domain-like 11
Globin-like Methyl-accepting chemotaxis protein (MCP) signaling domain 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
Acetyl-CoA synthetase-like ACP-like 11
Histidine-containing phosphotransfer domain, HPT domain Homodimeric domain of signal transducing histidine kinase 11
CoA-dependent acyltransferases Acetyl-CoA synthetase-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
Methylesterase CheB, C-terminal domain Chemotaxis receptor methyltransferase CheR, N-terminal domain 11
PreATP-grasp domain post-HMGL domain-like 11
PreATP-grasp domain Aldolase 11
Translation proteins ThrRS/AlaRS common domain 11
Radical SAM enzymes RuvA domain 2-like 11

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