SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Candidatus Blochmannia floridanus

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Graph of adjacent domain pairs.


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Domain combination pairs

279 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 64
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 65
Actin-like ATPase domain Actin-like ATPase domain 52
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 54
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 55
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 53
P-loop containing nucleoside triphosphate hydrolases Translation proteins 44
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 44
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 43
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 33
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 32
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 33
Class II aaRS and biotin synthetases Class II aaRS ABD-related 32
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 32
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 32
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 21
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 22
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 22
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 22
Nucleic acid-binding proteins Nucleic acid-binding proteins 22
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
Nucleic acid-binding proteins Translation proteins SH3-like domain 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 21
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 22
CBS-domain pair FAD-binding/transporter-associated domain-like 21
EF-G C-terminal domain-like EF-G C-terminal domain-like 22
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 21
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 22
Single hybrid motif CoA-dependent acyltransferases 21
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Alpha-L RNA-binding motif Pseudouridine synthase 21
Phospholipase D/nuclease Phospholipase D/nuclease 22
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 22
PDZ domain-like PDZ domain-like 22
Composite domain of metallo-dependent hydrolases Metallo-dependent hydrolases 22
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 22
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 21
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 21
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 21
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
HAD-like Ribosomal protein S5 domain 2-like 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 11
HisI-like all-alpha NTP pyrophosphatases 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
GroEL-intermediate domain like GroEL apical domain-like 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
Nucleic acid-binding proteins GAD domain-like 11
Periplasmic binding protein-like II GlnB-like 11
Band 7/SPFH domain Band 7/SPFH domain 11
Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
ClpP/crotonase ClpP/crotonase 11
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
PLP-binding barrel Alanine racemase C-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
Class II aaRS and biotin synthetases Translation proteins 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Macro domain-like Zn-dependent exopeptidases 11
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
ACT-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
CorA soluble domain-like Magnesium transport protein CorA, transmembrane region 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 11
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 11
Translation proteins Translation proteins 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
Lysozyme-like beta-lactamase/transpeptidase-like 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
MesJ substrate recognition domain-like PheT/TilS domain 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
Epsilon subunit of F1F0-ATP synthase N-terminal domain Epsilon subunit of F1F0-ATP synthase C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Adenine nucleotide alpha hydrolases-like MesJ substrate recognition domain-like 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
NAD(P)-binding Rossmann-fold domains Tetrapyrrole methylase 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
Formyltransferase FMT C-terminal domain-like 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 11
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 11
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 11
Translation proteins Ribosomal protein S5 domain 2-like 11
NAD(P)-binding Rossmann-fold domains Siroheme synthase middle domains-like 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
GroEL equatorial domain-like GroEL apical domain-like 11
Carbamate kinase-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 11
Carbamate kinase-like ACT-like 11
Nitrite and sulphite reductase 4Fe-4S domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
DNA clamp DNA clamp 11
THUMP domain-like Adenine nucleotide alpha hydrolases-like 11
PIN domain-like DNA/RNA polymerases 11
Domain of the SRP/SRP receptor G-proteins Signal peptide-binding domain 11
PreATP-grasp domain Rudiment single hybrid motif 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
Translation proteins ThrRS/AlaRS common domain 11
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 11
Carbon-nitrogen hydrolase ABC transporter transmembrane region 11
Nqo1 middle domain-like Nqo1C-terminal domain-like 11
FKBP-like FKBP-like 11
THUMP domain-like Rhodanese/Cell cycle control phosphatase 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
RNase III domain-like dsRNA-binding domain-like 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
Chorismate mutase II NAD(P)-binding Rossmann-fold domains 11
Thiolase-like Thiolase-like 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
Flavoproteins Ferredoxin reductase-like, C-terminal NADP-linked domain 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
NAD(P)-binding Rossmann-fold domains 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
Nucleic acid-binding proteins RuvA domain 2-like 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
Zinc beta-ribbon DNA primase core 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 11
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 11
PheT/TilS domain Putative DNA-binding domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 11
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 11
L30e-like alpha/beta knot 11
6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 11
Nqo5-like HydB/Nqo4-like 11
ACT-like ACT-like 11
ACT-like NAD(P)-binding Rossmann-fold domains 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
UROD/MetE-like UROD/MetE-like 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 11
Chorismate mutase II 6-phosphogluconate dehydrogenase C-terminal domain-like 11
Ribosomal protein L6 Ribosomal protein L6 11
PTS system fructose IIA component-like PTS IIb component 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
Adenine nucleotide alpha hydrolases-like Rhodanese/Cell cycle control phosphatase 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
Class II aaRS and biotin synthetases SufE/NifU 11
Putative DNA-binding domain P-loop containing nucleoside triphosphate hydrolases 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Rad51 N-terminal domain-like Rad51 N-terminal domain-like 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
Nucleotidyltransferase Poly A polymerase C-terminal region-like 11
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
Triger factor/SurA peptide-binding domain-like FKBP-like 11
Translation proteins EF-G C-terminal domain-like 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
HesB-like domain Fe-S cluster assembly (FSCA) domain-like 11
HD-domain/PDEase-like Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
Ribonuclease H-like DNA/RNA polymerases 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 11
Ribulose-phoshate binding barrel Ribulose-phoshate binding barrel 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
Flavoproteins Riboflavin synthase domain-like 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
PIN domain-like Ribonuclease H-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
Nucleic acid-binding proteins PheT/TilS domain 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
TolB, N-terminal domain Tricorn protease N-terminal domain 11
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 11
Carbamate kinase-like NAD(P)-binding Rossmann-fold domains 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
PreATP-grasp domain PreATP-grasp domain 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
DNA primase core DNA primase DnaG, C-terminal domain 11
Translation proteins PRC-barrel domain 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
Trypsin-like serine proteases PDZ domain-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
FMN-binding split barrel UbiD C-terminal domain-like 11
Class II aaRS and biotin synthetases ThrRS/AlaRS common domain 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
Ribokinase-like Nucleotidylyl transferase 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 11
Zinc beta-ribbon DNA primase DnaG, C-terminal domain 11
Putative DNA-binding domain Translation proteins 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite/Sulfite reductase N-terminal domain-like 11
PreATP-grasp domain Methylglyoxal synthase-like 11
Nucleotidylyl transferase Ribosomal protein L25-like 11
Putative DNA-binding domain Initiation factor IF2/eIF5b, domain 3 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
Siroheme synthase middle domains-like Tetrapyrrole methylase 11

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