SUPERFAMILY 1.75 HMM library and genome assignments server

Domain combination pairs in Buchnera aphidicola BCc

All pairs of domain combinations at the superfamily level are listed here.
The identification of domain pairs does not account for the possibility of non-contiguous domains. Inserted, or interlaced, domains are seen as having a simple pair ordering.

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Adjacent domain pairs graph

Graph of adjacent domain pairs.


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Domain combination pairs

207 domain combination pairs.
Click on a column heading to sort that column, or the 'View' button to see domain architetures for that domain pair combination.

Superfamily (N) Superfamily (C) Number of occurrances Number unique
Nucleotidylyl transferase Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 66
Actin-like ATPase domain Actin-like ATPase domain 63
NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 53
Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) 44
P-loop containing nucleoside triphosphate hydrolases Translation proteins 44
P-loop containing nucleoside triphosphate hydrolases P-loop containing nucleoside triphosphate hydrolases 44
P-loop containing nucleoside triphosphate hydrolases EF-G C-terminal domain-like 33
Alpha-L RNA-binding motif Pseudouridine synthase 31
ValRS/IleRS/LeuRS editing domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 33
ValRS/IleRS/LeuRS editing domain Nucleotidylyl transferase 33
Nucleic acid-binding proteins Nucleic acid-binding proteins 33
Nucleic acid-binding proteins Class II aaRS and biotin synthetases 32
EF-G C-terminal domain-like EF-G C-terminal domain-like 33
Ribosomal protein S5 domain 2-like Ribosomal protein S5 domain 2-like 22
Class II aaRS and biotin synthetases Class II aaRS ABD-related 22
Nucleotidyltransferase Poly A polymerase C-terminal region-like 22
Domain of the SRP/SRP receptor G-proteins P-loop containing nucleoside triphosphate hydrolases 22
Translation proteins EF-G C-terminal domain-like 22
P-loop containing nucleoside triphosphate hydrolases post-AAA+ oligomerization domain-like 21
Aminoacid dehydrogenase-like, N-terminal domain NAD(P)-binding Rossmann-fold domains 21
Translation proteins SH3-like domain Nucleic acid-binding proteins 22
Sigma2 domain of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 22
tRNA-binding arm Class II aaRS and biotin synthetases 21
Coiled-coil domain of nucleotide exchange factor GrpE Head domain of nucleotide exchange factor GrpE 21
ABC transporter transmembrane region P-loop containing nucleoside triphosphate hydrolases 21
P-loop containing nucleoside triphosphate hydrolases Restriction endonuclease-like 22
Single hybrid motif CoA-dependent acyltransferases 22
P-loop containing nucleoside triphosphate hydrolases Ribosomal protein S5 domain 2-like 22
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Ribosomal protein S5 domain 2-like 22
Thiamin diphosphate-binding fold (THDP-binding) TK C-terminal domain-like 22
Actin-like ATPase domain Heat shock protein 70kD (HSP70), peptide-binding domain 22
NAD(P)-binding Rossmann-fold domains 6-phosphogluconate dehydrogenase C-terminal domain-like 22
Class II aaRS and biotin synthetases ThrRS/AlaRS common domain 22
DnaJ/Hsp40 cysteine-rich domain HSP40/DnaJ peptide-binding domain 11
Nucleic acid-binding proteins P-loop containing nucleoside triphosphate hydrolases 11
Pre-protein crosslinking domain of SecA Helical scaffold and wing domains of SecA 11
Ribosomal protein L6 Ribosomal protein L6 11
Translation initiation factor IF3, N-terminal domain Translation initiation factor IF3, C-terminal domain 11
GroEL-intermediate domain like GroEL apical domain-like 11
Class II aaRS and biotin synthetases Translation proteins 11
PK beta-barrel domain-like Phosphoenolpyruvate/pyruvate domain 11
Class II aaRS and biotin synthetases Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) 11
Rho N-terminal domain-like P-loop containing nucleoside triphosphate hydrolases 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) ThrRS/AlaRS common domain 11
Nucleic acid-binding proteins RuvA domain 2-like 11
Ribosomal protein L7/12, oligomerisation (N-terminal) domain ClpS-like 11
Carbamoyl phosphate synthetase, small subunit N-terminal domain Class I glutamine amidotransferase-like 11
PUA domain-like Ribosomal protein S5 domain 2-like 11
Class II aaRS and biotin synthetases Anticodon-binding domain of PheRS 11
Ribosomal protein S5 domain 2-like GHMP Kinase, C-terminal domain 11
2Fe-2S ferredoxin-like Formate dehydrogenase/DMSO reductase, domains 1-3 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Type II DNA topoisomerase 11
GroEL equatorial domain-like GroEL-intermediate domain like 11
Phosphoenolpyruvate/pyruvate domain PK C-terminal domain-like 11
DNA-glycosylase Nudix 11
Ribosomal protein S5 domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
PIN domain-like 5' to 3' exonuclease, C-terminal subdomain 11
P-loop containing nucleoside triphosphate hydrolases TRCF domain-like 11
GroEL equatorial domain-like GroEL apical domain-like 11
Translation proteins ThrRS/AlaRS common domain 11
Translation proteins Translation proteins 11
Zinc beta-ribbon DNA primase DnaG, C-terminal domain 11
EF-G C-terminal domain-like Ribosomal protein S5 domain 2-like 11
PLP-binding barrel Alanine racemase C-terminal domain-like 11
Cytochrome c oxidase subunit II-like, transmembrane region Cupredoxins 11
Nucleotidylyl transferase Alpha-L RNA-binding motif 11
6-phosphogluconate dehydrogenase C-terminal domain-like 6-phosphogluconate dehydrogenase C-terminal domain-like 11
Sm-like ribonucleoproteins Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
Aldolase 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 11
Thiolase-like Thiolase-like 11
Nucleotidylyl transferase Ribosomal protein L25-like 11
Translation proteins PRC-barrel domain 11
FAD/NAD(P)-binding domain FAD/NAD-linked reductases, dimerisation (C-terminal) domain 11
Nqo1 middle domain-like Nqo1C-terminal domain-like 11
Carbamate kinase-like ACT-like 11
UBA-like Elongation factor Ts (EF-Ts), dimerisation domain 11
P-loop containing nucleoside triphosphate hydrolases EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases TrpR-like 11
Insert subdomain of RNA polymerase alpha subunit C-terminal domain of RNA polymerase alpha subunit 11
Domain of the SRP/SRP receptor G-proteins Signal peptide-binding domain 11
Ribonuclease PH domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
PK beta-barrel domain-like PK C-terminal domain-like 11
Ribosomal protein S5 domain 2-like Ribonuclease PH domain 2-like 11
Ribosomal protein S5 domain 2-like HSP90 C-terminal domain 11
ThrRS/AlaRS common domain Class II aaRS ABD-related 11
Glutathione synthetase ATP-binding domain-like Carbamoyl phosphate synthetase, large subunit connection domain 11
Chorismate mutase II Periplasmic binding protein-like II 11
Nucleotidylyl transferase An anticodon-binding domain of class I aminoacyl-tRNA synthetases 11
ACT-like NAD(P)-binding Rossmann-fold domains 11
RNase III domain-like dsRNA-binding domain-like 11
Adenine nucleotide alpha hydrolases-like PheT/TilS domain 11
L9 N-domain-like Ribosomal protein L9 C-domain 11
Periplasmic binding protein-like II GlnB-like 11
Glutathione synthetase ATP-binding domain-like Glutathione synthetase ATP-binding domain-like 11
Chaperone J-domain DnaJ/Hsp40 cysteine-rich domain 11
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase HSP90 C-terminal domain 11
P-loop containing nucleoside triphosphate hydrolases Signal peptide-binding domain 11
Ribosomal protein S5 domain 2-like Nucleic acid-binding proteins 11
Nucleic acid-binding proteins Rad51 N-terminal domain-like 11
Nucleotidylyl transferase tRNA-binding arm 11
Adenine nucleotide alpha hydrolases-like MesJ substrate recognition domain-like 11
P-loop containing nucleoside triphosphate hydrolases Helical scaffold and wing domains of SecA 11
Formyltransferase FMT C-terminal domain-like 11
Nqo1 FMN-binding domain-like Nqo1C-terminal domain-like 11
Zn-dependent exopeptidases Bacterial exopeptidase dimerisation domain 11
Eukaryotic type KH-domain (KH-domain type I) Nucleic acid-binding proteins 11
Carbamoyl phosphate synthetase, large subunit connection domain Methylglyoxal synthase-like 11
RBP11-like subunits of RNA polymerase C-terminal domain of RNA polymerase alpha subunit 11
DNA clamp DNA clamp 11
Carbamate kinase-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 11
Ribonuclease PH domain 2-like Nucleic acid-binding proteins 11
2Fe-2S ferredoxin-like 4Fe-4S ferredoxins 11
Chaperone J-domain HSC20 (HSCB), C-terminal oligomerisation domain 11
NagB/RpiA/CoA transferase-like D-ribose-5-phosphate isomerase (RpiA), lid domain 11
PreATP-grasp domain Carbamoyl phosphate synthetase, large subunit connection domain 11
IlvD/EDD N-terminal domain-like LeuD/IlvD-like 11
UROD/MetE-like UROD/MetE-like 11
Prokaryotic type KH domain (KH-domain type II) Rad51 N-terminal domain-like 11
Tubulin nucleotide-binding domain-like Tubulin C-terminal domain-like 11
Ribosomal protein S5 domain 2-like Eukaryotic type KH-domain (KH-domain type I) 11
ACT-like ACT-like 11
PUA domain-like P-loop containing nucleoside triphosphate hydrolases 11
Insert subdomain of RNA polymerase alpha subunit RBP11-like subunits of RNA polymerase 11
Translation proteins Initiation factor IF2/eIF5b, domain 3 11
OMPA-like OmpA-like 11
HesB-like domain Fe-S cluster assembly (FSCA) domain-like 11
Nqo1 FMN-binding domain-like Nqo1 middle domain-like 11
Obg GTP-binding protein N-terminal domain P-loop containing nucleoside triphosphate hydrolases 11
PreATP-grasp domain PreATP-grasp domain 11
4Fe-4S ferredoxins Formate dehydrogenase/DMSO reductase, domains 1-3 11
Glucocorticoid receptor-like (DNA-binding domain) P-loop containing nucleoside triphosphate hydrolases 11
CBS-domain pair FAD-binding/transporter-associated domain-like 11
Transcription factor NusA, N-terminal domain Rad51 N-terminal domain-like 11
HisI-like all-alpha NTP pyrophosphatases 11
P-loop containing nucleoside triphosphate hydrolases Initiation factor IF2/eIF5b, domain 3 11
Translation proteins Ribosomal protein S5 domain 2-like 11
Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex CoA-dependent acyltransferases 11
Prokaryotic type KH domain (KH-domain type II) Ribosomal protein S3 C-terminal domain 11
CarD-like P-loop containing nucleoside triphosphate hydrolases 11
Zinc beta-ribbon DNA primase core 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
Putative DNA-binding domain Putative DNA-binding domain 11
Ribosomal protein S5 domain 2-like Type II DNA topoisomerase 11
HSP40/DnaJ peptide-binding domain HSP40/DnaJ peptide-binding domain 11
Ribonuclease PH domain 2-like Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 11
Sigma3 and sigma4 domains of RNA polymerase sigma factors Sigma3 and sigma4 domains of RNA polymerase sigma factors 11
Ribonuclease PH domain 2-like Ribonuclease PH domain 2-like 11
PheT/TilS domain Class II aaRS and biotin synthetases 11
Rad51 N-terminal domain-like Rad51 N-terminal domain-like 11
Prokaryotic type KH domain (KH-domain type II) Prokaryotic type KH domain (KH-domain type II) 11
Transcription factor NusA, N-terminal domain Prokaryotic type KH domain (KH-domain type II) 11
Putative DNA-binding domain PheT/TilS domain 11
N-utilization substance G protein NusG, N-terminal domain Translation proteins SH3-like domain 11
DNA ligase/mRNA capping enzyme, catalytic domain RuvA domain 2-like 11
Type II DNA topoisomerase GyrA/ParC C-terminal domain-like 11
P-loop containing nucleoside triphosphate hydrolases Pre-protein crosslinking domain of SecA 11
Single hybrid motif Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex 11
Glutathione synthetase ATP-binding domain-like Methylglyoxal synthase-like 11
PheT/TilS domain Anticodon-binding domain of PheRS 11
Riboflavin synthase domain-like Ferredoxin reductase-like, C-terminal NADP-linked domain 11
Thiamin diphosphate-binding fold (THDP-binding) DHS-like NAD/FAD-binding domain 11
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases tRNA-binding arm 11
Nucleic acid-binding proteins Prokaryotic type KH domain (KH-domain type II) 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Mechanosensitive channel protein MscS (YggB), C-terminal domain 11
HAD-like Ribosomal protein S5 domain 2-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Nucleotidylyl transferase 11
P-loop containing nucleoside triphosphate hydrolases FtsH protease domain-like 11
ClpP/crotonase ClpP/crotonase 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Nucleic acid-binding proteins 11
P-loop containing nucleoside triphosphate hydrolases TGS-like 11
Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS) Translation proteins 11
Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain Nucleotidylyl transferase 11
Rho N-terminal domain-like Nucleic acid-binding proteins 11
PIN domain-like DNA/RNA polymerases 11
Enolase N-terminal domain-like Enolase C-terminal domain-like 11
PIN domain-like Ribonuclease H-like 11
ValRS/IleRS/LeuRS editing domain tRNA-binding arm 11
PreATP-grasp domain Glutathione synthetase ATP-binding domain-like 11
S-adenosyl-L-methionine-dependent methyltransferases Putative methyltransferase TM0872, insert domain 11
Ribosomal L11/L12e N-terminal domain Ribosomal protein L11, C-terminal domain 11
Ribonuclease H-like DNA/RNA polymerases 11
DNA primase core DNA primase DnaG, C-terminal domain 11
5' to 3' exonuclease, C-terminal subdomain Ribonuclease H-like 11
Carbamate kinase-like NAD(P)-binding Rossmann-fold domains 11
GreA transcript cleavage protein, N-terminal domain FKBP-like 11
Diaminopimelate epimerase-like Diaminopimelate epimerase-like 11
Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 Eukaryotic type KH-domain (KH-domain type I) 11
Adenine nucleotide alpha hydrolases-like Argininosuccinate synthetase, C-terminal domain 11
Chaperone J-domain HSP40/DnaJ peptide-binding domain 11
MesJ substrate recognition domain-like PheT/TilS domain 11
PreATP-grasp domain Methylglyoxal synthase-like 11
Mechanosensitive channel protein MscS (YggB), transmembrane region Sm-like ribonucleoproteins 11
Nucleic acid-binding proteins GAD domain-like 11
Methionyl-tRNA synthetase (MetRS), Zn-domain Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 11
P-loop containing nucleoside triphosphate hydrolases Prokaryotic type KH domain (KH-domain type II) 11
DNA ligase/mRNA capping enzyme, catalytic domain Nucleic acid-binding proteins 11
Translation proteins EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain 11
Class II aaRS and biotin synthetases GAD domain-like 11
CarD-like TRCF domain-like 11
Nqo5-like HydB/Nqo4-like 11
Putative DNA-binding domain Anticodon-binding domain of PheRS 11
Transcription factor NusA, N-terminal domain Nucleic acid-binding proteins 11
ACT-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain 11
N-terminal domain of DnaB helicase P-loop containing nucleoside triphosphate hydrolases 11
5' to 3' exonuclease, C-terminal subdomain DNA/RNA polymerases 11
dsRNA-binding domain-like Ribosomal protein S5 domain 2-like 11
Putative DNA-binding domain Class II aaRS and biotin synthetases 11

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