SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Staphylococcus epidermidis RP62A

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

535 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 2313
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 111
Actin-like ATPase domain Actin-like ATPase domain 105
CheY-like C-terminal effector domain of the bipartite response regulators 91
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 93
GroES-like NAD(P)-binding Rossmann-fold domains 82
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 75
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 74
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 74
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 72
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 72
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 72
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 61
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 53
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 52
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 51
PreATP-grasp domain Rudiment single hybrid motif 52
Acyl-CoA N-acyltransferases (Nat) Acyl-CoA N-acyltransferases (Nat) 52
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 53
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 52
P-loop containing nucleoside triphosphate hydrolases Translation proteins 55
Single hybrid motif CoA-dependent acyltransferases 41
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 41
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 41
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 41
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 44
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 42
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 41
Class II aaRS and biotin synthetases Class II aaRS ABD-related 43
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 44
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 43
HAMP domain-like Homodimeric domain of signal transducing histidine kinase 43
Thiolase-like Thiolase-like 41
HAMP domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 43
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 41
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 33
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 32
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 33
Nucleic acid-binding proteins RuvA domain 2-like 33
Alpha-L RNA-binding motif Pseudouridine synthase 31
Translation proteins EF-G C-terminal domain-like 33
Phospholipase D/nuclease Phospholipase D/nuclease 32
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 32
Metallo-dependent phosphatases 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain 31
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 33
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
PLP-binding barrel Alanine racemase C-terminal domain-like 31
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 33
"Winged helix" DNA-binding domain NagB/RpiA/CoA transferase-like 31
Composite domain of metallo-dependent hydrolases Metallo-dependent hydrolases 33
Phosphoenolpyruvate/pyruvate domain Phosphohistidine domain 33
PTS system IIB component-like Phoshotransferase/anion transport protein 33
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
EF-G C-terminal domain-like EF-G C-terminal domain-like 33
Calcium ATPase, transduction domain A HAD-like 33
LysM domain Cysteine proteinases 33
HAD-like Calcium ATPase, transmembrane domain M 33
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 32
Nucleic acid-binding proteins Nucleic acid-binding proteins 33
Cation efflux protein transmembrane domain-like Cation efflux protein cytoplasmic domain-like 31
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 22
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 21
Carbamate kinase-like ACT-like 21
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 22
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 21
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 22
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
lambda repressor-like DNA-binding domains Periplasmic binding protein-like I 21
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 22
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 22
Cadherin-like Cadherin-like 22
GAF domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 22
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 22
Periplasmic binding protein-like II MetI-like 22
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 21
P-loop containing nucleoside triphosphate hydrolases CBS-domain pair 21
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 21
ACT-like ACT-like 21
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 21
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 21
"Winged helix" DNA-binding domain C-terminal domain of arginine repressor 21
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 22
"Winged helix" DNA-binding domain C-terminal domain of transcriptional repressors 22
LysM domain LysM domain 22
P-loop containing nucleoside triphosphate hydrolases Hypothetical protein YjiA, C-terminal domain 21
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Nucleic acid-binding proteins Translation proteins SH3-like domain 22
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 22
Sigma2 domain of RNA polymerase sigma factors C-terminal effector domain of the bipartite response regulators 21
NAD(P)-binding Rossmann-fold domains ACT-like 22
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 21
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 21
Trypsin-like serine proteases PDZ domain-like 21
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 22
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 21
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
PurM N-terminal domain-like PurM C-terminal domain-like 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 21
Acyl-CoA N-acyltransferases (Nat) tRNA-binding arm 21
CorA soluble domain-like Magnesium transport protein CorA, transmembrane region 21
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 22
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 22
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 21
Enolase N-terminal domain-like Enolase C-terminal domain-like 21
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 21
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
ThrRS/AlaRS common domain Class II aaRS and biotin synthetases 22
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Ribosomal protein S5 domain 2-like EF-G C-terminal domain-like 22
Rhodanese/Cell cycle control phosphatase SirA-like 21
tRNA-binding arm Class II aaRS and biotin synthetases 21
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 22
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 21
Triger factor/SurA peptide-binding domain-like FKBP-like 22
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 22
L30e-like alpha/beta knot 21
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 22
Nitrite/Sulfite reductase N-terminal domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 22
Rhodanese/Cell cycle control phosphatase DsrEFH-like 21
Aminopeptidase/glucanase lid domain Zn-dependent exopeptidases 21
SirA-like DsrEFH-like 21
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 22
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 22
Homeodomain-like SIS domain 21
P-loop containing nucleoside triphosphate hydrolases ACT-like 21
"Winged helix" DNA-binding domain Chorismate lyase-like 11
Homeodomain-like Homeodomain-like 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Class II aaRS and biotin synthetases C-terminal domain of transcriptional repressors 11
THUMP domain-like Adenine nucleotide alpha hydrolases-like 11
GroEL-intermediate domain like GroEL apical domain-like 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 11
P-loop containing nucleoside triphosphate hydrolases HRDC-like 11
FAD/NAD(P)-binding domain Nitrite and sulphite reductase 4Fe-4S domain-like 11
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 11
Ribonuclease H-like DNA/RNA polymerases 11
"Winged helix" DNA-binding domain PTS-regulatory domain, PRD 11
CarD-like TRCF domain-like 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Ribonuclease H-like PsbU/PolX domain-like 11
Penicillin binding protein dimerisation domain Penicillin-binding protein 2x (pbp-2x), c-terminal domain 11
Class II aaRS and biotin synthetases Translation proteins 11
TGS-like Class II aaRS ABD-related 11
NAD(P)-binding Rossmann-fold domains Siroheme synthase middle domains-like 11
Nucleic acid-binding proteins HD-domain/PDEase-like 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
PUA domain-like Nucleotidylyl transferase 11
"Winged helix" DNA-binding domain CBS-domain pair 11
DNA clamp DNA clamp 11
Ribosomal protein L6 Ribosomal protein L6 11
PPK N-terminal domain-like Phospholipase D/nuclease 11
YrdC/RibB RibA-like 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
Nucleotide-diphospho-sugar transferases UDP-Glycosyltransferase/glycogen phosphorylase 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
Homeodomain-like Probable bacterial effector-binding domain 11
R1 subunit of ribonucleotide reductase, N-terminal domain Homing endonucleases 11
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 11
TGS-like Class II aaRS and biotin synthetases 11
RuvA domain 2-like BRCT domain 11
Formate/glycerate dehydrogenase catalytic domain-like Serine metabolism enzymes domain 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Homocysteine S-methyltransferase FAD-linked oxidoreductase 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Nucleotidyltransferase PHP domain-like 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
CBS-domain pair FAD-binding/transporter-associated domain-like 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
Cysteine proteinases Zn-dependent exopeptidases 11
Putative DNA-binding domain Multiheme cytochromes 11
Nucleotidyltransferase TGS-like 11
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 11
PreATP-grasp domain PreATP-grasp domain 11
Glucose permease domain IIB Duplicated hybrid motif 11
GIY-YIG endonuclease RuvA domain 2-like 11
MoeA N-terminal region -like MoeA C-terminal domain-like 11
ACP-like ACP-like 11
MFS general substrate transporter P-loop containing nucleoside triphosphate hydrolases 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
PheT/TilS domain Putative DNA-binding domain 11
"Winged helix" DNA-binding domain HRDC-like 11
NusB-like S-adenosyl-L-methionine-dependent methyltransferases 11
DNA polymerase beta, N-terminal domain-like PHP domain-like 11
Nucleotidyltransferase Poly A polymerase C-terminal region-like 11
Sensory domain-like PYP-like sensor domain (PAS domain) 11
FAD/NAD(P)-binding domain Nitrite/Sulfite reductase N-terminal domain-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
DNA primase core N-terminal domain of DnaB helicase 11
cAMP-binding domain-like "Winged helix" DNA-binding domain 11
RuvA domain 2-like RuvA domain 2-like 11
HD-domain/PDEase-like TGS-like 11
MFS general substrate transporter "Winged helix" DNA-binding domain 11
FMN-linked oxidoreductases FAD/NAD(P)-binding domain 11
Arabinanase/levansucrase/invertase Concanavalin A-like lectins/glucanases 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
Glutamyl tRNA-reductase catalytic, N-terminal domain NAD(P)-binding Rossmann-fold domains 11
Homing endonucleases Homing endonucleases 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Urease metallochaperone UreE, N-terminal domain Urease metallochaperone UreE, C-terminal domain 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
Serine metabolism enzymes domain ACT-like 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Homing endonucleases PFL-like glycyl radical enzymes 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
Globin-like Riboflavin synthase domain-like 11
Aconitase iron-sulfur domain LeuD/IlvD-like 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
CoA-dependent acyltransferases Acetyl-CoA synthetase-like 11
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 11
PDZ domain-like ClpP/crotonase 11
MgtE N-terminal domain-like CBS-domain pair 11
PIN domain-like Ribonuclease H-like 11
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
Formyltransferase FMT C-terminal domain-like 11
Zinc beta-ribbon DNA primase core 11
Penicillin-binding protein 2x (pbp-2x), c-terminal domain Penicillin-binding protein 2x (pbp-2x), c-terminal domain 11
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 11
Ribonuclease H-like Nucleic acid-binding proteins 11
Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Pyrimidine nucleoside phosphorylase C-terminal domain 11
ALDH-like Dehydroquinate synthase-like 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
Rudiment single hybrid motif Aldolase 11
PUA domain-like S-adenosyl-L-methionine-dependent methyltransferases 11
"Winged helix" DNA-binding domain Iron-dependent repressor protein, dimerization domain 11
Zinc beta-ribbon N-terminal domain of DnaB helicase 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases Obg GTP-binding protein C-terminal domain 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
P-loop containing nucleoside triphosphate hydrolases Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 11
HisI-like all-alpha NTP pyrophosphatases 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
GroEL equatorial domain-like GroEL apical domain-like 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
Class II aaRS and biotin synthetases SufE/NifU 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
NAD(P)-binding Rossmann-fold domains Serine metabolism enzymes domain 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
HprK N-terminal domain-like Thioesterase/thiol ester dehydrase-isomerase 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
P-loop containing nucleoside triphosphate hydrolases Smc hinge domain 11
Translation proteins PRC-barrel domain 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
Resolvase-like Homeodomain-like 11
HD-domain/PDEase-like Nucleotidyltransferase 11
ACP-like NAD(P)-binding Rossmann-fold domains 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
Ribonuclease H-like RuvA domain 2-like 11
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III TK C-terminal domain-like 11
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 11
Class II aaRS and biotin synthetases YbaK/ProRS associated domain 11
PTS-regulatory domain, PRD Phoshotransferase/anion transport protein 11
P-loop containing nucleoside triphosphate hydrolases SMR domain-like 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
PH0987 N-terminal domain-like Cyclophilin-like 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
Metallo-hydrolase/oxidoreductase Rhodanese/Cell cycle control phosphatase 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
Periplasmic binding protein-like II ACT-like 11
Glutathione synthetase ATP-binding domain-like Single hybrid motif 11
Nucleotidylyl transferase tRNA-binding arm 11
Class II aaRS and biotin synthetases GAD domain-like 11
"Winged helix" DNA-binding domain PLP-dependent transferases 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
Sensory domain-like Homodimeric domain of signal transducing histidine kinase 11
"Winged helix" DNA-binding domain Actin-like ATPase domain 11
"Winged helix" DNA-binding domain PRTase-like 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 11
PDZ domain-like PGBD-like 11
4Fe-4S ferredoxins ARM repeat 11
Flavoproteins Riboflavin synthase domain-like 11
Epsilon subunit of F1F0-ATP synthase N-terminal domain Epsilon subunit of F1F0-ATP synthase C-terminal domain 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
Trigger factor ribosome-binding domain FKBP-like 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
Tetrapyrrole methylase all-alpha NTP pyrophosphatases 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
Nucleotidylyl transferase Riboflavin kinase-like 11
P-loop containing nucleoside triphosphate hydrolases Rad50 coiled-coil Zn hook 11
PHP14-like Phospholipase D/nuclease 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 11
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Alkaline phosphatase-like 11
Nitrite and sulphite reductase 4Fe-4S domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
CBS-domain pair MgtE membrane domain-like 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
Bacterial immunoglobulin/albumin-binding domains Bacterial immunoglobulin/albumin-binding domains 11
FAD/NAD(P)-binding domain HI0933 insert domain-like 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Nucleotide-binding domain Nucleotide-binding domain 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
"Winged helix" DNA-binding domain Dimeric alpha+beta barrel 11
TGS-like ACT-like 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
Hsp33 domain HSP33 redox switch-like 11
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Nucleic acid-binding proteins 11
alpha-helical ferredoxin Nucleotide-binding domain 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
lambda repressor-like DNA-binding domains RmlC-like cupins 11
Eukaryotic type KH-domain (KH-domain type I) P-loop containing nucleoside triphosphate hydrolases 11
PTS-regulatory domain, PRD PTS-regulatory domain, PRD 11
Bacterial adhesins Bacterial adhesins 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Phospholipase D/nuclease P-loop containing nucleoside triphosphate hydrolases 11
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
"Winged helix" DNA-binding domain NAD(P)-binding Rossmann-fold domains 11
NAD(P)-binding Rossmann-fold domains Glutamyl tRNA-reductase dimerization domain 11
UDP-Glycosyltransferase/glycogen phosphorylase UDP-Glycosyltransferase/glycogen phosphorylase 11
"Winged helix" DNA-binding domain PTS system IIB component-like 11
Nucleic acid-binding proteins PheT/TilS domain 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
Concanavalin A-like lectins/glucanases Cadherin-like 11
Sensory domain-like HAMP domain-like 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Nucleotidyltransferase PAP/OAS1 substrate-binding domain 11
Thioredoxin-like Thioredoxin-like 11
6-phosphogluconate dehydrogenase C-terminal domain-like ACT-like 11
CoA-dependent acyltransferases ACP-like 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
PIN domain-like DNA/RNA polymerases 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Acetyl-CoA synthetase-like Acetyl-CoA synthetase-like 11
Glutathione synthetase ATP-binding domain-like post-HMGL domain-like 11
DNA polymerase beta, N-terminal domain-like Nucleotidyltransferase 11
Rhomboid-like TPR-like 11
RNase III domain-like dsRNA-binding domain-like 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
HprK N-terminal domain-like PEP carboxykinase-like 11
P-loop containing nucleoside triphosphate hydrolases MOP-like 11
(Trans)glycosidases Glycosyl hydrolase domain 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
PUA domain-like PUA domain-like 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
Methylated DNA-protein cysteine methyltransferase domain Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11
S13-like H2TH domain Glucocorticoid receptor-like (DNA-binding domain) 11
Nucleic acid-binding proteins BRCT domain 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
Nucleic acid-binding proteins S-adenosyl-L-methionine-dependent methyltransferases 11
Tex N-terminal region-like RuvA domain 2-like 11
MFS general substrate transporter MFS general substrate transporter 11
Actin-like ATPase domain HD-domain/PDEase-like 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite/Sulfite reductase N-terminal domain-like 11
PK beta-barrel domain-like PK C-terminal domain-like 11
(Trans)glycosidases Cyclophilin-like 11
Translation proteins Ribosomal protein S5 domain 2-like 11
HAMP domain-like PYP-like sensor domain (PAS domain) 11
Acetyl-CoA synthetase-like NAD(P)-binding Rossmann-fold domains 11
DNA-glycosylase Nudix 11
Rhodanese/Cell cycle control phosphatase Rhodanese/Cell cycle control phosphatase 11
N-terminal domain of MutM-like DNA repair proteins Glucocorticoid receptor-like (DNA-binding domain) 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
Translation proteins Translation proteins 11
YbaK/ProRS associated domain Class II aaRS ABD-related 11
Obg GTP-binding protein N-terminal domain Obg GTP-binding protein C-terminal domain 11
Glutathione synthetase ATP-binding domain-like Aldolase 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Pyrimidine nucleoside phosphorylase C-terminal domain 11
post-HMGL domain-like Single hybrid motif 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
Macro domain-like Zn-dependent exopeptidases 11
R1 subunit of ribonucleotide reductase, N-terminal domain Hedgehog/intein (Hint) domain 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Aldolase Single hybrid motif 11
HMA, heavy metal-associated domain HMA, heavy metal-associated domain 11
Putative DNA-binding domain Antibiotic binding domain of TipA-like multidrug resistance regulators 11
lambda integrase-like, N-terminal domain DNA breaking-rejoining enzymes 11
NTF2-like beta-lactamase/transpeptidase-like 11
Chorismate mutase II Aldolase 11
GroES-like GroES-like 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Flavoproteins Ferredoxin reductase-like, C-terminal NADP-linked domain 11
KaiA/RbsU domain PP2C-like 11
Formate dehydrogenase/DMSO reductase, domains 1-3 ADC-like 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
YhbC-like, N-terminal domain YhbC-like, C-terminal domain 11
"Winged helix" DNA-binding domain GAF domain-like 11
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 11
Hedgehog/intein (Hint) domain PFL-like glycyl radical enzymes 11
DNA methylase specificity domain DNA methylase specificity domain 11
CBS-domain pair Thioesterase/thiol ester dehydrase-isomerase 11
NAD-binding domain of HMG-CoA reductase Substrate-binding domain of HMG-CoA reductase 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
DNA repair protein MutS, domain III SMR domain-like 11
PreATP-grasp domain Methylglyoxal synthase-like 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
FMN-linked oxidoreductases Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
CoA-dependent acyltransferases NAD(P)-binding Rossmann-fold domains 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
Rudiment single hybrid motif Single hybrid motif 11
PK C-terminal domain-like Phosphohistidine domain 11
DeoB insert domain-like Alkaline phosphatase-like 11
ClpP/crotonase PGBD-like 11
Iron-dependent repressor protein, dimerization domain C-terminal domain of transcriptional repressors 11
"Winged helix" DNA-binding domain Phoshotransferase/anion transport protein 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
HMA, heavy metal-associated domain HAD-like 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
Cystatin/monellin Cysteine proteinases 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
PreATP-grasp domain Single hybrid motif 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
Nucleotidyltransferase ACT-like 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
Nucleic acid-binding proteins GAD domain-like 11
Globin-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
Bacterial adhesins Hypothetical protein PA1324 11
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 11
Pyruvate-ferredoxin oxidoreductase, PFOR, domain III Thiamin diphosphate-binding fold (THDP-binding) 11
Thioredoxin-like FAD/NAD(P)-binding domain 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
CheY-like Homeodomain-like 11
4'-phosphopantetheinyl transferase 4'-phosphopantetheinyl transferase 11
"Winged helix" DNA-binding domain Class II aaRS and biotin synthetases 11
Translation proteins ThrRS/AlaRS common domain 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
TGS-like ThrRS/AlaRS common domain 11
PHP domain-like AF1531-like 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
Aldolase post-HMGL domain-like 11
Hedgehog/intein (Hint) domain Homing endonucleases 11
Aspartate/glutamate racemase Aspartate/glutamate racemase 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
Hypothetical protein PA1324 Hypothetical protein PA1324 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
beta-lactamase/transpeptidase-like Penicillin-binding protein 2x (pbp-2x), c-terminal domain 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
Sensory domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Lysozyme-like beta-lactamase/transpeptidase-like 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
CoA-dependent acyltransferases CoA-dependent acyltransferases 11
UROD/MetE-like UROD/MetE-like 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
ParB/Sulfiredoxin KorB DNA-binding domain-like 11
TPR-like TPR-like 11
HD-domain/PDEase-like ACT-like 11
Ribonuclease H-like P-loop containing nucleoside triphosphate hydrolases 11
Eukaryotic type KH-domain (KH-domain type I) HD-domain/PDEase-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
PUA domain-like alpha/beta knot 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
PTS-regulatory domain, PRD PTS system IIB component-like 11
PreATP-grasp domain post-HMGL domain-like 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
Thiamin pyrophosphokinase, catalytic domain Thiamin pyrophosphokinase, substrate-binding domain 11
PLP-dependent transferases Ornithine decarboxylase C-terminal domain 11
Glutamyl tRNA-reductase catalytic, N-terminal domain Glutamyl tRNA-reductase dimerization domain 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
"Winged helix" DNA-binding domain LexA/Signal peptidase 11
Acetyl-CoA synthetase-like ACP-like 11
MgtE N-terminal domain-like MgtE membrane domain-like 11
Nucleotidylyl transferase Nucleic acid-binding proteins 11
SacY-like RNA-binding domain PTS-regulatory domain, PRD 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
PreATP-grasp domain Aldolase 11
HprK N-terminal domain-like CBS-domain pair 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
Acyl-CoA N-acyltransferases (Nat) Protein kinase-like (PK-like) 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
Tex N-terminal region-like Nucleic acid-binding proteins 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
TrmE connector domain P-loop containing nucleoside triphosphate hydrolases 11
Tex N-terminal region-like Ribonuclease H-like 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
PK beta-barrel domain-like Phosphohistidine domain 11
"Winged helix" DNA-binding domain GntR ligand-binding domain-like 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
Rudiment single hybrid motif post-HMGL domain-like 11
NTF2-like Penicillin binding protein dimerisation domain 11
PPK N-terminal domain-like PHP14-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11

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