SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Cycloclasticus sp. P1

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

579 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
ISP domain Bet v1-like 223
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 2112
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 1711
Nucleotide cyclase EAL domain-like 1411
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 135
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 112
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 103
Thioredoxin-like GST C-terminal domain-like 101
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 104
PYP-like sensor domain (PAS domain) Nucleotide cyclase 99
P-loop containing nucleoside triphosphate hydrolases Translation proteins 96
Thiolase-like Thiolase-like 81
Actin-like ATPase domain Actin-like ATPase domain 83
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 75
cAMP-binding domain-like "Winged helix" DNA-binding domain 71
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 74
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 74
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 74
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 74
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 73
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 74
CheY-like Homodimeric domain of signal transducing histidine kinase 66
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 63
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 61
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 63
CheY-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 66
CheY-like EAL domain-like 66
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 63
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 63
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 55
HAD-like Calcium ATPase, transmembrane domain M 54
CheY-like Homeodomain-like 52
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 55
Ribosomal protein S5 domain 2-like P-loop containing nucleoside triphosphate hydrolases 54
PYP-like sensor domain (PAS domain) EAL domain-like 55
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 53
CheY-like C-terminal effector domain of the bipartite response regulators 51
GroES-like NAD(P)-binding Rossmann-fold domains 52
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 54
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 53
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 52
Translation proteins EF-G C-terminal domain-like 53
CheY-like Nucleotide cyclase 55
Calcium ATPase, transduction domain A HAD-like 54
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 43
PYP-like sensor domain (PAS domain) PYP-like sensor domain (PAS domain) 44
PreATP-grasp domain Rudiment single hybrid motif 42
Riboflavin synthase domain-like 2Fe-2S ferredoxin-like 42
Nucleic acid-binding proteins Nucleic acid-binding proteins 43
FKBP-like Triger factor/SurA peptide-binding domain-like 44
Ferredoxin reductase-like, C-terminal NADP-linked domain 2Fe-2S ferredoxin-like 42
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 44
EF-G C-terminal domain-like EF-G C-terminal domain-like 42
HAMP domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 44
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 42
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 43
HAMP domain-like Homodimeric domain of signal transducing histidine kinase 44
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 43
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 42
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 43
CheY-like P-loop containing nucleoside triphosphate hydrolases 41
PurM N-terminal domain-like PurM C-terminal domain-like 42
PYP-like sensor domain (PAS domain) GAF domain-like 44
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 31
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 33
Alpha-L RNA-binding motif Pseudouridine synthase 31
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 32
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 32
PYP-like sensor domain (PAS domain) CheY-like 33
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 33
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 32
CheY-like CheY-like 33
Translation proteins SH3-like domain Nucleic acid-binding proteins 32
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 32
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 31
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 31
ACT-like ACT-like 33
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 32
Aldolase post-HMGL domain-like 32
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 32
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 32
PDZ domain-like PDZ domain-like 32
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 31
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 33
Cation efflux protein transmembrane domain-like Cation efflux protein cytoplasmic domain-like 32
Homodimeric domain of signal transducing histidine kinase Histidine-containing phosphotransfer domain, HPT domain 33
CheY-like Histidine-containing phosphotransfer domain, HPT domain 33
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Histidine-containing phosphotransfer domain, HPT domain 33
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 32
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
Metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 32
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 32
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 32
FAD-binding/transporter-associated domain-like FAD-linked oxidases, C-terminal domain 31
GAF domain-like Nucleotide cyclase 33
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 22
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Nucleotide cyclase 22
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases 22
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 21
Nucleotidyltransferase Poly A polymerase C-terminal region-like 22
Single hybrid motif CoA-dependent acyltransferases 22
TSP type-3 repeat OmpA-like 22
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 21
NAD(P)-binding Rossmann-fold domains UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
ThrRS/AlaRS common domain Class II aaRS and biotin synthetases 22
Nucleotidyltransferase Nucleotidyltransferase substrate binding subunit/domain 22
TrkA C-terminal domain-like TrkA C-terminal domain-like 22
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 22
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
Thioredoxin-like Nqo1 middle domain-like 22
Glutathione synthetase ATP-binding domain-like Single hybrid motif 21
Aconitase iron-sulfur domain LeuD/IlvD-like 22
HAMP domain-like PYP-like sensor domain (PAS domain) 22
6-phosphogluconate dehydrogenase C-terminal domain-like UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 21
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 22
MoeA N-terminal region -like MoeA C-terminal domain-like 21
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 21
NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains 22
Phospholipase D/nuclease Phospholipase D/nuclease 22
HD-domain/PDEase-like Nucleotidyltransferase 22
Lysozyme-like LysM domain 22
Nqo1 middle domain-like Nqo1C-terminal domain-like 22
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 21
Carbamate kinase-like ACT-like 22
MgtE N-terminal domain-like MgtE membrane domain-like 21
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 22
CheY-like GAF domain-like 22
FMN-binding split barrel UbiD C-terminal domain-like 21
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 21
Histidine-containing phosphotransfer domain, HPT domain EAL domain-like 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 22
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 22
Metal cation-transporting ATPase, ATP-binding domain N Calcium ATPase, transmembrane domain M 21
LysM domain LysM domain 22
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 21
PreATP-grasp domain Single hybrid motif 21
Trypsin-like serine proteases PDZ domain-like 21
RmlC-like cupins RmlC-like cupins 21
GreA transcript cleavage protein, N-terminal domain FKBP-like 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase EAL domain-like 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 22
PLP-binding barrel Alanine racemase C-terminal domain-like 21
Thioredoxin-like Nqo1C-terminal domain-like 22
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 22
Cytochrome c Cytochrome c 22
PP2C-like Protein kinase-like (PK-like) 21
HMA, heavy metal-associated domain HAD-like 22
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
Homodimeric domain of signal transducing histidine kinase Nucleotide cyclase 22
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 21
Nucleotidyltransferase ACT-like 22
TPR-like TPR-like 22
Translation proteins Ribosomal protein S5 domain 2-like 21
MgtE N-terminal domain-like CBS-domain pair 21
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 22
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 22
DNA methylase specificity domain DNA methylase specificity domain 22
NAD(P)-binding Rossmann-fold domains ACT-like 22
Thioredoxin-like Nqo1 FMN-binding domain-like 22
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 22
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 22
CBS-domain pair FAD-binding/transporter-associated domain-like 21
Chaperone J-domain HSP40/DnaJ peptide-binding domain 22
CBS-domain pair MgtE membrane domain-like 21
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 22
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 22
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 22
GAF domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Metal cation-transporting ATPase, ATP-binding domain N HAD-like 21
GAF domain-like Homodimeric domain of signal transducing histidine kinase 22
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 22
Rudiment single hybrid motif Single hybrid motif 21
Lysozyme-like beta-lactamase/transpeptidase-like 22
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 22
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 22
Homodimeric domain of signal transducing histidine kinase EAL domain-like 22
ClpP/crotonase ClpP/crotonase 21
Histidine-containing phosphotransfer domain, HPT domain Nucleotide cyclase 22
Formate dehydrogenase/DMSO reductase, domains 1-3 ADC-like 22
Nitrite/Sulfite reductase N-terminal domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 22
HD-domain/PDEase-like ACT-like 22
Nucleic acid-binding proteins RuvA domain 2-like 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Calcium ATPase, transduction domain A Metal cation-transporting ATPase, ATP-binding domain N 21
ACT-like Formyltransferase 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Zinc beta-ribbon DNA primase core 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
NAD(P)-binding Rossmann-fold domains Glutathione synthetase ATP-binding domain-like 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
FliG FliG 11
Nucleic acid-binding proteins PheT/TilS domain 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 11
Zn-dependent exopeptidases Fibronectin type III 11
TGS-like ThrRS/AlaRS common domain 11
NAD(P)-binding Rossmann-fold domains Tetrapyrrole methylase 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
FMN-binding split barrel Riboflavin synthase domain-like 11
EspE N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
Sensory domain-like HAMP domain-like 11
cAMP-binding domain-like HD-domain/PDEase-like 11
"Winged helix" DNA-binding domain Class II aaRS and biotin synthetases 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
Hemerythrin-like EAL domain-like 11
PUA domain-like alpha/beta knot 11
Aldolase Single hybrid motif 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
"Winged helix" DNA-binding domain C-terminal domain of transcriptional repressors 11
GAF domain-like EAL domain-like 11
Aldehyde ferredoxin oxidoreductase, N-terminal domain Aldehyde ferredoxin oxidoreductase, C-terminal domains 11
Heme-dependent peroxidases Heme-dependent peroxidases 11
NagB/RpiA/CoA transferase-like NagB/RpiA/CoA transferase-like 11
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 11
FMN-linked oxidoreductases FAD/NAD(P)-binding domain 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite/Sulfite reductase N-terminal domain-like 11
HRDC-like HRDC-like 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
N-terminal domain of MutM-like DNA repair proteins Glucocorticoid receptor-like (DNA-binding domain) 11
Ribosomal protein S5 domain 2-like HSP90 C-terminal domain 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
PurS-like Class I glutamine amidotransferase-like 11
Prokaryotic type I DNA topoisomerase Zinc beta-ribbon 11
Aconitase B, N-terminal domain Aconitase iron-sulfur domain 11
PPK N-terminal domain-like Phospholipase D/nuclease 11
Urease metallochaperone UreE, N-terminal domain Urease metallochaperone UreE, C-terminal domain 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
DNA-glycosylase Nudix 11
Actin-like ATPase domain HD-domain/PDEase-like 11
GroEL-intermediate domain like GroEL apical domain-like 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
Nqo1 FMN-binding domain-like alpha-helical ferredoxin 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
Epsilon subunit of F1F0-ATP synthase N-terminal domain Epsilon subunit of F1F0-ATP synthase C-terminal domain 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Alpha subunit of glutamate synthase, C-terminal domain 11
cAMP-binding domain-like cAMP-binding domain-like 11
NAD(P)-binding Rossmann-fold domains Siroheme synthase middle domains-like 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 11
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 11
TGS-like Class II aaRS and biotin synthetases 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
Nucleic acid-binding proteins S-adenosyl-L-methionine-dependent methyltransferases 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
Single hybrid motif FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
Putative DNA-binding domain P-loop containing nucleoside triphosphate hydrolases 11
FAD/NAD(P)-binding domain Nitrite and sulphite reductase 4Fe-4S domain-like 11
Chorismate mutase II ACT-like 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
Thiamin diphosphate-binding fold (THDP-binding) Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 11
PHP domain-like AF1531-like 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Sensory domain-like Homodimeric domain of signal transducing histidine kinase 11
NAD(P)-binding Rossmann-fold domains ClpP/crotonase 11
C-type lectin-like S-adenosyl-L-methionine-dependent methyltransferases 11
HD-domain/PDEase-like TGS-like 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Trigger factor ribosome-binding domain FKBP-like 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
PurS-like FGAM synthase PurL, linker domain 11
HlyD-like secretion proteins HlyD-like secretion proteins 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleic acid-binding proteins 11
lambda repressor-like DNA-binding domains Cyanase C-terminal domain 11
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 11
GroEL equatorial domain-like GroEL apical domain-like 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
Methionine synthase domain Methionine synthase activation domain-like 11
Translation proteins ThrRS/AlaRS common domain 11
NAD(P)-binding Rossmann-fold domains 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
PPK N-terminal domain-like PHP14-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
Homocysteine S-methyltransferase Dihydropteroate synthetase-like 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
Glycerol-3-phosphate (1)-acyltransferase Acyl-CoA N-acyltransferases (Nat) 11
Putative DNA-binding domain Initiation factor IF2/eIF5b, domain 3 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
Nucleic acid-binding proteins GAD domain-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
PHP14-like Phospholipase D/nuclease 11
6-phosphogluconate dehydrogenase C-terminal domain-like ClpP/crotonase 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
L30e-like alpha/beta knot 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
HAMP domain-like Histidine-containing phosphotransfer domain, HPT domain 11
Adenine nucleotide alpha hydrolases-like MesJ substrate recognition domain-like 11
Nucleic acid-binding proteins BRCT domain 11
Succinyl-CoA synthetase domains Succinyl-CoA synthetase domains 11
beta-lactamase/transpeptidase-like Penicillin-binding protein associated domain 11
Adenine nucleotide alpha hydrolases-like DHS-like NAD/FAD-binding domain 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Homocysteine S-methyltransferase Methionine synthase domain 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
Periplasmic binding protein-like II Lysozyme-like 11
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 11
S-adenosyl-L-methionine-dependent methyltransferases NAD(P)-binding Rossmann-fold domains 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
UROD/MetE-like UROD/MetE-like 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
Cytidine deaminase-like Dihydrofolate reductase-like 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
Translation proteins PRC-barrel domain 11
Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) Thioredoxin-like 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) FMN-linked oxidoreductases 11
Nucleotide-binding domain FAD-linked reductases, C-terminal domain 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
NTF2-like Sec-C motif 11
Class II aaRS and biotin synthetases C-terminal domain of transcriptional repressors 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
PurS-like PurM C-terminal domain-like 11
Acid proteases Glutathione synthetase ATP-binding domain-like 11
MesJ substrate recognition domain-like PheT/TilS domain 11
Quinoprotein alcohol dehydrogenase-like Cytochrome c 11
Ribosomal protein L6 Ribosomal protein L6 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
Single hybrid motif FAD/NAD(P)-binding domain 11
Methionine synthase domain Cobalamin (vitamin B12)-binding domain 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
Nucleotide-diphospho-sugar transferases Nucleotide-diphospho-sugar transferases 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
Aminoacid dehydrogenase-like, N-terminal domain Isocitrate/Isopropylmalate dehydrogenase-like 11
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
YhbC-like, N-terminal domain YhbC-like, C-terminal domain 11
Dihydropteroate synthetase-like Cobalamin (vitamin B12)-binding domain 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
all-alpha NTP pyrophosphatases all-alpha NTP pyrophosphatases 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
alpha-helical ferredoxin Nucleotide-binding domain 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HSP90 C-terminal domain 11
RuvA domain 2-like MCP/YpsA-like 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
Nucleotidyltransferase substrate binding subunit/domain Nucleotidyltransferase substrate binding subunit/domain 11
FMN-linked oxidoreductases Alpha subunit of glutamate synthase, C-terminal domain 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
Dihydropteroate synthetase-like Methionine synthase activation domain-like 11
Nucleotidyltransferase Nucleotidyltransferase 11
Glutamyl tRNA-reductase catalytic, N-terminal domain NAD(P)-binding Rossmann-fold domains 11
Aminopeptidase/glucanase lid domain Zn-dependent exopeptidases 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
CorA soluble domain-like Magnesium transport protein CorA, transmembrane region 11
FAD/NAD(P)-binding domain HI0933 insert domain-like 11
PIN domain-like DNA/RNA polymerases 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
TolB, N-terminal domain Tricorn protease N-terminal domain 11
RuvA domain 2-like BRCT domain 11
PDZ domain-like ClpP/crotonase 11
Zinc beta-ribbon DNA primase DnaG, C-terminal domain 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
Single hybrid motif Single hybrid motif 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
Ribokinase-like Nucleotidylyl transferase 11
FAD-linked reductases, C-terminal domain 4Fe-4S ferredoxins 11
Dihydropteroate synthetase-like Methionine synthase domain 11
Acylphosphatase/BLUF domain-like YrdC/RibB 11
PreATP-grasp domain PreATP-grasp domain 11
Siroheme synthase middle domains-like Tetrapyrrole methylase 11
4'-phosphopantetheinyl transferase 4'-phosphopantetheinyl transferase 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
FMN-binding split barrel 2Fe-2S ferredoxin-like 11
PheT/TilS domain Putative DNA-binding domain 11
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase Nitrous oxide reductase, N-terminal domain 11
Ammonium transporter EAL domain-like 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
Carbamate kinase-like PUA domain-like 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
S13-like H2TH domain Glucocorticoid receptor-like (DNA-binding domain) 11
Cobalamin (vitamin B12)-binding domain P-loop containing nucleoside triphosphate hydrolases 11
DNA primase core DNA primase DnaG, C-terminal domain 11
Thioesterase/thiol ester dehydrase-isomerase Thioesterase/thiol ester dehydrase-isomerase 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
Transmembrane di-heme cytochromes a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 11
RuvA domain 2-like JAB1/MPN domain 11
FAD/NAD(P)-binding domain 4Fe-4S ferredoxins 11
FAD/NAD(P)-binding domain Nitrite/Sulfite reductase N-terminal domain-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-dependent enzymes 11
Hsp33 domain HSP33 redox switch-like 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
PurM N-terminal domain-like Class I glutamine amidotransferase-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
Protein kinase-like (PK-like) Protein kinase-like (PK-like) 11
RNase III domain-like dsRNA-binding domain-like 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Nucleotidylyl transferase Ribosomal protein L25-like 11
Ribonuclease H-like HRDC-like 11
Cupredoxins Cupredoxins 11
4Fe-4S ferredoxins ADC-like 11
Ammonium transporter PYP-like sensor domain (PAS domain) 11
TGS-like Class II aaRS ABD-related 11
S-adenosyl-L-methionine-dependent methyltransferases DNA methylase specificity domain 11
post-HMGL domain-like Single hybrid motif 11
Formyltransferase FMT C-terminal domain-like 11
Barwin-like endoglucanases Sporulation related repeat 11
cAMP-binding domain-like Rhodanese/Cell cycle control phosphatase 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 11
Nucleotidyltransferase substrate binding subunit/domain HD-domain/PDEase-like 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
YrdC/RibB RibA-like 11
PIN domain-like Ribonuclease H-like 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 11
TGS-like ACT-like 11
CarD-like TRCF domain-like 11
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 11
Sensory domain-like PYP-like sensor domain (PAS domain) 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
PHP domain-like UDP-Glycosyltransferase/glycogen phosphorylase 11
TrmE connector domain P-loop containing nucleoside triphosphate hydrolases 11
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
FMN-binding split barrel Ferredoxin reductase-like, C-terminal NADP-linked domain 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
YajQ-like YajQ-like 11
PreATP-grasp domain Methylglyoxal synthase-like 11
HAMP domain-like CheY-like 11
DsbC/DsbG N-terminal domain-like Thioredoxin-like 11
2Fe-2S ferredoxin-like ADC-like 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
NAD(P)-binding Rossmann-fold domains Isocitrate/Isopropylmalate dehydrogenase-like 11
Carbamate kinase-like Acyl-CoA N-acyltransferases (Nat) 11
Homocysteine S-methyltransferase Methionine synthase activation domain-like 11
Zinc beta-ribbon Prokaryotic SH3-related domain 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
FGAM synthase PurL, linker domain PurM N-terminal domain-like 11
Macro domain-like Zn-dependent exopeptidases 11
CheC-like Surface presentation of antigens (SPOA) 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
vWA-like TPR-like 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
NusB-like S-adenosyl-L-methionine-dependent methyltransferases 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
Periplasmic binding protein-like II ACT-like 11
Ammonium transporter Nucleotide cyclase 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
EAL domain-like HD-domain/PDEase-like 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
HMA, heavy metal-associated domain Cation efflux protein transmembrane domain-like 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
Hemerythrin-like CheY-like 11
Aconitase B, N-terminal domain LeuD/IlvD-like 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
YbaK/ProRS associated domain Class II aaRS ABD-related 11
PurS-like PurM N-terminal domain-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
Homocysteine S-methyltransferase Cobalamin (vitamin B12)-binding domain 11
DNA clamp DNA clamp 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 11
Class II aaRS and biotin synthetases Translation proteins 11
CheY-like HD-domain/PDEase-like 11
2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain Alkaline phosphatase-like 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
Translation proteins Translation proteins 11
Nucleotidylyl transferase Nucleic acid-binding proteins 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
P-loop containing nucleoside triphosphate hydrolases Cobalamin (vitamin B12)-dependent enzymes 11
Nucleotide-diphospho-sugar transferases RmlC-like cupins 11
FKBP-like FKBP-like 11
Voltage-gated potassium channels NAD(P)-binding Rossmann-fold domains 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain ACT-like 11
Sensory domain-like GAF domain-like 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
Acetyl-CoA synthetase-like ACP-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
TK C-terminal domain-like Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 11
Rad51 N-terminal domain-like Rad51 N-terminal domain-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases Nucleic acid-binding proteins 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
Class II aaRS and biotin synthetases YbaK/ProRS associated domain 11
GIY-YIG endonuclease RuvA domain 2-like 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
Glutathione synthetase ATP-binding domain-like TrkA C-terminal domain-like 11
Nudix Thiamin phosphate synthase 11
Cobalamin (vitamin B12)-binding domain Methionine synthase activation domain-like 11
P-loop containing nucleoside triphosphate hydrolases HRDC-like 11
Nitrite and sulphite reductase 4Fe-4S domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
PurM C-terminal domain-like Class I glutamine amidotransferase-like 11
Chorismate mutase II Periplasmic binding protein-like II 11
MoaD/ThiS ThiG-like 11
Glutamyl tRNA-reductase catalytic, N-terminal domain Glutamyl tRNA-reductase dimerization domain 11
Methylated DNA-protein cysteine methyltransferase domain Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11
Fe-S cluster assembly (FSCA) domain-like P-loop containing nucleoside triphosphate hydrolases 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
Leukotriene A4 hydrolase N-terminal domain Metalloproteases ("zincins"), catalytic domain 11
Zinc beta-ribbon Zinc beta-ribbon 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
Ribonuclease H-like DNA/RNA polymerases 11
Nucleotidyltransferase substrate binding subunit/domain ACT-like 11
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 11
Nucleotidyltransferase TGS-like 11
Sensory domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
GroES-like GroES-like 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
Putative DNA-binding domain Translation proteins 11
Dihydropteroate synthetase-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
FGAM synthase PurL, linker domain Class I glutamine amidotransferase-like 11
Metallo-hydrolase/oxidoreductase Rhodanese/Cell cycle control phosphatase 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
Zn-dependent exopeptidases LysM domain 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
Nucleotidylyl transferase tRNA-binding arm 11
FGAM synthase PurL, linker domain PurM C-terminal domain-like 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
HAMP domain-like GAF domain-like 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
NAD(P)-binding Rossmann-fold domains Glutamyl tRNA-reductase dimerization domain 11
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 11
Phase 1 flagellin Phase 1 flagellin 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11

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