SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Hyphomonas neptunium ATCC 15444

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

  • For a list of unique full length architectures for this genome click here (can be slow).
Adjacent domain pairs graph

Graph of adjacent domain pairs.


Add or remove domain pairs

The links below permit the addition or removal of specific sets of domain combination pairs.


Jump to [ Top of page · Add/remove domain pairs · Domain combination pairs ]

Add or remove genomes

Change the list of genome two-letter codes in the 'Include genomes' box to include domain-pairs from those genomes.
Change the list of genomes in the 'Exclude genomes' box to exclude domain-pairs from those genomes.
List of all two-letter genome codes.

Add or remove genomes:
Include genomes:
Exclude genomes:


Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes ]

Domain combination pairs

587 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
Acyl-CoA dehydrogenase NM domain-like Acyl-CoA dehydrogenase C-terminal domain-like 324
GroES-like NAD(P)-binding Rossmann-fold domains 213
Homodimeric domain of signal transducing histidine kinase ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 2012
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 1911
Thioredoxin-like GST C-terminal domain-like 192
Homeodomain-like Tetracyclin repressor-like, C-terminal domain 161
Metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 158
"Winged helix" DNA-binding domain Periplasmic binding protein-like II 151
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 122
Multidrug efflux transporter AcrB transmembrane domain Multidrug efflux transporter AcrB transmembrane domain 116
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 105
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB transmembrane domain 105
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains 105
Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains Multidrug efflux transporter AcrB transmembrane domain 105
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 106
Actin-like ATPase domain Actin-like ATPase domain 105
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 104
Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains 94
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 93
Nucleotide cyclase EAL domain-like 95
PYP-like sensor domain (PAS domain) ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 98
TPR-like TPR-like 84
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 84
P-loop containing nucleoside triphosphate hydrolases Translation proteins 87
Thiolase-like Thiolase-like 82
PYP-like sensor domain (PAS domain) Homodimeric domain of signal transducing histidine kinase 76
CheY-like C-terminal effector domain of the bipartite response regulators 71
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 73
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 72
Multidrug resistance efflux transporter EmrE Multidrug resistance efflux transporter EmrE 72
FAD/NAD(P)-binding domain FAD/NAD(P)-binding domain 75
FAD/NAD(P)-binding domain FAD-linked reductases, C-terminal domain 73
Homodimeric domain of signal transducing histidine kinase CheY-like 66
Formate/glycerate dehydrogenase catalytic domain-like NAD(P)-binding Rossmann-fold domains 62
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
MurD-like peptide ligases, catalytic domain MurD-like peptide ligases, peptide-binding domain 63
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 63
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase CheY-like 66
PLP-binding barrel Alanine racemase C-terminal domain-like 51
Glutathione synthetase ATP-binding domain-like Rudiment single hybrid motif 52
Thioesterase/thiol ester dehydrase-isomerase Thioesterase/thiol ester dehydrase-isomerase 52
PreATP-grasp domain Rudiment single hybrid motif 52
Homeodomain-like Homeodomain-like 53
Calcium ATPase, transduction domain A HAD-like 43
PurM N-terminal domain-like PurM C-terminal domain-like 43
P-loop containing nucleoside triphosphate hydrolases Homeodomain-like 42
Homeodomain-like Ribonuclease H-like 41
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 43
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 43
Calcium ATPase, transduction domain A Calcium ATPase, transmembrane domain M 43
Alpha-L RNA-binding motif Pseudouridine synthase 42
ClpP/crotonase ClpP/crotonase 43
"Winged helix" DNA-binding domain Dimeric alpha+beta barrel 41
Nucleic acid-binding proteins Nucleic acid-binding proteins 44
P-loop containing nucleoside triphosphate hydrolases "Winged helix" DNA-binding domain 44
Enolase N-terminal domain-like Enolase C-terminal domain-like 41
P-loop containing nucleoside triphosphate hydrolases TPR-like 43
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 41
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 44
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 43
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 43
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 41
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 43
"Winged helix" DNA-binding domain GntR ligand-binding domain-like 42
C-terminal effector domain of the bipartite response regulators TPR-like 44
HAD-like Calcium ATPase, transmembrane domain M 43
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 43
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 32
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain 32
DPP6 N-terminal domain-like alpha/beta-Hydrolases 31
TrkA C-terminal domain-like TrkA C-terminal domain-like 32
Lysozyme-like beta-lactamase/transpeptidase-like 33
PYP-like sensor domain (PAS domain) CheY-like 33
Trypsin-like serine proteases PDZ domain-like 32
Nucleic acid-binding proteins RuvA domain 2-like 33
ParB/Sulfiredoxin KorB DNA-binding domain-like 31
EF-G C-terminal domain-like EF-G C-terminal domain-like 33
"Winged helix" DNA-binding domain Chorismate lyase-like 31
Class II aaRS and biotin synthetases Class II aaRS ABD-related 33
ACT-like ACT-like 33
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 33
L30e-like alpha/beta knot 31
Triger factor/SurA peptide-binding domain-like FKBP-like 32
cAMP-binding domain-like "Winged helix" DNA-binding domain 31
CheY-like Homeodomain-like 31
CheY-like P-loop containing nucleoside triphosphate hydrolases 31
Protein kinase-like (PK-like) TPR-like 32
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
FAD-binding/transporter-associated domain-like FAD-linked oxidases, C-terminal domain 31
MurCD N-terminal domain MurD-like peptide ligases, catalytic domain 31
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 31
Peptidase/esterase 'gauge' domain alpha/beta-Hydrolases 32
Nucleotidyltransferase Nucleotidyltransferase substrate binding subunit/domain 33
MurCD N-terminal domain MurD-like peptide ligases, peptide-binding domain 31
Macro domain-like Zn-dependent exopeptidases 31
2Fe-2S ferredoxin-like CO dehydrogenase ISP C-domain like 31
Translation proteins EF-G C-terminal domain-like 33
Cobalamin (vitamin B12)-dependent enzymes Cobalamin (vitamin B12)-binding domain 31
PDZ domain-like PDZ domain-like 32
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 33
CBS-domain pair FAD-binding/transporter-associated domain-like 31
P-loop containing nucleoside triphosphate hydrolases C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
FabD/lysophospholipase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 22
Nitrite/Sulfite reductase N-terminal domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 22
PreATP-grasp domain Single hybrid motif 21
P-loop containing nucleoside triphosphate hydrolases Glucocorticoid receptor-like (DNA-binding domain) 22
Acetyl-CoA synthetase-like ACP-like 22
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 22
Carboxypeptidase regulatory domain-like Porins 21
FAD/NAD(P)-binding domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 21
Cytochrome c Cytochrome c 22
P-loop containing nucleoside triphosphate hydrolases C-terminal effector domain of the bipartite response regulators 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, first 3 domains 21
Glutathione synthetase ATP-binding domain-like Single hybrid motif 21
GroES-like GroES-like 21
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 22
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 22
Phosphoglucomutase, first 3 domains Phosphoglucomutase, C-terminal domain 21
N-terminal domain of alpha and beta subunits of F1 ATP synthase P-loop containing nucleoside triphosphate hydrolases 21
Translation proteins SH3-like domain Nucleic acid-binding proteins 22
Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain 21
PYP-like sensor domain (PAS domain) PYP-like sensor domain (PAS domain) 22
P-loop containing nucleoside triphosphate hydrolases Class I glutamine amidotransferase-like 21
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 22
Cryptochrome/photolyase, N-terminal domain Cryptochrome/photolyase FAD-binding domain 22
Chaperone J-domain HSP40/DnaJ peptide-binding domain 22
PYP-like sensor domain (PAS domain) Nucleotide cyclase 22
MoeA N-terminal region -like Molybdenum cofactor biosynthesis proteins 21
NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains 22
Rudiment single hybrid motif Single hybrid motif 21
HAMP domain-like ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 22
Nucleotidyltransferase ACT-like 22
CheY-like Nucleotide cyclase 22
HAMP domain-like Homodimeric domain of signal transducing histidine kinase 22
HCP-like HCP-like 21
Molybdenum cofactor biosynthesis proteins MoeA C-terminal domain-like 21
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 22
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 22
LuxS/MPP-like metallohydrolase LuxS/MPP-like metallohydrolase 22
EspE N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 22
Carbamate kinase-like ACT-like 22
MurE/MurF N-terminal domain MurD-like peptide ligases, peptide-binding domain 21
Fe,Mn superoxide dismutase (SOD), N-terminal domain Fe,Mn superoxide dismutase (SOD), C-terminal domain 22
"Winged helix" DNA-binding domain GAF domain-like 22
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 21
Penicillin binding protein dimerisation domain beta-lactamase/transpeptidase-like 22
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 22
MoeA N-terminal region -like MoeA C-terminal domain-like 21
Leukotriene A4 hydrolase N-terminal domain Metalloproteases ("zincins"), catalytic domain 21
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 22
Single hybrid motif CoA-dependent acyltransferases 22
Homeodomain-like SIS domain 21
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain 21
Double Clp-N motif P-loop containing nucleoside triphosphate hydrolases 21
Thiolase-like FabD/lysophospholipase-like 22
Phosphohistidine domain Phosphoenolpyruvate/pyruvate domain 22
PA domain Zn-dependent exopeptidases 21
Nucleotidyltransferase Poly A polymerase C-terminal region-like 22
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 22
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 22
MurE/MurF N-terminal domain MurD-like peptide ligases, catalytic domain 21
HlyD-like secretion proteins HlyD-like secretion proteins 22
CheY-like CheY-like 22
Cupredoxins Cupredoxins 21
NAD(P)-binding Rossmann-fold domains ACT-like 22
Class II aaRS and biotin synthetases ThrRS/AlaRS common domain 22
PYP-like sensor domain (PAS domain) EAL domain-like 22
N-terminal domain of alpha and beta subunits of F1 ATP synthase C-terminal domain of alpha and beta subunits of F1 ATP synthase 21
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
Class I glutamine amidotransferase-like Homeodomain-like 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
Methionine synthase domain Cobalamin (vitamin B12)-binding domain 11
Thiolase-like NAD(P)-binding Rossmann-fold domains 11
DNA repair protein MutS, domain I P-loop containing nucleoside triphosphate hydrolases 11
P-loop containing nucleoside triphosphate hydrolases MOP-like 11
Transmembrane di-heme cytochromes YceI-like 11
Ribonuclease H-like RuvA domain 2-like 11
DNA ligase/mRNA capping enzyme, catalytic domain BRCT domain 11
GroEL-intermediate domain like GroEL apical domain-like 11
Adenine nucleotide alpha hydrolases-like GMP synthetase C-terminal dimerisation domain 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Poly A polymerase C-terminal region-like ACT-like 11
Tricorn protease N-terminal domain DPP6 N-terminal domain-like 11
Tex N-terminal region-like Nucleic acid-binding proteins 11
CorA soluble domain-like Magnesium transport protein CorA, transmembrane region 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
GAF domain-like Phosphohistidine domain 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
"Winged helix" DNA-binding domain Acyl-CoA N-acyltransferases (Nat) 11
Nucleotide-diphospho-sugar transferases IpsF-like 11
PHP14-like Phospholipase D/nuclease 11
lambda integrase-like, N-terminal domain DNA breaking-rejoining enzymes 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
FAD/NAD(P)-binding domain Nitrite/Sulfite reductase N-terminal domain-like 11
Cobalamin (vitamin B12)-binding domain Methionine synthase activation domain-like 11
GIY-YIG endonuclease RuvA domain 2-like 11
4'-phosphopantetheinyl transferase 4'-phosphopantetheinyl transferase 11
DNA-glycosylase Nudix 11
Probable ACP-binding domain of malonyl-CoA ACP transacylase ACP-like 11
DNA/RNA polymerases Lesion bypass DNA polymerase (Y-family), little finger domain 11
Nucleic acid-binding proteins S-adenosyl-L-methionine-dependent methyltransferases 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
Metal cation-transporting ATPase, ATP-binding domain N Calcium ATPase, transmembrane domain M 11
Nucleic acid-binding proteins Putative DNA-binding domain 11
Ribosomal protein L6 Ribosomal protein L6 11
RuvA domain 2-like RuvA domain 2-like 11
Ribonuclease H-like HRDC-like 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
NAD(P)-binding Rossmann-fold domains UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 11
Actin-like ATPase domain HD-domain/PDEase-like 11
PheT/TilS domain Putative DNA-binding domain 11
Translation proteins Ribosomal protein S5 domain 2-like 11
Translation proteins ThrRS/AlaRS common domain 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
Dihydropteroate synthetase-like Cobalamin (vitamin B12)-binding domain 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Elongation factor Ts (EF-Ts), dimerisation domain Elongation factor Ts (EF-Ts), dimerisation domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase DNA mismatch repair protein MutL 11
FliG FliG 11
GIY-YIG endonuclease C-terminal UvrC-binding domain of UvrB 11
Ribosomal protein S5 domain 2-like DNA mismatch repair protein MutL 11
ATP-dependent DNA ligase DNA-binding domain DNA ligase/mRNA capping enzyme, catalytic domain 11
Zinc beta-ribbon DNA primase core 11
Lysozyme-like PGBD-like 11
Thiolase-like ACP-like 11
cAMP-binding domain-like FabD/lysophospholipase-like 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
HMA, heavy metal-associated domain HAD-like 11
"Winged helix" DNA-binding domain S-adenosyl-L-methionine-dependent methyltransferases 11
Glutathione synthetase ATP-binding domain-like Phosphoenolpyruvate/pyruvate domain 11
HD-domain/PDEase-like Nucleotidyltransferase 11
FAD-linked oxidoreductase ALDH-like 11
TGS-like Class II aaRS and biotin synthetases 11
Adenine nucleotide alpha hydrolases-like Adenine nucleotide alpha hydrolases-like 11
Hypothetical protein SAV1430 Fe-S cluster assembly (FSCA) domain-like 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
Methionine synthase domain Methionine synthase activation domain-like 11
Nucleic acid-binding proteins BRCT domain 11
Dimeric alpha+beta barrel Dimeric alpha+beta barrel 11
GAF domain-like Phosphoenolpyruvate/pyruvate domain 11
Aconitase iron-sulfur domain LeuD/IlvD-like 11
FKBP-like FKBP-like 11
Thiolase-like alpha/beta-Hydrolases 11
Single hybrid motif Single hybrid motif 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD CoaB-like 11
Glutamine synthetase/guanido kinase GatB/YqeY motif 11
alpha/beta-Hydrolases FMN-binding split barrel 11
HRDC-like HRDC-like 11
Periplasmic binding protein-like II ACT-like 11
OMPA-like OmpA-like 11
FAD/NAD(P)-binding domain PurM C-terminal domain-like 11
Trigger factor ribosome-binding domain Triger factor/SurA peptide-binding domain-like 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
Methylglyoxal synthase-like Cytidine deaminase-like 11
Nucleotidylyl transferase Riboflavin kinase-like 11
Adenine nucleotide alpha hydrolases-like DHS-like NAD/FAD-binding domain 11
YjeF N-terminal domain-like Ribokinase-like 11
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain "Winged helix" DNA-binding domain 11
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 11
Formin homology 2 domain (FH2 domain) ClpP/crotonase 11
Tryptophan synthase beta subunit-like PLP-dependent enzymes ACT-like 11
CarD-like TRCF domain-like 11
Heme-dependent peroxidases Heme-dependent peroxidases 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 11
ClpP/crotonase 6-phosphogluconate dehydrogenase C-terminal domain-like 11
FAD/NAD(P)-binding domain PurM N-terminal domain-like 11
CBS-domain pair EAL domain-like 11
Nucleotidylyl transferase tRNA-binding arm 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Pili subunits GspK insert domain-like 11
Class I glutamine amidotransferase-like GMP synthetase C-terminal dimerisation domain 11
Integrin alpha N-terminal domain Integrin alpha N-terminal domain 11
GspK insert domain-like GspK insert domain-like 11
NAD(P)-binding Rossmann-fold domains Serine metabolism enzymes domain 11
HAMP domain-like Nucleotide cyclase 11
Acyl-CoA N-acyltransferases (Nat) Carbon-nitrogen hydrolase 11
Dihydropteroate synthetase-like Methionine synthase activation domain-like 11
P-loop containing nucleoside triphosphate hydrolases C-terminal UvrC-binding domain of UvrB 11
Formyltransferase Bacterial luciferase-like 11
Ribonuclease H-like Nucleic acid-binding proteins 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
FAD/NAD(P)-binding domain 4Fe-4S ferredoxins 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Homodimeric domain of signal transducing histidine kinase Histidine-containing phosphotransfer domain, HPT domain 11
Nucleic acid-binding proteins ArfGap/RecO-like zinc finger 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) PRTase-like 11
N-terminal domain of MutM-like DNA repair proteins Glucocorticoid receptor-like (DNA-binding domain) 11
ACP-like alpha/beta-Hydrolases 11
Class I glutamine amidotransferase-like LD-carboxypeptidase A C-terminal domain-like 11
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 11
Toll/Interleukin receptor TIR domain P-loop containing nucleoside triphosphate hydrolases 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
HCP-like PGBD-like 11
PurM C-terminal domain-like PurM C-terminal domain-like 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
Nqo1 middle domain-like Nqo1C-terminal domain-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) Alpha subunit of glutamate synthase, C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain ACT-like 11
CheY-like Histidine-containing phosphotransfer domain, HPT domain 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Glutathione synthetase ATP-binding domain-like Succinyl-CoA synthetase domains 11
HAMP domain-like EAL domain-like 11
MgtE N-terminal domain-like CBS-domain pair 11
TerB-like Chaperone J-domain 11
Riboflavin synthase domain-like Riboflavin synthase domain-like 11
NAD(P)-binding Rossmann-fold domains TrkA C-terminal domain-like 11
2Fe-2S ferredoxin-like alpha-helical ferredoxin 11
PIN domain-like DNA/RNA polymerases 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
YhbC-like, N-terminal domain YhbC-like, C-terminal domain 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
Homeodomain-like Methylated DNA-protein cysteine methyltransferase, C-terminal domain 11
PreATP-grasp domain Methylglyoxal synthase-like 11
Probable ACP-binding domain of malonyl-CoA ACP transacylase alpha/beta-Hydrolases 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Quinoprotein alcohol dehydrogenase-like Cytochrome c 11
RuvA domain 2-like DNA helicase RuvA subunit, C-terminal domain 11
lambda repressor-like DNA-binding domains Periplasmic binding protein-like I 11
Adhesin YadA, collagen-binding domain Pili subunits 11
DNA repair protein MutS, domain II DNA repair protein MutS, domain III 11
Bacterial luciferase-like ACP-like 11
GroEL equatorial domain-like GroEL apical domain-like 11
R1 subunit of ribonucleotide reductase, N-terminal domain PFL-like glycyl radical enzymes 11
CBS-domain pair Homodimeric domain of signal transducing histidine kinase 11
PPK N-terminal domain-like Phospholipase D/nuclease 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Thiolase-like Thioesterase/thiol ester dehydrase-isomerase 11
CBS-domain pair Inosine monophosphate dehydrogenase (IMPDH) 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
FabD/lysophospholipase-like NAD(P)-binding Rossmann-fold domains 11
FMN-linked oxidoreductases Nitrite and sulphite reductase 4Fe-4S domain-like 11
Trigger factor ribosome-binding domain FKBP-like 11
UDP-Glycosyltransferase/glycogen phosphorylase UDP-Glycosyltransferase/glycogen phosphorylase 11
PH0987 N-terminal domain-like Cyclophilin-like 11
Aminoacid dehydrogenase-like, N-terminal domain Isocitrate/Isopropylmalate dehydrogenase-like 11
(Trans)glycosidases Glycosyl hydrolase domain 11
RNase III domain-like dsRNA-binding domain-like 11
(Trans)glycosidases Beta-D-glucan exohydrolase, C-terminal domain 11
Nucleotidyltransferase substrate binding subunit/domain ACT-like 11
N-terminal domain of bifunctional PutA protein ALDH-like 11
Thioredoxin-like TPR-like 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
PIN domain-like Ribonuclease H-like 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
Nucleotide-diphospho-sugar transferases Trimeric LpxA-like enzymes 11
Acetyl-CoA synthetase-like Acetyl-CoA synthetase-like 11
PurM N-terminal domain-like PurM N-terminal domain-like 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
Translation proteins Translation proteins 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
Formyltransferase Acetyl-CoA synthetase-like 11
CBS-domain pair MgtE membrane domain-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
Nucleic acid-binding proteins GAD domain-like 11
YrdC/RibB RibA-like 11
HMA, heavy metal-associated domain Calcium ATPase, transmembrane domain M 11
"Winged helix" DNA-binding domain LexA/Signal peptidase 11
NAD(P)-binding Rossmann-fold domains alpha/beta-Hydrolases 11
FAD-binding/transporter-associated domain-like Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain 11
ParB/Sulfiredoxin S-adenosyl-L-methionine-dependent methyltransferases 11
Class I glutamine amidotransferase-like Adenine nucleotide alpha hydrolases-like 11
Heme-dependent catalase-like Class I glutamine amidotransferase-like 11
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
alpha/beta-Hydrolases alpha/beta-Hydrolases 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
Tricorn protease N-terminal domain Composite domain of metallo-dependent hydrolases 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
Nucleotide-binding domain Nucleotide-binding domain 11
Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 11
NAD(P)-binding Rossmann-fold domains Succinyl-CoA synthetase domains 11
Glutathione synthetase ATP-binding domain-like Phosphohistidine domain 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
P-loop containing nucleoside triphosphate hydrolases HRDC-like 11
TGS-like ThrRS/AlaRS common domain 11
Carbamate kinase-like PUA domain-like 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
Glutamine synthetase, N-terminal domain Glutamine synthetase/guanido kinase 11
Alpha-L RNA-binding motif S-adenosyl-L-methionine-dependent methyltransferases 11
Kelch motif Kelch motif 11
Bacterial muramidases Lysozyme-like 11
Calcium ATPase, transduction domain A Metal cation-transporting ATPase, ATP-binding domain N 11
GAF domain-like Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain 11
Ribonuclease H-like DNA/RNA polymerases 11
S13-like H2TH domain Glucocorticoid receptor-like (DNA-binding domain) 11
Nucleotidyltransferase substrate binding subunit/domain Nucleotidyltransferase substrate binding subunit/domain 11
N-terminal domain of MutM-like DNA repair proteins S13-like H2TH domain 11
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 11
ClpP/crotonase NAD(P)-binding Rossmann-fold domains 11
C-terminal effector domain of the bipartite response regulators Protein kinase-like (PK-like) 11
DNA repair protein MutS, domain III P-loop containing nucleoside triphosphate hydrolases 11
NAD(P)-binding Rossmann-fold domains Siroheme synthase middle domains-like 11
Acetyl-CoA synthetase-like Bacterial luciferase-like 11
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
RuvA domain 2-like BRCT domain 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
Cadherin-like Soluble quinoprotein glucose dehydrogenase 11
Probable ACP-binding domain of malonyl-CoA ACP transacylase NAD(P)-binding Rossmann-fold domains 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
C-terminal UvrC-binding domain of UvrB RuvA domain 2-like 11
Class II aaRS and biotin synthetases GAD domain-like 11
NAD(P)-binding Rossmann-fold domains Isocitrate/Isopropylmalate dehydrogenase-like 11
N-acetylmuramoyl-L-alanine amidase-like PGBD-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
Class II aaRS and biotin synthetases C-terminal domain of transcriptional repressors 11
Adhesin YadA, collagen-binding domain Adhesin YadA, collagen-binding domain 11
Formyltransferase FMT C-terminal domain-like 11
Formate dehydrogenase/DMSO reductase, domains 1-3 ADC-like 11
PreATP-grasp domain PreATP-grasp domain 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11
Nucleic acid-binding proteins DNA helicase RuvA subunit, C-terminal domain 11
Thiolase-like Probable ACP-binding domain of malonyl-CoA ACP transacylase 11
Composite domain of metallo-dependent hydrolases Composite domain of metallo-dependent hydrolases 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
DPP6 N-terminal domain-like Metallo-dependent hydrolases 11
MetI-like MetI-like 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
Hsp33 domain HSP33 redox switch-like 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
FAD/NAD(P)-binding domain Nitrite and sulphite reductase 4Fe-4S domain-like 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
Aspartate/glutamate racemase Aspartate/glutamate racemase 11
Serine metabolism enzymes domain ACT-like 11
CBS-domain pair Nucleotide cyclase 11
Periplasmic binding protein-like II Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain 11
alpha-helical ferredoxin Nucleotide-binding domain 11
Rhodanese/Cell cycle control phosphatase Rhodanese/Cell cycle control phosphatase 11
Nucleotide-diphospho-sugar transferases Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain 11
NagB/RpiA/CoA transferase-like NagB/RpiA/CoA transferase-like 11
Resolvase-like KorB DNA-binding domain-like 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
FabD/lysophospholipase-like alpha/beta-Hydrolases 11
ATP-dependent DNA ligase DNA-binding domain Nucleic acid-binding proteins 11
ACT-like Formyltransferase 11
HMA, heavy metal-associated domain Calcium ATPase, transduction domain A 11
TolB, N-terminal domain Tricorn protease N-terminal domain 11
YlxR-like L30e-like 11
PKD domain 3-carboxy-cis,cis-mucoante lactonizing enzyme 11
DPP6 N-terminal domain-like Composite domain of metallo-dependent hydrolases 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain II 11
all-alpha NTP pyrophosphatases all-alpha NTP pyrophosphatases 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
Ribokinase-like Nucleotidylyl transferase 11
Dihydropteroate synthetase-like Methionine synthase domain 11
Nicotinate/Quinolinate PRTase N-terminal domain-like Nicotinate/Quinolinate PRTase C-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
Class II aaRS and biotin synthetases Translation proteins 11
TGS-like ACT-like 11
NAD(P)-binding Rossmann-fold domains 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Zinc beta-ribbon Prokaryotic SH3-related domain 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
TPR-like Clavaminate synthase-like 11
Nucleotidyltransferase TGS-like 11
Transmembrane di-heme cytochromes a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
HD-domain/PDEase-like ACT-like 11
TrmE connector domain P-loop containing nucleoside triphosphate hydrolases 11
dUTPase-like dUTPase-like 11
Nucleic acid-binding proteins PheT/TilS domain 11
Composite domain of metallo-dependent hydrolases YjgF-like 11
Nitrite/Sulfite reductase N-terminal domain-like Nitrite/Sulfite reductase N-terminal domain-like 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
NAD(P)-binding Rossmann-fold domains Tetrapyrrole methylase 11
Barwin-like endoglucanases Sporulation related repeat 11
Formate/glycerate dehydrogenase catalytic domain-like Serine metabolism enzymes domain 11
ISP domain Bet v1-like 11
DNA methylase specificity domain DNA methylase specificity domain 11
Formyltransferase ACP-like 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
beta-lactamase/transpeptidase-like Penicillin-binding protein associated domain 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
HD-domain/PDEase-like TGS-like 11
PilZ domain-like PilZ domain-like 11
Single hybrid motif Thiamin diphosphate-binding fold (THDP-binding) 11
Galactose mutarotase-like E set domains 11
Formate/glycerate dehydrogenase catalytic domain-like ACT-like 11
NAD(P)-binding Rossmann-fold domains ACP-like 11
DnaK suppressor protein DksA, alpha-hairpin domain Glucocorticoid receptor-like (DNA-binding domain) 11
Single hybrid motif TK C-terminal domain-like 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
CBS-domain pair CheY-like 11
NusB-like S-adenosyl-L-methionine-dependent methyltransferases 11
Rad51 N-terminal domain-like Rad51 N-terminal domain-like 11
Metal cation-transporting ATPase, ATP-binding domain N HAD-like 11
DNA clamp DNA clamp 11
FabD/lysophospholipase-like ACP-like 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
Thiamin diphosphate-binding fold (THDP-binding) Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 11
FAD-linked reductases, C-terminal domain 4Fe-4S ferredoxins 11
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
Phospholipase D/nuclease Phospholipase D/nuclease 11
PPK N-terminal domain-like PHP14-like 11
MgtE N-terminal domain-like MgtE membrane domain-like 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Histidine-containing phosphotransfer domain, HPT domain 11
NAD(P)-binding Rossmann-fold domains LDH C-terminal domain-like 11
Creatinase/prolidase N-terminal domain Creatinase/aminopeptidase 11
Translation proteins "Winged helix" DNA-binding domain 11
Nudix "Winged helix" DNA-binding domain 11
PDZ domain-like ClpP/crotonase 11
Siroheme synthase middle domains-like Tetrapyrrole methylase 11
PP2C-like Protein kinase-like (PK-like) 11
Nucleotidyltransferase Nucleotidyltransferase 11
Heat shock protein 70kD (HSP70), peptide-binding domain Heat shock protein 70kD (HSP70), C-terminal subdomain 11
FAD-binding/transporter-associated domain-like CO dehydrogenase flavoprotein C-terminal domain-like 11
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
Nucleotidyltransferase substrate binding subunit/domain Poly A polymerase C-terminal region-like 11
Starch-binding domain-like Porins 11
CBS-domain pair ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 11
PUA domain-like alpha/beta knot 11
S-adenosylmethionine synthetase S-adenosylmethionine synthetase 11
Carbon-nitrogen hydrolase Adenine nucleotide alpha hydrolases-like 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) FMN-linked oxidoreductases 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
alpha-helical ferredoxin ARM repeat 11
FabD/lysophospholipase-like Thioesterase/thiol ester dehydrase-isomerase 11
Tex N-terminal region-like Ribonuclease H-like 11
6-phosphogluconate dehydrogenase C-terminal domain-like UDP-glucose/GDP-mannose dehydrogenase C-terminal domain 11
PKD domain YVTN repeat-like/Quinoprotein amine dehydrogenase 11
"Winged helix" DNA-binding domain "Winged helix" DNA-binding domain 11
P-loop containing nucleoside triphosphate hydrolases RecA protein, C-terminal domain 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
Nucleic acid-binding proteins Anticodon-binding domain of PheRS 11
N-terminal domain of bifunctional PutA protein FAD-linked oxidoreductase 11
Folate-binding domain Aminomethyltransferase beta-barrel domain 11
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 11
Ribonuclease H-like P-loop containing nucleoside triphosphate hydrolases 11
PEP carboxykinase N-terminal domain PEP carboxykinase-like 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphoenolpyruvate/pyruvate domain 11
MFS general substrate transporter MFS general substrate transporter 11
3-carboxy-cis,cis-mucoante lactonizing enzyme YVTN repeat-like/Quinoprotein amine dehydrogenase 11
Nitrite and sulphite reductase 4Fe-4S domain-like Nitrite and sulphite reductase 4Fe-4S domain-like 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
N-terminal nucleophile aminohydrolases (Ntn hydrolases) SIS domain 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
Translation proteins PRC-barrel domain 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
CO dehydrogenase molybdoprotein N-domain-like Molybdenum cofactor-binding domain 11
Prokaryotic type I DNA topoisomerase Zinc beta-ribbon 11
"Winged helix" DNA-binding domain HRDC-like 11
TGS-like Class II aaRS ABD-related 11
P-loop containing nucleoside triphosphate hydrolases CarD-like 11
Metallo-dependent hydrolases YjgF-like 11
DNA repair protein MutS, domain II P-loop containing nucleoside triphosphate hydrolases 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
RmlC-like cupins Homeodomain-like 11
Tricorn protease N-terminal domain Metallo-dependent hydrolases 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
FMN-linked oxidoreductases Alpha subunit of glutamate synthase, C-terminal domain 11
Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain Phosphohistidine domain 11
GAF domain-like Nucleotide cyclase 11
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
DNA repair protein MutS, domain I DNA repair protein MutS, domain III 11
Chemotaxis receptor methyltransferase CheR, N-terminal domain S-adenosyl-L-methionine-dependent methyltransferases 11
Tex N-terminal region-like RuvA domain 2-like 11
FAD/NAD(P)-binding domain HI0933 insert domain-like 11
6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like 11
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 11
Metallo-hydrolase/oxidoreductase SCP-like 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11

Jump to [ Top of page · Add/remove domain pairs · Add/remove genomes · Domain combination pairs ]